Synthesis of Novel Antitumor Agent 1-Methoxy-5,10-dioxo-5,10-dihydro-1H-benzo[g]isochromene...
1
2004 Benzopyran derivatives Benzopyran derivatives R 0350 Synthesis of Novel Antitumor Agent 1-Methoxy-5,10-dioxo-5,10-dihydro-1H-ben- zo[g]isochromene Carboxylic Acid (3-Dimethylaminopropyl)amide with a Dual Role Pd(II) Catalyst. — A convenient and simple method for the synthesis of the potent antitumor agent BCH-2051 (IX) involving the easy formation of the 1,3-disub- stituted cyclic alkenyl ether (V) with a dual role Pd(II) catalyst as the key step is described. — (MONDAL, S.; NOGAMI, T.; ASAO, N.; YAMAMOTO*, Y.; J. Org. Chem. 68 (2003) 24, 9496-9498; Dep. Chem., Grad. Sch. Sci., Tohoku Univ., Aoba, Sendai 980, Japan; Eng.) — C. Hettrich 14- 150
-
Upload
somnath-mondal -
Category
Documents
-
view
212 -
download
0
Transcript of Synthesis of Novel Antitumor Agent 1-Methoxy-5,10-dioxo-5,10-dihydro-1H-benzo[g]isochromene...
2004 Benzopyran derivatives
Benzopyran derivativesR 0350 Synthesis of Novel Antitumor Agent 1-Methoxy-5,10-dioxo-5,10-dihydro-1H-ben-
zo[g]isochromene Carboxylic Acid (3-Dimethylaminopropyl)amide with a Dual Role Pd(II) Catalyst. — A convenient and simple method for the synthesis of thepotent antitumor agent BCH-2051 (IX) involving the easy formation of the 1,3-disub-stituted cyclic alkenyl ether (V) with a dual role Pd(II) catalyst as the key step is described. — (MONDAL, S.; NOGAMI, T.; ASAO, N.; YAMAMOTO*, Y.; J. Org. Chem. 68 (2003) 24, 9496-9498; Dep. Chem., Grad. Sch. Sci., Tohoku Univ., Aoba, Sendai 980, Japan; Eng.) — C. Hettrich
14- 150