TABLE OF CONTENTS

AN OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA & IMMUNOLOGY

March 2013 � Volume 1 � Issue 2

Th

JACI: Ina “bedsideThe asth

Clinical M

The Journal1710. POSService, 32

A Special Thank-You to Our Reviewers

109

REVIEW AND FEATURE ARTICLES

Clinical Management

Severe asthma: An expanding and mounting clinical challenge

110 Matthew C. Bell, MD, and William W. Busse, MD, Madison, Wis

Continuing Medical Education examination: Severe asthma: An expanding and mountingclinical challenge

122

Grand Rounds

Asthma adherence management for the clinician

123 Andrew G. Weinstein, MD, Wilmington, Del

Continued on page 8A

is month’s theme: Asthma

About the Cover

As reflected on this month’s cover, the theme of theissue is asthma. The clinician instructing the patienton the spirometry maneuver highlights the practicalfocus of The Journal of Allergy and Clinical Immu-nology: In Practice. Note also that the January issue of

Practice is in the rack on the wall, emphasizing its role as” resource.ma theme is highlighted by our three lead review articles: Ouranagement review series continues with Matthew C. Bell and

William W. Busse (p. 110) comprehensively reviewing the clinical mani-festations andmanagement options for patients with severe asthma. In ourfirst Grand Rounds review, Andrew G. Weinstein (p. 123) presentsa patient with asthma for whom adherence barriers were identified andaddressed and then provides a summary of the various types of adherencebarriers and their recommended interventions. Stephen P. Peters (p. 129)provides the first installment of our Chief Complaint Review Series, inwhichhedescribes examples of several patients presentingwithdyspnea anddiscusses a practical, systematic approach to the clinical evaluation of thiscommon symptom.These reviews, alongwith relevant original articles andbrief reports, are indicated by the red starburst icon in the Table of Contents.

of Allergy and Clinical Immunology: In Practice (ISSN: 2213-2198) is published bimonthly by Elsevier Inc., 360 Park Avenue South, New York, NY 10010-TMASTER: Send address changes to The Journal of Allergy and Clinical Immunology: In Practice, Elsevier Health Sciences Division Subscription Customer51 Riverport Lane, Maryland Heights, MO 63043.

TABLE OF CONTENTS, continued The Journal of Allergy and Clinical Immunology: In Practice

Chief Complaint

When the chief complaint is (or should be) dyspnea in adults

129 Stephen P. Peters, MD, PhD, FAAAAI, FACP, FCCP, FCPP, Winston-Salem, NC

AAAAI Committee Papers

Climate change and our environment: The effect on respiratory and allergic disease

137 Charles S. Barnes, PhD, Neil E. Alexis, PhD, MHS, MS, Jonathan A. Bernstein, MD, John R. Cohn, MD, Jeffrey G. Demain, MD,Elliott Horner, PhD, Estelle Levetin, PhD, Andre Nel, MD, PhD, and Wanda Phipatanakul, MD, MS, Kansas City, Mo; Chapel Hill, NC;Cincinnati, Ohio; Philadelphia, Pa; Anchorage, Alaska; Atlanta, Ga; Tulsa, Okla; Los Angeles, Calif; and Boston, Mass

Management of difficult-to-treat atopic dermatitis

142 Peter D. Arkwright, MB, DPhil, Cassim Motala, MD, Hamsa Subramanian, MD, Jonathan Spergel, MD, PhD, Lynda C. Schneider, MD, andAndreas Wollenberg, MD, for the Atopic Dermatitis Working Group of the Allergic Skin Diseases Committee of the AAAAI, Manchester,United Kingdom; Cape Town, South Africa; St Louis, Mo; Philadelphia, Pa; Boston, Mass; and Munich, Germany

ORIGINAL ARTICLES

Evaluation of the modified asthma predictive index in high-risk preschool children

152 Timothy S. Chang, PhD, Robert F. Lemanske Jr., MD, Theresa W. Guilbert, MD, MS, James E. Gern, MD, Michael H. Coen, PhD,Michael D. Evans, MS, Ronald E. Gangnon, PhD, C. David Page, PhD, and Daniel J. Jackson, MD, Madison, Wis

Quality of life, health care utilization, and control in older adults with asthma

157 Jacqueline A. Ross, MD, Ye Yang, MS, Peter X.K. Song, PhD, Noreen M. Clark, PhD, and Alan P. Baptist, MD, MPH, Ann Arbor, Mich

Reassessment of omalizumab-dosing strategies and pharmacodynamics in inner-city childrenand adolescents

163

Christine A. Sorkness, PharmD, Jeremy J. Wildfire, MS, Agustin Calatroni, MA, MS, Herman E. Mitchell, PhD, William W. Busse, MD,George T. O’Connor, MD, MS, Jacqueline A. Pongracic, MD, Kristie Ross, MD, Michelle A. Gill, MD, PhD, Meyer Kattan, MD, CM,Wayne J. Morgan, MD, CM, Stephen J. Teach, MD, MPH, Peter J. Gergen, MD, MPH, Andrew H. Liu, MD, and Stanley J. Szefler, MD,Madison, Wis; Chapel Hill, NC; Boston, Mass; Chicago, Ill; Cleveland, Ohio; Dallas, Tex; New York, NY; Tucson, Ariz; Washington, DC;Bethesda, Md; and Denver, Colo

Biologic mechanisms of environmental tobacco smoke in children with poorly controlledasthma: Results from a multicenter clinical trial

172

Jason E. Lang, MD, Allen J. Dozor, MD, Janet T. Holbrook, PhD, MPH, Edward Mougey, PhD, Sankaran Krishnan, MD, Shawn Sweeten, BS,Robert A. Wise, MD, W. Gerald Teague, MD, Christine Y. Wei, MS, David Shade, JD, and John J. Lima, PharmD, for the American LungAssociation-Asthma Clinical Research Centers, Orlando and Jacksonville, Fla; Valhalla, NY; Baltimore, Md; and Charlottesville, Va

Prospective evaluation of an anaphylaxis education mini-handout: The AAAAI anaphylaxiswallet card

181

Vivian Hernandez-Trujillo, MD, FAAAAI, and F. Estelle R. Simons, MD, FAAAAI, Miami, Fla; and Winnipeg, MB, Canada

International study of risk-mitigating factors and in-flight allergic reactions to peanut andtree nut

186

Matthew Greenhawt, MD, MBA, MSc, Fiona MacGillivray, Geraldine Batty, Maria Said, and Christopher Weiss, PhD, Ann Arbor and BattleCreek, Mich; and Hornsby, New South Wales, Australia

Continued on page 9A

The Journal of Allergy and Clinical Immunology: In Practice TABLE OF CONTENTS, continued

CLINICAL COMMUNICATIONS

Systemic contact dermatitis to ethanol

195 Wayne Wolverton, DO, and Satyen Gada, MD

The basophil activation test identified carminic acid as an allergen inducing anaphylaxis

197 Naoya Sugimoto, MD, Masao Yamaguchi, MD, PhD, Yusuke Tanaka, MD, Yuko Nakase, MD, Hiroyuki Nagase, MD, PhD,Hiroshi Akiyama, PhD, and Ken Ohta, MD, PhD

Cross-reactivity between royal jelly and Dermatophagoides pteronyssinus

200 Leticia Vila, MD, PhD, Borja Bartolome, PhD, and Ana Moreno, MD

ASK THE EXPERT

When to discontinue venom immunotherapy: The role of retesting to venom

202 Phillip Lieberman, MD, and David Golden, MD

Online Repository material

Video available online at www.jaci-inpractice.org

Theme article

CME activity available online at www.jaci-inpractice.org

Continuing Medical Education (CME) credit is available to readers who successfully complete examinations accompanying selected reviewarticles. This CME opportunity furthers the joint educational goals of the Journal and its sponsoring foundation, the American Academy ofAllergy, Asthma & Immunology (AAAAI). The self-directed examinations can be taken at the JACI: In Practice Web site (www.jaci-inpractice.org). Credit is administered by the AAAAI.

Statements and opinions expressed in the articles and communications herein are those of the author(s) and not necessarily those of the Editor, publisher, or the American Academy ofAllergy, Asthma & Immunology. The Editor, publisher, and the American Academy of Allergy, Asthma & Immunology disclaim any responsibility or liability for such material anddo not guarantee, warrant, or endorse any product or service advertised in this publication, nor do they guarantee any claim made by the manufacturer of such product or service.