T and B Cell Costimulation

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T and B Cell Costimulation Robert H. Carter, MD [email protected] Div. Rheumatology, Dept. Medicine Dept. Microbiology Program in Cellular and Molecular Biology Program in Immunology

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T and B Cell Costimulation. Robert H. Carter, MD [email protected] Div. Rheumatology, Dept. Medicine Dept. Microbiology Program in Cellular and Molecular Biology Program in Immunology University of Alabama at Birmingham. Germinal Center, WT CD19, SRBC Day 7. Red pulp. FDC. Germinal - PowerPoint PPT Presentation

Transcript of T and B Cell Costimulation

  • T and B Cell CostimulationRobert H. Carter, [email protected]. Rheumatology, Dept. MedicineDept. MicrobiologyProgram in Cellular and Molecular BiologyProgram in ImmunologyUniversity of Alabama at Birmingham

  • PNA Alexa 488 GreenCD35 Alexa 350 BlueKi-67 Alexa 555 RedIgD Bio SA-Cy5 goldGerminal Center, WT CD19, SRBC Day 7 CentralarterioleGerminalCenterMarginal Sinus Endothelial cellFDCMarginal zoneRed pulp

  • Structure of a Folliclehypermutation affinity maturationclass switch

  • Antigen Binding and Processing

    CD40MHCClass II mIgMB cell

  • Resting T Cell

    T cellT CellReceptor

  • Partial T-B Collaboration-Anergy

  • Priming of T Cell-CD40L

    CD28T cell

  • T-B Collaboration-CD80

    CD40

  • PrimedB CellCD28T-B Collaboration-CTLA4CD80

  • Collaboration blocked? AnergyBlocking AgentsCD80CD28T cellCD40Lanti-CD40LCTLA4IgB cell


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