Synthesis and Cytostatic Activities of New 6-Substituted Purinylcarbonucleosides Derived from Indan.
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2002 nucleic acids nucleic acids U 0700 40 - 221 Synthesis and Cytostatic Activities of New 6-Substituted Purinyl- carbonucleosides Derived from Indan. — A novel series of racemic 6-substituted purinylcarbonucleosides such as (VIII), (IX) and (XII) is syn- thesized from cis-1,3-indandimethanol as the key intermediate. The products are tested for their cytostatic activity. Moderate effects are observed for (VIII) and (IX), whereas a higher potency is found for (XII). — (FER- NANDEZ, FRANCO; GARCIA-MERA, XERARDO; MORALES, MALVIN; RODRIGUEZ-BORGES, JOSE E.; DE CLERCQ, ERIC; Synthesis (2002) 8, 1084-1090; Dep. Quim. Org., Fac. Farm., Univ. Santiago de Compostela, E-15782 Santiago de Compostela, Spain; EN) 1
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Transcript of Synthesis and Cytostatic Activities of New 6-Substituted Purinylcarbonucleosides Derived from Indan.
2002 nucleic acids
nucleic acidsU 0700
40 - 221Synthesis and Cytostatic Activities of New 6-Substituted Purinyl-carbonucleosides Derived from Indan. — A novel series of racemic6-substituted purinylcarbonucleosides such as (VIII), (IX) and (XII) is syn-thesized from cis-1,3-indandimethanol as the key intermediate. The productsare tested for their cytostatic activity. Moderate effects are observed for(VIII) and (IX), whereas a higher potency is found for (XII). — (FER-NANDEZ, FRANCO; GARCIA-MERA, XERARDO; MORALES, MALVIN;RODRIGUEZ-BORGES, JOSE E.; DE CLERCQ, ERIC; Synthesis (2002) 8,1084-1090; Dep. Quim. Org., Fac. Farm., Univ. Santiago de Compostela,E-15782 Santiago de Compostela, Spain; EN)
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