Table of Contents · Sandra A. Moriarity, Senior Production Editor Sharon L. Quimby, Managing...

Table of ContentsNeurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015

EDITOR’S CORNER

e137 The first anniversary issueJ. Dalmau

EDITORIAL

e140 Unique invariant CD81 T cell population persistsin MSJ.J. Sabatino, Jr and S.S. Zamvil

Companion article, e107

ARTICLES

e107 ab T-cell receptors frommultiple sclerosis brain lesionsshow MAIT cell–related featuresK. Held, L. Bhonsle-Deeng, K. Siewert, W. Sato,E. Beltrán, S. Schmidt, G. Rühl, J.K.M. Ng, P. Engerer,M. Moser, W.E.F. Klinkert, H. Babbe, T. Misgeld,H. Wekerle, D.-A. Laplaud, R. Hohlfeld, andK. Dornmair

Editorial, e140

e119 Complement activity is associatedwithdisease severityin multifocal motor neuropathyL. Vlam, E.A. Cats, O. Harschnitz, M.D. Jansen,S. Piepers, J.H. Veldink, H. Franssen, A.C.J. Stork,E. Heezius, S.H.M. Rooijakkers, B.L. Herpers,J.A. van Strijp, L.H. van den Berg, andW.L. van der Pol

e109 Expanding spectrum of neurologic manifestationsin patients with NLRP3 low-penetrancemutationsE. Schuh, P. Lohse, B. Ertl-Wagner, M. Witt,M. Krumbholz, M. Frankenberger, L.-A. Gerdes,R. Hohlfeld, and T. Kümpfel

e111 Hippocampal volume and depressive symptoms arelinked to serum IL-18 in schizophreniaP. Bossù, F. Piras, I. Palladino, M. Iorio, F. Salani,A. Ciaramella, C. Chiapponi, C. Caltagirone, andG. Spalletta

e120 Oral contraceptives combined with interferon b inmultiple sclerosisC. Pozzilli, L. De Giglio, V.T. Barletta, F. Marinelli,F.D. Angelis, V. Gallo, V.A. Pagano, S. Marini,M.C. Piattella, V. Tomassini, and P. Pantano

e123 Hematologic modifications in natalizumab-treatedmultiple sclerosis patients: An 18-monthlongitudinal studyC. Bridel, Y. Beauverd, K. Samii, andP.H. Lalive

e113 Acute lower motor neuron syndrome andspinal cord gray matter hyperintensities inHIV infectionI.I. Bogoch, M.R. Wilson, D.A. Chad, and N. Venna

e121 Aquaporin-4 antibody isoform binding specificities donot explain clinical variations in NMOJ. Kitley, M. Woodhall, M.I. Leite, J. Palace,A. Vincent, and P. Waters

e117 Randomized phase 1b trial of MOR103, a humanantibody to GM-CSF, in multiple sclerosisC.S. Constantinescu, A. Asher, W. Fryze,W. Kozubski, F. Wagner, J. Aram, R. Tanasescu,R.P. Korolkiewicz, M. Dirnberger-Hertweck,S. Steidl, S.E. Libretto, T. Sprenger, andE.W. Radue

e124 Myopathy with anti-HMGCR antibodies: Perimysiumand myofiber pathologyA. Alshehri, R. Choksi, R. Bucelli, and A. Pestronk

e122 ILAE type 3 hippocampal sclerosis in patients withanti-GAD–related epilepsyR.L. Glover, L.V. DeNiro, P.A. Lasala,K.M. Weidenheim, J.J. Graber, and A. Boro

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e132 Predictive value of early brain atrophy on response inpatients treated with interferon b

F.C. Pérez-Miralles, J. Sastre-Garriga,A. Vidal-Jordana, J. Río, C. Auger, D. Pareto,M. Tintoré, A. Rovira, and X. Montalban

e127 Caspr2 autoantibodies target multiple epitopesA.L. Olsen, Y. Lai, J. Dalmau, S.S. Scherer, andE. Lancaster

e129 Impact of MS genetic loci on familialaggregation, clinical phenotype, and diseasepredictionF. Esposito, C. Guaschino, M. Sorosina, F. Clarelli,L. Ferre’, E. Mascia, S. Santoro, M. Pagnesi,M. Radaelli, B. Colombo, L. Moiola, M. Rodegher,E. Stupka, V. Martinelli, G. Comi, andF.M. Boneschi

VIEWS & REVIEWS

e110 Aquaporin-4 autoimmunityA. Zekeridou and V.A. Lennon

e135 Acute optic neuritis: Unmet clinical needs and modelfor new therapiesS.L. Galetta, P. Villoslada, N. Levin, K. Shindler,H. Ishikawa, E. Parr, D. Cadavid, andL.J. Balcer

e134 Update on biomarkers in neuromyelitisopticaE. Melamed, M. Levy, P.J. Waters, D.K. Sato,J.L. Bennett, G.R. John, D.C. Hooper,A. Saiz, A. Bar-Or, H.J. Kim, L. Pandit,M.I. Leite, N. Asgari, N. Kissani, R. Hintzen,R. Marignier, S. Jarius, J. Marcelletti, T.J. Smith,M.R. Yeaman, and M.H. Han, on behalf of theGJCF-ICC&BR

CLINICAL/SCIENTIFIC NOTES

e108 Varicella-zoster virus encephalitis localized to thebilateral medial temporal lobesR. Yajima, K. Utsumi, T. Ishihara, M. Kanazawa,K. Okamoto, I. Kawachi, and M. Nishizawa

e114 Allergic encephalitis with gelastic status epilepticusinduced by wasp stingR. Jimenez-Sanders, R. Behrouz, andN. Tsakadze

e118 Posterior cortical and white matter changes on MRI inanti-AMPA receptor antibody encephalitisM. Elamin, R. Lonergan, R.P. Killeen, S. O’Riordan,N. Tubridy, and C. McGuigan

e128 Diagnostic value of MRI in inflammatory myositisT.T. Lai and T. Mozaffar

e130 Earlier treatment of NMDAR antibody encephalitis inchildren results in a better outcomeS. Byrne, C.Walsh, Y. Hacohen, E. Muscal, J. Jankovic,A. Stocco, R.C. Dale, A. Vincent, M. Lim, and M. King

e125 Widespread arterial infection by varicella-zoster virusexplains refractory giant cell arteritisD.Gilden, T.White, S.L. Galetta, F. Fogt, andM.A. Nagel

e126 Transient anti-NMDAR encephalitis in a newborn infantdue to transplacental transmissionM. Hilderink, M.J. Titulaer, M.W.J. Schreurs, K. Keizer,and J.E.H. Bunt

e136 Sleep disorder, chorea, and dementia associated withIgLON5 antibodiesM.M. Simabukuro, L. Sabater, T. Adoni, R.G. Cury,M.S. Haddad, C.H. Moreira, L. Oliveira,M. Boaventura, R.C. Alves, L.A. Soster, R. Nitrini,C. Gaig, J. Santamaria, J. Dalmau, and F. Graus

Table of Contentscontinued


e131 Anti-MOG antibodies are frequently associated withsteroid-sensitive recurrent optic neuritisK. Chalmoukou, H. Alexopoulos, S. Akrivou,P. Stathopoulos, M. Reindl, and M.C. Dalakas

CORRECTION

e133 Encephalomyeloneuropathy with CRMP-5antibodies in a patient with a primary mediastinalserinoma

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Cover image: HMGCR-antibody associated myopathy with involvement of perimysialconnective tissue and muscle fibers demonstrated by abnormal alkaline phosphatase stain.See “Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology.”

Table of Contentscontinued


Neurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015

VISION: Neurology: Neuroimmunology & Neuroinflammation will bethe premier peer-reviewed journal for experts in the fields ofNeuroimmunology and Neuroinflammation.

MISSION: Neurology: Neuroimmunology & Neuroinflammation willprovide neurologists with peer-reviewed articles, editorials, andreviews to enhance patient care, education, and clinical &translational research.

EditorNeurology: Neuroimmunology & NeuroinflammationJosep O. Dalmau, MD, PhDICREA-University of BarcelonaBarcelona, SpainUniversity of PennsylvaniaPhiladelphia, PATel: 612-928-6400Toll-free: 800-957-3182 (US)Fax: [email protected]

Editor-in-ChiefNeurology®Robert A. Gross, MD, PhD, FAANProfessor of Neurology and of Pharmacology and PhysiologyStrong Epilepsy CenterUniversity of Rochester Medical CenterRochester, NYTel: 612-928-6400Toll-free: 800-957-3182 (US)Fax: [email protected]

Editorial InquiriesTel: 612-928-6400Toll-free: 800-957-3182 (US)Fax: [email protected]

Academy OfficersTerrence L. Cascino, MD, FAAN, PresidentRalph L. Sacco, MD, MS, FAAN, President ElectJames C. Stevens, MD, FAAN, Vice PresidentAaron E. Miller, MD, FAAN, SecretaryLisa M. Shulman, MD, FAAN, TreasurerTimothy A. Pedley, MD, FAAN, Past President

Executive Office, American Academy of NeurologyCatherine M. Rydell, CAE, Executive Director/CEO201 Chicago AveMinneapolis, MN 55415Tel: 612-928-6100

Editorial OfficePatricia K. Baskin, MS, Executive EditorKathleen M. Pieper, Managing Editor, NeurologySandra A. Moriarity, Senior Production EditorSharon L. Quimby, Managing Editor, Neurology® Clinical PracticeMorgan S. Sorenson, Managing Editor, Neurology: Neuroimmunology

& NeuroinflammationLee Ann Kleffman, Managing Editor, Neurology® GeneticsCynthia S. Abair, MA, Senior Graphics EditorRobert J. Witherow, Senior Editorial AssociateKaren Skaja, Editorial AssociateAndrea R. Wagner, Editorial AssistantKaitlyn Aman Ramm, Editorial AssistantKristen Swendsrud, Editorial Assistant

PublisherWolters KluwerBaltimore, MD

Publishing StaffKim Jansen, Executive PublisherAlexandra Lazerow, Production Team Leader, AAN JournalsStephanie Abrahams, Senior Production EditorNick Strickland, Production Associate






EDITORNeurology: Neuroimmunology & NeuroinflammationJosep O. Dalmau, MD, PhDICREA-University of BarcelonaBarcelona, SpainUniversity of PennsylvaniaPhiladelphia, PA

EDITOR-IN-CHIEFNeurologyRobert A. Gross, MD, PhD, FAANProfessor of Neurology and of Pharmacology and PhysiologyStrong Epilepsy CenterUniversity of Rochester Medical CenterRochester, NY

DEPUTY EDITORSNeurologyDavid S. Knopman, MD, FAANProfessor of NeurologyDepartment of NeurologyCollege of MedicineMayo ClinicRochester, MN

Neurology: Neuroimmunology & NeuroinflammationScott S. Zamvil, MD, PhD, FAANDepartment of NeurologyUniversity of California, San FranciscoSan Francisco, CA

ASSOCIATE EDITORSNeurology: Neuroimmunology & NeuroinflammationMichael Heneka, MDUniversity of BonnBonn, GermanySpecialties: Neurodegeneration, stroke

Robyn S. Klein, MD, PhDWashington University School of MedicineSt. Louis, MOSpecialty: Infectious disease

Friedmann Paul, MDCharite University HospitalBerlin, GermanySpecialties: Multiple sclerosis, neuromyelitis optica, neuroimaging(magnetic resonance imaging, optical coherence tomography)

Lan Zhou, MD, PhDMount Sinai School of MedicineNew York, NYSpecialty: Neuromuscular

EDITORIAL BOARDRohit Aggarwal, MD, MS, University of Pittsburgh, Pittsburgh, PASergio E. Baranzini, PhD, University of San Francisco, San Francisco, CASusanne Benseler, MD, Calgary, Alberta, CanadaJeffrey L. Bennett, MD, PhD, FAAN, University of Colorado, Aurora, COSéverine Boillée, PhD, Hôpital de la Salpêtriere, Paris, FranceMatthijs C. Brouwer, MD, PhD, Adademic Medical Center, Amsterdam,The Netherlands

David B.Clifford,MD, FAAN,WashingtonUniversity School ofMedicine,St. Louis, MO

Russell C. Dale, MBChB, MRCP, PhD, University of Sydney, Sydney,Australia

Oscar H. Del Brutto, MD, FAAN, Clinica, Kennedy, Guayaquil,Ecuador

Thomas G. Forsthuber, MD, University of Texas, San Antonio, TXJoseph El Khoury, MD, Massachusetts General Hospital, Boston, MAMarkus P. Kummer, PhD, University of Bonn, Bonn, GermanyJun Li, MD, PhD, Vanderbilt University, Nashville, TNLin Mei, MD, PhD, Georgia Regents University, Augusta, GeorgiaChristopher Power, MD, University of Alberta, Alberta, CanadaRichard M. Ransohoff, MD, Biogen Idec, Boston, MAChristine Stadelmann, MD, University of Göttingen, Göttingen,Germany

Israel Steiner, MD, Rabin Medical Center, Petach Tikva, IsraelLawrence Steinman, MD, FAAN, Stanford University, Stanford, CAJesper Tegnér, PhD, MSc, Karolinska University Hospital, Stockholm,Sweden

Maarten J. Titulaer, MD, PhD, Erasmus Medical Center, Rotterdam,The Netherlands

Hugh J. Willison, MBBS, PhD, University of Glasgow, Glasgow, UK

LEVEL OF EVIDENCE REVIEW TEAMMelissa J. Armstrong, MD, Baltimore, MDRichard L. Barbano, MD, PhD, FAAN, Rochester, NYRichard M. Dubinsky, MD, MPH, FAAN, Kansas City, KSJeffrey J. Fletcher, MD, MSc, Ann Arbor, MIGary M. Franklin, MD, MPH, FAAN, Seattle, WADavid S. Gloss II, MD, MPH&TM, Danville, PAJohn J. Halperin, MD, FAAN, Summit, NJJason Lazarou, MSc, MD, Toronto, Ontario, CanadaSteven R. Messé, MD, FAAN, Philadelphia, PAPushpa Narayanaswami, MBBS, DM, FAAN, Boston, MAAlex Rae-Grant, MD, Cleveland, OH






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