TABLE OF CONTENTS

Th_PM_OS1: PDEs in Biomedical Image Analysis A Template-Propagation Method for Segmentation of Filamentous Structures in Electron Tomograms...............................................................................1 Sriram Subramaniam, Peijun Zhang, David Germain, Tracey Rouault, NIH; Weicheng Shen, SAIC;

A New Approach for 3D Segmentation of Cellular Tomograms Obtained Using Three-Dimensional Electron Microscopy ..........................................................5 Alberto Bartesaghi, Guillermo Sapiro, University of Minnesota; Stanton Lee, Jon Lefman, Sharon Wahl, Sriram Subramaniam, National Institutes of Health; Jan Orenstein, George Washington University;

DT-MRI Estimation, Regularization and Fiber Tractography..................................9 Rachid Deriche, INRIA; David Tschumperle, INRIA; Christophe Lenglet, INRIA

A Hybrid 3D Segmentation Framework.....................................................................13 Dimitris Metaxas, Rutgers University

Variational Methods and Partial Differential Equations in Cardiac Image Analysis ..............................................................................................................17 Nikos Paragios, Ecole Nationale des Ponts et Chaussees

Image Interpolation Based on Optimal Mass Preserving Mappings .......................21 Lei Zhu, Allen Tannenbaum, Georgia Institute of Technology

Th_PM_OS2: Advanced Methods in Ultrasound Imaging Dual-Mode Ultrasound Phased Arrays for Imaging and Therapy ..........................25 Emad Ebbini, University of Minnesota; Hui Yao, University of Minnesota

Microbubbles for Ultrasound Diagnosis and Therapy..............................................29 J. Fowlkes, Oliver Kripfgans, Paul Carson, University of Michigan

Velocity Vector Estimation in Synthetic Aperture Flow and B-Mode Imaging .....33 Jorgen Jensen, Technical University of Denmark

Coded Excitation Methods in Biomedical Ultrasound ..............................................37 Matthew O'Donnell, Yao Wang, University of Michigan

Imaging Tissue Mechanical Properties Using Impulsive Acoustic Radiation Force.............................................................................................................41 Mary Scott Soo, Mark Palmeri, Kathryn Nightingale, Amy Congdon, Kristin Frinkley, Gregg Trahey, Duke University

Motion Tracking for Palpation Imaging.....................................................................45 Timothy Hall, Jingfeng Jiang, University of Wisconsin

3D Intravascular Ultrasound Palpography for Vulnerable Plaque Detection........49 Ton van der Steen, Erasmus Medical Centre

Th_PM_OS3: Imaging of Gene Expression: From Microarrays to In Vivo Studies Automated Interpretation of Subcellular Location Patterns....................................53 Robert Murphy, Carnegie Mellon University

M-FISH Image Registration and Classification.........................................................57 Yu-Ping Wang, UMKC

Super-Resolution Tracking of Weak Fluorescent Markers in 3D: Application in Dissecting Mechanics of Chromosome Segregation using Fluorescence Imaging and Molecular Genetics in Yeast..................................................................61 Gaudenz Danuser, The Scripps Research Institute

Pareto Depth Sampling Distributions for Gene Ranking .........................................65 Alfred Hero, Sepidarseh Zareparsi, Anand Swaroop, University of Michigan; Gilles Fleury, ESE

Automated Confocal Microscopy: The Way of Achieving both Quality and Quantity in 3D Image Cytometry................................................................................69 Michal Kozubek, Petr Matula, Pavel Matula, Masaryk University

High Resolution Detection of Chromosome Abnormalities with Single Copy Fluorescence In Situ Hybridization.............................................................................73 Peter Rogan, Joan Knoll, Children's Mercy Hospital and Clinics

Th_PM_OC4: Image Segmentation Cortical Surface Flattening Using Least Square Conformal Mapping with Minimal Metric Distortion...........................................................................................77 Lili Ju, Josh Stern, Kelly Rehm, Kirt Schaper, David Rottenberg, University of Minnesota; Monica Hurdal, Florida State University

Anatomical Guided Segmentation with Non-Stationary Tissue Class Distributions in an Expectation-Maximization Framework.....................................81 Kilian Pohl, W. Eric Grimson, MIT; Sylvain Bouix, Ron Kikinis, Harvard

Segmentation of 3D Deformable Objects with Level Set Based Prior Models........85 Jing Yang, Hemant Tagare, Lawrence Staib, James Duncan, Yale University

Skeletonzation by Blocks for Large 3D Datasets: Application To Brain Microcirculation............................................................................................................89 Celine Fouard, Gregoire Malandain, INRIA; Steffen Prohaska, Zuse Institute Berlin (ZIB); Malte Westerhoff, INDEED Visual Concept; Francis Cassot, INSERM U455; Christophe Mazel, Didier Asselot, TGS Europe; Jean-Pierre Marc-Vergnes, INSER

Segmentation of Connective Tissue in the Optic Nerve Head Using an Anisotropic Markov Random Field ............................................................................93 Vicente Grau, LSU Eye Center; J. Crawford Downs, Claude Burgoyne, LSU Eye Center

Level Set Method for Skull-Stripping MR Brain Images .........................................97 Haihong Zhuang, Daniel Valentino, University of California Los Angeles

Normalization of Joint Image-Intensity Statistics in MRI using the Kullback-Leibler Divergence.....................................................................................101 Neil Weisenfeld, Simon Warfield, Brigham and Women's Hospital/Harvard Medical School

Microarray Gene Expression Data Analysis ............................................................105 Yuhua Ding, Jacqueline Fairley, George Vachtsevanos, Andrew Gardner, Georgia Inst. Technology; Petia Simeonova, National Institute for Occupational Safety and Health

Robust Unsupervised Tissue Classification in MR Images.....................................109 Dzung Pham, Jerry Prince, Johns Hopkins University

Likelihood Function Analysis for Segmentation of Mammographic Masses for Various Margin Groups .............................................................................................113 Lisa Kinnard, Georgetown University, Howard University; Shih-Chung Lo, Georgetown University; Erini Makariou, Georgetown University; Teresa Osicka, Georgetown University; Paul Wang, Howard University; Matthew Freedman, Georgetown University; Mohamed Chouikha, Howard University

Fr_AM_P1: Image Segmentation I Quality Processing of Microarray Image Data through Image Inpainting and Texture Synthesis ........................................................................................................117 Paul O'Neill, George Magoulas, Xiaohui Liu, Brunel Univeristy

Toward Leukocyte Recognition Using Morphometry, Texture And Color ..........121 Daniela Sabino, Luciano Costa, USP; Marco Zago, Edgar Rizzatti, FMRP-USP

4-D Lesion Detection Using Expectation-Maximization and Hidden Markov Model............................................................................................................................125 Jeffrey Solomon, Sensor Systems, Inc.; Arun Sood, George Mason University

Segmentation of in-vitro Endothelial Cell Networks................................................129 Fabrizio Lamberti, Bartolomeo Montrucchio, Politecnico di Torino

Vascular Segmentation in Three-Dimensional Rotational Angiography Based on Maximum Intensity Projections................................................................133 Rui Gan, Albert C. S. Chung, Wilbur C. K. Wong, Department of Computer Science, the Hong Kong University of Science and Technology; Simon C.H. Yu, The Prince of Wales Hospital

A New Image Segmentation And Smoothing Model ...............................................137 Song Gao, Tien Bui, Department of Computer Science, Concordia University

An Adaptive Speed Term Based on Generalized Fuzzy Operator for Level Set Segmentation...............................................................................................141 Yazhong Lin, Wufan Chen, First Military Medical University

Tissue Color Images Segemntation Using Artificial Neural Networks..................145 Mohamed Sammouda, Mohamed Benaichouche, Prince Sultan University; Rachid Sammouda, Sharjah University; Noboru Niki, Tokushima University

Image Segmentation with the Combination of the PCA- and ICA-Based Modes of Shape Variation..........................................................................................149 Juha Koikkalainen, Helsinki University of Technology; Jyrki Lötjönen, VTT Information Technology

Automatic 2D Segmentation of the Left Ventricle in Tagged Cardiac MRI Using Motion Information .........................................................................................153 Julien Milles, Anneke van Susteren, Theo Arts, CARIM - Maastricht University; Patrick Clarysse, Pierre Croisille, Isabelle Magnin, CREATIS - INSA Lyon University

Hierarchical Segmentation of Multiple Sclerosis Lesions in Multi-Sequence MRI ..............................................................................................................................157 Guillaume Dugas-Phocion, Miguel Angel Gonzalez Ballester, Grégoire Malandain, Nicholas Ayache, INRIA Sophia; Christine Lebrun, Stéphane Chanalet, Caroline Bensa, CHU Pasteur, Service de Neurologie

Combining Fuzzy Logic and Level Set Methods for 3D MRI Brain Segmentation ...............................................................................................................161 Cybèle Ciofolo, Christian Barillot, IRISA/CNRS; Pierre Hellier, IRISA/INRIA

Multiresolution Automatic Segmentation of T1-Weighted Brain MR Images .....165 Mahmood Zeydabadi, Reza A. Zoroofi, Hamid Soltanian-zadeh, Engineering Faculty, Tehran University

Fr_AM_P2: Shape Analysis Meta-Analysis of Functional Imaging Studies Using a Geometric Model of the Cortical Surface................................................................................................169 Roberto Toro, Yves Burnod, Institut des Sciences Cognitives

Large Deformation Minimum Mean Squared Error Template Estimation for Computational Anatomy............................................................................................173 Brad Davis, Peter Lorenzen, Sarang Joshi, University of North Carolina

3D Model-Based Vascular Tree Analysis Using Differential Geometry................177 Kun-Chang Yu, William Higgins, The Pennsylvania State University; Erik Ritman, Mayo Clinic

A New Method for Robust Contour Tracking In Cardiac Image Sequences .......181 Shoujun Zhou, Wufan Chen, Dept.of BME, The First Military Medical University; Bin Liang, Guang Dong Branch of Network Security Bureau of China

Toward Real-Time, Physically-Correct Soft Tissue Behavior Simulation ............185 Yuan-Fang Wang, Dan Koppel, Shivkumar Chandrasekaran, University of California

Local Weak Form Geometric Active Contours for Medical Image Segmentation ...............................................................................................................189 H.F. Liu, H.P. Ho, P.C. Shi, HKUST

Population Analysis of Knee Cartilage Thickness Maps using Model Based Correspondence...........................................................................................................193 Tomos Williams, Christopher Taylor, University of Manchester; John Waterton, Andrew Holmes, AstraZeneca

Correspondence Recovery In 2-View Mammography ............................................197 Yan Qiu, Dmitry Goldgof, Lihua Li, Sudeep Sarkar, Yong Zhang, Sorin Anton, University of South Florida

NERVES -- Level Sets for Interactive 3D Segmentation of Nerve Channels........201 Nils Hanssen, Zbigniew Burgielski, Thomas Jansen, Marc Lievin, Lutz Ritter, Bartosz v. Rymon-Lipinski, Erwin Keeve, Research Center Caesar

Fr_AM_P3: MRI Acquisition and Analysis Longitudinal Measurements of Signal Intensity as a Potential Marker for Cartilage Degeneration in Osteoarthritis ...........................................................205 Josephine Naish, University of Manchester; Graham Vincent, imorphics; Mike Bowes, imorphics; Manish Kothari, Synarc Inc.; David White, Synarc Inc.; John Waterton, AstraZeneca; Chris Taylor, University of Manchester

Iterative Image Reconstruction in MRI With Separate Magnitude and Phase Regularization .............................................................................................................209 Jeffrey Fessler, Doug Noll, The University of Michigan

Matched Filter vs. Least-Squares for Multiple-Coil MRI ......................................213 Molly Scheffe, G. P. Zientara, Brigham & Women's Hospital

Parallel Imaging with Prior Information for Dynamic MRI..................................217 Feng Huang, James Akao, Andrew Rubin, George Duensing, MRI Devices Corporation

Analysis of Serial MR Images of Joints ....................................................................221 Kelvin Leung, Derek Hill, King's College London; Rolf Heckemann, Daniel Rueckert, Joseph Hajnal, Imperial College; Nadeem Saeed, Keith Brooks, Jacky Buckton, Kumar Changani, David Reid, GlaxoSmithKline

Computed Simultaneous Imaging of Multiple Functional Biomarkers.................225 Yue Wang, Virginia Tech; Rujirutana Srikanchana, Peter Choyka, National Institutes of Health; Jianhua Xuan, The Catholic University of America; Zsolt Szabo, Johns Hopkins Medical Institutions

Risk for Alcoholism And Developmental Defects of Specific Brain Structures: A MR Morphometric Study...................................................................229 George Antony, Vivek Benegal, P.N. Jayakumar, National Institute Of Mental Health And Neurosiences

Multi-Resolution Hierarchical Blind Recovery of Biochemical Markers of Brain Cancer In MRSI ...............................................................................................233 Shuyan Du, Paul Sajda, Columbia University; Xiangling Mao, Dikoma Shungu, Mount Sinai School of Medicine

Optimal Variable-Density k-Space Sampling in MRI.............................................237 Jin Hyung Lee, Dwight Nishimura, Brad Osgood, Stanford University

On the Regularization of SENSE and Space-RIP in Parallel MR Imaging ..........241 William Hoge, Bruno Madore, Walid Kyriakos, Brigham and Women's Hospital and Harvard Medical School; Dana Brooks, Northeastern University

Fr_AM_P4: Image Guided Diagnosis, Surgery and Therapy Computer Aided Monitoring of Fibrous Dysplasia Disease in Craniofacial Bones ......................................................................................................245 Jianhua Yao, Michael Collins, John Butman, National Institute of Health; Janice Lee, Univerisity of California at San Francisco

Automatic Quantification of Pupil Dilation Under Stress ......................................249 Julien Jomier, Erwann Rault, Stephen Aylward, University of North Carolina at Chapel Hill

Classification of Breast MRI Lesions Using A Backpropagation Neural Network (BNN)...............................................................................................253 Lina Arbach, Alan Stolpen, Joseph Reinhardt, University of Iowa

Improved Prediction of Prostate Cancer Recurrence Based on an Automated Tissue Image Analysis System ...............................................................257 Mikhail Teverovskiy, Vinay Kumar, Junshui Ma, Angeliki Kotsianti, David Verbel, Ho-Yuen Pang, Yevgen Vengrenyuk, Stephen Fogarasi, Olivier Saidi, Aureon Biosciences Corporation; Ali Tabesh, University of Arizona

Distance Contained Centerline for Virtual Endoscopy...........................................261 Liu Jianfei, Zhang Xiaopeng, Institute of Automation, Chinese Academy of Sciences; Frederic Blaise, ISA INRIA Lorraine

Image-Guidance for Cardiac Surgery Using Dynamic Autostereoscpic Display System ............................................................................................................265 Hongen Liao, Nobuhiko Hata, Takeyoshi Dohi, Graduate School of Information Science and Technology, The University of Tokyo

Image-Based Rendering And Modeling In Video-Endoscopy................................269 Yuan-Fang Wang, Dan Koppel, Hua Lee, University of California

Method for Assessing Augmented Reality Needle Guidance Using a Virtual Biopsy Task ....................................................................................................273 Damion Shelton, Roberta Klatzky, Carnegie Mellon University; George Stetten, University of Pittsburgh

New Function for Accurate MR-Guided Microwave Ablation Using Vertically Opened 0.5-T MR System ..........................................................................................276 Koichiro Sato, Yoshimasa Kurumi, Shigeyuki Naka, Koichi Demura, Hisanori Shiomi, Tohru Tani, Shiga University of Medical Science; Shigehiro Morikawa, Toshiro Inubushi, Shiga University of Medical Science; Hasnine A Haque, GE-Yokogawa Medical Systems

A Virtual Reality Based 3D Real-Time Interactive Brachytherapy Simulation of Needle Insertion and Seed Implantation...........................................280 Xiaogang Wang, Aaron Fenster, Imaging Research Laboratories, Robarts Research Institute

Automatic Detection of Head Refixation Errors in Fractionated Stereotactic Radiotherapy (FSR)....................................................................................................284 Shidong Li, Daniele Rigamonti, Lawrence Kleinberg, Shanjin He, Theodore DeWeese, Johns Hopkins University School of Medicine; Jason Geng, Dezhi Liu, Genex Technologies Inc.

Haptic Guided Seeding of MRA Images for Semi-Automatic Segmentation........288 Erik Vidholm, Ingela Nyström, Ewert Bengtsson, Uppsala University, Centre for Image Analysis; Xavier Tizon, Swedish University of Agricultural Sciences, Centre for Image Analysis

Colon Straightening Based on an Elastic Mechanics Model...................................292 Zhan Zhang, Michael Ackerman, Office of High Performance Computing & Communications, National Library of Medicine; Jixing Li, Electronic Information College, Wuhan University

MRI-Guided Laser Thermal Ablation: Model and Parameter Estimates Relating MR Thermometry Images to Cell Death...................................................296 Michael Breen, David Wilson, Gerald Saidel, Case Western Reserve University; Kim Butts, Stanford University; Lili Chen, Fox Chase Cancer Center

Fr_AM_OC1: Cardiac Imaging and Motion Vorticity Imaging of Diastolic Cardiac Inflow by Phase-Contrast MRI...............300 William Kerwin, Edward Gill, Jason Cooke, University of Washington; Jean Hertzberg, Heather Chluda, Robin Shandas, University of Colorado, Boulder

The Choice of Tracking Feature In Ultrasound-Based Strain Imaging Analysis ........................................................................................................................304 Weichuan Yu, James Duncan, Yale University

Bimodal Myocardial Motion Analysis from B-mode and Tissue Doppler Ultrasound ...................................................................................................................308 Michael Sühling, Muthuvel Arigovindan, Michael Unser, Swiss Federal Institute of Technology Lausanne (EPFL); Christian Jansen, Patrick Hunziker, University Hospital Basel

Automated Tracking of Multiple Body Parts in Video Recordings of Neonatal Seizures ........................................................................................................312 Abdul Sami, Nicolaos Karayiannis, University of Houston; James Frost, Jr., Merrill Wise, Eli Mizrahi, Baylor College of Medicine

A Posteriori Navigator Echo for Perfusion Imaging of The Liver With Contrast Ultrasound ...................................................................................................316 Gilles Renault, Frédérique Frouin, Alain Herment, Inserm; François Tranquart, Aurore Bleuzen, CIT Ultrasons

Generalized Robust Point Matching Using An Extended Free-Form Deformation Model: Application to Cardiac Images ..............................................320 Ning Lin, James Duncan, Yale University

Fr_AM_OC2: Diffusion Tensor Imaging Towards Diffusion Profile Image Registration ........................................................324 Hui Zhang, Paul Yushkevich, James Gee, University of Pennsylvania

DT-MRI Data Visualisation using the Dual Tree Complex Wavelet Transform....................................................................................................................328 Nick Kingsbury, Argyris Zymnis, Cambridge University Engineering Department, Signal Processing Group; Alonso Pena, Department of Radiology and Academic Neurosurgery Unit, University of Cambridge

Modelling Noise-Induced Fibre-Orientation Error in Diffusion-Tensor MRI .....332 Philip Cook, Daniel Alexander, University College London; Geoffrey Parker, University of Manchester

DT-MRI Regularization Using Anisotropic Tensor Field Filtering.......................336 Miguel Angel Rodriguez-Florido, Juan Ruiz-Alzola, Centro de Tecnologia Medica y Dto. Ing. Telemática de la Universidad de Las Palmas de Gran Canaria; Carl-Fredrik Westin, Laboratory of Mathematics in Imaging, Harvard Medical School

Constrained Free Form Deformation Based Algorithm for Geometric Distortion Correction of Echo Planar Diffusion Tensor Images ............................340 Siamak Ardekani, Usha Sinha, University of California Los Angeles

Towards a Shape Model of White Matter Fiber Bundles Using Diffusion Tensor MRI ..............................................................................................................................344 Isabelle Corouge, Guido Gerig, University of North Carolina; Sylvain Gouttard, ESCPE Lyon

Fr_AM_OC3: Image Reconstruction I: Model Based Maximum-Lesion-Detectability Reconstruction Using Penalized Maximum Likelihood .................................................................................................348 Jinyi Qi, Ronald H Huesman, Lawrence Berkeley National Laboratory

Quasi-Maximum Likelihood Blind Deconvolution of Images Acquired Through Scattering Media .........................................................................................352 Michael Bronstein, Alexander Bronstein, Yehoshua Zeevi, Michael Zibulevsky, Technion - Israel Institute of Technology

Reconstruction of 2D Pet Data with Monte Carlo Generated Natural Pixels.......356 Charles Byrne, University of Massachusetts, Lowell; Stefaan Vandenberghe, University of Massachusetts, University Ghent; Ed Soares, College of the Holy Cross; Ignace Lemahieu, University Ghent; Stephen Glick, University Of Massachusetts Medical School

Analytical Approach to Channelized Hotelling Observer Performance For Regularized Tomographic Image Reconstruction ...................................................360 Anastasia Yendiki, Jeffrey Fessler, The University of Michigan

Fourier-Based Forward and Back-Projectors in Iterative Fan-Beam Tomographic Image Reconstruction.........................................................................364 Yingying Zhang, Jeffrey Fessler, University of Michigan

Covariance of Kinetic Parameter Estimators Based on Time Activity Curve Reconstructions: Preliminary Study on 1D Dynamic Imaging...................368 Sangtae Ahn, Jeffrey Fessler, Thomas Nichols, Robert Koeppe, University of Michigan

Fr_AM_OC4: Functional Brain Mapping Nonlinear Dimension Reduction of fMRI Data: The Laplacian Embedding Approach .....................................................................................................................372 Olivier Faugeras, Bertrand Thirion, INRIA Sophia Antipolis

Incremental Activation Detection in fMRI Series Using Kalman Filtering ..........376 Alexis Roche, Jean-Baptiste Poline, Pierre-Jean Layahe, CEA/SHFJ

Imaging Cortical Oscillations During Sustained Visuomotor Coordination in MEG.........................................................................................................................380 Karim Jerbi, Sylvain Baillet, Line Garnero, Cognitive Neuroscience and Brain Imaging Laboratory; Jean-Philippe Lachaux, Mental Processes and Brain Activation Laboratory INSERM U280

The Influence of Heart Beat and Respiration on Functional Connectivity Networks ......................................................................................................................384 Silke Dodel, SHFJ; Jean-Baptiste Poline, SHFJ; Jean-Luc Anton, IFR 45 "Sciences du cerveau"; Matthew Brett, Cognition and Brain Sciences Unit, Médical Research Council

Controling The False Positive Detection Rate In Fuzzy Clustering of fMRI Data....................................................................................................................388 Hesamoddin Jahanian, Institute for Studies In Theoritical Physics and Mathematics (IPM); Hamid Soltanian Zadeh, Gholam Ali Hossein Zadeh, University of Tehran

Outlier Detection for Robust Region-Based Estimation of the Hemodynamic Response Function in Event-Related fMRI..............................................................392 Philippe Ciuciu, Alexis Roche, SHFJ/CEA; Jérôme Idier, IRCCyN/CNRS; Christophe Pallier, INSERM U562/SHFJ

Fr_PM_P1: Atlases and Computational Anatomy Matching of Diffusion Tensor Images using Gabor Features.................................396 Ragini Verma, Christos Davatzikos, University of Pennsylvania

A Deformable Brodmann Area Atlas........................................................................400 Paul Rasser, Philip Ward, Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia; Patrick Johnston, Centre for Mental Health Studies, Newcastle, Australia; Paul Thompson, Laboratory of Neuro Imaging, University of California Los Angeles School of Medicine, Los Angeles, USA

Performance-Based Multi-Classifier Decision Fusion for Atlas-Based Segmentation of Biomedical Images..........................................................................404 Torsten Rohlfing, Daniel Russakoff, Calvin Maurer, Stanford University; Robert Brandt, Indeed - Visual Concepts GmbH; Randolf Menzel, Freie Universitaet Berlin

Non-Rigid Registration Algorithm With Spatially Varying Stiffness Properties.....................................................................................................................408 Valerie Duay, Swiss Federal Institute of Technology, Lausanne ; Pierre-Francois D'Haese, Rui Li, Benoit Dawant, Vanderbilt University

Building a 4D Atlas of the Cardiac Anatomy and Motion Using MR Imaging ....412 Dimitrios Perperidis, Raghavendra Chandrashekara, Maria Lorenzo-Valdes, Gerardo-Ivar Sanchez-Ortiz, Anil Rao, Daniel Rueckert, Imperial College London, Department of Computing; Raad Mohiaddin, Royal Brompton and Harefield NHS Trust

Grid-Enabled Automatic Construction of A Two-Chamber Cardiac PDM from a Large Database of Dynamic 3D Shapes ....................................................................416 Sebastian Ordas, Loic Boisrobert, Matias Bossa, Salvador Olmos, Alejandro Frangi, Aragon Institute of Engineering Research; Huguet Marina, CETIR Sant Jordi; Marcos Laucelli, GridSystems

Finite Element Mesh Generation and Remeshing from Segmented Medical Images............................................................................................................420 Ashraf Mohamed, Johns Hopkins University; Christos Davatzikos, University of Pennsylvania

Automated Identification of Microstructures on Histology Slides.........................424 Constandine Katsinis, Sokol Petushi, Chip Coward, Aydin Tozeren, Drexel University; Fernando Garcia, Graduate Hospital

Cortical Surface Parameterization by P-Harmonic Energy Minimization...........428 Anand Joshi, Richard Leahy, University of Southern California; Paul Thompson, David Shattuck, University of California Los Angeles

Diffusion Smoothing on Brain Surface via Finite Element Method.......................432 Moo Chung, University of Wisconsin-Madison; Jonathan Taylor, Stanford University

Clustering On Image Boundary Regions for Deformable Model Segmentation ...............................................................................................................436 Joshua Stough, Stephen Pizer, Edward Chaney, Manjari Rao, University of North Carolina at Chapel Hill

A Probabilistic Framework for the Detection and Tracking in Time of Multiple Sclerosis Lesions ..........................................................................................440 Allon Shahar, Hayit Greenspan, Tel-Aviv University

Modeling of Tumor Conspicuity In Hepatic CT Images: Combined Compartment and Vascular Models .........................................................................444 Marek Kretowski, Technical University of Bialystok; Pierrick Coupe, Johanne Bezy-Wendling, Rennes University

Fr_PM_P2: Image Motion and Sequence Analysis Analysis of Time-Varying Psoriasis Lesion Image Patterns ...................................448 Bjarne Ersbøll, DTU; Allan Nielsen, IMM-DTU; Gabriela Maletti, KVL; David Delgado Gómez, IMM-DTU

Relationship Between the Morphology and Functionality of Articular Surfaces. Applications to 3D Navigation ..................................................................452 Gwenael Guillard, Chafiaa Hamitouche, Julio Daniel Gil Cano, Christian Roux, ENST Bretagne; Eric Stindel, CHU de Brest, Hopital de la Cavale Blanche

Measuring Blood Cells Velocity in Microvessels from a Single Image: Application to In Vivo and In Situ Confocal Microscopy........................................456 Nicolas Savoire, Georges Le Goualher, Aymeric Perchant, François Lacombe, Mauna Kea Technologies; Grégoire Malandain, Nicholas Ayache, INRIA - Epidaure

Parametric Analysis of Main Motion : Application To The Assessment of Left Ventricular Wall Motion by MR Imaging........................................................460 Nadjia Kachenoura, Cinta Ruiz Doninguez, Annie Delouche, Odile Jolivet, Frederique Frouin, U494 INSERM; Alban Redheuil, Benoit Diebold, Service D'Echocardiographie HEGP ;Elie Mousseaux, Service de Radiologie Cardiovasculaire

Meshfree Cardiac Motion Analysis Using Composite Material Model and Total Lagrangian Formulation..................................................................................464 Pengcheng Shi, Huafeng Liu, Alexandra Wong, Ken Wong, Hong Kong University of Science and Technology; Albert Sinusas, Yale University

Cardiac Motion Tracking in Tagged MR Images Using a 4D B-spline Motion Model and Nonrigid Image Registration.....................................................468 Raghavendra Chandrashekara, Daniel Rueckert, Imperial College; Raad Mohiaddin, Royal Brompton and Harefield NHS Trust

Effects of Breathing Motion On The Spatial Resolution In Microscopic Imaging Techniques of Rodents ................................................................................472 Wilfried Mai, Cristian Badea, Charles Wheeler, Laurence Hedlund, G. Johnson, Center for In Vivo Microscopy

Tracking Fluorescent Cells With Coupled Geometric Active Contours ...............476 Christophe Zimmer, Jean-Christophe Olivo-Marin, Institut Pasteur; Bo Zhang, ENST

Respiratory Motion Estimation From Slowly Rotating X-Ray Projections..........480 Rongping Zeng, Jeffrey Fessler, James Balter, The University of Michigan

Non-Rigid Image Transformation for Assessing Changes in Fluorescence Imaging Data of Molecular Activity in Time-Dependent Geometries ...................484 Kostas Marias, Stelios Orphanoudakis, Institute of Computer Science-FORTH; Jorge Ripoll, Inst. of Electronic Structure & Laser - FORTH; Vasilis Ntziachristos, MGH / Harvard Medical School

Fr_PM_P3: Ultrasound Imaging Image Analysis of Doppler Echocardiography for Patients with Atrial Fibrillation...................................................................................................................488 Oron Shechner, Hayit Greenspan, Mickey Sheinovitz, Micha Feinberg, Tel Aviv University

Three-Dimensional Reconstruction of Tracked Freehand Ultrasound Using Non-Rigid Registration....................................................................................492 Graeme Penney, Krista Joosten, Marloes Letteboer, Max Viergever, Wiro Niessen, Image Sciences Institute

Automatic Segmentation of Prostate Boundaries From Abdominal Ultrasound Images Using Priori Knowledge............................................................496 Nacim Betrouni, Jean Rousseau, Maximilien Vermandel, ITM; Maouche Salah, USTL

Advantages in Using Multi-Frequency Driving to Enhance Ultrasound Contrast Microbubble Non-Linearities for Optimizing Echo Particle Image Velocimetry Techniques .............................................................................................500 Hairong Zheng, Osama Mukdadi, Hyoung Bum Kim, Jean Hertzberg, University of Colorado at Boulder; Robin Shandas, The Children's Hospital, Denver

Numerical Modeling of Ultrasound Imaging Using Contrast Agents for Particle Image Velocimetry In Vivo..........................................................................504 Osama Mukdadi, H.B. Kim, J.R. Hertzberg, University of Colorado; Robin Shandas, University of Colorado and The Children’s Hospital, Denver

Quantitation of Regional Myocardial Function During Short-Lived Events With Ultrasound Imaging ..........................................................................................508 Eileen McMahon, Jianwen Wang, Josef Korinek, Marek Belohlavek, Stig Urheim, Mayo Clinic

Atomic Layer Deposition for Fabricating Capacitive Micromachined Ultrasonic Transducers: Initial Characterization ...................................................512 Lingli Liu, Osama Mukdadi, Hyoung Kim, Jean Hertzberg, Robin Shandas, Victor Bright, University of Colorado at Boulder

A Study of Pressure-Dependent Attenuation In Ultrasound Contrast Imaging ........................................................................................................................516 Meng-Xing Tang, J. Noble, Oxford University; Robert Eckersley, Imperial College London

Monitoring Angiogenesis in Human Melanoma Xenografts using Contrast-Enhanced Ultrasound .................................................................................................520 Raymond Ro, Drexel University/Thomas Jefferson University; Flemming Forsberg, Ji-Bin Liu, Kathryn James, Magdalena Potoczek, Levon Nazarian, Thomas Jefferson University; Peter Lewin, Drexel University

Interactive Rendering of Real-Time Volumetric Ultrasound Images....................523 Gregory Bredthauer, Olaf von Ramm, Duke University

A Novel Closed Form Solution for Ultrasound Calibration ...................................527 Emad Boctor, Anand Viswanathan, Michael Choti, Russell Taylor, Gabor Fichtinger, Gregory Hager, The Johns Hopkins University

Quantitative Analysis of Circumferential Plaque Distribution in Human Coronary Arteries in Relation to Local Vessel Curvature......................................531 Andreas Wahle, Mark Olszewski, Sarah Vigmostad, Kathleen Braddy, Theresa Brennan, James Rossen, Krishnan Chandran, Milan Sonka, The University of Iowa; Ruben Medina, Universidad de Los Andes; A Coskun, Northeastern University; Charles Feldman, Peter Stone, Brigham & Women's Hospital

The Accuracy of Blood Velocity Measurement Using Ultrasound.........................535 Siobhan Meagher, Tamie Poepping, John Cosgroave, Clive Greated, Peter Hoskins, Univeristy of Edinburgh

A Software Package for Portable Three-Dimensional Ultrasound Imaging.........539 Tiantian Zhang, X. Xu, Rensselaer Polytechnic Institute; Xinlin Chen, Hubei Women & Children's Hospital

Simultaneous Elastic Image Registration and Elastic Modulus Reconstruction.............................................................................................................543 Paul Barbone, Nachiket Gokhale, Michael Richards, Assad Oberai, Boston University; Marvin Doyley, Dartmouth College

Speckle Reduction on Ultrasound Image by Variational Methods and Adaptive Lagrangian Multipliers..............................................................................547 Arnaud Ogier, Pierre Hellier, Christian Barillot, IRISA

Fr_PM_P4: Image Reconstruction & Restoration I A Method for Reconstructing Label Images From a Few Projections, as Motivated by Electron Microscopy ...........................................................................551 Hstau Liao, Gabor Herman, The Graduate Center, CUNY

A Fast Fully 4D Incremental Gradient Reconstruction Algorithm for List Mode PET Data ...................................................................................................555 Quanzheng Li, Evren Asma, Richard Leahy, University of Southern California

Three-Dimensional Multi-Resolution Statistical Reconstruction for Tomosynthesis .............................................................................................................559 Pei Chen, Kenneth E. Barner, University of Delaware

A "Brick" Caching Scheme for 3D Medical Imaging .............................................563 Jianchun Li, Christos Papachristou, Case Western Reserve University; Raj Shekhar, Cleveland Clinic Foundation

3D Region of Interest X-Ray CT for Geometric Magnification from Multiresolution Acquisitions......................................................................................567 Greg Tisson, Paul Scheunders, Dirk Van Dyck, University of Antwerp

Ultra-Fast 3D Filtered Backprojection On Commodity Graphics Hardware ......571 Klaus Mueller, Fang Xu, Stony Brook University

Image Reconstruction from Truncated Cone-Beam Projections ...........................575 Hermann Schomberg, Philips Research Hamburg

Alternating Minimization Algorithm for Dual Energy X-ray CT..........................579 Joseph O'Sullivan, Jasenka Benac, Washington University; Jeffrey Williamson, Virginia Commonwealth University

Fr_PM_OS1: Atlases and Nonrigid Registration Genetic Influences on Human Brain Morphology...................................................583 Theo van Erp, Tyrone Cannon, Helen Tran, Amber Wobbekind, University of California Los Angeles Department of Psychology; Matti Huttunen, Jouko Lönnqvist, Department of Mental Health, National Public Health Institute of Finland; Oili Salonen, Leena Valanne, Veli-Pekka Poutanen, Carl-Gustav Standertskjöld-Nordenstam, Department of Radiology, University of Helsinki, Helsinki, Finland; Arthur Toga, Paul Thompson, Laboratory of Neuroimaging, University of California Los Angeles School of Medicine, Los Angeles

Morphological Classification of Medical Images using Nonlinear Support Vector Machines..........................................................................................................587 Christos Davatzikos, Dinggang Shen, Zhiqiang Lao, Zhong Xue, Bilge Karacali, University of Pennsylvania

Inverse Consistent Registration with Object Boundary Constraints ....................591 Gary Christensen, University of Iowa

Shape Averaging with Diffeomorphic Flows for Atlas Creation............................595 Brian Avants, James Gee, University of Pennsylvania

Challenges and Progress Toward Quantitative Deformation Morphometry of Gyral Anatomy .......................................................................................................599 Colin Studholme, Corina Drapaca, Valerie Cardenas, Michael Weiner, U.C.S.F.

Brain Warping with Implicit Representations.........................................................603 Alexia Leow, Paul Thomspon, Hillary Protas, Sung Cheng Huang, University of California Los Angeles

Fr_PM_OS2: Dynamic Image Formation and Analysis Dynamic SPECT Imaging: Exploring A New Frontier in Medical Imaging ........607 Grant Gullberg, E. O. Lawrence Berkeley National Laboratory

Tracer Kinetic Parametric Imaging in PET.............................................................612 Richard Carson, National Institutes of Health

Phase-Correlated Dynamic CT..................................................................................616 Marc Kachelriess, Institute of Medical Physics (IMP)

Level Set Methods for Dynamic Tomography .........................................................620 Yonggang Shi, William Karl, Boston University

Imaging the Evolution of Three-Dimensional Myocardial Strains using a Fast MR Imaging Technique .....................................................................................624 Smita Sampath, Nael Osman, Jerry Prince, Johns Hopkins University

Spatio-Temporal Modeling and Adaptive Acquisition for Cardiac MRI..............628 Nitin Aggarwal, Saptarshi Bandyopadhyay, Yoram Bresler, University of Illinois, Urbana-Champaign

Fr_PM_OS3: Public Domain Software Packages for Biomedical Imaging 3D Slicer.......................................................................................................................632 Steve Pieper, Isomics, Inc.; Michael Halle, Ron Kikinis, Surgical Planning Laboratory, Brigham and Women's Hospital

Simulation of Advanced Ultrasound Systems using Field II ..................................636 Jørgen Jensen, Techn. University of Denmark

SCIRun/BioPSE: Integrated Problem Solving Environment for Bioelectric Field Problems and Visualization..............................................................................640 Rob MacLeod, David Weinstein, Davison de St. Germain, Christopher Johnson, Steven Parker, University of Utah; Dana Brooks, Northeastern University

DUFF: Software Tools for Visualization and Processing of Neuroimaging Data.....................................................................................................644 David Shattuck, Allan MacKenzie-Graham, Arthur Toga, University of California Los Angeles Laboratory of Neuro Imaging

Software Process: The Key to Developing Robust, Reusable and Maintainable Open-Source Software........................................................................648 William Schroeder, Luis Ibanez, Kenneth Martin, Kitware, Inc.

Electromagnetic Brain Mapping using BrainStorm................................................652 Sylvain Baillet, Cognitive Neuroscience & Brain Imaging Lab; John Mosher, Los Alamos National Laboratory; Richard Leahy, Signal and Image Processing Group, University of Southern California

Fr_PM_OC4: Optical Imaging & Microscopy Automatic Quantification of Microtubule Dynamics ..............................................656 Stathis Hadjidemetriou, James Duncan, Yale University; Derek Toomre, David Tuck, Yale University School of Medicine

Extended Depth-of-Focus for Multi-Channel Microscopy Images: A Complex Wavelet Approach ..................................................................................660 Brigitte Forster, Dimitri Van De Ville, Jesse Berent, Daniel Sage, Michael Unser, Swiss Federal Institute of Technology Lausanne

A Multiple Target Approach for Single Quantum Dot Tracking ..........................664 Stephane Bonneau, Laurent Cohen, Ceremade; Maxime Dahan, Laboratoire Kastler-Brossel

Deep Tissue Imaging Approaches By Direct Capture of Two-Photon Absorption ...................................................................................................................668 Tong Ye, Warren Warren, Martin Fischer, Department of Radiology, University of Pennsylvania; Wolfgan Wagner, Peifang Tian, Department of Chemistry, Princeton University; Gunay Yurtsever, Department of Bioengineering, University of Pennsylvania

Reduction of Physiological Interference in Optical Functional Neuroimaging Using Eigenvector-Based Spatial Filtering .....................................672 Yiheng Zhang, Dana Brooks, Northeastern University; Maria Franceschini, David Boas, Mass General Hospital

A Method for Dynamically Suppressing Sidelobes in Optical Coherence Tomography ................................................................................................................676 Daniel Marks, Paul Carney, Stephen Boppart, University of Illinois at Urbana-Champaign

3-D Multispectral Monitoring of Living Cell Signaling Using Confocal-Imaging And FPGA Processing ................................................................680 Marianne Sowa Resat, James Solinsky, H. Wiley, Kenneth Perrine, Thomas Seim, PNNL; Scott Budge, Utah State University

Development of A Percutaneous Optical Imaging System for Tracking Vascular Gene Expression: An Ultrasound-Guided Ex Vivo Feasibility Study..........................................................................................................684 Sourav Kar, Ananda Kumar, Xiaoming Yang, Johns Hopkins University

In Vivo Multi Lifetime Discrimination Using Time Domain Fluorescence Imaging ........................................................................................................................688 Frederic Lesage, Alexander Belenkov, ART Recherches et Technologies Avancees Inc.

An Integrated Fibered Confocal Microscopy System for In Vivo And In Situ Fluorescence Imaging -- Applications to Endoscopy in Small Animal Imaging ........................................................................................................................692 Aymeric Perchant, Georges Le Goualher, Magalie Genet, Bertrand Viellerobe, Frederic Berier, Mauna Kea Technologies

Sa_AM_P1: Image Registration Evaluation of a Similarity-Based Elastography Technique using Four Similarity Metrics .......................................................................................................696 Michael Miga, Megan Rothney, Vanderbilt University; Chad Washington, University of Mississippi School of Medicine

Subpixel Registration in Renal Perfusion MR Image Sequence ............................700 Ying Sun, Jose' Moura, Department of Electrical and Computer Engineering, Carnegie Mellon University; Chien Ho, Department of Biological Sciences, Carnegie Mellon University

Local Feature Matching Using Entropic Graphs ....................................................704 Huzefa Neemuchwala, Alfred Hero, Paul Carson, Charles Meyer, University of Michigan, Ann Arbor

2D-3D Vascular Registration Between Digital Subtraction Angiographic (DSA) And Magnetic Resonance Angiographic (MRA) Images ....708 Albert Chung, H.M. Chan, The Hong Kong University of Science and Technology; Simon Yu, The Prince of Wales Hospital; William Wells, Brigham and Women's Hospital, Harvard Medical School

Multi-Channel Registration of Diffusion Tensor Images Using Directional Information..................................................................................................................712 Gustavo Rohde, Sinisa Pajevic, Carlo Pierpaoli, National Institues of Health

Ground Truth Data for Validation of Nonrigid Image Registration Algorithms ...................................................................................................................716 Yi-Yu Chou, Oskar Skrinjar, Department of Biomedical Engineering, Georgia Institute of Technology

Model Based Symmetric Information Theoretic Large Deformation Multi-Modal Image Registration...............................................................................720 Peter Lorenzen, Brad Davis, Sarang Joshi, University of North Carolina at Chapel Hill

A Unified Feature-Based Registration Method for Multimodality Images...........724 Jie Zhang, Anand Rangarajan, University of Florida

Quadrature-Based Image Registration Method using Mutual Information.........728 Clinton Fookes, Anthony Maeder, Queensland University of Technology

Differential Evolution with Powell's Direction Set Method in Medical Image Registration .................................................................................................................732 Robert Dony, Xiaoyan Xu, University of Guelph

An Extendable Registration Similarity Metric for Anatomical Image Sequence Alignment....................................................................................................736 Rongkai Zhao, Michael Gabriel, Geneva Belford, University of Illinois at Urbana-Champaign

Surface Matching Algorithms for Computer Aided Reconstructive Plastic Surgery.........................................................................................................................740 Suchendra Bhandarkar, Ananda Chowdhury, Yarong Tang, Ernest Tollner, University of Georgia; Jack Yu, Medical College of Georgia

Sa_AM_P2: Image Reconstruction & Restoration II Symmetry-Based 3D Brain Reconstruction..............................................................744 Smadar Gefen, Yingli Fan, Louise Bertrand, Jonathan Nissanov, Drexel University

Penalized Likelihood Transmission Image Reconstruction : Unconstrained Monotonic Algorithms................................................................................................748 Somesh Srivastava, University of Michigan, Ann Arbor; Jeffrey Fessler, EECS Dept., University of Michigan

A Geometric Approach to Parameter Estimation from Tomographic Data.........752 Alexey Chernyavskiy, Ross Whitaker, University of Utah

Compact Representation of PET 3D System Response Matrices...........................756 William Worstell, Haris Kudrolli, John Nevin, Stephen Adler, Leonid Romanov, PhotoDetection Systems, Inc.

Volterra-Type Nonlinear Image Restoration of Medical Imagery Using Principal Dynamic Modes ..........................................................................................760 Synho Do, Vasilis Marmarelis, University of Southern California; Dae Shin, Jeong-Won Jeong, Tae-Seong Kim, Alfred E. Mann Institute for Biomedical Engineering

A Bayesian Approach to Image Restoration ............................................................764 Andreas Wrangsjö, Magnus Borga, Hans Knutsson, Medical Informatics

Robust Filtering Strategies for Soft Tissue Young's Modulus Characterization .........................................................................................................768 Pengcheng Shi, Huafeng Liu, Hong Kong University of Science and Technology; Albert Sinusas, Yale University

Analysis of Spatial-Temporal Regularization Methods for Linear Inverse Problems from a Common Statistical Framework ..................................................772 Yiheng Zhang, Alireza Ghodrati, Dana Brooks, Northeastern University

New Method of Image Reconstruction from Projections........................................776 Artyom Grigoryan, The University of Texas at San Antonio; Shih-Chia Liu, EE Dept., University of Texas at San Antonio

An Imaging Method In Diffraction Tomography Based On The Topological Derivative.....................................................................................................................780 Gonzalo Feijoo, Sandia National Laboratories

Fast Spiral Fourier Transform for Iterative MR Image Reconstruction..............784 Michael Lustig, Jacob Tsaig, Jin Hyung Lee, David Donoho, Stanford University

An Adaptive Window Approach for Poisson Noise Reduction and Structure Preserving in Confocal Microscopy ..........................................................................788 Alain Trubuil, INRA-MIA; Charles Kervrann, IRISA-INRIA Rennes / INRA-MIA

Sa_AM_P3: Image Analysis and Quality Assessment Regional Lung Ventilation from Volumetric CT Scans Using Image Warping Functions .....................................................................................................792 Smita Krishnan, Kenneth Beck, Joseph Reinhardt, Katherine Carlson, Eric Hoffman, University of Iowa; Brett Simon, Johns Hopkins Med. Inst; Richard Albert, Denver Health Medical Center and University of Colorado

Search Space Partitioning Using Convex Hull and Concavity Features for Fast Medical Image Retrieval ....................................................................................796 Phillip Mlsna, Nikolay Sirakov, Northern Arizona University

Using Grey-Level And Shape Information for Decomposing Proteins In 3D Images ..........................................................................................................................800 Ida-Maria Sintorn, Swedish University of Agricultural Sciences, Centre for Image Anaysis; Susana Mata, Rey Juan Carlos University, Department of Computer Science, Statistics and Telematics

Quantitative Analysis of Volumetric TPLSM Data.................................................804 Agustin Ifarraguerri, Beverly Thompson, Science Applications International Corporation; Philbert Tsai, Beth Friedman, Chris Schaffer, Varda Lev-Ram, Roger Tsien, David Kleinfeld, University of California at San Diego; Jeff Squier, Colorado School of Mines

A Minimum Reliable Scale Selection In 3D Images ................................................808 Christopher Wyatt, Virginia Tech; Yaorong Ge, PointDx, Inc.

Enhanced Snake-Based Segmentation of Vocal Folds.............................................812 Sonya Allin, John Galeotti, George Stetten, Carnegie Mellon University; Seth Dailey, Brigham and Women's Hospital

Image Enhancement by The Tensor Transform......................................................816 Artyom Grigoryan, The University of Texas at San Antonio; Fatma Arslan, EE Dept., University of Texas at San Antonio

Trilateral Filtering for Biomedical Images...............................................................820 Wilbur C. K. Wong, Albert C. S. Chung, Department of Computer Science, The Hong Kong University of Science and Technology, HK; Simon C. H. Yu, Department of Diagnostic Radiology and Organ Imaging, The Prince of Wales Hospital, HK

Evaluation of Reproducibility for Perfusion Assessment of Tumors in MRI .......824 Edward Ashton, Seung Kim, VirtualScopics, LLC

Cardiac MR Image Segmentation: Quality Assessment of STACS .......................828 Charnchai Pluempitiwiriyawej, Jose Moura, Electrical and Computer Engineering, Carnegie Mellon University; Yi-Jen Lin Wu, Chien Ho, Pittsburgh NMR Center for Biomedical Reseach, Carnegie Mellon University;

Model-Observer Based Quality Measures for Decompressed Medical Images ..........................................................................................................................832 Dunling LI, Murray Loew, George Washington University

Medical Software Control Quality Using the 3D Mojette Projector......................836 Jean-Pierre Guedon, Myriam Servieres, Nicolas Normand, IRCCyN - IVC Polytech'Nantes; Stephane Beaumont, Radiotherapy Dpt, Hospital Center

Focal Cartilage Defect Progression Detection: Measurement of Precision and Variation in Natural Characteristics of Cartilage Thickness Maps Derived from 3D MRI Data .......................................................................................840 Monica Barbu-McInnis, Jose Tamez-Pena, Saara Totterman, VirtualScopics

Sa_AM_P4: Functional Neuroimaging I An Exploratory Approach to Modelling Effective Connectivity............................844 Jagath Rajapakse, Kanyan Yang, Nanyang Technological University

Identification of A Large-Scale Functional Network In Functional Magnetic Resonance Imaging .....................................................................................................848 Pierre Bellec, Guillaume Marrelec, Vincent Perlbarg, Saâd Jbabdi, Odile Jolivet, Mélanie Pélégrini-Issac, Habib Benali, INSERM, IFR 49; Julien Doyon, Univeristy of Montreal

Selection of Spatially Independent Components to Explain Functional Connectivity In fMRI .................................................................................................852 Vincent Perlbarg, Pierre Bellec, Habib Benali, Guillaume Marrelec, Saâd Jbabdi, Inserm

Combining Voxel Intensity And Cluster Extent With A Permutation Test Framework ..................................................................................................................856 Satoru Hayasaka, VA SF Medical Center; Thomas Nichols, University of Michigan

Semi-Blind Deconvolution of Neural Impulse Response in Event-Related fMRI Using a Gibbs Sampler ....................................................................................860 Salima Makni, Philippe Ciuciu, Jean Baptiste Poline, SHFJ/CEA; Jérôme Idier, IRCCyN/CNRS

Fusion of Simultaneous fMRI/EEG Data Based on the Electro-Metabolic Coupling.......................................................................................................................864 Pierre-Jean Lahaye, Jean-Baptiste Poline, CEA, IFR 49; Sylvain Baillet, Line Garnero, LENA / CNRS, IFR 49

Reversible Jump Markov Chain Monte Carlo Signal Detection In Functional Neuroimaging Analysis...............................................................................................868 Ana Lukic, Miles Wernick, Yongyi Yang, Illinois Institute of Technology; Nikolas Galatsanos, University of Ioannina; Stephen Strother, University Minnesota and VA Medical Center

Analysis of Correlated Activity in fMRI Data by Artificial Neural Networks .....872 Marotesa Voultsidou, University of Crete; Silke Dodel, Service Hospitalier Frederic Joliot; Michael Herrmann, Goettingen University

An fMRI Activation Method Using Complex Data .................................................876 Daniel Rowe, Department of Biophysics, Medical College of Wisconsin; Brent Logan, Division of Biostatistics, Medical College of Wisconsin

Sa_AM_OC1: MRI - New Approaches and Methods Reconstruction of 3D Dense Cardiac Motion From Tagged MR Sequences ........880 Hsun-Hsien Chang, José Moura, Yijen Wu, Kazuya Sato, Chien Ho, Carnegie Mellon University

Dynamic Range of Harmonic Phase Magnetic Resonance Imaging (HARP-MRI) ...............................................................................................................884 Vijay Parthasarathy, Jerry Prince, Johns Hopkins University; Moriel NessAiver, University of Maryland School of Medicine

Combined Tag Tracking and Myocardium Motion Reconstruction from Planar Tagged MR Image Data Without User-Defined Myocardial Contours.................888 Thomas Denney, Xiang Deng, Auburn University

Accelerated Parallel Magnetic Resonance Imaging by Adaptive K-Space Sampling ......................................................................................................................892 Nitin Aggarwal, Yoram Bresler, University of Illinois, Urbana-Champaign

Motion Artifact Reduction in MRI through Generalized DFT..............................896 Hans Knutsson, Mats Andersson, Magnus Borga, Medical Informatics, Dept. of Biomedical Engineering, Linköping University; Lars Wigström, Andreas Sigfridsson, Center for Medical Image Science and Visualization, Linköping University

Unique Planar Color Coding of Fiber Bundles And Its Application To Fiber Integrity Quantification..............................................................................................900 Mathias Schlueter, Jan Rexilius, Horst Hahn, Heinz Peitgen, MeVis; Bram Stieltjes, German Cancer Research Center

Sa_AM_OC2: Image Registration 4D Image Warping for Measurement of Longitudinal Brain Changes .................904 Dinggang Shen, University of Pennsylvania

Consistent Groupwise Non-Rigid Registration for Atlas Construction.................908 K.K. Bhatia, J.V. Hajnal, B.K. Puri, A.D. Edwards, D. Rueckert, Imperial College London

A Simulated Charged Fluid for Deformable Models...............................................912 Herng-Hua Chang, Daniel Valentino, University of California Los Angeles

Isolation and Minimization of Effects of Motion on fMRI Using Multiple Reference Images ........................................................................................................916 Rui Liao, Jeffrey Krolik, Duke University; Martin McKeown, University of British Columbia

Symmetric, Transitive, Geometric Deformation And Intensity Variation Invariant Nonrigid Image Registration ....................................................................920 Oskar Skrinjar, Georgia Institute of Technology; Hemant Tagare, Yale Univeristy

Non-Rigid Registration of Shapes Via Diffeomorphic Point Matching.................924 Hongyu Guo, Anand Rangarajan, University of Florida; S. Joshi, University of North Carolina; L. Younes, Johns Hopkins University

Sa_AM_OC3: Image Reconstruction II: Analytic Directional Interpolation of Sparsely Sampled Cone-Beam CT Sinogram Data ..............................................................................................................................928 Matthias Bertram, Georg Rose, Dirk Schäfer, Philips Research Laboratories; Jens Wiegert, Til Aach, University of Lübeck

Exact 3D Cone-Beam Reconstruction From Projections Obtained Over a Wobble Trajectory on a C-ARM...............................................................................932 Krishnakumar Ramamurthi, Jerry Prince, Johns Hopkins University; Norbert Strobel, Siemens Medical Solutions

Gridding-Based Three-Dimensional Image Reconstruction From Projections With Arbitrary Directions .........................................................................................936 Pawel Penczek, Robert Renka, The University of North Texas; Hermann Schomberg, Philips Research

An Observer Model Evaluation of Simultaneous Reconstruction And Motion Estimation for Emission Tomography......................................................................940 Zixiong Cao, David Gilland, University of Florida; Bernard Mair, North Carolina State University; Benjamin Tsui, Johns Hopkins University

Cerebral Aneurysm Hemodynamics Modeling from 3D Rotational Angiography ................................................................................................................944 Juan Cebral, Marcelo Castro, George Mason University; James Burgess, Christopher Putman, Inova Fairfax Hospital

Multiple-Image Computed Tomography..................................................................948 Miles Wernick, Jovan Brankov, Dean Chapman, Mark Anastasio, Illinois Institute of Technology; Zhong Zhong, Brookhaven National Laboratory; Carol Muehleman, Jun Li, Rush Medical College

Sa_AM_OC4: Ultrasound Imaging A Regularized Approach to Freehand Ultrasound Elastography of Breast Lesions..............................................................................................................952 Claire Pellot-Barakat, Michael Insana, Jerome Mai, Jean Tsou, Karen Lindfors, UC Davis; Frederique Frouin, Alain Herment, INSERM U494; Patrick Von Behren, Siemens Medical Solutions

Comparison of Doppler Ultrasound Flow Resistance Indices in Beta-Thalassemic, Sickle Cell Anemic and Control Mice.......................................956 Ekatherina Stoyanova, Guy Cloutier, University of Montreal Hospital Research Center; Marie Trudel, Institut de Recherches Cliniques de Montréal; F. Foster, Sunnybrook and Women’s College Health Sciences Centre

Oblique Needle Segmentation for 3D Trus-Guided Robot-Aided Transperineal Prostate Brachytherapy..............................................................................................960 Zhouping Wei, Lori Gardi, Donal Downey, Aaron Fenster, Robarts Research Institute

Coded Pulse Excitation for Ultrasonic Strain Imaging...........................................964 Jie Liu, Michael Insana, University of California, Davis

3-D High Resolution Images of Ultrasonic Transmission Tomography Compared To Magnetic Resonance And Optical Images .......................................968 Jeong-Won Jeong, Dae Shin, Tae-Seong Kim, Chengzheng Huang, Alfred E. Mann Institute for Biomedical Engineering; Synho Do, Manbir Singh, Vasilis Marmarelis, University of Southern California

Spatial Angular Compounding For Ultrasound Elastography ..............................972 Udomchai Techavipoo, Quan Chen, Tomy Varghese, James Zagzebski, Ernest Madsen, University of Wisconsin-Madison

Sa_PM_P1: Functional Neuroimaging II Detecting Cortical Activations from fMRI Data Using a Recursive STAP Algorithm..........................................................................................................976 Elizabeth Thompson, Purdue University Fort Wayne; Scott Holland, Vincent Schmithorst, Cincinnati Children's Hospital Medical Center

Detection of Functional Networks In The Resting Brain ........................................980 Yong He, Yufeng Zang, Tianzi Jiang, Yingli Lu, National Laboratory of Pattern Recognition, Institute of Automation; Xuchu Weng, Laboratory for Higher Brain Function, Institute of Psychology

Independent Component Analysis of Complex-Valued Functional Magnetic Resonance Imaging Data by Complex Nonlinearities .............................................984 Vince Calhoun, Institute of Living/Yale University; Tulay Adali, Yiou Li, University of Maryland Baltimore County

Dimensionality and Degrees of Freedom in fMRI Data Analysis - A Comparative Study .....................................................................................................988 Joakim Rydell, Magnus Borga, Hans Knutsson, Peter Lundberg, Linköping University

Selection of Temporal Models for Event-Related fMRI .........................................992 Sophie Donnet, Marc Lavielle, Université Paris-Sud; Philippe Ciuciu, Jean-Baptiste Poline, SHFJ/CEA

Simultaneous Estimation of Kinetic Parameters and the Input Function from DCE-MRI Data: Theory and Simulation........................................................996 Zhu Han, Z. Jane Wang, K. J. Ray Liu, University of Maryland, College Park; Yue Wang, Virginia Polytechnic Institute and State University

Solving for Motion and Activation Simultaneously in an fMRI Experiment with Multiple Stimulus Conditions .........................................................................1000 Jeff Orchard, University of Waterloo; M. Atkins, Simon Fraser University

Relevance Vector Machine Analysis of Functional Neuroimages ........................1004 Dimitris Tzikas, Aristeidis Likas, Nikolaos Galatsanos, University of Ioannina; Ana Lukic, Miles Wernick, Illinois Institute of Technology

Clustering-Based Framework for Comparing fMRI Analysis Methods .............1008 Hamid Soltanian-Zadeh, Henry Ford Health System; Gholam-Ali Hossein-Zadeh, Ali-Mohammad Golestani, University of Tehran

Comparison of Supervised And Unsupervised Linear Methods for Recovering Task-Relevant Activity In EEG...........................................................1012 An Luo, Paul Sajda, Adam Gerson, Columbia University

Sa_PM_P2: MRI Cardiac and Diffusion Imaging Constrained Projection Reconstruction for Reduced Encoding MR Diffusion Tensor Imaging .........................................................................................................1016 Yi Jiang, Edward Hsu, Duke University

Distortion Correction using Mutual Information in 3D Diffusion Tensor Microscopy.................................................................................................................1020 Nilesh Mistry, Edward Hsu, Dept. of Biomedical Engineering, Duke University

A Level Set Method for Building Anatomical Connectivity Paths Between Brain Areas Using DTI.............................................................................................1024 Saâd Jbabdi, Pierre Bellec, Guillaume Marrelec, Habib Benali, INSERM

Recovery of Intra-voxel Structure from HARD DWI...........................................1028 Yunmei Chen, Weihong Guo, Qingguo Zeng, Guojun He, Baba Vemuri, Yijun Liu, University of Florida

Statistical Analysis of a Nonlinear Estimator for ADC and Its Application to Optimizing Diffusion Weighting Factors................................................................1032 Zhizhou Wang, Baba Vemuri, Evren Ozarslan, Yunmei Chen, Thomas Mareci, University Of Florida

Fiber Orientation Mapping Using Generalized Diffusion Tensor Imaging ........1036 Evren Ozarslan, Baba Vemuri, Thomas Mareci, University of Florida

PDE Denoising of MR Diffusion Tensor Imaging Data ........................................1039 Bin Chen, Edward Hsu, Duke University

A New Method to Measure Cross Sectional Area of Vessels in MRI Image and Its Application in Stenosis Detection ...............................................................1043 Jing Jiang, Ming Dong, Waye State University; E. Mark Haacke, MRI Insitute

Improved Reconstruction of Dynamic Cardiac Perfusion MRI with Use of a Reference Frame.........................................................................................1047 Dmitri Riabkov, Ed Di Bella, University of Utah

A Technique for Improving Tag Contrast Persistence in SSFP MRI Imaging Using Adaptive Flip Angle ........................................................................1051 El-Sayed Ibrahim, Nael Osman, Johns Hopkins University

Detecting the Onset of Myocardial Contraction for Establishing Inverse Electro-Mechanical Coupling in XMR Guided RF Ablation ...............................1055 Gerardo Sanchez-Ortiz, Raghavendra Chandrashekara, Imperial College London; Maxime Sermesant, Kawal Rhode, Reza Razavi, Derek Hill, Daniel Rueckert, Imperial College London

Spatial-Spectral Fat Suppression In Phase-Contrast Coronary Flow Imaging ......................................................................................................................1059 Ersin Bayram, Robert Kraft, W. Hundley, Craig Hamilton, Wake Forest University Health Sciences

Reconstruction of the Heart Boundary from Undersampled Cardiac MRI using Fourier Shape Descriptors and Local Basis Functions ......................1063 Simon Arridge, Iason Kastanis, UCL; Avi Silver, Derek Hill, Reza Ravazi, KCL

Simplified Gamma-Variate Fitting of Perfusion Curves ......................................1067 Antoinette Chan, Sarah Nelson, University of California, San Francisco

Sa_PM_P3: Optical Imaging and Microscopy Contaminant Detection: Improving Template Matching Based Particle Selection for Cryo-Electron Microscopy ................................................................1071 Yuanxin Zhu, Bridget Carragher, Clinton Potter, The Scripps Research Institute

Estimating Alignment Errors in Sets of Images.....................................................1075 Philip Baldwin, Pawel Penczek, The University of Texas Houston Medical School

Dynamic Light Transport Through Scattering and Absorbing Media : A Study Based on the Radiative Transfer Equation .............................................1079 Rachid Elaloufi, University College London; Rémi Carminati, Jean-Jacques Greffet, Ecole Centrale Paris

A Time and Photon Efficient Method of 3D Microscopic Imaging......................1083 Shuhong Li, Cha-Mei Tang, Creatv MIcroTech, Inc.; Cha-Min Tang, University of Maryland

How Accurately Can a Single Molecule be Localized When Imaged Through an Optical Microscope?............................................................................1087 Raimund Ober, Sripad Ram, Sally Ward, University of Texas Southwestern Medical Center

Confocal Microendoscope for Use in OB/GYN Applications ...............................1091 Josh Udovich, Andrew Rouse, Angelique Kano, Shona Kroto, Arthur Gmitro, University of Arizona

Penalty/Modified Barrier Function Method for Diagnostic Imaging Using Area and Point Illumination Geometries in Fluorescence-Enhanced Optical Tomography ..............................................................................................................1095 Ranadhir Roy, Anuradha Godavarty, Alan Thompson, Eva Sevick-Muraca, Texas A&M University

Contrast Enhancement and Artifact Reduction for Projected Index Computed Tomography ...........................................................................................1099 Adam Zysk, Daniel Marks, P Carney, Stephen Boppart, University of Illinois at Urbana-Champaign

Adaptive Finite Element Methods for Fluorescence Enhanced Frequency Domain Optical Tomography: Forward Imaging Problem..................................1103 Amit Joshi, Eva Sevick-Muraca, Alan Thompson, Texas A & M University; Wolfgang Bangerth, University of Texas

Direct Reconstruction of Kinetic Parameter Images in Fluorescence Optical Diffusion Tomography..............................................................................................1107 Adam Milstein, Seungseok Oh, Kevin Webb, Charles Bouman, Purdue University

Amplified Bimorph Scanning Mirror for Optical Coherence Tomography.......1111 Paul Patterson, Patrick Mills, Jason Zara, George Washington University

A Spatial Truncation Approach to the Analysis of Optical Imaging of the Retina in Humans and Cats .....................................................................................1115 Michael Abramoff, Young Kwon, Randy Kardon, University of Iowa Hospitals and Clinics; Daniel Ts'o, SUNY Health Sciences; Pete Soliz, Kestrel co; Simone Berriga, Kestrel co; Hingbin Li, SUNY

Precision, Repeatability And Validation of Indirect 3D Anthropometric Measurements With Light-Based Imaging Techniques ........................................1119 Reyes Enciso, Emmanuel Alexandroni, Krystal Benyamein, Robert Keim, James Mah, University of Southern California

Enhancement of Microtubules In EM Tomography .............................................1123 Ming Jiang, Qiang Ji, Rensselaer Polytechnic Institute; Bruce McEwen, Wadsworth Center

Sa_PM_P4: Detection, Classification and Image Retrieval Feature Based Statistical Analysis of Structural MR Data for Automatic Detection of Focal Cortical Dysplastic (FCD) Lesions ..........................................1127 Siddharth Srivastava, Dirk Vandermeulen, Frederik Maes, Paul Suetens, MIC/PSI/ESAT Katholieke University Leuven; Wim Van Paesschen, Dept. Of Neurology, University Hospital, Gasthuisberg; Patrick Dupont, Dept. Of Nuclear Medicine, University Hospital, Gasthuisberg

Full-Field Mammogram Analysis Based On The Identification of Normal Regions .......................................................................................................................1131 Yajie Sun, Charles Babbs, Edward Delp, Purdue University

Detection of Bronchovascular pairs on HRCT Lung Images Through Relational Learning ..................................................................................................1135 Mithun Prasad, Arcot Sowmya, School of Computer Science and Engineering

Automated Classification of Subcellular Patterns In Multicell Images Without Segmentation Into Single Cells .................................................................1139 Kai Huang, Robert Murphy, Department of Biological Science & Center for Automated Learning and Discovery,Carnegie Mellon University

MR Signal Inhomogeneity Correction for Visual And Computerized Atherosclerosis Lesion Assessment .........................................................................1143 Olivier Salvado, David Wilson, Jasjit Suri, Case Western Reserve University; Claudia Hillenbrand, Shaoxiong Zhang, University Hospitals of Cleveland

Feature Selection for The Characterization of Ultrasonic Images of The Placenta Using Texture Classification ....................................................................1147 Pedro Linares, P. J. McCullagh, N. D. Black, University of Ulster; J. Dornan, Royal Jubilee Maternity Service

Multi-set Multi-temporal Canonical Analysis of Psoriasis Images ......................1151 David Delgado Gomez, Allan Nielsen, Bjarne Ersboll, Informatics and Mathematical Modelling; Gabriela Maletti, The Royal Veterinary and Agricultural University, Department of Agricultural Sciences

Qualitative Asymmetry Measure for Melanoma Detection ..................................1155 Michele d'Amico, Massimo Ferri, University di Bologna; Ignazio Stanganelli, Istituto Oncologico Romagnolo

An Approximately Complete String Representation of Local Object Boundary Features for Concept-Based Biomedical Image Retrieval ....................................1159 Sennay Ghebreab, Erasmus MC, University Medical Center Rotterdam; Arnold Smeulders, University of Amsterdam

Mammogram Retrieval Based On Incremental Learning ....................................1163 Issam El Naqa, Washington University; Yongyi Yang, Nikolas Galatsanos, Miles Wernick, Illinois Institute of Technology

Sa_PM_OS1: Wavelets in Biomedical Imaging Wavelet-Based fMRI Statistical Analysis and Spatial Interpretation: A Unifying Approach................................................................................................1167 Dimitri Van De Ville, Thierry Blu, Michael Unser, Swiss Federal Institute of Technology Lausanne

Penalized Partially Linear Models using Orthonormal Wavelet Bases with an Application to fMRI Time Series.............................................................................1171 Jalal Fadili, GREYC CNRS UMR 6072; Ed Bullmore, Brain Mapping Unit University of Cambridge

Multiscale Analysis of fMRI Data with Mixture of Gaussian Densities ..............1175 Francois Meyer, Xilin Shen, University of Colorado at Boulder

Artifact Free Image Denoising with Morlet Integrated Wavelets........................1179 Peter Heinlein, Image Diagnost GmbH

Wavelet Analysis of Gene Expression (WAGE).....................................................1183 Federico Turkheimer, Dawn Duke, Linda Moran, Manuel Graeber, Imperial College London

Fusion of Brushlet and Wavelet Denoising Methods for Nuclear Images...........1188 Andrew Laine, Elsa Angelini, Y. Jin, P. Esser, R. Van Heertum, Columbia University

Fast Multiresolution Photon-Limited Image Reconstruction...............................1192 Rebecca Willett, Rice University; Robert Nowak, University of Wisconsin

Sa_PM_OS2: Recent Advances in MRI: Methodologies and Applications Fast-Scan Imaging ....................................................................................................1196 Craig Meyer, University of Virginia

Parallel Imaging: System Design and Limitations.................................................1200 Steven Wright, Mary McDougall, Krishna Kurpad, David Brown, Dept. of Electrical Engineering, Texas A&M University

Parallel Imaging: Some Signal Processing Issues and Solutions ..........................1204 Zhi-Pei Liang, Dan Xu, Lei Yuan, University of Illinois at Urbana-Champaign; Lei Ying, University of Wisconsin-Milwaukee

Technical Challenges in Functional Neuroimaging...............................................1208 Douglas Noll, University of Michigan

Cardiac MRI..............................................................................................................1211 Leon Axel, NYU School of Medicine

Triple Quantum Filtered Sodium MRI of Primary Brain Tumors .....................1215 Fernando Boada, Denise Davis, Kevin Walter, Alejandro Torres-Trejo, Douglas Kondziolka, Walter Bartynski, Frank Lieberman, University of Pittsburgh

Sa_PM_OS3: Image Formation and Analysis in Microscopy Neurite Tracing in Fluorescence Microscopy Images using Ridge Filtering and Graph Searching: Principles and Validation..................................................1219 Erik Meijering, Erasmus MC - University Medical Center Rotterdam; Mathews Jacob, J.-C. Floyd Sarria, Pascal Steiner, Harald Hirling, Michael Unser, Swiss Federal Institute of Technology Lausanne

A Deconvolution Method for Confocal Microscopy with Total Variation Regularization ...........................................................................................................1223 Nicolas Dey, Laure Blanc-Faraud, Josianne Zerubia, INRIA/I3S; Christophe Zimmer, Jean-Christophe Olivo-Marin, Institut Pasteur; Zvi Kam, Weizmann Institute of Science

Quantitative Imaging: How to Measure Size Features in Digitized Images........1227 Lucas van Vliet, Piet Verbeek, Ian Young, Delft University of Technology

On the Feasibility of Axial Tracking of Fluorescent Nano-Particles Using a Defocusing Model......................................................................................................1231 Nadja Subotic, Dimitri Van De Ville, Michael Unser, Swiss Federal Institute of Technology Lausanne

Detection and Tracking of Rolling Leukocytes from Intravital Microscopy ......1235 Scott Acton, Nilanjan Ray, University of Virginia

Interacting Multiple Model Based Method to Track Moving Fluorescent Biological Spots .........................................................................................................1239 Jean-Christophe Olivo-Marin, Auguste Genovesio, Bo Zhang, Institut Pasteur

Cell-Based Screening for Function..........................................................................1243 Zvi Kam, Tal Shay, Suha Naffar-Abu-Amara, Yael Paran, Eli Zamir, Yuvalal Liron, Benjamin Geiger, Weizmann

Sa_PM_OC4: Shape Analysis Differentiable Minimin Shape Distance For Incorporating Topological Priors in Biomedical Imaging ..................................................................................1247 Yonggang Shi, William Karl, Boston University

Representing Multi-Figure Anatomical Objects....................................................1251 Qiong Han, Conglin Lu, Shawn Liu, Stephen Pizer, Sarang Joshi, Andrew Thall, University of North Carolina, Chapel Hill

Bone Model Morphing for Enhanced Surgical Visualization...............................1255 Kumar Rajamani, Martin Styner, M. E. Müller Institute for Surgical Technology and Biomechanics; Sarang Joshi, Medical Image Analysis Group, University of North Carolina, Chapel Hill

Compact Support Radial Basis Functions for Soft Tissue Deformation .............1259 Mark Wachowiak, Xiaogang Wang, Aaron Fenster, Terry Peters, Robarts Research Institute

Simultaneous Recovery of Left Ventricular Shape and Motion Using Meshfree Particle Framework .................................................................................1263 Pengcheng Shi, Huafeng Liu, Alexandra Wong, Hong Kong University of Science and Technology; Albert Sinusas, Yale University

Population Classification Based on Structural Morphometry of Cortical Sulci .............................................................................................................1267 Edouard Duchesnay, Jean-François Mangin, Alexis Roche, Denis Rivière, Dimitri Papadopoulos-Orfanos, Yann Cointepas, SHFJ/CEA

An Automated Method for Finding Curves of Sulcal Fundi On Human Cortical Surfaces.......................................................................................................1271 Xiaodong Tao, Jerry Prince, The Johns Hopkins University; Christos Davatzikos, University of Pennsylvania

Volumetric Harmonic Brain Mapping....................................................................1275 Xianfeng Gu, University of Florida; Tony Chan, University of California Los Angeles; Paul Thompson, LONI, University of California Los Angeles Medical School; Shing-Tung Yau, Harvard University; Yalin Wang, Mathematics Department

Predictive Modeling of Anatomic Structures Using Canonical Correlation Analysis ......................................................................................................................1279 Tianming Liu, Dinggang Shen, Christos Davatzikos, University of Pennsylvania

Statistical Surface-Based Morphometry Using a Non-Parametric Approach ....1283 Dimitrios Pantazis, Richard Leahy, Signal and Image Processing Institute, Electrical Engineering, University of Southern California; Thomas Nichols, Department of Biostatistics, University of Michigan; Martin Styner, Institute for Surgical Technology and Biomechanics, University of Bern

Su_AM_P1: Image Segmentation II Automatic Delimitation of Lung Fields on Chest Radiographs............................1287 Ana Mendonça, Jorge Silva, Aurélio Campilho, INEB - Instituto de Engenharia Biomédica

Segmentation and Separation of Point Like Fluorescent Markers in Digital Images............................................................................................................1291 Patrick Karlsson, Joakim Lindblad, Centre for Image Analysis

A Supervised Method for Calculation of Perfusion/Diffusion Mismatch Volume In Acute Stroke ...........................................................................................1295 Olaniiyi Osuntokun, Karmen Yoder, Askiel Bruno, Indiana University School Of Medicine; Judy James, Indiana University- Purdue University, Indianapolis; Evan Morris, Indiana University- Purdue University, Indianapolis; Indiana University School Of Medicine

Domain Partitioning Level Set Surface for Topology Constrained Multi-Object Segmentation......................................................................................1299 Gary Ho, Pengcheng Shi, Hong Kong University of Science and Technology

Breast Mass Segmentation on Digital Mammograms by a Combined Deterministic Annealing Method.............................................................................1303 AiZe Cao, Qing Song, XuLei Yang, Sheng Liu, Nanyang Technological University

A Fuzzy C-Means (FCM) Based Algorithm for Intensity Inhomogeneity Correction and Segmentation of MR Images.........................................................1307 Weijie Chen, Maryellen Giger, The University of Chicago

An Adaptive Fuzzy Segmentation of Intravascular Ultrasound Images .............1311 Esmeraldo Santos Filho, Akira Tanaka, Takahiro Iwamoto, Tohoku University; Makoto Yoshizawa, Information Sinergy Center; Yoshifumi Saijo, Tomoyuki Yambe, Shin-ichi Nitta, Institute of Development, Aging and Cancer

Segmentation of Ultrasonic Images Using Learning Vector Quantization Network......................................................................................................................1315 Michael Rychagov, Yuri Masloboev, Stanislav Ilin, Moscow Institute of Electronic Technology (Technical University)

Segmentation of Arterial Geometry From Ultrasound Images Using Balloon Models ........................................................................................................................1319 Chaoquan Chen, Tamie Poepping, Jason Beech-Brandt, Steven Hammer, Paul Allan, William Easson, Peter Hoskins, University of Edinburgh; Richard Baldock, Bill Hill, MRC Human Genetics Unit

Comparison of Ventricular Geometry for Two Real Time 3D Ultrasound Machines With Three Dimensional Level Set ........................................................1323 Andrew Laine, Elsa Angelini, Ryo Otsuka, Sunishi Homma, Columbia University

Sequential vs Simultaneous Stochastic Segmentation ...........................................1327 Eilat Vardi-Gonen, Gabor Herman, The Graduate Center, CUNY

Su_AM_P2: EEG, MEG and Novel Imaging Modalities Single-Cell Level Continuous Observation of Microorganism Galvanotaxis Using High-Speed Vision..........................................................................................1331 Naoko Ogawa, Koichi Hashimoto, Masatoshi Ishikawa, University of Tokyo; Hiromasa Oku, PRESTO, JST

EEG Cortical Imaging: A Vector Field Approach for Laplacian Denoising and Missing Data Estimation...................................................................................1335 Teodor Alecu, Sviatoslav Voloshynovskiy, Thierry Pun, University of Geneva

Line-source Modeling and Estimation with Magnetoencephalography..............1339 Imam Yetik, Arye Nehorai, University of Illinois at Chicago; Carlos Muravchik, Universidad Nacional de La Plata, Argentina; Jens Haueisen, Neurological University Hospital, Philosophenweg 3D, Germany

Data-Driven Cortex Parcelling : A Regularization Tool for the EEG/MEG Inverse Problem......................................................................................................................1343 Jean Daunizeau, Habib Benali, Imagerie Médicale Quantitative (U494), INSERM, Paris, France; Jeremie Mattout, Institute of Cognitive Neurosciences, London,UK; Jean-Marc Lina, Bernard Goulard, CRM, Montreal, Canada

Frequency Dispersion of Wave Velocity in Arterial Vessels.................................1347 Xiaoming Zhang, Mostafa Fatemi, James Greenleaf, Mayo Clinic College of Medicine

Development of Microwave Tomography for Functional Cardiac Imaging.......1350 Serguei Semenov, Vitaly Posukh, Alexander Bulyshev, Thomas Williams, Paula Clark, Carolinas Medical Center; Yuri Sizov, Troitsk Institute of Innovative and Thermonuclear Research; Boris Voinov, Scientific Research Insitutte of Experimental Physics

Nanoparticle-Enhanced Proton Computed Tomography: A Monte Carlo Simulation Study.......................................................................................................1353 Reinhard Schulte, Vladimir Bashkirov, Loma Linda University Medical Center; David Williams, Hartmut Sadrozinski, University of California at Santa Cruz; Tianfang Li, Zhengrong Liang, State University New York Stony Brook; Steven Peggs, Todd Satogata, Brookhaven National Laboratory

Better Conditioning the MEG/EEG Inverse Problem: The Multivariate Source Prelocalization Approach ............................................................................1361 Jeremie Mattout, University College London; Jean Daunizeau, Centre de Recherches Mathematiques; Melanie Pelegrini-Issac, U483 INSERM; Line Garnero, UPR640 CNRS; Habib Benali, U494 INSERM

microRT: A Conformal Small Animal Irradiator .................................................1365 Daniel Low, Sasa Mutic, Perry Grigsby, Milos Vicic, Joseph Deasy, Andrew Hope, Washington University

Microwave Breast Imaging with an Under-Determined Reconstruction Parameter Mesh........................................................................................................1369 Paul Meaney, Qianqian Fang, Margaret Fanning, Sarah Pendergrass, Timothy Raynolds, Colleen Fox, Keith Paulsen, Dartmouth College

Su_AM_P3: PET, SPECT and X-ray Imaging Prompt Gamma-Ray Imaging for Small Animals .................................................1373 Robin Gardner, Libai Xu, North Carolina State University

Volumetric Micro-CT System for In Vivo Microscopy.........................................1377 Cristian Badea, Laurence Hedlund, Charles Wheeler, Wilfried Mai, G. Johnson, Duke University Medical Center

A Likelihood-Based Framework for Quantification of Brain Receptor PET Studies in The Pixel Domain ...........................................................................1381 Z. Jane Wang, Zhu Han, K. J. Ray Liu, UMD, CP; Zsolt Szabo, Johns Hopkins University Medical Institution; József Varga, University of Debrecen, Hungary

Effect of Detector Scatter Restoration on Image Spatial Resolution and Partial Volume ..........................................................................................................1384 Otman Sarrhini, Simon-Alexandre Lhussier, M'hamed Bentourkia, Université de Sherbrooke

Can the Specificity of MRI Breast Imaging be Improved by Fusing 3D MRI Volume Data Sets with FDG PET? ................................................................1388 Marilyn E. Noz, Linda Moy, Fabio Ponzo, Elissa Kramer, NYU; Gerald Maguire Jr, Royal Institute of Technology;

Lesion Quantification In Dual-Modality Mammography Using Expectation Maximization With Attenuation Correction ..........................................................1392 Heng Li, Yibin Zheng, Mitali J. More, Patricia J. Goodale, Mark B. Williams, University of Virginia

Application of a PET Device with 1.5 mm FWHM Intrinsic Spatial Resolution to Breast Cancer Imaging .....................................................................1396 Irving Weinberg, David Beylin, Steve Yarnall, Edward Anashkin, Pavel Stepanov, Sergei Dolinsky, Naviscan PET System

Assessing The Similarity of Spatial Configurations Using Distance Differences and Bending Energy: Application To Chromosomal Interphase Arrangements In HeLa Cell Clones..................................................................................................1400 Juntao Gao, Roland Eils, German Cancer Research Center; Daniela Köhler, Irina Solovei, Thomas Cremer, Ludwig Maximilians University; Julian Mattes, German Cancer Research Center and Ludwig Maximilians University

Algorithm to Extend Reconstruction Field-of-View..............................................1404 Jiang Hsieh, Ed Chao, Jean-Baptiste Thibault, Brian Grekowicz, Amy Horst, Scott McOlash, Tom Myers, GE Medical Systems

A New, Fast, Relaxation-Free, Convergent, Hessian-based, Ordered-Subsets Algorithm for Emission Tomography.....................................................................1408 Ing-Tsung Hsiao, Chang-Gung University, Taiwan; Anand Rangarajan, Department of Computer and Information Science and Engineering, University of Florida; Parmeshwar Khurd, Gene Gindi, Department of Electrical and Computer Engineering, SUNY at Stony Brook

Optimized Radiographic Spectra for Digital Subtraction Angiography in the Mouse .........................................................................................................................1412 Ming De Lin, Cristian Badea, G. Johnson, Duke University

Tomographic Reconstruction From an Uncontrolled Sensor Trajectory ...........1416 Chris Baker, Christian Debrunner, William Hoff, Jamon Bowen, Colorado School of Mines; Mohamed Mahfouz, University of TN, Oak Ridge National Laboratories

A Hierarchical Algorithm for Fast Backprojection in Helical Cone-Beam Tomography ..............................................................................................................1420 Jeffrey Brokish, Yoram Bresler, University of Illinois at Urbana-Champaign

Fast Reconstruction for Unconstrained Cone Beam Tomosynthesis ...................1424 Beilei Wang, Kenneth Barner, University of Delaware; Denny Lee, Direct Radiography Corporation

Noise Analysis for Diffraction Enhanced Imaging ................................................1428 Miles Wernick, Jovan Brankov, Alejandro Saiz-Herranz, Illinois Institute of Technology

Effect of Scan Duration on Lesion Detectability in PET Oncology Imaging ......1432 Phillip Cheng, Paul Kinahan, Jae-Seung Kim, Thomas Lewellen, University of Washington; Claude Comtat, Service Hospitalier Frédéric Joliot; Carole Lartizien, ANIMAGE-CERMEP

Su_AM_P4: Non-Rigid Registration 2-D Electrophoresis Gel Registration Using Feature Matching ...........................1436 Mike Rogers, Jim Graham, University of Manchester; Robert Tonge, Astra Zenica

Intermodality Nonrigid Breast-Image Registration ..............................................1439 Ioana Coman, Department of Mathematics and Computer Science, Ithaca College; Andrzej Krol, David Feiglin, Wei Li, Department of Radiology, SUNY Upstate Medical University; Edward Lipson, Department of Physics, Syracuse University; James Mandel, Department of Civil and Environmental Engineering, Syracuse University; Karl Baum, Mehmet Unlu, Department of Electrical Engineering and Computer Science, Syracuse University;

Nonrigid Registration of Medical Image by Maxwell Model of Viscoelasticity ............................................................................................................1443 Songyuan Tang, Tianzi Jiang, Institute of Automation, Chinese Academy of Sciences

Evaluation of Cardiac PET-MRI Registration Methods Using a Numerical Breathing Phantom...................................................................................................1447 Mika Pollari, Timo Mäkelä, Helsinki University of Technology; Jyrki Lötjönen, VTT Information Technology; Nicoleta Pauna, Patrick Clarysse, CREATIS INSA; Anthonin Reilhac, McGill University;

Elastic Registration of Gel Electrophoresis Images Based on Landmarks and Intensities ...................................................................................................................1451 Pascal Cathier, Siemens Medical Solutions; Stefan Woerz, Karl Rohr, International University in Germany

Fully Elastic Multi-Modality Image Registration Using Mutual Information....1455 Bilge Karacali, University of Pennsylvania

Multi-Modal Non-Rigid Registration Using a Stochastic Gradient Approximation ..........................................................................................................1459 Mathieu De Craene, Aloys du Bois d'Aische, Benoît Macq, Université Catholique de Louvain; Florian Kipfmueller, Neil Weisenfeld, Steven Haker, Simon Warfield, Brigham and Women's Hospital

Deformable Registration of Male Pelvises in CT Images......................................1463 Yiqiang Zhan, Dinggang Shen, University of Pennsylvania; Russell Taylor, Johns Hopkins University

Su_AM_OS1: Optical Tomographic Imaging Optical Tomographic Imaging of Small Tissue Volumes: From Rat Brains to Human Finger Joints............................................................................................1467 Andreas Hielscher, A.D. Klose, A. Bluestone, J.M. Lasker, B. Moa-Anderson, J.M. Masciotti, G. Abdoulaev, Columbia University; A. Scheel, Georg-August-University; M. Stewart, SUNY Downstate Medical Center; U. Netz, J. Beuthan, Charité-University Medicine

Image-Quality Assessment in Optical Tomography..............................................1471 Matthew Kupinski, Eric Clarkson, The University of Arizona

Fluorescence Molecular Tomography: New Detection Schemes for Acquiring High Information Content Measurements ...........................................1475 Vasilis Ntziachristos, Edward Graves, Ralf Schultz, Jorge Ripoll, Harvard University

High-Resolution Functional Photoacoustic Tomography .....................................1478 Lihong Wang, Xueding Wang, Geng Ku, George Stoica, Texas A&M University

Fluorescence-Enhanced Optical Imaging and Tomography for Cancer Diagnostics .................................................................................................................1482 Eva Sevick-Muraca, Texas A&M University

Time Domain Optical Tomography ........................................................................1486 Simon Arridge, University College London

Su_AM_OS2: Methods for Functional Brain Mapping Probabilistic ICA for fMRI......................................................................................1490 Christian Beckmann, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain

Subspace Models for Functional MRI Data Analysis............................................1494 Ola Friman, Laboratory of Mathematics in Imaging, Brigham and Women's Hospital, Harvard Medical School

New Procedures for False Discovery Control ........................................................1498 Christopher Genovese, Carnegie Mellon University; Elisha Merriam, University of Pittsburgh

Effective Connectivity Analysis: Testing Commonalities and Differences Across Multi-Subjects' Network by State-Space Model........................................1502 Moon-ho Ho, McGill University

A Closed-Form Method for Improving Inter-Subject Coherence in Diffusion Tensor Magnetic Resonance Imaging .....................................................................1506 Nicholas Lange, Harvard University; Derek Jones, Carlo Pierpaoli, National Institutes of Health

SUMA: An Interface for Surface-Based Intra- and Inter-Subject Analysis with AFNI ..................................................................................................................1510 Ziad Saad, Richard Reynolds, Robert Cox, Scientific and Statistical Computing Core, National Institute of Mental Health; Brenna Argall, Shruti Japee, Laboratory of Brain and Cognition, National Institute of Mental Health

Su_AM_OC3: Novel Imaging Modalities Magneto-Optical Detection of Weak Magnetic Fields...........................................1512 J Talmadge, J Eden, J Gao, University of Illinois at Urbana-Champaign

Micro-CT System for Small Animal Imaging with Ultrafast Laser-Based X-Ray Source.............................................................................................................1516 Andrzej Krol, Charles Chamberlain, SUNY Upstate Medical University; Jean-Claude Kieffer, Liming Chen, INRS-Énergie et Matériaux, Université du Québec; Remy Toth, INRS-Énergie et Matériaux, Université du Québec; Ioana Coman, Department of Computer Science and Mathematics, Ithaca College; Edward Lipson, R.E. Kincaid, Department of Physics, Syracuse University

Bionano-Imaging Analysis in Cell Behavior Study................................................1521 Pushkar Mukewar, Georgia Institute of Technology; May Wang, School of Biomedical Engineering, Georgia Institute of Technology and Emory University

Evaluation of Arterial Endothelial Function Using Transit Times of Artificially Induced Pulses...........................................................................................................1525 Jonathan Maltz, Thomas Budinger, Lawrence Berkeley National Lab

Hyperspectral Imaging of Biological Targets: The Difference A High Resolution Spectral Dimension And Multivariate Analysis Can Make..................................1529 Jerilyn Timlin, David Haaland, Michael Sinclair, Monica Manginell, Susan Brozik, Sandia National Labs; M. Juanita Martinez, Margaret Werner-Werner-Washburne, John Guzowski, University of New Mexico

Developing Metrology for Tissue Engineering: Collinear Optical Coherence and Confocal Fluorescence Microscopies.......................................................................1533 Joy Dunkers, Forrest Landis, Marcus Cicerone, James Cooper, Newell Washburn, NIST

Su_AM_OC4: Image Guided Surgery & Therapy Radiofrequency Thermal Ablation: 3D MR-histology Correlation for Localization of Cell Death in MR Lesion Images ..................................................1537 Michael Breen, Roee Lazebnik, Jonathan Lewin, Case Western Reserve University; Sherif Nour, University Hospitals of Cleveland; David Wilson, Case Western Reserve University

A Segmentation-Based Automatic Navigation Technique for Virtual Endoscopy..................................................................................................................1541 Bruno Carvalho, University of Pennsylvania; Gabor Herman, The Graduate Center - CUNY

Refining the Sonic Flashlight for Interventional Procedures ...............................1545 Wilson Chang, George Stetten, University of Pittsburgh; Nikhil Amesur, Michael Horowitz, University of Pittsburgh Medical Center

Assessment of Radiation Mediated Gene Therapy Via Multi-Modality Imaging ......................................................................................................................1549 Chad Haney, Adrian Parasca, Kazuhiro Ichikawa, Martyna Elas, Marta Zamora, Xiaobing Fan, Gregory Karczmar, Howard Halpern, Charles Pelizzari, University of Chicago

Application of Support Vector Clustering to the Visualization of Medical Images ........................................................................................................................1553 Cristina Garcia, Jose Moreno, Universidad Central de Venezuela

Detection of The Functional Knee Center Using The Mean Helical Axis: Application In Computer Assisted High Tibial Osteotomy ..................................1557 J. Daniel Gil, Chafiaâ Hamitouche, Christian Roux, LaTIM - INSERM and ENST Bretagne; Gwenaël Guillard, LaTIM - INSERM; Eric Stindel, LaTIM - INSERM and Hôpital de la Cavale Blanche