Table of Common Herbs and Supplements

42
Table of Common Herbs and Supplements

Transcript of Table of Common Herbs and Supplements

Table of Common Herbs and Supplements

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Aca

i (ah

-sig

h-EE

)◆

◆B

erry

from

Sou

th a

nd

Cen

tral

Am

eric

a

Ant

i-can

cer

Ant

i-oxi

dant

Ant

i-inf

lam

mat

ory

No

scie

ntifi

c st

udie

s do

ne o

n us

e fo

r m

edic

al c

ondi

tion

s

Alle

rgic

to

acai

or

plan

ts in

pal

m fa

mily

May

aff

ect

MR

I res

ults

AD

Rs:

Hyp

erte

nsio

nG

I ble

edin

gU

lcer

s

Juic

e, c

apsu

le, p

owde

r,

tabl

ets

Wid

ely

used

, no

spec

ific

dosi

ng

Alo

e V

era

“bur

n pl

ant”

“l

ily o

f the

des

ert”

◆◆

Leav

es c

onta

in a

cle

ar g

el t

hat

can

be u

sed

topi

cally

◆◆

Gre

en p

art

of le

af t

hat

surr

ound

s

gel p

rodu

ces

juic

e or

dri

ed

subs

tanc

e (l

atex

) th

at c

an b

e

take

n or

ally

◆◆

Use

d ba

ck 6

000

year

s to

Eg

ypti

an t

imes

Scie

ntifi

c st

udie

s sh

ow b

enef

it

for

topi

cal g

el h

ealin

g bu

rns

and

abra

sion

s; h

owev

er, m

ay n

ot

wor

k fo

r de

ep s

urgi

cal w

ound

s or

ra

diat

ion

wou

nds

Laxa

tive

aff

ect

take

n or

ally

Inac

tiva

tes

HSV

2 vi

rus

Bac

teri

osta

tic

prop

erti

es

Con

tain

s st

erol

s w

ith

an

ti-in

flam

mat

ory

prop

erti

es

* Tox

icol

ogy

stud

y of

ora

l who

le le

af e

xtra

ct f

ound

ris

k of

car

cino

geni

city

in la

b an

imal

s* T

opic

al a

loe

has

no k

now

n si

de e

ffec

tsA

DR

s w

ith

oral

alo

e:Lo

wer

s bl

ood

suga

r by

sti

mul

atin

g in

sulin

Dia

rrhe

a/ab

d.cr

amps

Arr

hyth

mia

from

hyp

okal

emia

Con

tac

derm

atit

is, s

ting

ing,

sor

enes

sA

cute

hep

atit

is, r

enal

failu

re, n

ephr

itis

Abo

rtifa

cent

, may

↑ut

erin

e bl

eedi

ngA

void

in p

regn

ancy

and

lact

atio

nA

void

per

iope

rati

vely

; has

cau

sed

blee

ding

Top

ical

alo

e on

ly

Use

of

oral

alo

e no

t re

c-om

men

ded

due

to s

afet

y co

ncer

ns

Use

of

IM a

nd IV

alo

e ha

ve b

een

asso

ciat

ed

wit

h de

ath

Avo

id if

hx

of a

llerg

ies

to

any

mem

ber

of L

iliac

eae

fam

ily (

tulip

s, li

lies,

hya

-ci

nths

, oni

ons,

asp

arag

us,

and

garl

ic)

Ash

wag

anda

“w

itha

nia

som

nife

ra”

Use

s: A

dapt

ogen

Ant

i-art

hrit

is

Ant

i-agi

ng

Type

2 D

iabe

tes

Mel

litus

Hyp

erlip

idem

ia

Park

inso

n’s

dise

ase

* Do

not

use

in p

regn

ancy

: has

bee

n us

ed a

s ab

orti

face

ntA

DR

s:↓

bp↓

bs↑

WB

C↑

plat

elet

s↓

tes

tost

eron

e/FS

H le

vels

DR

UG

INT

ERA

CT

ION

S:A

lcoh

ol, s

edat

ives

, anx

ioly

tics↑

sed

atio

nA

void

wit

h di

uret

ics-↑

effe

cts

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↑hy

pogl

ycem

iaA

ntih

yper

tens

ives

↑hy

pote

nsio

nTh

yroi

d ho

rmon

es-a

lter

eff

ect

In c

apsu

les,

tab

lets

, tea

Tabl

ets

are

stan

dard

ized

Dos

e: 1

-6 g

in c

apsu

le o

r te

a qd

Or

3-12

g in

com

bina

tion

w

ith

othe

r he

rbs

Pedi

atri

c do

sage

: (8-

12

year

s on

ly)

2g q

d fo

r no

>6

0 da

ys

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Asi

an G

inse

ng

“Kor

ean

gins

eng”

“C

hine

se g

inse

ng”

◆◆

Not

e: S

iber

ian

gins

eng

is n

ot

gins

eng

at a

ll

Use

s: a

dapt

ogen

, sta

min

a, m

enta

l an

d ph

ysic

al p

erfo

rman

ce

Hep

atit

is C

Men

opau

se

Erec

tile

dys

func

tion

Hyp

erte

nsio

n

Dia

bete

s m

ellit

us

Stud

ies:

may

low

er b

lood

glu

cose

; m

ay h

elp

imm

une

func

tion

NC

CA

M r

esea

rch

curr

entl

y in

ca

ncer

and

Alz

heim

er’s

dis

ease

↑T

cell

and

lym

phoc

yte

acti

vity

May

inhi

bit

RN

A t

ype

viru

ses

May

hav

e an

tiox

idan

t pr

oper

ties

* Ris

k al

lerg

ic r

eact

ions

* Not

rec

omm

ende

d in

pre

gnan

cy/l

acta

tion

due

to

horm

onal

and

tox

ic e

ffec

ts, t

erat

ogen

* ↑ r

isk

brea

st c

ance

r-st

imul

ates

bre

ast

canc

er c

ells

* avo

id in

ast

hma,

arr

hyth

mia

, HTN

, psy

chia

tric

dis

orde

r

* sto

p pr

e-op

erat

ivel

y du

e to

ble

edin

g ef

fect

AD

Rs:

H/A

GI d

istu

rban

ce, a

ppet

ite

chan

ges

Slee

p di

stur

banc

e

Arr

hyth

mia

Ane

mia

Stev

ens-

John

sons

Syn

drom

e

↑es

trog

enic

eff

ects

Men

stru

al c

hang

es, ↑

blee

ding

Mas

talg

ia, b

reas

t gr

owth

Man

ia in

bip

olar

dis

orde

r

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts ↑

or↓

bs

anti

hype

rten

sive

s-al

ter

effe

ct

anti

psyc

hoti

cs ↑

seda

tion

, ↑ef

fect

estr

ogen

↑ef

fect

seda

tive

s ↑

seda

tion

Roo

t is

dri

ed fo

r ta

blet

s,

caps

ules

, ext

ract

s, t

eas

Tabl

et a

nd c

apsu

le

stan

dard

ized

to

4 %

gi

nsen

osid

es (

acti

ve

ingr

edie

nt)

Shor

t te

rm u

se: u

p to

2

g/da

y Pa

nax

gins

eng

Long

-ter

m u

se: 1

g/d

ay

Pana

x gi

nsen

g

Not

e: g

inse

ng is

add

ed

to m

any

com

mer

cial

be

vera

ges

curr

entl

y

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Pan

ax G

inse

ng “

Am

eric

an g

inse

ng”

See

Asi

an G

inse

ng

Use

s: A

DH

D, c

hron

ic H

epat

itis

B,

CH

F, d

emen

tia,

CA

D, h

yper

lipid

emia

, m

enop

ausa

l sym

ptom

s, IT

P, M

RSA

, di

abet

ic r

enal

dis

ease

See

abov

eSe

e ab

ove

Ast

ralg

us “

milk

vet

ch”

◆◆

Trad

itio

nal C

hine

se M

edic

ine

for

imm

unit

y, c

ance

rs, a

nd h

epat

itis

◆◆

In le

gum

e fa

mily

◆◆

300

spec

ies

grow

in N

orth

Am

er-

ica;

som

e to

xic

to li

vest

ock

Und

er s

tudy

: pot

enti

al b

enef

its

for

imm

une

syst

em, l

iver

,hea

rt, a

nd

adju

ncti

ve c

ance

r th

erap

y

2005

Coc

hran

e st

udy:

som

e im

mun

e st

imul

atio

n an

d ↓

N/V

in c

olor

ecta

l ca

ncer

Ant

ioxi

dant

eff

ects

Use

d in

CA

D a

nd D

M

Use

d in

hep

atit

is, H

IV,

hepa

topr

otec

tion

Che

mot

hera

py s

ide

effe

cts

Men

tal p

erfo

rman

ce

Smok

ing

cess

atio

n

UR

I, bu

rns

* som

e as

trag

alus

spe

cies

, mos

tly

not

foun

d in

di

etar

y su

pple

men

ts u

sed,

mig

ht b

e to

xic.

Som

e sp

ecie

s to

xic

leve

ls o

f se

leni

um a

nd s

ome

cont

ain

neur

otox

in s

wai

nson

ine

whi

ch h

as c

ause

d “l

oco-

wee

d” p

oiso

ning

in a

nim

als.

Die

tary

sup

plem

ent

astr

algu

s is

gen

eral

ly c

onsi

dere

d sa

fe fo

r m

ost

adul

ts

DR

UG

INT

ERA

CT

ION

S

may

inte

ract

wit

h im

mun

e su

ppre

ssan

ts, s

uch

as

can

cer

drug

cyc

loph

osph

amid

e an

d or

gan

tran

spla

nt d

rugs

.

AD

Rs:

↓B

S,↓

HR

, ↓B

S

Dia

rrhe

a

Ble

edin

g: in

tera

cts

wit

h an

tico

agul

ants

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Avo

id in

imm

une

diso

rder

s, t

rans

plan

ts,

blee

ding

dis

orde

rs

Roo

t us

ed in

tea

s, s

oups

, ca

psul

es, e

xtra

cts,

tin

ctur

e,

IM a

nd IV

No

spec

ific

dosi

ng

reco

mm

enda

tion

s

Mos

tly

used

as

drie

d ro

ot,

cons

ider

ed n

on-t

oxic

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Bilb

erry

“H

uckl

eber

ry”

“E

urop

ean

blue

berr

y”◆

◆R

elat

ed t

o bl

uebe

rry

◆◆

Ber

ries

or

drie

d le

aves

ar

e m

edic

inal

◆◆

Use

d fo

r 10

00 y

ears

in E

urop

ean

folk

med

icin

es, e

spec

ially

for

scur

vy

and

diar

rhea

Con

tain

s an

thoc

yano

side

s (t

ype

of fl

avin

oid)

:↑m

icro

circ

ulat

ion,

an

tiox

idan

t, p

late

let

inhi

bito

r,

anti

-infla

mm

ator

y,↓

capi

llary

fr

agili

ty, p

rese

rves

end

othe

lium

Ath

eros

cler

osis

Peri

pher

al v

ascu

lar

dise

ase

Dia

bete

s m

ellit

us

Pept

ic u

lcer

dis

ease

Dia

rrhe

a

Cat

arac

ts a

nd g

lauc

oma

Ret

inop

athy

4 st

udie

s sh

owed

no

bene

fit fo

r ni

ght

visi

on

1 st

udy

show

ed p

ossi

ble

anti

prol

if-er

ativ

e ef

fect

s on

col

on c

ance

r ce

lls

Not

eno

ugh

scie

ntifi

c ev

iden

ce fo

r ot

her

indi

cati

ons

AD

R:

↓B

P

↓ o

r↑ b

lood

sug

ar

Dia

rrhe

a, n

ause

a

Hep

atot

oxic

ity

Ble

edin

g

Dru

g in

tera

ctio

ns:

anti

coag

ulan

ts→↑

blee

ding

anti

diab

etic

age

nts-↑↓

blo

od s

ugar

anti

hype

rten

sive

s→↓

BP

estr

ogen

-may↓

abso

rpti

on

Avo

id in

alle

rgy

to b

lueb

erri

es o

r sa

me

fam

ily

of b

erri

es

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

In d

ried

leav

es, b

erri

es,

extr

act,

tin

ctur

e, c

apsu

les,

ta

blet

s

No

spec

ific

dosi

ng

reco

mm

enda

tion

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Bla

ck C

ohos

h “b

lack

sna

kero

ot”

“bug

bane

” “b

ugw

ort”

◆◆

Not

sam

e as

blu

e co

hosh

◆◆

Con

tain

s sa

licyl

ic a

cid

◆◆

Mem

ber

of b

utte

rcup

fam

ily◆

◆U

sed

in N

ativ

e A

mer

ican

and

A

mer

ican

folk

med

icin

e fo

r m

enop

ausa

l sx,

indu

ctio

n of

la

bor,

rhe

umat

ism

Men

opau

sal s

ympt

oms

m

ost

trad

itio

nal

Stud

y re

sult

s m

ixed

on

this

.◆

◆N

CC

AM

stu

dy—

faile

d to

rel

ieve

ni

ght

swea

ts a

nd h

ot fl

ashe

s◆

◆N

IH 2

008—

inad

equa

te s

uppo

rt

for

use

◆◆

Ger

man

E C

omm

issi

on—

appr

oved

fo

r m

enop

ausa

l sx,

not

>6

mon

ths

◆◆

Nor

th A

mer

ican

Men

opau

se

Soci

ety

(200

4) r

ecom

men

ds◆

◆In

suff

icie

nt s

tudi

es fo

r sa

fety

>6

mon

ths

or fo

r rh

eum

atis

m

* Uni

ted

Stat

es P

harm

acop

eia:

wom

en s

houl

d di

scon

tinu

e us

e of

bla

ck c

ohos

h an

d co

nsul

t a

heal

th c

are

prac

titi

oner

if t

hey

have

a li

ver

diso

rder

or

dev

elop

sym

ptom

s of

live

r tr

oubl

e, s

uch

as

abdo

min

al p

ain,

dar

k ur

ine,

or

jaun

dice

.

seve

ral c

ase

repo

rts

of h

epat

itis

and

live

r fa

ilure

; not

kn

own

if bl

ack

coho

sh w

as c

ause

Avo

id in

pre

gnan

cy/l

acta

tion

; can

indu

ce la

bor

AD

Rs:

Stom

ach

pain

,con

stip

atio

n

H/A

, ras

h, d

izzi

ness

Ble

edin

g, b

ruis

ing

↑ri

sk C

VA

Mas

talg

ia, u

teri

ne b

leed

ing

↑ri

sk h

orm

one-

asso

ciat

ed fe

mal

e ca

ncer

s

Hep

atot

oxic

ity

Dru

g In

tera

ctio

ns

CYP

450

2D

6 dr

ugs

Ant

icoa

gula

nt d

rugs

↑ b

leed

ing

from

sa

licyl

ate

ingr

edie

nt

Ant

ihyp

erte

nsiv

es-↓

BP

Hep

atot

oxic

dru

gs→

liver

failu

re

Che

mot

hera

peut

ic d

rugs

Tam

oxife

n, a

ntie

stro

gens

, HR

T, O

CP→

estr

ogen

ic

effe

ct

thyr

oid→

hype

rthy

roid

ism

Extr

act

from

dri

ed r

hizo

me

and

root

In c

aple

ts, c

apsu

les,

pow

-de

red

root

, dri

ed r

hizo

me,

te

a, t

inct

ure

OTC

: Bla

ck C

ohos

h as

Rem

ifem

in in

dos

age

20

mg

bid

Oth

er b

rand

s:

Men

opau

se S

uppo

rt

Estr

oven

(in

clud

es o

ther

in

gred

ient

s)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

But

terb

ur “

Pet

adol

ex”

pa

tent

ed n

ame

◆◆

pere

nnia

l shr

ub◆

◆le

af, r

oot

and

rhiz

ome

used

for

extr

act

Ast

hma

Alle

rgic

rhi

niti

s

Mig

rain

e pr

ophy

laxi

s

smoo

th m

uscl

e re

laxa

nt

leuk

otri

ene

and

CO

X-2

inhi

bito

r

anti

chol

iner

gic

effe

ct p

ossi

ble

Stud

ies

show

as

muc

h ef

fect

iven

ess

as

anti

hist

amin

e fo

r al

lerg

ies

Som

e st

udie

s sh

ow e

ffec

tive

ness

for

mig

rain

e tr

eatm

ent

Con

flict

ing

resu

lts

on a

sthm

a

DA

NG

ER: N

AT

UR

AL

PR

OD

UC

T C

ON

TA

INS

PYR

RO

LIZI

DIN

E A

LKA

LOID

(PA

’S) →

CA

USE

LI

VER

DA

MA

GE

AN

D R

ISK

CA

RC

INO

GEN

ICIT

Y

* Onl

y bu

tter

bur

prod

ucts

tha

t ha

ve b

een

pr

oces

sed

to r

emov

e P

As

and

are

labe

led

or

cer

tifie

d as

PA

-fre

e sh

ould

be

used

.

Avo

id if

alle

rgic

to

ASt

erac

eae

fam

ily =

ragw

eed,

m

arig

old,

dai

sies

, chr

ysan

them

ums

Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

Bel

chin

g, a

bd p

ain,

N/V

/D

Dep

ress

ion

Uri

nary

ret

enti

on

Ras

h, p

ruri

tus

Prur

itus

eye

s, a

sthm

a

drow

sine

ss

Dru

g In

tera

ctio

ns

Cal

cium

cha

nnel

blo

cker

s

Ant

icho

liner

gics

↑sx

Vas

odila

tors

(va

sodi

late

s)

Test

oste

rone↓

it

Chr

onot

rope

s an

d is

otro

pes→

nega

tive

act

ivit

y

Soft

gel,

pow

der,

tin

ctur

e,

extr

act,

cap

sule

Extr

act

is s

tand

ardi

zed

Alle

rgic

rhi

niti

s: P

etas

in

(Tes

alin

) 8m

g up

to

QID

Ast

hma:

Pet

afor

ce

50-1

50m

g bi

d-ti

d pr

n

Mig

rain

e pr

even

tion

: Pe

tado

lex

50-7

5mg

bid

up

to

4 m

onth

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Cat

’s C

law

◆◆

Cen

tral

and

Sou

th A

mer

ica

◆◆

Dat

es t

o us

e by

Inca

s

Stud

ies

show

pos

sibl

e be

nefit

in r

heu-

mat

oid

arth

riti

s an

d os

teoa

rthr

itis

In v

itro

stu

dy: p

ossi

ble

use

as

anti

vira

l, an

titu

mor

age

nt

imm

unos

tim

ulan

t

Ant

i-inf

lam

mat

ory

effe

ct

Enha

nces

DN

A r

epai

r

↑ph

agoc

ytos

is

Free

rad

ical

sca

veng

er

Poss

ible

res

earc

h on

Alz

heim

er’s

di

seas

e be

nefit

* som

e pr

epar

atio

ns f

rom

Per

u m

ay b

e co

ntam

inat

ed w

ith

fung

us, o

ther

her

bs,

aero

bes

and

be t

oxic

AD

Rs:

Seda

tion

↓B

P

↓es

trad

iol a

nd p

roge

ster

one

One

rep

ort

rena

l fai

lure

in S

LE p

atie

nt

Avo

id in

pre

gnan

cy/l

acta

tion

; tra

diti

onal

use

as

abo

rtifa

cent

Avo

id w

ith

hx a

utoi

mm

une

dise

ase,

hyp

oten

sion

, re

nal t

rans

plan

t, r

enal

dis

ease

, im

mun

osup

pres

sion

, bl

eedi

ng d

isor

ders

DR

UG

INT

ERA

CT

ION

S:

CYP

3A

4 ↑

leve

ls

anti

hype

rten

sive

s↓B

P

anti

arrh

ythm

ics:

↑ a

rrhy

thm

ias

anti

coag

ulan

ts:↑

blee

ding

ris

k

calc

ium

cha

nnel

blo

cker

s: ↑

effe

ct

imm

unos

uppr

essa

nts:↓

leve

ls

neph

roto

xic

drug

s: →

rena

l fai

lure

iron

:↓ab

sorp

tion

Cap

sule

, tab

let,

tin

ctur

e,

tea,

bar

k/le

aves

/roo

ts

in d

ried

, cut

or

po

wde

red

form

s

Gen

eral

use

: 250

-100

0mg

1-3

x/da

y

Free

ze d

ried

ext

ract

: 10

0mg/

day

Oth

er fo

rms

avai

labl

e

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Cha

mom

ile◆

◆G

erm

an c

ham

omile

is m

ore

com

mon

for

supp

lem

ents

Stud

ies:

◆◆

indi

cate

som

e be

nefit

for

gene

ral-

ized

anx

iety

dis

orde

r◆

◆be

nefit

for

infa

nt c

olic

, chi

ldre

n’s

diar

rhea

, GI u

pset

◆◆

bene

fit fo

r m

outh

ulc

ers

in r

adia

-ti

on o

r ch

emot

hera

py

Com

mon

use

s fo

r ra

diat

ion

skin

is

sues

, wou

nd h

ealin

g, a

nxie

ty

Ant

i-inf

lam

mat

ory

and

an

ti-s

pasm

odic

eff

ects

Seda

tive

eff

ects

may

be

from

bin

ding

to

ben

zodi

azep

ine

rece

ptor

s

* Avo

id in

alle

rgie

s to

dai

sy fa

mily

: rag

wee

d, c

hrys

an-

them

ums,

mar

igol

ds, a

nd d

aisi

es: r

isk

of a

naph

y-la

xis

or o

ther

alle

rgic

rea

ctio

n

* avo

id w

ith

alle

rgie

s to

oni

ons,

gar

lic, a

nd a

rtem

esia

* avo

id t

akin

g w

ith

alco

hol

AD

Rs:

Seda

tion

↓B

P, B

S, ↑

hear

t ra

te

Vom

itin

g

Ast

hma

Alt

er m

ense

s

↑ b

leed

ing

risk

DR

UG

INT

ERA

CT

ION

S:

CYP

450

inte

ract

ions

CN

S de

pres

sant

s: ↑

seda

tion

War

fari

n:↑

INR

Ant

idia

beti

c ag

ents

: ↓ B

S

Ant

icoa

gula

nts:

↑bl

eedi

ng r

isk

Ant

iarr

hyth

mic

s: ↑

hea

rt r

ate

Flow

ers

used

to

mak

e ta

b-le

ts, e

xtra

ct, t

ea, c

ream

s,

mou

th r

inse

, bat

h ad

diti

ves

Tea:

up

to 8

g dr

ied

flow

ers

Cap

sule

s: u

p to

16

00 m

g/da

y

Cre

am: 2

%-1

0%

cham

omile

ext

ract

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Dan

delio

n◆

◆us

ed in

Nat

ive

Am

eric

an a

nd

Ara

bic

med

icin

e

Use

s: li

ver

or k

idne

y to

nics

Diu

reti

cs

GI d

istu

rban

ces

Hig

h V

itam

in A

con

tent

and

hig

h po

tass

ium

con

tent

in d

ried

her

b

Stud

ies:

no

scie

ntifi

c ev

iden

ce fo

r m

edic

al c

ondi

tion

s

May

hav

e di

uret

ic a

nd im

mun

e-m

odul

atin

g ef

fect

s

May

hav

e an

tiox

idan

t ef

fect

s

* som

e al

lerg

ies/

anap

hyla

xis

to d

ande

lions

* som

e re

port

s of

GI u

pset

wit

h us

e

* do

not

use

wit

h ga

llbla

dder

dis

ease

as ↑

bile

sec

reti

on

AD

Rs:

Ast

hma

exac

erba

tion

↓pl

atel

ets

↑po

tass

ium

V t

ach,

V fi

b

↓bs

Alt

ers

estr

ogen

, pro

gest

eron

e, F

SH

DR

UG

INTE

RA

CTI

ON

S:

Ant

idia

beti

c ag

ents

, est

roge

ns (↑

effe

ct),

diu

reti

cs

(↑ef

fect

), n

iaci

n (↑

effe

ct);

anti

arrh

ythm

ics ↑

arr

hyth

mia

Leav

es a

nd r

oots

or

who

le

plan

t, u

sed

fres

h or

dri

ed

in t

eas,

cap

sule

s, o

r ex

trac

ts.

Dan

delio

n le

aves

use

d in

sa

lads

or

as c

ooke

d gr

een

Flow

ers

used

for

win

e

Don

g Q

uai

◆◆

from

Ang

elic

a si

nens

is p

lant

D

ysm

enor

rhea

l

Men

opau

sal s

ympt

oms

Men

stru

al H

/A

Poss

ible

ant

i-inf

lam

mat

ory,

an

tiox

idan

t ef

fect

s

Poss

ible

ant

ispa

smod

ic, G

I st

imul

ant

effe

cts

Poss

ible

ant

ipla

tele

t ef

fect

(c

oum

arin

der

ivat

ive)

Ant

iarr

hyth

mic

eff

ect

* avo

id in

pre

gnan

cy/l

acta

tion

; can

cau

se u

teri

ne

cont

ract

ions

and

con

geni

tal m

alfo

rmat

ions

* avo

id in

ble

edin

g di

sord

ers,

do

not

use

wit

h an

tico

agul

ants

* pos

sibl

e ca

rcin

ogen

ic p

oten

tial

AD

Rs:

Seda

tion

↓bp

GI s

ympt

oms

Ble

edin

g

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts

Hor

mon

al m

edic

atio

ns

anti

hype

rten

sive

s

Roo

t us

ed fo

r ca

psul

e

or t

able

ts

Med

icin

al u

se s

afet

y

is u

ncle

ar

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Echi

nace

a “p

urpl

e co

neflo

wer

”Im

mun

e-st

imul

ant

Use

d fo

r U

RIs

and

oth

er in

fect

ions

, in

clud

ing

wou

nds

Stud

ies:

con

flict

ing

stud

ies

on u

sefu

l-ne

ss fo

r tr

eati

ng U

RIs

, som

e po

siti

ve

NC

CA

M s

tudy

ing

usef

ulne

ss fo

r im

mun

ity

Ger

man

E c

omm

issi

on a

ppro

ved

for

trea

tmen

t of

col

ds, c

hron

ic r

espi

ra-

tory

and

GU

tra

ct in

fect

ions

Use

d fo

r ge

nita

l her

pes

May

hav

e an

ti-in

flam

mat

ory,

ant

ifun-

gal,

and

free

rad

ical

sca

veng

er e

ffec

ts

May

be

imm

une

supp

ress

ant

or

imm

une

stim

ulan

t

* Pot

enti

al a

naph

ylac

tic

or a

llerg

ic r

eact

ions

, ast

hma,

es

peci

ally

wit

h al

lerg

y to

dai

sy fa

mily

: mar

igol

ds,

chry

sant

hem

ums,

dai

sies

, rag

wee

d.

* Alle

rgie

s m

ore

com

mon

in t

hose

who

are

ato

pic,

w

ith

ecze

ma

or a

sthm

a

* Avo

id in

peo

ple

need

ing

imm

unos

uppr

essi

on

* Avo

id in

pre

gnan

cy/l

acta

tion

* Dis

cont

inue

bef

ore

surg

ery

or m

ay a

ffec

t w

ound

he

alin

g an

d in

fect

ion

rate

* Avo

id in

aut

oim

mun

e di

seas

e, c

olla

gen

vasc

ular

di

seas

e, H

IV, l

iver

dis

ease

, MS,

TB

AD

Rs:

Ras

hes

GI s

ide

effe

cts

Diz

zine

ss, n

ervo

usne

ss, H

/A

Atr

ial f

ibri

llati

on, p

alpi

tati

ons

HTN

Ast

hma

exac

erba

tion

May

agg

rava

te a

utoi

mm

une

dise

ase

or in

crea

se

imm

une

resp

onse

DR

UG

INT

ERA

CT

ION

S:

Am

oxic

illin

: rha

bdom

yoly

sis,

dea

th

Ant

icoa

gula

nts:↑

blee

ding

Cor

tico

ster

oids

:↓im

mun

osup

pres

sive

eff

ect

Stat

ins,

ace

tam

inop

hen:↑

risk

hep

atot

oxic

ity

Plan

t an

d ro

ots

used

to

mak

e ju

ice

(exp

ress

ed),

te

as, e

xtra

cts,

oth

er fo

rms.

Dos

e: U

RI 5

00-1

000m

g ti

d

Dos

e: p

edia

tric

dos

ing

usua

lly w

eigh

t-ba

sed,

see

ot

her

sour

ces

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Ephe

dra

“ma

huan

g”◆

◆ev

ergr

een

shru

b th

at h

as b

een

used

50

00 y

ears

in In

dia

and

Chi

na◆

◆po

wer

ful s

tim

ulan

t of

ner

vous

0s

yste

m a

nd h

eart

use

d to

tre

at

resp

irat

ory

cond

itio

ns, f

lu,

asth

ma,

feve

r

Use

s:

Wei

ght

loss

Ener

gy s

uppl

emen

t

Ath

leti

c pe

rfor

man

ce

Am

phet

amin

e-lik

e; p

rim

ary

com

po-

nent

is e

phed

rine

Stud

ies:

hig

her

rate

of c

alls

to

pois

on

cont

rol c

ente

rs a

bout

sev

ere

side

ef

fect

s

Stud

ies:

↑ri

sk s

trok

e, H

TN, c

ardi

ac

prob

lem

s, G

I sid

e ef

fect

s

Ris

ks o

f ben

efit

for

shor

t te

rm w

eigh

t lo

ss is

out

wei

ghed

by

risk

s

* US

bann

ed s

ale

of d

ieta

ry s

uppl

emen

ts w

ith

ephe

dra

in 2

004

* rep

orts

of

stro

ke, M

I, su

dden

dea

th

* can

wor

sen

diab

etes

, CV

D, r

enal

dis

ease

* can

cau

se s

eizu

res

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

Anx

iety

, psy

chos

is, t

rem

ors

Dry

mou

th, G

I irr

itat

ion,

nau

sea

HTN

, arr

hyth

mia

, hea

rt d

amag

e

Uri

nary

obs

truc

tion

Slee

p pr

oble

ms

DR

UG

INT

ERA

CT

ION

S:

Ane

sthe

tics

-alt

er e

ffec

t, ↑

bp

ETO

H-p

sych

osis

wit

h ca

ffei

ne

Caf

fein

e-↑

toxi

city

Ant

idia

beti

c ag

ents↓

effe

ct

anti

conv

ulsa

nts↓

effe

ct

ergo

t al

kalo

ids↑

hype

rten

sive

cri

sis

phen

othi

azin

es↑

arrh

ythm

ia, d

eath

Dri

ed s

tem

s an

d le

aves

m

ake

tabl

ets,

tin

ctur

es,

caps

ules

, tea

s

Ephe

dra

still

allo

wed

in

Chi

nese

her

bal r

emed

ies

and

teas

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Even

ing

Pri

mro

se O

il (E

PO

) Ye

llow

flow

er:

◆◆

cont

ains

gam

ma-

linol

enic

aci

d (G

LA),

ess

enti

al fa

tty

acid

, re

quir

ed b

y th

e bo

dy a

nd

obta

ined

from

the

die

t.

Use

s: e

czem

a, in

flam

mat

ion

Mas

talg

ia, P

MS

Men

opau

se s

ympt

oms

Can

cer

Dia

bete

s m

ellit

us

Stud

ies:

sho

w s

ome

bene

fit fo

r rh

eum

atoi

d ar

thri

tis,

ecz

ema,

PM

S, m

asta

lgia

May

hav

e an

ti-in

flam

mat

ory,

va

sodi

lato

ry, a

nd a

nti-p

late

let

ef

fect

s

* Not

for

preg

nanc

y/la

ctat

ion:

↑ri

sk c

ompl

icat

ions

, ru

ptur

e of

mem

bran

es

AD

Rs:

GI u

pset

H/A

Ras

h

Dep

ress

ion

Seiz

ures

in p

ts w

itho

ut s

eizu

re r

isk

DR

UG

INT

ERA

CT

ION

S:

Ane

sthe

sia:

↓se

izur

e th

resh

old

Ant

icoa

gula

nts:↑

blee

ding

ris

k

Ant

ihyp

erte

nsiv

es:↓

bp

TCA

s: ↓

seiz

ure

thre

shol

d

Ant

isei

zure

age

nts:↑

risk

sei

zure

s

Oil

extr

acte

d fr

om s

eeds

an

d pu

t in

cap

sule

s

Prod

ucts

sta

ndar

dize

d

for

8% G

LA a

nd 7

2%

linol

eic

acid

Fenu

gree

k◆

◆us

ed b

ack

to E

gypt

ian

tim

es◆

◆U

sed

to in

duce

chi

ldbi

rth

◆◆

Use

d to

hel

p di

gest

ion

and

men

opau

se s

ympt

oms

Use

d in

coo

king

Use

d fo

r di

abet

es m

ellit

us

Hyp

erlip

idem

ia

Loss

of a

ppet

ite

Stim

ulat

es m

ilk p

rodu

ctio

n

* Avo

id in

pre

gnan

cy

AD

Rs:

Blo

atin

g, fl

atul

ence

, dia

rrhe

a

Hyp

ogly

cem

ia

Hyp

okal

emia

Mis

carr

iage

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

-↓he

pato

toxi

city

Ana

lges

ics-

addi

tive

eff

ects

Ant

icoa

gula

nts-↑

blee

ding

ris

k

Ant

idia

beti

c ag

ents

-↑hy

pogl

ycem

ia

Seed

s ar

e gr

ound

and

ta

ken

oral

ly o

r pu

t in

pa

ste

for

skin

Dos

e: 2

5 g

seed

pow

der

daily

in d

ivid

ed d

oses

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Feve

rfew

“ba

chel

or’s

but

tons

” “w

ild c

ham

omile

”◆

◆U

sed

as a

ntip

yret

ic b

y

anci

ent

Gre

eks

Mig

rain

e he

adac

hes

Psor

iasi

s

Ast

hma

Tinn

itus

N/V

Stud

ies:

Sugg

est

may

hel

p pr

even

t (n

ot

acut

ely

trea

t) m

igra

ine

head

ache

s an

d rh

eum

atoi

d ar

thri

tis

pain

* Alle

rgic

ris

k w

ith

ragw

eed,

chr

ysan

them

um a

llerg

ies

* Not

for

use

in p

regn

ancy

/lac

tati

on, c

an c

ause

m

isca

rria

ge, p

rem

atur

e bi

rth

* Avo

id in

chi

ldre

n* A

void

pri

or t

o su

rger

y or

den

tal p

roce

dure

sA

DR

s:C

anke

r so

res,

sor

e to

ngue

Loss

of a

ppet

ite

Nau

sea/

GI s

ympt

oms

Ris

k w

orse

ned

depr

essi

onD

izzi

ness

, fat

igue

,anx

iety

Palp

itat

ions

, ↑he

art

rate

DR

UG

INT

ERA

CT

ION

S:A

ntic

oagu

lant

s: ↑

blee

ding

ris

kV

asod

ilato

rs:↑

vas

odili

tati

on

Dri

ed le

aves

pri

mar

ily u

sed

Stem

s an

d ro

ots

som

e-ti

mes

use

d

Extr

acts

, tab

lets

, cap

sule

s

Stan

dard

ized

dos

e: u

p to

25

0mg

daily

Take

wit

h fo

od

Gar

lic◆

◆ed

ible

her

b fr

om L

ily fa

mily

Use

s: h

yper

lipid

emia

CA

D, H

TN

Col

on a

nd g

astr

ic c

ance

r

UR

I pre

vent

ion

PVD

Stud

ies:

on

low

erin

g ch

oles

tero

l, ha

d va

ryin

g be

nefit

Stud

ies:

pos

itiv

e fo

r

decr

easi

ng B

P an

d

decr

easi

ng a

ther

oscl

eros

is

Stud

y: s

how

s af

fect

s di

lati

on a

nd

cons

tric

tion

of b

lood

ves

sels

* saf

e fo

r m

ost

adul

ts* d

oes

have

blo

od-t

hinn

ing

effe

ct; s

top

pre-

oper

ativ

ely

* mild

ris

k al

lerg

y, m

ostl

y ra

w fo

rm; c

ross

-alle

rgie

s w

ith

onio

ns, l

eeks

, chi

ves

AD

Rs:

Raw

: hal

itos

is,G

I ups

et, b

ody

odor

Con

tact

der

mat

itis

, blis

ters

Ble

edin

gA

sthm

a, r

hini

tis

DR

UG

INT

ERA

CT

ION

S:A

ntic

oagu

lant

s ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bpA

ntid

iabe

tic

agen

ts ↓

or ↑

bsA

nest

heti

cs p

rolo

ng e

ffec

tA

ceta

min

ophe

n-al

ters

eff

ect

Prot

ease

inhi

bito

rs ↓

effe

ctO

CP

wit

h es

trog

en ↓

effe

ct

Raw

, coo

ked,

dri

ed,

pow

dere

d

Dos

e: 6

00-9

00 m

g ga

rlic

po

wde

r (i

n st

anda

rdiz

ed

1.3%

alli

cin

acti

ve in

gred

i-en

t) d

aily

in d

ivid

ed d

oses

Or

3-5m

g al

licin

dai

ly

(equ

ival

ent

to 2

-5 g

fr

esh

garl

ic)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gin

ger

◆◆

trop

ical

pla

nt o

ften

use

d in

A

sian

med

icin

e

Use

s: p

ost-

surg

ical

and

m

otio

n na

usea

GI u

pset

Che

mot

hera

py n

ause

a

Preg

nanc

y na

usea

(h

yper

emes

is g

ravi

daru

m)

Art

hrit

is p

ain,

mus

cle

pain

Stud

ies:

sho

rt-t

erm

eff

ecti

vene

ss in

pr

egna

ncy

naus

ea, v

aria

ble

effe

ctiv

e-ne

ss in

oth

er fo

rms

naus

ea

Stud

ies:

on

infla

mm

atio

n on

goin

g

May

inhi

bit

sero

toni

n 5-

HT 3

rece

ptor

s in

GI t

ract

May

inhi

bit

plat

elet

agg

rega

tion

May

hav

e lip

id-lo

wer

ing,

an

tihy

pert

ensi

ve e

ffec

t

* Avo

id in

lact

atio

n/sa

fety

not

est

ablis

hed

* Avo

id p

eri-o

pera

tive

ly d

ue t

o bl

eedi

ng r

isk

* Avo

id in

CA

D, a

rrhy

thm

ia h

isto

ry

AD

Rs:

Mos

tly

wit

h po

wde

red

ging

er: b

loat

ing,

gas

, he

artb

urn,

nau

sea

Dep

ress

ion

Arr

hyth

mia

s

↑ b

leed

ing

risk

DR

UG

INT

ERA

CT

ION

S:

Cal

cium

cha

nnel

blo

cker

s↓bp

Ant

idia

beti

c ag

ents

↓bs

Car

diac

age

nts-

may

alt

er e

ffec

t

anti

coag

ulan

ts↑

blee

ding

ris

k

anti

arrh

ythm

ics ↑

risk

Fres

h, p

owde

r, t

able

ts

Dos

e: u

p to

4 g

/day

in

divi

ded

dose

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gin

gko

“Jap

anes

e si

lver

apr

icot

” “f

ossi

l tre

e”◆

◆se

eds

of G

ingk

o tr

ee u

sed

for

thou

sand

s of

yea

rs in

Tra

diti

onal

C

hine

se M

edic

ine

Use

s: m

emor

y en

hanc

emen

t

Prev

enti

on A

lzhe

imer

’s d

isea

se

and

dem

enti

as

Isch

emic

str

oke

Dec

reas

e in

term

itte

nt c

laud

icat

ion

MS

Tinn

itus

Sexu

al d

ysfu

ncti

on

Stud

ies:

mos

t st

udie

s sh

ow n

o im

prov

emen

t fo

r m

emor

y or

pre

ven-

tion

of d

emen

tia

or d

ecre

asin

g B

P

Stud

ies:

min

imal

ben

efit

pos

sibl

e fo

r in

term

itte

nt c

laud

icat

ion

and

tinn

itus

(v

aria

ble)

; bei

ng s

tudi

ed fo

r el

ectr

ic

shoc

k m

emor

y lo

ss

* Pos

sibl

e se

vere

alle

rgic

rea

ctio

ns

* Avo

id p

re-o

pera

tive

ly o

r be

fore

den

tal p

roce

dure

s,

incr

ease

d bl

eedi

ng r

isk

* No

raw

gin

gko

seed

s, c

onta

in t

oxin

tha

t ca

n ca

use

seiz

ures

and

dea

th

AD

Rs:

H/A

, diz

zine

ss

GI s

ympt

oms

↑bl

eedi

ng r

isk

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

: ↑bs

Ant

icoa

gula

nts ↑

blee

ding

Ant

icon

vuls

ants

↓ef

fect

Ant

ihyp

erte

nsiv

es ↓

bp

Ant

ipsy

chot

ics

can

caus

e pr

iapi

sm

Estr

ogen

s m

ay h

ave

estr

ogen

ic e

ffec

t

Nife

dipi

ne ↑

conc

entr

atio

ns

Prilo

sec ↓

leve

ls

SSR

Is↑

ser

oton

in s

yndr

ome

Traz

adon

e ri

sk c

oma

Gin

gko

leaf

abs

trac

ts u

sed

in t

able

ts, c

apsu

les,

tea

s an

d sk

in p

repa

rati

ons

Als

o in

nut

riti

on b

ars,

su

blin

gual

spr

ay

Stan

dard

ized

ext

ract

s

Dos

e: 8

0-24

0mg/

day

divi

ded

in b

id-t

id

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Gol

dens

eal “

yello

w r

oot”

◆◆

Nat

ive

Am

eric

an r

emed

y◆

◆N

ow g

row

n co

mm

erci

ally

due

to

shor

t su

pplie

s

UR

I’s

Dig

esti

ve d

isor

ders

, dia

rrhe

a

Som

e ca

ncer

s

Vag

init

is

Wou

nds

Can

ker

sore

s

Chl

oroq

uine

res

ista

nt m

alar

ia

Hyp

erlip

idem

ia

Stim

ulat

es im

mun

e sy

stem

Stud

ies:

sho

w s

ome

anti

bact

eria

l ef

fect

and

lipi

d-lo

wer

ing

effe

ct;

Stud

ies:

pos

sibl

e be

nefit

for

diar

rhea

an

d ey

e in

fect

ions

* Avo

id in

pre

gnan

cy/l

acta

tion

; con

tain

s be

rber

ine

whi

ch c

an c

ause

jaun

dice

* Not

for

infa

nts

or y

oung

chi

ldre

n

AD

Rs:

Arr

hyth

mia

s, B

rady

card

ia

H/A

,↓B

P

↓bl

ood

suga

r

GI i

rrit

atio

n, n

ause

a

Dry

muc

ous

mem

bran

es

Seiz

ures

DR

UG

INT

ERA

CT

ION

S:

Ant

ipla

tele

t ag

ents

Ant

ilipe

mic

age

nts ↑

effe

ct

Ant

imal

aria

ls-a

ddit

ive

effe

cts

Bet

a bl

ocke

rs-c

hang

es e

ffec

t

Phen

ylep

hrin

e-↑

effe

cts

War

fari

n-↓

effe

cts

Stem

s an

d ro

ots

drie

d fo

r ex

trac

ts a

nd t

eas

Mou

th r

inse

s

Som

etim

es c

ombi

ned

wit

h Ec

hina

cea

for

UR

Is

Tabl

ets/

caps

ules

0.

5-1g

po

tid

Extr

act:

0.3

ml-1

ml

Als

o IV

and

oph

thal

mic

fo

rms

Hoo

dia

“kal

ahar

i cac

tus”

◆◆

Kal

ahar

i bus

hmen

ate

thi

s to

su

ppre

ss h

unge

r an

d th

irst

w

hile

hun

ting

App

etit

e su

ppre

ssan

t (w

eigh

t lo

ss)

whi

le e

leva

ting

ene

rgy

Stud

ies:

non

e pu

blis

hed

Dru

g ri

sks,

inte

ract

ions

, adv

erse

eff

ects

hav

e no

t be

en s

tudi

ed

Avo

id in

pre

gnan

cy

Oft

en c

ombi

ned

wit

h gr

een

tea

or c

hrom

ium

Dri

ed e

xtra

cts

from

ste

ms

and

root

s m

ake

caps

ules

, ex

trac

ts, p

owde

rs, t

eas,

ch

ewab

le t

able

ts

Dos

e: D

ried

ext

ract

up

to

800m

g/da

y

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Hor

se C

hest

nut

“buc

keye

”◆

◆O

nly

seed

ext

ract

is s

afe

◆◆

Do

not

use

any

othe

r pa

rts

of

plan

t, w

hich

may

be

toxi

c

Use

d fo

r ch

roni

c ve

nous

insu

ffic

ienc

y

Use

d fo

r an

kle

edem

a,

nigh

t le

g cr

amps

Stud

ies

show

it is

as

effe

ctiv

e fo

r ve

nous

insu

ffic

ienc

y as

sup

port

ive

com

pres

sion

sto

ckin

gs

* Con

trai

ndic

ated

in h

epat

ic a

nd r

enal

impa

irm

ent;

in

flam

mat

ory

bow

el d

isea

se* C

ontr

aind

icat

ed in

late

x al

lerg

yA

void

in p

regn

ancy

/lac

tati

onA

DR

s: c

alf s

pasm

GI u

pset

Ble

edin

gR

enal

/liv

er d

amag

eD

RU

G IN

TER

AC

TIO

NS:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts ↑

hypo

glyc

emia

anti

hype

rten

sive

↑ h

ypot

ensi

on

Dos

e: 3

00 m

g ex

trac

t bi

d

Topi

cal g

el 3

-4 x

/day

Use

for

shor

t te

rm o

nly

Stan

dard

ized

for

15

-20%

esc

in

Kav

a “k

ava

kava

”◆

◆M

embe

r of

pep

per

fam

ily◆

◆C

erem

onia

l bev

erag

e in

So

uth

Paci

fic

Use

s: a

nxie

ty

Inso

mni

a

Men

opau

sal s

ympt

oms

NC

CA

M s

tudi

es h

alte

d du

e to

ris

k

of s

ever

e liv

er d

amag

e

Earl

ier

stud

ies

show

ed s

ome

bene

fit

wit

h an

xiet

y, b

ut d

ange

rs

outw

eigh

ris

ks

May

impa

ct c

ereb

ella

r an

d

GA

BA

func

tion

s

* Ris

k of

sev

ere

liver

dam

age,

incl

udin

g liv

er f

ailu

re

and

hepa

titi

s* R

isk

dyst

onia

(ab

norm

al m

uscl

e m

ovem

ents

)A

DR

s:D

row

sine

ssA

taxi

aD

izzi

ness

, dys

kine

sia

H/A

Tach

ycar

dia

Con

tact

der

mat

itis

, kav

a de

rmop

athy

(ra

sh fr

om

long

-ter

m w

ith

yello

w d

isco

lora

tion

)G

I ups

et, ↑

tran

sam

inas

esPa

rkin

soni

smD

RU

G IN

TER

AC

TIO

NS:

Ace

tam

inop

hen ↑

liver

tox

icit

yPs

ycho

trop

ics-

alte

red

men

tal s

tatu

sET

OH

↑to

xici

tyA

nxio

lyti

cs ↑

effe

ctSe

dati

ves ↑

effe

ctO

pioi

ds ↑

seda

tion

, CN

S de

pres

sion

Roo

t an

d rh

izom

e m

ake

beve

rage

s, c

apsu

les,

ta

blet

s, e

xtra

cts,

to

pica

l sol

utio

ns

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Lave

nder

“En

glis

h la

vend

er”

Use

s: a

nxie

ty, d

epre

ssio

n

Inso

mni

a

GI u

pset

Alo

peci

a

Topi

cal a

ntis

epti

c

arom

athe

rapy

Stud

ies:

do

not

conf

irm

any

ben

efit

s fo

r ce

rtai

n ex

cept

for

alop

ecia

use

d to

pica

lly

* Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

H/A

, pho

tose

nsit

ivit

y

GI s

ympt

oms

Skin

pig

men

t ch

ange

s

DR

UG

INT

ERA

CT

ION

S

Anx

ioly

tics

↑si

de e

ffec

t

Seda

tive

s↑ s

ide

effe

ct

Ant

idep

ress

ants

↑ s

ide

effe

ct

Dri

ed la

vend

er t

eas

or

extr

acts

can

be

take

n or

ally

Esse

ntia

l oils

can

be

mad

e fr

om fl

ower

s an

d us

ed

topi

cally

and

in a

rom

a-th

erap

y; p

oiso

nous

if

take

n in

tern

ally

Lico

rice

Roo

t◆

◆G

lycy

rrhi

zin

is m

ost

dang

erou

s co

mpo

und

◆◆

Dec

lycy

rrhi

zina

ted

form

“D

GL”

is

saf

er

Use

s: s

tom

ach

ulce

r, h

epat

itis

Sore

thr

oat,

bro

nchi

tis

Stud

ies:

non

e sh

ow s

igni

fican

t ef

fec-

tive

ness

exc

ept

IV fo

rm fo

r H

epat

itis

C

, not

ava

ilabl

e in

US

* gly

cyrr

hizi

n ca

n→ lo

w p

otas

sium

, hig

h bl

ood

pres

sure

, sal

t an

d w

ater

ret

enti

on, a

ll ri

sks

for

CV

D: A

VO

ID

* hig

h le

vels

of

licor

ice

affe

ct c

orti

sone

* Not

for

pre

gnan

cy—

can

caus

e pr

eter

m la

bor

* Not

for

hyp

erte

nsio

n or

CA

D

AD

Rs:

DR

UG

INT

ERA

CT

ION

S:

Avo

id w

ith

med

icat

ions

tha

t af

fect

pot

assi

um,

diur

etic

s, p

redn

ison

e

Ant

iarr

hyth

mic

s-↑

risk

Ant

icoa

gula

nts ↑

blee

ding

Imm

unos

uppr

essa

nts ↓

effe

ct

Ant

idia

beti

cs a

lter

eff

ect

Ant

ihyp

erte

nsiv

es ↓

effe

ct

Use

DG

L fo

rm in

stea

d—m

uch

safe

r

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Milk

Thi

stle

“ho

ly t

hist

le”,

“s

ilym

arin

”◆

◆U

sed

for

thou

sand

s of

yea

rs fo

r liv

er a

ssis

tanc

e

Use

s: c

hron

ic h

epat

itis

Cir

rhos

is

Live

r da

mag

e fr

om d

rugs

and

tox

ins;

al

coho

lic li

ver

dise

ase

Hyp

erlip

idem

ia

Dec

reas

e in

sulin

res

ista

nce

if ha

ve

DM

and

cir

rhos

is

Ant

i-bre

ast,

cer

vica

l, pr

osta

te c

ance

r

Stud

ies:

pri

or s

tudi

es s

how

ed b

enef

it

prot

ecti

ng a

nd p

rom

otin

g gr

owth

of

live

r ce

lls; l

ater

stu

dies

con

flict

ing

resu

lts

Stud

y: b

enef

it in

Hep

atit

is C

sho

wed

fe

wer

, mild

er li

ver

dise

ase

sym

ptom

s bu

t no

aff

ect

on a

mou

nt o

f vir

al lo

ad

* Avo

id in

alle

rgie

s in

dai

sy fa

mily

: rag

wee

d,

chry

sant

hem

ums,

dai

sies

, mar

igol

d.

* Not

rec

omm

ende

d in

pre

gnan

cy/l

acta

tion

AD

Rs:

↓bs

GI s

ide

effe

cts

H/A

, ins

omni

a

Exac

erba

tes

hem

ocho

mat

osis

arth

ralg

ia

DR

UG

INT

ERA

CT

ION

S

Alc

ohol↓

alco

hol-i

nduc

ed h

epat

oxic

ity

Stat

ins-

inhi

bits

eff

ects

Ant

ineo

plas

tic

drug

s ↑

effe

cts

Ant

idia

beti

c ag

ents

↓bs

Sily

mar

in, a

ctiv

e in

gred

i-en

t, fr

om s

eeds

use

d to

m

ake

tinc

ture

s, c

apsu

les,

ex

trac

ts

Gen

eral

ly c

onsi

dere

d sa

fe

Dos

e: 2

30-8

00m

g/da

y di

vide

d in

2-3

dos

es

Non

i “In

dian

mul

berr

y”◆

◆H

isto

ry o

f top

ical

use

for

join

t pa

in

and

derm

atol

ogic

al is

sues

Use

d in

juic

e as

hea

lth

toni

c

Use

d fo

r ch

roni

c co

ndit

ions

e.g

. di

abet

es, c

ardi

ovas

cula

r di

seas

e

Use

d fo

r ca

ncer

, hea

ring

loss

Stud

ies:

ear

ly s

tudi

es s

how

an

ti-c

ance

r ef

fect

, ant

ioxi

dant

, an

d im

mun

e-st

imul

atin

g ef

fect

s

NC

CA

M s

tudy

-on

pros

tate

can

cer

NC

I stu

dy-o

n br

east

can

cer

prev

enti

on

* Ris

k of

live

r to

xici

ty

* Hig

h in

pot

assi

um-a

void

in r

enal

dis

ease

* Not

for

use

in p

regn

ancy

(ha

s be

en

trad

itio

nal a

bort

iface

nt)

AD

Rs:

↓bp

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts-

cont

ains

Vit

amin

K in

som

e,

not

all p

repa

rati

ons

AC

E in

hibi

tors

↑po

tass

ium

Num

erou

s ot

hers

tha

t af

fect

pot

assi

um

Frui

t us

ed in

frui

t ju

ices

, m

ostl

y w

ith

grap

e

Frui

t an

d le

aves

can

mak

e ta

blet

s, c

apsu

les,

tea

s

Dos

e: u

p to

2 o

z tw

ice

daily

x 3

mon

ths

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Pep

perm

int

Oil

◆◆

Cro

ss b

etw

een

spea

rmin

t

and

wat

erm

int

Seas

onin

g an

d m

edic

inal

Nau

sea,

GI u

pset

, ind

iges

tion

IBS

UR

I, H

/A

asth

ma

Mus

cula

r, a

ntis

pasm

odic

or

ne

rve

pain

Hal

itos

is

Nas

al c

onge

stio

n

Stud

ies:

pep

perm

int

may

hel

p IB

S

Stud

ies:

pep

perm

int

wit

h ca

raw

ay

mig

ht h

elp

indi

gest

ion

* Oil

is s

afe

in s

mal

l dos

es

* Not

for

preg

nanc

y/la

ctat

ion

AD

Rs:

Hea

rtbu

rn

Abd

omin

al p

ain

Acu

te r

enal

failu

re

Con

tact

der

mat

itis

Bur

ning

mou

th s

yndr

ome

DR

UG

INT

ERA

CT

ION

S:

Ant

acid

s/H

2 bl

ocke

rs/P

PIs—

may

pre

mat

urel

y di

ssol

ve e

nter

ic c

oati

ng

CYP

450

inte

ract

ions

pos

sibl

e

Esse

ntia

l oil

of p

eppe

rmin

t

In s

mal

l dos

es in

cap

sule

s or

liqu

ids

In t

eas

Mix

ed w

ith

othe

r in

gred

i-en

ts in

top

ical

pre

para

tion

s

Dos

ing:

PO d

iges

tive

: 0.2

-0.4

ml t

id

(ave

rage

qd

is 6

-12

gtts

)

Cap

sule

s: 1

-2 c

aps

po t

id

½ h

our

ac.

Teas

wit

h dr

ied

leav

es

Topi

cal p

repa

rati

ons

Red

Clo

ver

“mea

dow

clo

ver”

◆◆

Legu

me

fam

ily◆

◆C

onta

ins

phyt

oest

roge

ns w

hich

ac

t lik

e es

trog

en◆

◆Pa

st u

se p

ertu

ssis

, ast

hma,

br

onch

itis

, can

cer

Use

d fo

r m

enop

ausa

l sym

ptom

s

Mas

talg

ia

Ost

eopo

rosi

s

Ben

ign

pros

tati

c hy

pert

roph

y

Hyp

erlip

idem

ia

Stud

ies:

not

eno

ugh

evid

ence

for

effe

ctiv

enes

s or

saf

ety

in m

enop

ause

Stud

ies:

NC

CA

M s

tudy

ing

how

it

affe

cts

pros

tate

cel

ls

Stud

y: if

cau

ses

endo

met

rial

ca

ncer

ris

k

* Pre

gnan

cy/l

acta

tion

: uns

afe

in m

edic

inal

am

ount

s

* may

incr

ease

ris

k of

bre

ast

canc

er o

r ot

her

horm

one-

sens

itiv

e ca

ncer

s

AD

Rs:

Mas

talg

ia

Men

stru

al c

hang

es

Vag

inal

spo

ttin

g

H/A

, ras

h

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

Tam

oxife

n-al

tere

d ef

fect

Estr

ogen

s-al

tere

d ef

fect

Flow

ers

used

in t

able

ts,

caps

ules

, tea

s, e

xtra

cts

Dos

e: 4

0-80

mg

red

clov

er

isof

lavo

nes/

day

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Rho

diol

a◆

◆co

nsid

ered

ada

ptog

en

Use

d fo

r en

ergy

and

exe

rcis

e en

hanc

emen

t

Fati

gue

gene

raliz

ed a

nxie

ty d

isor

der

blad

der

canc

er

hypo

xia

Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

Inso

mni

a↑

BP

Der

mat

itis

Irri

tabi

lity

Dry

mou

thLe

ukoc

ytos

isD

RU

G IN

TER

AC

TIO

NS:

Ant

idep

ress

ants

—ad

diti

ve e

ffec

tsA

nxio

lyti

cs—

addi

tive

eff

ects

CN

S de

pres

sant

s—ad

diti

ve e

ffec

tsO

pioi

ds—

addi

tive

eff

ects

Ant

ihyp

erte

nsiv

es—

addi

tive

eff

ects

Cap

sule

s: 1

00-4

g da

ily

Sage

◆◆

Fert

ility

dru

g in

anc

ient

Egy

pt◆

◆C

lean

sed

and

stop

ped

blee

ding

in

ulce

rs/w

ound

s in

anc

ient

Gre

ece

Spic

e an

d se

ason

ing

Use

d fo

r m

outh

infla

mm

atio

n an

d so

re t

hroa

ts

Use

d fo

r in

dige

stio

n

Use

d fo

r m

enop

ausa

l sym

ptom

s

Use

d to

impr

ove

moo

d an

d bo

ost

mem

ory/

perf

orm

ance

Stud

ies:

sho

w m

enta

l and

moo

d im

prov

emen

ts; m

emor

y bo

osti

ng

in o

lder

adu

lts

Stud

ies:

sho

w t

hink

ing/

le

arni

ng im

prov

emen

t in

A

lzhe

imer

’s d

isea

se

Stud

ies:

sho

w e

ssen

tial

oil

has

anti

mic

robi

al p

rope

rtie

s

* sa

fe,b

ut s

ome

vari

etie

s co

ntai

n TH

UJO

NE

whi

ch c

an

affe

ct n

ervo

us s

yste

m, c

ausi

ng r

estl

essn

ess,

tre

mor

, se

izur

es, r

enal

tox

icit

yIn

gest

ing

sage

pow

der

can

caus

e as

thm

aIn

flam

mat

ion

wit

h sk

in c

onta

ct* A

void

in p

regn

ancy

-ris

k ab

orti

face

nt a

nd h

orm

onal

eff

ects

* Con

trai

ndic

ated

in s

eizu

re d

isor

ders

AD

Rs:

Seiz

ures

Con

tact

der

mat

itis

Hyp

erte

nsio

nSe

dati

onD

RU

G IN

TER

AC

TIO

N:

Ant

idia

beti

c dr

ugs↑

hypo

glyc

emia

Ant

icon

vuls

ants

-alt

ered

eff

ects

Thyr

oid

horm

ones

-alt

ered

eff

ects

Dri

ed le

aves

, ess

enti

al

oils

, spr

ays,

ext

ract

s

Men

opau

sal s

x:

120m

g qd

Phar

yngi

tis:

15%

spr

ay

Moo

d en

hanc

emen

t:

drie

d le

af,

300-

600m

g qd

Alz

heim

er’s

: es

sent

ial o

ils

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Saw

Pal

met

to “

dwar

f pal

m”

na

tive

to

US

“cab

bage

pal

m”

◆◆

Sem

inol

e N

ativ

e A

mer

ican

s us

ed

for

urin

ary

sym

ptom

s

Use

s: p

rost

ate

(BPH

) pr

oble

ms

pros

tati

tis

Pelv

ic p

ain

Bla

dder

pro

blem

s

Pros

tate

can

cer

Libi

do is

sues

Alo

peci

a

Incr

ease

s te

stos

tero

ne

May

be

anti

-infla

mm

ator

y an

d im

mun

e st

imul

ant

Stud

ies:

con

flict

ing

repo

rts

of

bene

fits

on B

PH s

ympt

oms

Doe

s no

t af

fect

PSA

on

stud

ies

Bei

ng s

tudi

ed fo

r af

fect

on

pr

osta

te c

ance

r

Ger

man

E C

omm

issi

on a

ppro

ves

fo

r B

PH e

arly

sta

ges

I and

II

* Mild

GI s

ympt

oms

can

be ↓

by

taki

ng w

ith

food

* Do

not

use

in p

regn

ancy

/lac

tati

on d

ue t

o

horm

onal

eff

ects

AD

Rs

Abd

omin

al p

ain

Dia

rrhe

a

N/V

Fati

gue

Sexu

al d

ysfu

ncti

on

DR

UG

INT

ERA

CT

ION

S:

Ant

ibio

tics

(C

ipro

, Azi

thro

myc

in e

spec

ially

)—ad

diti

ve

effe

cts

And

roge

ns—↓

effe

ct

Ant

icoa

gula

nts—

↑bl

eedi

ng

Ant

i-inf

lam

mat

orie

s —ad

diti

ve e

ffec

ts

Who

le o

r gr

ound

ber

ries

or

drie

d fr

uit.

In li

quid

ext

ract

s, t

able

ts,

caps

ules

, as

infu

sion

or

tea,

top

ical

for

alop

ecia

Dos

e of

cap

sule

: 320

mg

qd

Gro

und,

who

le o

r dr

ied

berr

ies—

1 or

2 q

d

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

SAM

e

S-ad

enos

ylm

ethi

onin

e

Met

hion

ine

is c

onve

rted

to

SAM

e w

ith

enzy

me

met

hion

ine

aden

osyl

tr

ansf

eras

e (M

AP)

Alc

ohol

ic li

ver

dise

ase→

liver

di

seas

e ha

s ↓

hepa

tic

SAM

e w

hich

glut

athi

one

need

ed fo

r he

pati

c de

toxi

ficat

ion

and

prev

enti

on o

f ox

idat

ive

liver

dam

age

Dep

ress

ion

Ost

eoar

thri

tis

AD

HD

Fibr

omya

lgia

Ana

lges

ic, a

nti-i

nfla

mm

ator

y

SAM

e tr

ansm

ethy

lati

on n

eces

sary

to

syn

thes

ize

and

met

abol

ize

neu-

rotr

ansm

itte

rs, p

rote

ins,

hor

mon

es,

and

mem

bran

e ph

osph

olip

ids

Prod

ucti

on o

f SA

Me

asso

ciat

ed w

ith

adeq

uate

B12

and

fola

te le

vels

SAM

e co

nver

ted

to S

-ade

nosy

l-ho

moc

yste

ine

whi

ch →

glut

athi

one

liver

ant

ioxi

dant

Can

↑do

pam

ine

and

nore

pine

phri

ne

2006

Coc

hran

e: n

o ev

iden

ce fo

r or

ag

ains

t us

e in

alc

ohol

ic li

ver

dise

ase

2008

Coc

hran

e: r

evie

w o

n O

A

use

pend

ing

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

AD

Rs:

Diz

zine

ss, H

/A, p

alpi

tati

ons

Dia

phor

esis

, ras

h, it

chy

or h

ot e

ar

Anx

iety

, ins

omni

a, fa

tigu

e

Ano

rexi

a, c

onst

ipat

ion,

N/V

/D, d

ry m

outh

AV

OID

IN B

IPO

LAR

DIS

EASE

→M

AN

IA

OR

HYP

OM

AN

IA

AV

OID

IN C

AD

, TH

RO

MB

OEM

BO

LISM

, RIS

K

HO

MO

CYS

TEI

NEM

IA

MA

Y W

OR

SEN

PA

RK

INSO

NS

SX

DR

UG

INT

ERA

CT

ION

S:

Sero

toni

nerg

ic/S

SRI→

sero

toni

n sy

ndro

me

St. J

ohn’

s W

ort→

sero

toni

n sy

ndro

me

Tric

yclic

ant

idep

ress

ants→

sero

toni

n sy

ndro

me

Tram

adol→

sero

toni

n sy

ndro

me

MA

OI→

sero

toni

n sy

ndro

me,

hyp

erte

nsiv

e cr

isis

Dex

trom

etho

rpha

n→se

roto

nin

synd

rom

e

Mep

erid

ine→

sero

toni

n sy

ndro

me

Levo

dopa

↓ef

fect

Tabl

et o

nly

in U

S

Poor

bio

avai

labi

lity

due

to

first

pas

s ef

fect

Dos

e: 8

00-1

600

mg/

day

in

2-3

divi

ded

dose

s

Mon

itor

glu

cose

, LFT

s

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

St. J

ohn’

s W

ort

“hyp

eric

um”

“g

oat’

s w

eed”

◆◆

Flow

er b

loom

s ar

ound

feas

t ti

me

of S

t. Jo

hn t

he B

apti

st in

late

June

.◆

◆us

ed fo

r ce

ntur

ies

to t

reat

men

tal

dise

ase,

ner

vous

ness

, as

seda

tive

◆◆

used

to

trea

t m

alar

ia, a

nd w

as

balm

for

wou

nds,

bur

ns, a

nd

inse

ct b

ites

.

Use

d fo

r de

pres

sion

, anx

iety

and

sl

eep

diso

rder

s

Use

d fo

r PM

S, s

easo

nal a

ffec

tive

di

sord

er, s

omat

ofor

m d

isor

ders

.

Use

d fo

r A

DH

D, b

urni

ng m

outh

sy

ndro

me,

OC

D.

Stud

ies

show

: the

re m

ay n

ot b

e

any

mor

e ef

fect

iven

ess

than

pl

aceb

o fo

r m

ajor

dep

ress

ion

of

mod

erat

e se

veri

ty

Ano

ther

stu

dy N

CC

AM

and

NIM

H

show

ed n

eith

er a

ntid

epre

ssan

t

nor

St. J

ohn’

s W

ort

trea

ted

mild

de

pres

sion

any

mor

e ef

fect

ivel

y

than

pla

cebo

Coc

hran

e re

view

200

8: b

ette

r th

an

plac

ebo

and

sim

ilar

to s

tand

ard

anti

-de

pres

sant

s w

ith

few

er s

ide

effe

cts

Hyp

erfo

rin

com

pone

nt in

hibi

ts

neur

onal

upt

ake

of d

opam

ine,

se

roto

nin,

nor

epin

ephr

ine,

GA

BA

an

d L-

glut

amat

e

* Avo

id u

se w

ith

othe

r an

tide

pres

sant

s; c

an le

ad t

o se

roto

nin

synd

rom

e. D

o no

t us

e w

ith

MA

OIs

.

* STO

P 5-

14 d

ays

pre-

oper

ativ

ely

* Do

not

use

wit

h su

icid

al id

eati

on

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

Dro

wsi

ness

GI s

ympt

oms

Hyp

erte

nsio

n/hy

pert

ensi

ve c

risi

s

(cou

ld a

ct li

ke M

AO

I)

Man

ia

Sero

toni

n sy

ndro

me

Del

iriu

m

Con

fusi

on

psyc

hosi

s

MI

Palp

itat

ions

↑TS

H

↑A

CTH

Phot

osen

siti

vity

Dry

mou

th

dizz

ines

s

Flow

erin

g to

ps u

sed

fo

r te

as, t

able

ts,

caps

ule,

ext

ract

s,

liqui

ds, t

opic

al a

gent

s

Stan

dard

ized

ext

ract

do

se: 3

00 m

g po

tid

fo

r 4-

6 w

eeks

Sudd

en d

isco

ntin

uati

on

may

cau

se a

dver

se r

eact

ion

(con

tinue

s)

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

St. J

ohn’

s W

ort

(con

tinue

d)D

RU

G IN

TER

AC

TIO

NS:

Ane

sthe

tics

SSR

I ant

idep

ress

ants

-ser

oton

in s

yndr

ome

Ant

ican

cer

drug

s

anti

coag

ulan

ts↓

effe

ct

anti

hype

rten

sive

s ↑

bp

alco

hol-↑

seda

tion

\ or

al c

ontr

acep

tive

s-↓

cont

race

ptio

n, p

ossi

bly

brea

k-th

roug

h bl

eedi

ng

Cyc

losp

orin

and

tra

nspl

ant

drug

s↓

Dig

oxin

-↓se

rum

leve

l

Stat

ins-↓

leve

l

HIV

dru

gs-m

ay a

ffec

t

Seiz

ure

drug

s-m

ay a

ffec

t

OTC

col

d/flu

med

s—m

ay ↑

MA

O in

hibi

tion

Tea

Tre

e O

il◆

◆U

sed

by A

ustr

alia

n ab

orig

ines

for

cent

urie

s◆

◆Fr

om t

ea t

ree

Use

s: a

thle

te’s

foot

(ti

nea

pedi

s), n

ail

fung

us (

onyc

hom

ycos

is)

wou

nds,

and

infe

ctio

ns

acne

dand

ruff

lice

oral

can

didi

asis

skin

lesi

ons

anti

bact

eria

l;ant

ifung

ual;

anti

-MR

SA

Stud

y: s

how

ed b

enef

it fo

r tr

eatm

ent

of w

ound

s of

MR

SA

Stud

ies:

hav

e sh

own

som

e po

siti

ve

bene

fit fo

r ac

ne, o

nych

omyc

osis

, ti

nea

pedi

s an

d da

ndru

ff

* Do

not

take

ora

lly; p

oiso

nous

, can

lead

to

com

a,

espe

cial

ly in

chi

ldre

n

* Can

be

topi

cal i

rrit

ant

or c

ause

con

tact

der

mat

itis

* Can

be

used

top

ical

ly in

pre

gnan

cy a

ccor

ding

to

Ulb

righ

t

AD

Rs:

Con

tact

der

mat

itis

Skin

dry

ness

Oto

toxi

city

if in

still

ed in

ear

DR

UG

INT

ERA

CT

ION

S:

Topi

cal d

ryin

g ag

ents

↑dr

ynes

s

Tret

inoi

n ↑

dry

ness

Use

d to

pica

lly, 5

%-1

00%

oi

l, sa

fer

in a

dult

s

Topi

cal u

se in

you

ng b

oy

of s

tylin

g ge

l and

sha

mpo

o ca

used

bre

ast

grow

th

Is in

som

e m

outh

was

hes,

bu

t ba

sed

on t

he c

once

rns

wit

h or

al u

se, d

o no

t re

com

men

d

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Thu

nder

God

Vin

e◆

◆Fo

und

in C

hina

◆◆

Use

d in

Tra

diti

onal

Chi

nese

M

edic

ine

for

over

acti

vity

of

imm

une

syst

em o

r in

flam

mat

ion

Use

s in

clud

e M

S, S

LE, r

heum

atoi

d ar

thri

tis(

RA

)

Use

d fo

r ex

cess

ive

men

ses

HIV

/AID

S

Hyp

erlip

idem

ia

oste

oart

hrit

is

May

hav

e im

mun

e st

imul

ant

effe

cts,

to

o

Stud

ies:

sho

w a

nti-c

ance

r an

d an

ti-

infla

mm

ator

y ef

fect

s

Stud

ies:

sho

w s

uppr

essi

on o

f im

mun

e sy

stem

eff

ect

Stud

ies:

sho

wed

ben

efit

s fo

r R

A p

ain

as g

ood

as s

ulfa

sala

zine

* HIG

HLY

PO

ISO

NO

US

LEA

VES

, FLO

WER

S A

ND

SK

IN O

F R

OO

T

* Avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

GI s

ympt

oms

UR

I sym

ptom

s

Loss

of b

one

min

eral

den

sity

Dec

reas

e m

ale

fert

ility

Alo

peci

a, r

ash,

H/A

DR

UG

INT

ERA

CT

ION

S;

Ant

ihyp

erte

nsiv

es-a

lter

eff

ect

DM

AR

Ds

(ant

i-inf

lam

mat

orie

s)-↑

effe

ct

Imm

unos

uppr

essa

nts-↑

effe

cts

Extr

acts

mad

e fr

om

SKIN

NED

roo

t

No

cons

iste

nt, h

igh-

qual

ity

prod

ucts

are

mad

e in

the

U

S ye

t; C

hine

se p

rodu

cts

may

not

be

relia

ble

Tur

mer

ic “

Indi

an s

affr

on”

◆◆

Rel

ated

to

ging

er, b

itte

r ta

ste,

go

ld c

olor

◆◆

Use

d fo

r sp

ice

and

colo

r◆

◆U

sed

in T

radi

tion

al C

hine

se M

edi-

cine

and

Ayu

rved

ic M

edic

ine

for

liver

func

tion

, dig

esti

on, m

enst

rual

re

gula

tion

and

art

hrit

is p

ain

Topi

cally

, use

d fo

r w

ound

hea

ling

and

ecze

ma

Use

d or

ally

for

ulce

rs, c

ance

r,

GI p

robl

ems,

infla

mm

atio

n,

and

galls

tone

s

Stud

ies:

cur

cum

in c

hem

ical

in

turm

eric

has

ant

i-inf

lam

mat

ory,

an

ti-c

ance

r, a

nd a

ntio

xida

nt

prop

erti

es in

ear

ly s

tudi

es

NC

CA

M fu

ndin

g st

udie

s on

: AR

DS,

os

teop

oros

is a

nd li

ver

canc

er

* Hig

h do

ses

or lo

ng t

erm

use

hav

e ca

used

: G

I pro

blem

s an

d liv

er is

sues

* Do

not

use

if ha

ve g

allb

ladd

er d

isea

se; c

an w

orse

n

* Con

side

red

safe

as

spic

e in

pre

gnan

cy, b

ut c

an

stim

ulat

e ut

erus

in h

igh

dose

s, s

o un

safe

the

re.

AD

Rs:

GI p

robl

ems

Hyp

oten

sion

Alo

peci

a

Con

tact

der

mat

itis

DR

UG

INT

ERA

CT

ION

S:

anti

coag

ulan

ts↑

blee

ding

anti

diab

etic

age

nts↑

hypo

glyc

emia

anti

hype

rten

sive

s↓B

P ex

cess

ive

Rhi

zom

es (

unde

rgro

und

stem

s) (

dri

ed a

nd u

ses

as

oral

pow

der,

in c

apsu

les,

te

as, o

r liq

uid

extr

acts

.

Turm

eric

pas

te u

sed

on

ski

n.

Dos

e: r

oot

1.5-

7g in

di

vide

d da

ily d

oses

Tea:

1-1

.5 g

dri

ed r

oot

stee

ped

15 m

inut

es in

15

0ml w

ater

bid

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Val

eria

n “a

ll he

al”;

“g

arde

n he

liotr

ope”

◆◆

Use

d ba

ck t

o an

cien

t G

reec

e

and

Rom

e◆

◆D

escr

ibed

by

Hip

pocr

ates

and

G

alen

(fo

r in

som

nia)

Use

d fo

r sl

eep

diso

rder

s

Anx

iety

Dep

ress

ion

H/A

Arr

hyth

mia

May

be

aden

osin

e ag

onis

t

May

be

GA

BA

rec

epto

r m

odul

ator

May

hav

e C

NS

neur

opro

tect

ive

effe

cts

NC

CA

M r

esea

rchi

ng a

ffec

t on

sl

eep

in o

lder

adu

lts

and

Pa

rkin

son’

s pa

tien

ts

Stud

ies:

sug

gest

hel

ps in

som

nia,

not

en

ough

res

earc

h on

anx

iety

an

d de

pres

sion

Ger

man

E C

omm

issi

on a

ppro

ved

to

trea

t sl

eep

diso

rder

s fr

om n

ervo

us

cond

itio

ns a

nd r

estl

essn

ess

* Stu

dies

sho

w s

afe

for

shor

t pe

riod

s,

up t

o 4-

6 w

eeks

use

* Not

for

use

in p

regn

ancy

-pos

sibl

e

tera

toge

nic

effe

cts

AD

Rs:

Mor

ning

fati

gue

GI u

pset

Diz

zine

ss

H/A

Hal

luci

nati

ons

Ata

xia

↓H

R, ↓

BP

Dry

mou

th

Mus

cle

rela

xati

on

One

rep

ort

of w

ithd

raw

al s

x

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

↑ef

fect

anti

depr

essa

nts↑

effe

ct

benz

odia

zepi

nes ↑

effe

ct

CN

S de

pres

sant

s ↑

effe

ct

Ant

ihyp

erte

nsiv

es ↓

BP

Roo

ts a

nd r

hizo

mes

(u

nder

grou

nd s

tem

s)

mak

e ta

blet

s, t

eas,

ca

psul

es, l

iqui

d ex

trac

ts

Use

½ t

o 2

hour

s be

fore

be

d if

for

slee

p

Mon

itor

LFT

s

Dos

e:

Anx

iety

: 80-

300m

g po

qd

Inso

mni

a: 4

00-9

00 m

g 30

-60

min

. bef

ore

hs

CO

MM

ON

NA

ME

OF

HER

B/

BIO

LOG

ICA

L N

AM

E O

F H

ERB

DES

IRA

BLE

MED

ICIN

AL

AC

TIO

NS

OF

HER

BC

ON

TR

AIN

DIC

AT

ION

S A

ND

RIS

KS

(A

dver

se D

rug

Rea

ctio

ns o

r A

DR

s) O

F H

ERB

USU

AL

DO

SIN

G

OF

HER

B

Yohi

mbe

“yo

him

be b

ark”

◆◆

From

bar

k of

Afr

ican

ev

ergr

een

tree

Yohi

mbe

hyd

roch

lori

de fo

rm h

as

been

stu

died

for

erec

tile

dys

func

tion

Use

d fo

r fe

mal

e lib

ido,

SSR

I-in

duce

d lib

ido

issu

es

Use

d fo

r se

xual

dys

func

tion

, ap

hrod

isia

c

Use

d fo

r at

hlet

ic p

erfo

rman

ce

Stud

ies:

no

adeq

uate

stu

dies

don

e

Con

tain

s al

pha-

2 bl

ocke

r→↑

nore

pine

phri

ne

↑ch

olin

ergi

c an

d↑sy

mpa

thet

ic t

one

* Avo

id in

pre

gnan

cy: f

etal

tox

icit

y, u

teri

ne r

elax

atio

n

* Do

not

use

in la

ctat

ion

* Do

not

use

wit

h M

AO

inhi

bito

rs, c

auti

on w

ith

othe

r an

tide

pres

sant

s an

d ph

enot

hiaz

ines

* Do

not

use

wit

h ps

ychi

atri

c or

ren

al d

isor

ders

can

exac

erba

te

* one

rep

ort

hype

rten

sive

cri

sis

* ove

rdos

e-se

vere

eff

ects

, pos

sibl

y fa

tal

AD

Rs:

Inso

mni

a

↑ o

r↓ B

P

Irri

tabi

lity,

psy

chos

is

N/V

Anx

iety

H/A

Ren

al fa

ilure

Lupu

s-lik

e sy

ndro

me

DR

UG

INT

ERA

CT

ION

S:

anti

diab

etic↓

bs

benz

odia

zepi

nes ↑

seda

tion

ETO

H↑

into

xica

tion

Nal

oxon

e/na

ltre

xone

↑yo

him

bine

tox

icit

y,

alte

r op

ioid

wit

hdra

wal

sx

CN

S st

imul

ants↑

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

Cen

tral

sym

path

omim

etic

s ↑

yohi

mbi

ne t

oxic

ity

Som

e pr

oduc

ts c

onta

in

very

litt

le y

ohim

be

Bar

k us

ed in

cap

sule

s,

tabl

ets,

tea

Stan

dard

ized

yoh

imbe

av

aila

ble

by p

resc

ript

ion

Dos

e: 5

-50

mg

in

divi

ded

dose

s fo

r

erec

tile

dys

func

tion

Mon

itor

BP,

HR

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Aci

doph

ilus

◆◆

Mai

n ty

pes:

lact

obac

illus

spe

cies

(a

cido

philu

s, c

asei

, pla

ntar

um,

delb

ruec

kii)

◆◆

Bifi

doba

cter

ium

spe

cies

(br

evis

, in

fant

is, l

ongu

m)

Mai

ntai

n or

res

tore

mic

robi

al b

alan

ce

in G

I and

GU

tra

cts;

may

pro

duce

bac

teri

ocin

s an

d

lact

ic a

cid

whi

ch im

pair

gro

wth

of

pat

hoge

ns

* may

cau

se m

orbi

dity

or

mor

talit

y if

pati

ents

im

mun

ocom

prom

ised

or

debi

litat

ed.

Avo

id in

PR

EGN

AN

CY

(ris

k am

nion

itis

, se

psis

,end

omet

riti

s)

Avo

id w

ith

arti

ficia

l hea

rt v

alve

s, r

adia

tion

the

rapy

, or

al s

urge

ry, G

I sur

gery

, hem

e+ d

iarr

hea,

imm

uno-

com

prom

ised

, deb

ilita

ted

dosa

ge v

arie

s de

pend

ing

on n

umbe

r of

livi

ng o

rgan

-is

ms

in p

rodu

ct

som

e yo

gurt

s w

ith

liv

e cu

ltur

es

liqui

ds, c

apsu

les,

pow

ders

, ta

blet

s, m

ilk, v

agin

al a

nd

anal

sup

posi

tori

es

Som

e ar

e ke

pt r

efri

gera

ted

Take

2 h

ours

aft

er

anti

biot

ics

Do

not

take

wit

h im

mun

o-su

ppre

ssan

ts

Alp

ha L

ipoi

c A

cid

(ALA

)◆

◆Fo

und

espe

cial

ly in

pot

atoe

s,

spin

ach,

live

r an

d br

occo

li

Dia

bete

s m

ellit

us, c

atar

acts

, re

tino

path

y, p

erip

hera

l neu

ropa

thy,

an

d ne

phro

path

y fr

om D

M

HIV

, cir

rhos

is, g

lauc

oma

Lead

tox

icit

y

Isch

emic

inju

ry li

ver,

bra

in, h

eart

Bur

ning

mou

th s

yndr

ome

AC

TIO

N: I

MPR

OV

ES

MIC

RO

CIR

CU

LATI

ON

IN

PER

IPH

ERA

L N

EUR

OPA

THY

IN

DM

AC

TIO

N: A

NTI

OXI

DA

NT

AC

TIO

N: ↑

INSU

LIN

-STI

MU

LATE

D

GLU

CO

SE U

SE IN

DM

AC

TIO

N: ↑

CD

4 A

ND

CD

8 LE

VEL

S IN

HIV

* avo

id in

thi

amin

e de

ficie

ncy

(alc

ohol

ism

esp

ecia

lly)

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Cau

tion

wit

h bl

eedi

ng d

isor

ders

Inte

ract

ions

wit

h an

tico

agul

ants

, ant

ipla

tele

ts,

NSA

IDs/

ASA

may

↑bl

eedi

ng r

isk

May

↓ e

ffec

tive

ness

che

mot

hera

py

May

↓ b

lood

sug

ar a

nd w

orse

n hy

pogl

ycem

ia

Ver

tigo

, h/a

, N/V

, ras

h

Ora

l

IV

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Arg

inin

e◆

◆Se

mi-e

ssen

tial

am

ino

acid

◆◆

Espe

cial

ly in

cor

n, d

airy

, oat

s,

mea

t, g

rain

s, b

row

n ri

ce, n

uts,

ch

ocol

ate,

rai

sins

AC

TIO

N: P

REC

UR

SOR

OF

NIT

RIC

O

XID

E, A

VA

SOD

ILA

TOR

AC

TIO

N: ↑

REL

AXA

TIO

N O

F SM

OO

TH M

USC

LE

AC

TIO

N: ↓

WB

C A

DH

ESIO

N,

PLA

TELE

T A

GG

REG

ATI

ON

, FI

BR

IN F

OR

MA

TIO

N

IMM

UN

E ST

IMU

LAN

T

CA

D, C

HF,

HTN

, PV

D, h

yper

-lip

idem

ia, b

reas

t ca

ncer

, ast

hma

*AN

AP

HYL

AX

IS T

O IV

AR

GIN

INE

IN C

HIL

DR

EN;

*AT

RIO

VEN

TR

ICU

LAR

BLO

CK

h/a,

diz

zine

ss, a

typi

cal c

hest

pai

n

↑ b

leed

ing

risk

↑ o

r ↓

blo

od s

ugar

↓bp

Avo

id in

pre

gnan

cy a

nd la

ctat

ion

Avo

id a

fter

acu

te M

I

Avo

id IV

form

s in

aci

dosi

s or

hyp

oten

sion

Suff

icie

nt a

mou

nts

mad

e in

bod

y

If s

uppl

emen

ted,

cre

am,

caps

ule,

IV, n

utri

ent

bar

No

esta

blis

hed

stan

dard

s

Bee

Pol

len

◆◆

Flow

er p

olle

n co

llect

ed o

n bo

dies

of

wor

ker

bees

mix

ed w

ith

nect

ar

and

bee

saliv

a◆

◆C

omm

erci

al b

ee p

olle

n m

ay b

e ju

st

polle

n ha

rves

ted

from

pla

nts

◆◆

NO

T sa

me

as h

oney

or

roya

l jel

ly◆

◆C

onta

ins:

ess

enti

al a

min

o ac

ids,

es

sent

ial f

atty

aci

ds, h

orm

ones

, m

iner

als,

vit

amin

s B

and

C c

oen-

zym

es, s

tero

ls, l

ipid

s, c

arbo

hy-

drat

es, a

nd m

ore

Ath

leti

c pe

rfor

man

ce

Mem

ory

boos

ter

Mul

tipl

e sc

lero

sis

Men

opau

se a

nd P

MS

Red

uce

canc

er c

hem

othe

rapy

si

de e

ffec

ts

Ant

ioxi

dant

Imm

une

stim

ulan

t

Ant

ifung

al

* Alle

rgic

rea

ctio

ns: a

naph

ylax

is, e

dem

a,

shor

tnes

s of

bre

ath,

pru

ruti

s, e

osin

ophi

lia,

risk

ast

hma

exac

erba

tion

AD

Rs:

N/V

/D, a

bdom

inal

pai

n

Hep

atit

is

H/A

, mal

aise

Phot

osen

siti

vity

Ver

tigo

Hay

feve

r

Dec

reas

ed m

emor

y

Avo

id in

pre

gnan

cy/l

acta

tion

Con

trai

ndic

ated

in a

llerg

y to

pol

lens

Cap

sule

s, t

able

ts, l

iqui

d,

gran

ules

, ext

ract

s, fo

od

supp

lem

ents

No

stan

dard

ized

pro

duct

s

Oft

en in

com

bina

tion

pr

oduc

ts

Polle

n co

nten

t va

ries

de

pend

ing

on p

lant

and

ge

ogra

phic

loca

tion

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cap

sicu

m “

caye

nne”

“ch

ili p

eppe

r”

“pap

rika

” “c

apsa

icin

”◆

◆Po

ssib

ly c

apsa

icin

rel

ease

s su

b-st

ance

P fr

om n

euro

ns, w

hich

de

crea

ses

pain

sen

sati

on

Use

s: c

lott

ing

diso

rder

s

GI d

isor

ders

Clu

ster

hea

dach

e

Mus

culo

skel

etal

pai

n

Neu

ropa

thic

pai

n

Post

oper

ativ

e N

/V

Pere

nnia

l rhi

niti

s

May

be

imm

unos

uppr

essa

nt,

anti

-infla

mm

ator

y, a

ntim

icro

bial

* ris

k al

lerg

ic r

eact

ions

AD

Rs:

↑H

R, ↑

BP

tran

sien

tly

Topi

cal b

urni

ng o

n sk

in, c

onta

ct d

erm

atit

is

Phar

yngi

tis,

rhi

norr

hea

(nas

al)

Eye

burn

ing

and

tear

ing

Swea

ting

, flu

shin

g

DR

UG

INT

ERA

CT

ION

S

AC

E in

hibi

tors

↑co

ugh

Ant

iarr

hyth

mic

s ↑

HR

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↓bs

,↑in

sulin

Ant

iulc

er a

gent

s ↑

stom

ach

acid

Pow

der,

top

ical

cre

ams,

in

tran

asal

spr

ay

Zost

rix

crea

m c

onta

ins

0,02

5% c

apsa

icin

Law

enf

orce

men

t us

es in

pe

pper

spr

ay

Cho

ndro

itin

Sul

fate

◆◆

Glu

curo

nic

acid

and

gal

acto

sam

ine

mol

ecul

e◆

◆Fo

und

in m

amm

alia

n ca

rtila

ge,

supp

lem

ent

deri

ved

from

bov

ine,

sh

ark,

or

synt

heti

c m

ater

ial

◆◆

Cau

tion

wit

h bo

vine

typ

e: r

isk

bovi

ne s

pong

iform

enc

epha

lopa

thy

(Mad

Cow

Dis

ease

)

Use

s:

Ost

eoar

thri

tis,

esp

ecia

lly o

f hip

an

d kn

ee

Psor

iasi

s

May

hav

e an

ti-in

flam

mat

ory

May

be

prot

ecti

ve o

f joi

nt

* avo

id in

she

llfis

h al

lerg

y

* avo

id in

ble

edin

g di

sord

er, p

reop

erat

ivel

y

AD

Rs:

↑or↓

BP

Euph

oria

, H/A

Ast

hma

exac

erba

tion

Ble

edin

g ri

sk, ↓

hem

oglo

bin

DR

UG

INT

ERA

CT

ION

S

anti

coag

ulan

ts↑

blee

ding

Iron

↑ab

sorp

tion

In c

apsu

les

or c

ombi

ned

wit

h gl

ucos

amin

e

May

be

able

to

dose

in

term

itte

ntly

200-

400m

g/d

in d

ivid

ed

or o

ne d

ose

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cha

steb

erry

“vi

tex”

◆◆

Use

d by

mon

ks t

o de

crea

se s

exua

l de

sire

, tho

ught

to

prom

ote

chas

tity

Use

s: m

enop

ause

sym

ptom

s

Bre

ast

milk

pro

duct

ion

PMS

sym

ptom

s

Infe

rtili

ty

Acn

e

Stud

ies:

pos

sibl

e be

nefit

for

brea

st

pain

, inf

erti

lity,

PM

S, b

ut n

eeds

m

ore

stud

y

* Do

not

take

in p

regn

ancy

/la

ctat

ion

seco

ndar

y to

ho

rmon

al e

ffec

t

* Do

not

take

wit

h do

pam

ine

med

icat

ions

(s

ome

anti

psyc

hoti

cs, P

arki

nson

’s d

rugs

)

beca

use

affe

cts

dopa

min

e

* Do

not

take

wit

h or

al c

ontr

acep

tive

s or

hor

mon

e-re

late

d ca

ncer

(e.

g. b

reas

t ca

ncer

)

AD

Rs:

Acn

e

GI s

ympt

oms

Diz

zine

ss

Dep

ress

ion,

fati

gue

DR

UG

INT

ERA

CT

ION

S

Ant

ipsy

chot

ic a

gent

s as

abo

ve

Dop

amin

e ag

ents

as

abov

e

Dry

com

mer

cial

ext

ract

: up

to

40m

g/da

y

Liqu

id c

omm

erci

al e

xtra

ct:

1.8m

l/da

y

Dri

ed fr

uit-

up t

o

600m

g/da

y

Cin

nam

on

From

bar

k of

cin

nam

on t

ree

Man

y va

riet

ies;

Cey

lon

and

Chi

nese

(c

assi

a) c

inna

mon

mos

t co

mm

on

Use

s: d

iabe

tes

mel

litus

Bro

nchi

tis

GI s

ympt

oms,

loss

of a

ppet

ite

Ang

ina,

CA

D

Stud

ies:

lack

ing

supp

ort

* Avo

id c

onsu

min

g la

rge

amou

nts

of c

assi

a ci

nnam

on, b

ecau

se it

con

tain

s co

umar

in,

of t

he a

ntic

oagu

lant

fam

ily

* Alle

rgic

/hyp

erse

nsit

ivit

y re

acti

on

AD

Rs:

Ast

hma

Glo

ssit

is, g

ingi

viti

s, s

tom

atit

is

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

↓bs

Pow

ders

, ext

ract

s,

caps

ules

, tea

s

Dos

es: T

ype

II di

abet

es

mel

litus

up

to 6

g/da

y

for

40 d

ays

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Cra

nber

ry◆

◆N

o lo

nger

tho

ught

to

acid

ify u

rine

◆◆

Inst

ead,

con

tain

s pr

oant

ho-

cyan

idin

s w

hich

pre

vent

ba

cter

ial a

dhes

ion

in b

ladd

er

Use

s: t

reat

uri

nary

tra

ct in

fect

ions

Trea

t H

.pyl

ori s

tom

ach

infe

ctio

ns

that

cau

se u

lcer

s

Ant

ioxi

dant

Ant

ican

cer

Prev

ent

dent

al p

laqu

e

Stud

ies:

dis

pute

tha

t cr

anbe

rrie

s ca

n tr

eat

urin

ary

trac

t in

fect

ions

, but

the

y m

ay h

elp

PREV

ENT

them

Stud

ies:

may

pre

vent

E.c

oli o

rgan

ism

s fr

om a

dher

ing

in u

rina

ry t

ract

wal

ls

and

may

pre

vent

H.p

ylor

i org

anis

ms

from

sur

vivi

ng in

sto

mac

h

Stud

ies:

pos

sibl

e an

tiox

idan

t pr

oper

-ti

es; p

ossi

bly

prev

ents

den

tal p

laqu

e

* exc

ess

cran

berr

y ju

ice

can

caus

e G

I ups

et

* use

cau

tiou

sly

if ta

king

con

com

itan

t an

tico

agul

ants

or

asp

irin

, or

med

icat

ions

tha

t af

fect

live

r

AD

Rs:

↑ri

sk b

leed

ing

DR

UG

INT

ERA

CT

ION

S

Ant

ibio

tics

–ad

diti

ve

Ant

icoa

gula

nts ↑

blee

ding

Asp

irin

↑ b

leed

ing

Bev

erag

e, s

auce

s

and

jelli

es

Tabl

ets,

cap

sule

s

Dos

e: c

apsu

les

200-

800m

g da

ily in

div

ided

dos

es

Dos

e: ju

ice

cock

tail—

500m

l/da

y

Cre

atin

e◆

◆Pr

oduc

ed in

bod

y fr

om

amin

o ac

ids

◆◆

Stor

ed in

mus

cles

Use

: ath

leti

c pe

rfor

man

ce

enha

ncem

ent

Stud

ies:

con

flict

ing

repo

rts

abou

t po

ssib

le r

enal

dys

func

tion

Stud

ies:

eff

ects

onl

y in

sho

rt d

urat

ion

phys

ical

act

ivit

y

* Avo

id in

bip

olar

, arr

hyth

mia

, DM

AD

Rs:

H/A

, sed

atio

n, s

eizu

res

Arr

hyth

mia

, ede

ma

GI s

ympt

oms

Mus

cle

cram

ping

Agg

ress

ion,

irri

tabi

lity,

man

ia in

bip

olar

, de

pres

sion

, anx

iety

DR

UG

INT

ERA

CT

ION

S:

Ant

iarr

hyth

mic

s ↑

arrh

ythm

ia

Ant

idia

beti

c ag

ents

alt

er b

s

Diu

reti

cs ↑

effe

ct

NSA

IDS ↑

neph

roto

xici

ty

Avo

id w

ith

caff

eine

pr

oduc

ts

Dos

e: u

p to

25g

/dai

ly

by m

outh

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

DH

EA◆

◆Pr

oduc

ed b

y ad

rena

ls, l

iver

, te

stes

, neu

rons

◆◆

Con

vert

ed t

o D

HEA

S-S,

can

be

con

vert

ed t

o es

trog

ens

an

d an

drog

ens

Use

s: a

dren

al in

suff

icie

ncy

Dep

ress

ion

Obe

sity

Incr

ease

str

engt

h

Stud

ies:

No

bene

fit fo

r im

prov

ing

mem

ory

or

for

dise

ases

Ban

ned

subs

tanc

e: b

y N

atio

nal

Col

legi

ate

Ath

leti

c A

ssoc

iati

on

AD

Rs:

Dee

peni

ng v

oice

Arr

hyth

mia

, HTN

GI s

ympt

oms

Agi

tati

on, c

onfu

sion

, dep

ress

ion,

psy

chos

is

Insu

lin r

esis

tanc

e

DR

UG

INT

ERA

CT

ION

S

Ant

ihyp

erte

nsiv

es ↑

bp

Ant

ipsy

chot

ics ↑

man

ia

Lith

ium

↑m

ania

Ant

idia

beti

c ag

ents

↑in

sulin

res

ista

nce

Tabl

ets,

cap

sule

s, c

ream

s

Fish

Oil

“om

ega

3 oi

ls”

DH

A/E

PA◆

◆Fr

om o

ily fi

sh◆

◆C

onta

ins

DH

A o

meg

a 3

fatt

y ac

id

(doc

osah

exae

noic

aci

d) a

nd E

PA

(eic

osap

enta

enoi

c ac

id)

Use

s:

Hyp

ertr

igly

ceri

dem

ia

Prev

enti

on C

AD

May

be

anti

thro

mbo

geni

c

Mild

↓B

P

↓at

hero

scle

roti

c pl

aque

↓tr

igly

ceri

dem

ia

May

be

anti

-arr

hyth

mic

* avo

id in

fish

alle

rgy

* avo

id p

erio

pera

tive

ly d

ue t

o bl

eedi

ng r

isk

* avo

id in

pre

gnan

cy/l

acta

tion

due

to

risk

of

mer

cury

con

tam

inat

ion

* avo

id in

ble

edin

g di

sord

ers

AD

Rs:

↓B

P, ↑

LDL

↑A

lt in

cys

tic

fibro

sis

↑ri

sk m

ania

Fish

y ta

ste,

bel

chin

g

DR

UG

INT

ERA

CT

ION

S

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp

Vit

A a

nd D

may

cau

se t

oxic

ity

wit

h co

d liv

er o

il

Vit

E:↑

ble

edin

g

Dos

e: 2

-4 g

EP

A+D

HA

dai

ly

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se D

rug

Rea

c-ti

ons

or A

DR

s) O

F SU

PP

LEM

ENT

USU

AL

DO

SIN

G O

F

SUP

PLE

MEN

T

Flax

seed

oil/

seed

“l

inse

ed o

il”◆

◆Fl

axse

ed c

onta

ins

ligna

ns,

or p

hyto

estr

ogen

s◆

◆Fl

axse

ed o

il do

es n

ot

cont

ain

any

ligna

ns

Use

s: m

enop

ause

sym

ptom

s

Laxa

tive

Art

hrit

is

Hyp

erlip

idem

ia

Can

cer

Stud

ies:

sug

gest

hel

p lo

wer

lipi

ds if

lip

ids

are

elev

ated

Stud

ies:

sug

gest

alp

ha-li

nole

ic a

cid

(typ

e of

om

ega

3 fa

tty

acid

) co

n-ta

ined

wit

hin

help

s he

art

dise

ase

Stud

ies:

mix

ed r

esul

ts o

n ho

t fla

shes

Stud

ies:

sug

gest

mig

ht r

educ

e so

me

canc

ers’

ris

ks, u

ncle

ar

* Not

for

preg

nanc

y du

e to

ris

k of

spo

ntan

eous

del

iver

y

* Ris

k al

lerg

y, t

ype

I hyp

erse

nsit

ivit

y

AD

Rs:

Seve

re d

iarr

hea

Abd

omin

al p

ain,

bow

el o

bstr

ucti

on

↓pl

atel

et a

ggre

gati

on

↑ t

rigl

ycer

ides

May

aff

ect

sex

horm

ones

DR

UG

INT

ERA

CT

ION

S:

acet

amin

ophe

n↓ab

sorp

tion

anti

coag

ulan

ts ↑

ble

edin

g

anti

diab

etic

age

nts ↑

or ↓

bs

anti

hype

rten

sive

s ↓

bp

furo

sem

ide↓

abso

rpti

on

Flax

seed

oil

is in

liqu

id o

r ca

psul

e fo

rm

Flax

seed

who

le o

r cr

ushe

d ca

n be

mix

ed w

ith

wat

er

or u

sed

wit

h fo

od; a

lso

in

pow

der

form

Take

bot

h se

ed a

nd o

il in

su

ffic

ient

wat

er t

o av

oid

inte

stin

al o

bstr

ucti

on a

nd

cons

tipa

tion

Do

not

take

sam

e ti

me

as a

ny o

ther

med

icat

ions

or

sup

plem

ents

, as

may

de

crea

se a

bsor

ptio

n

Dos

e: o

il up

to

2g/d

aily

Dos

e: p

owde

r/flo

ur u

p to

60

g/da

ily, d

ivid

ed d

oses

w

ith

liqui

d up

to

4 w

eeks

Glu

cosa

min

eU

ses:

ost

eoar

thri

tis,

rh

eum

atoi

d ar

thri

tis

TMJ

Dia

bete

s m

ellit

us

Chr

onic

ven

ous

insu

ffic

ienc

y

Mos

t st

udie

s us

e gl

ucos

amin

e su

lfate

, so

me

wit

h ch

ondr

oiti

n

Coc

hran

e re

view

: sho

ws

good

ev

iden

ce fo

r m

inim

al im

prov

emen

t

in p

ain

of O

/A k

nee/

hip

* Avo

id in

pre

gnan

cy/l

acta

tion

* avo

id w

ith

hx o

f she

llfis

h or

iodi

ne a

llerg

y as

som

e pr

epar

atio

ns fr

om m

arin

e ex

oske

leto

ns

* cau

tion

in D

M-m

ay↑

bs

AD

Rs:

Diz

zine

ss, H

/A, s

omno

lenc

e

↑bp

,↑he

art

rate

, pal

pita

tion

s

GI s

ide

effe

cts

Ast

hma

exac

erba

tion

DR

UG

INT

ERA

CT

ION

S:

Ant

ihyp

erte

nsiv

es ↓

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

Ant

idia

beti

c ag

ents

↓in

sulin

pro

duct

ion

or ↑

insu

lin r

esis

tanc

e

Take

s av

erag

e 2-

4 w

eeks

fo

r be

nefit

Dos

e: 5

00m

g ti

d fo

r up

to

6 m

onth

s

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Gra

pese

ed E

xtra

ct◆

◆Le

aves

and

frui

t of

gra

pes

ha

ve b

een

used

med

icin

ally

si

nce

anci

ent

Gre

ece

◆◆

Extr

act

mad

e fr

om g

rape

see

ds

left

over

from

win

e-m

akin

g

Use

s: a

ther

oscl

eros

is, C

AD

Hyp

erlip

idem

ia

HTN

Cir

cula

tory

issu

es fr

om d

iabe

tes,

in

eye

s (m

acul

ar d

egen

erat

ion

and

vasc

ular

dis

ease

), p

erip

hery

Can

cers

edem

a

Stud

ies:

sho

w e

ffic

acy

for

chro

nic

veno

us in

suff

icie

ncy

and

extr

emit

y ed

ema

Stud

ies:

ben

efit

for

diab

etic

ret

ino-

path

y an

d an

tiox

idan

t ef

fect

s

Stud

ies

in p

roce

ss a

re lo

okin

g at

br

east

, pro

stat

e, c

olon

can

cer

prev

en-

tion

, Alz

heim

er’s

tre

atm

ent

* Avo

id in

per

iope

rati

ve p

erio

ds

* Avo

id in

pre

gnan

cy/l

acta

tion

* Avo

id w

ith

blee

ding

dis

orde

rs, i

ron

defic

ienc

y

AD

Rs:

H/A

, diz

zine

ss

HTN

Itch

y sc

alp

GI s

ympt

oms

DR

UG

INT

ERA

CT

ION

S:

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↑

effe

ct

Ant

idia

beti

c ag

ents

↓bs

Iron

↓ a

mou

nt

Dos

e: u

p to

300

mg/

d

by m

outh

in c

apsu

les

or

tab

lets

Gre

en T

ea “

Chi

nese

Tea

“Jap

anes

e Te

a”◆

◆A

ctiv

e in

gred

ient

is E

GC

G

Use

s: m

enta

l ale

rtne

ss

Wei

ght

loss

Hyp

erlip

idem

ia

Can

cer

trea

tmen

ts—

gast

ric,

br

east

, ski

n

Stud

ies:

mix

ed r

esul

ts o

n pr

even

tion

or

slo

win

g of

som

e ca

ncer

s

Stud

y: im

prov

es m

enta

l ale

rtne

ss,

likel

y fr

om c

affe

ine

* Avo

id if

on

anti

coag

ulan

ts a

s co

ntai

ns V

itam

in K

* Avo

id if

caf

fein

e-se

nsit

ive

* Avo

id u

sing

con

cent

rate

d gr

een

tea

extr

acts

if h

ave

or d

evel

op li

ver

issu

es; s

ome

risk

live

r to

xici

ty

AD

Rs:

Caf

fein

e-re

late

d: in

som

nia,

irri

tabi

lity,

pal

pita

tion

s,

GI u

pset

, uri

nary

freq

uenc

y, ↑

psyc

hiat

ric

sym

ptom

s

Prim

arily

use

d as

be

vera

ge b

y st

eam

ing

gr

een

tea

leav

es.

Can

be

mad

e in

to c

apsu

les

or p

ut w

ith

othe

r pr

oduc

ts.

Som

e to

pica

l pro

duct

s.

Dos

e: 2

50-9

50m

l tea

po

qd

up t

o 4

wee

ks fo

r C

AD

ben

efit

s

Dos

e: 4

00m

l tid

for

m

enta

l ale

rtne

ss

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Gua

rana

◆◆

Has

am

ong

high

est

caff

eine

co

nten

t of

all

plan

ts◆

◆G

uara

na=2

.5%

-7%

caf

fein

e◆

◆C

offe

e=1%

-2%

caf

fein

e

Use

s: c

ogni

tive

and

m

ood

enha

ncem

ent

obes

ity

* Not

to

be u

sed

in p

regn

ancy

/lac

tati

on d

ue t

o hi

gh

perc

enta

ge o

f caf

fein

e an

d as

soci

ated

ris

ks m

isca

r-ri

age,

IUG

R

* not

to

be u

sed

wit

h an

tico

agul

ants

, as

it d

ecre

ases

pl

atel

et a

ggre

gati

on

AD

Rs:

Rel

ated

to

caff

eine

con

tent

Agi

tati

on, a

nxie

ty, i

nsom

nia

Arr

hyth

mia

, hyp

erte

nsio

n

H/A

, GI s

ympt

oms

Tach

ycar

dia,

psy

chos

is, o

ther

s

↓pl

atel

et a

ggre

gati

on

DR

UG

INT

ERA

CT

ION

S:

Alc

ohol

↑ef

fect

Ana

lges

ics ↑

effe

ct

Ant

icoa

gula

nts ↑

blee

ding

anti

hype

rten

sive

s↓ef

fect

anti

biot

ics

alte

r ef

fect

CN

S de

pres

sant

s-an

tago

nist

ic

Ephe

drin

e-ad

diti

ve

Dop

amin

ergi

c-ad

diti

ve

Bet

ablo

cker

s-an

tago

nist

ic

othe

rs

Dry

ext

ract

dos

es s

houl

d no

t be

>3g

/day

Foun

d in

Bra

zilia

n so

das,

an

d in

crea

sing

ly in

US

ener

gy p

rodu

cts

and

en

ergy

dri

nks.

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Kel

p “s

eaw

eed”

◆◆

Bro

wn

seaw

eed

has

been

use

d fo

r fo

od a

nd m

edic

ine

◆◆

Con

tain

s so

dium

alg

inat

e

Use

s: a

ntic

oagu

lant

Ant

ivir

al

Wou

nd r

epai

r

goit

er

Wei

ght

loss

Can

cer

Evid

ence

ant

ioxi

dant

and

an

tiba

cter

ial a

ctio

ns

Ant

icoa

gula

nt e

ffec

t in

lab

* Iod

ine

may

cau

se h

yper

sens

itiv

ity

rash

incl

udin

g an

gioe

dem

a, T

TP, d

eath

* Not

for

preg

nanc

y/la

ctat

ion-

abor

tifa

cent

eff

ect

AD

Rs:

↓bp

in s

ome

spec

ies

Incr

ease

or

decr

ease

thy

roid

Laxa

tive

eff

ect

Ble

edin

g

Peri

pher

al n

euro

path

y fr

om a

rsen

ic c

onte

nt

Nep

hrot

oxic

ity

DR

UG

INT

ERA

CT

ION

SLa

xati

ves ↑

effe

ct

Ant

idia

beti

c ag

ents

↓bs

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp in

som

e

Estr

ogen

s-an

ties

trog

enic

eff

ect

Aqu

eous

ext

ract

, pow

der,

gr

anul

es, c

apsu

les,

tab

lets

No

stan

dard

izat

ion

of

iodi

ne c

onte

nt

Mel

aton

in

Neu

roho

rmon

e se

cret

ed b

y pi

neal

gl

and

due

to d

arkn

ess

Influ

ence

s ci

rcad

ian

rhyt

hm a

nd

slee

p in

itia

tion

Use

: sle

ep d

isor

ders

AD

HD

Alz

heim

er’s

dis

ease

May

impa

ct b

rain

sle

ep c

ente

r

Imm

une

stim

ulan

t

Ant

ioxi

dant

Jet

lag

* Do

not

use

in p

regn

ancy

/lac

tati

on

AD

Rs:

con

fusi

on

Dep

ress

ion

(tra

nsie

nt)

Diz

zine

ss

Dre

am d

istu

rban

ce

Dro

wsi

ness

Irri

tabi

lity

Neu

robe

havi

oral

alt

erat

ion

DR

UG

INT

ERA

CT

ION

SA

ntic

oagu

lant

s ↓

effe

ctiv

enes

s

Ant

ihyp

erlip

idem

ics ↑

athe

rosc

lero

sis

Ant

isei

zure

dru

gs ↑

seiz

ure

risk

Seda

tive

s ↑

seda

tion

Not

app

rove

d fo

r sa

fety

ov

er >

3 m

onth

s us

e

Dos

e: 0

.1-5

mg

in

eve

ning

po

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Pol

icos

anol

◆◆

Alc

ohol

s fr

om s

ugar

can

e w

ax

Use

: hyp

erch

oles

tero

lem

ia

Inhi

bits

cho

lest

erol

syn

thes

is in

live

r

LDL

degr

adat

ion

Ant

ioxi

dant

Stud

ies:

man

y fr

om C

uba,

sou

rce

of

suga

r ca

ne, s

ome

conf

licti

ng d

ata

from

non

-Cub

an s

tudi

es

AD

Rs

Ant

ipla

tele

t ef

fect

H/A

, diz

zy, ↓

BP

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents↓

bs

Ant

ihyp

erte

nsiv

es ↓

bp

Ant

ipar

kins

onia

ns ↑

dysk

ines

ias

Ant

icoa

gula

nts ↑

blee

ding

Nit

rate

s ↓

bp

Cap

sule

s, t

able

ts

Dos

e: 5

-80m

g/da

y up

to

3 ye

ars

Red

Yea

st R

ice

◆◆

Extr

act

from

ferm

enti

ng r

ice

w

ith

yeas

t◆

◆FD

A b

anne

d sa

le in

US

due

to

viol

atio

n, s

uppl

emen

t co

ntai

ned

lova

stat

in (

pres

crip

tion

sta

tin)

◆◆

FDA

war

ns n

ot t

o bu

y on

inte

rnet

du

e to

lova

stat

in c

ompo

nent

Use

: hyp

erlip

idem

ia

Con

tain

ste

rols

, fat

ty a

cids

, is

ofla

vone

s

Ant

i-inf

lam

mat

ory

pote

ntia

l

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs

Ras

h, a

naph

ylax

is

Diz

zine

ss, H

/A,

↓bp

↓bs

GI s

ympt

oms

↓H

gb, ↓

BU

N

DR

UG

INT

ERA

CT

ION

S

Alc

ohol

↑liv

er t

oxic

ity

CoQ

10 ↓

, nee

ds s

uppl

emen

t

Ant

idia

beti

c ↓

or ↑

bs

Ant

ihyp

erlip

idem

ics ↑

risk

adv

erse

eff

ects

Stat

ins ↑

ris

k ad

vers

e ef

fect

s

↑ri

sk r

habd

omyo

lysi

s w

ith

azal

ides

, cyc

losp

orin

e,

nefa

zodo

ne, o

ther

s

Gel

cap

sule

s

Do

not

take

wit

h gr

apef

ruit

ju

ice

or a

lcoh

ol

NA

TU

RA

L SU

PP

LEM

ENT

SD

ESIR

AB

LE M

EDIC

INA

L A

CT

ION

S O

F SU

PP

LEM

ENT

CO

NT

RA

IND

ICA

TIO

NS

AN

D R

ISK

S (A

dver

se

Dru

g R

eact

ions

or

AD

Rs)

OF

SUP

PLE

MEN

TU

SUA

L D

OSI

NG

OF

SU

PP

LEM

ENT

Soy

◆◆

Soyb

eans

con

tain

isof

lavo

nes,

si

mila

r to

est

roge

n

Use

s: m

enop

ausa

l sym

ptom

s

HTN

Hyp

erlip

idem

ia

Ost

eopo

rosi

s

Bre

ast

and

pros

tate

can

cer

(may

be

now

con

trai

ndic

ated

in b

reas

t ca

ncer

)

Stud

ies:

red

uces

LD

L ch

oles

tero

l

Stud

ies:

red

uces

hot

flas

hes

* Rar

e al

lerg

ies

* Avo

id s

oy in

hor

mon

e-re

late

d ca

ncer

s or

ris

k of

ca

ncer

s (b

reas

t, e

ndom

etri

al, o

vari

an)

AD

Rs:

Mild

GI s

ympt

oms

H/A

DR

UG

INT

ERA

CT

ION

S

Ant

icoa

gula

nts ↑

blee

ding

Ant

ihyp

erte

nsiv

es ↓

bp

Tam

oxife

n in

terf

eres

wit

h ef

fect

s

Estr

ogen

inte

rfer

es w

ith

effe

cts

Soyb

eans

, tof

u, s

oy m

ilk

Pow

ders

, cap

sule

s, s

uppl

e-m

ents

and

nut

riti

on b

ars

Dos

e: 1

0-10

6g p

o bi

d

Dos

e: 2

5 g

soy

daily

for

CA

D r

isk

Spir

ulin

a “b

lue-

gree

n al

gae”

Use

s: d

iabe

tes,

hyp

erlip

idem

ia

Alle

rgic

rhi

niti

s

Wei

ght

loss

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

H/A

, N/V

hepa

toto

xici

ty

Dos

e: D

M 1

g p

o bi

d

wit

h m

eals

Dos

e: a

llerg

ic r

hini

tis

1000

-200

0mg

qd

x12

wee

ks

Wild

Yam

Use

s: h

yper

lipid

emia

Men

opau

sal s

ympt

oms

* avo

id in

pre

gnan

cy/l

acta

tion

AD

Rs:

GI u

pset

, con

tact

der

mat

itis

DR

UG

INT

ERA

CT

ION

S

Ant

idia

beti

c ag

ents

↓bs

Hor

mon

es a

lter

ed e

ffec

ts

Topi

cal-v

agin

al c

ream

s

Cap

sule

s: 2

50m

g 1-

3x/d

ay

n RefeRenCeS:Herbs At A Glance. (2013). NIH National Center

for Complementary and Alternative Medicine retrieved at http://nccam.nih.gov/health/herbs ataglance.htm (Natural Standard Database Web site and Natural Medicines Comprehensive Data-base Web site are resources)

Sanoski, C.A., & Sucich, M.I. (2011). Herbal Notes: A Complementary & Alternative Medicine Pocket Guide. Philadelphia: F.A. Davis.

Ulbright, C. (2011). Davis’ Pocket Guide to Herbs and Sup-plements. Philadelphia: F.A. Davis. (Note: author is founder of Natural Standard Research Collabora-tion and Chief Editor, Journal of Dietary Supplements).