B I O a B S O R B a B L E R E D E F I N E D

SYNERGYTM

Everolimus-Eluting Platinum Chromium Coronary Stent System

INTRODUCING THE

SYNERGYTM Everolimus-Eluting Stent System featuring the innovative SynchronyTM Bioabsorbable Coating

The result:

Freedom from Long-Term Polymer Exposure, Optimal Healing and Easier, More Confident Deliverability.*

The SYNERGY Stent System redefines bioabsorbable

drug-eluting stent technology by delivering the safety and

efficacy of Everolimus with synchronized drug release

and polymer absorption over an optimal 3-month period.*

It does this on an ultra-thin Platinum Chromium platform

and high-performance stent delivery system.

*Boston Scientific Data on File

Freedom from Long-Term Polymer Exposure

Drug elution is complete at 3 months*

Polymer gone shortly after drug elution is complete*

anti-Inflammatory benefit of Everolimus remains in tissue during entire time of polymer absorption*

Other bioabsorbable polymers take 3 to 10 times longer to absorb, causing long gaps between full drug elution and full polymer absorption

1 PLGA = Polylactic Glycolic Acid2 Garg, S, J Am Coll Cardiol. 2010;56(10s1):S43-S78. doi:10.1016 3 World J Cardiol 2011 March 26; 3(3): 84-924 Presented by Stephen Windecker, MD, TCT2012* Boston Scientific Data on File

The SYNERGY stent‘s Synchrony™ Bioabsorbable Coating is made up of a hydrophilic

PLGA1 polymer and Everolimus drug which absorb and elute in a synchronized manner

– making it the only DES with 3-month drug release and polymer absorption.

POlymER IS GONE WhEN NO lONGER NEEDED

Time (months)

Mas

s Re

mai

ning

(%)

100 -

80 -

60 -

40 -

20 -

0 -0 3 6 9 12 18

- - - - - -

PLGAEverolimus

Time (months)

Mas

s Re

mai

ning

(%)

100 -

80 -

60 -

40 -

20 -

0 -0 3 6 9

- - - -

PLABA9

Time (months)

Mas

s Re

mai

ning

(%)

100 -

80 -

60 -

40 -

20 -

0 -0 3 6 9

- - - -

PLLASirolimus

Time (months)

Mas

s Re

mai

ning

(%)

100 -

80 -

60 -

40 -

20 -

0 -0 3 6 9

- - - -

PLLAEverolimus

BioMatrix Flex™2 + Nobori™3 Orsiro™4 Absorb™ BVS3 Polymer Coating: PLAAbsorption Time: > 9 months

Polymer Coating: PLLAAbsorption Time: > 12 months

Polymer Scaffold: PLLAPolymer Coating: PDLLAAbsorption Time: > 2 years

Bioabsorbable Polymer-Coated Stents Bioabsorbable Scaffold

B i o a B s o r B a B l e R E D E F I N E D

SYNERGY™ + Synchrony™

Optimal HealingFUNCTIONAl ENDOThElIAlIzATION AND PASSIvE vASCUlAR RESPONSE

Three design features function in synergy to allow for healthy endothelialization

and passive vascular response comparable to a Platinum Chromium (PtCr) OMEGATM

Bare Metal Stent (BMS) at 3 months.1

1 Presented by Gregory J. Wilson, MD. ACC 20112 Presented by Ian T. Meredith, MBBS, PhD, EuroPCR 20133 From SYNERGY DFU. Indications, contraindications, warnings, precautions and instructions for use can be found in the product labeling supplied with each device.* Boston Scientific Data on File

OMEGA™ Bare Metal

Stent

SYNERGY™ Stent

B i o a B s o r B a B l e R E D E F I N E D

23

1

30 days 90 days

1. Everolimus drug: similar drug dose and release kinetics as PROMUS Element™ Stent Safety and efficacy shown in the EvOlvE trial 2-year outcomes2:

•1.1 %TLR •0 %StentThrombosis •0.10mm6-monthIn-StentLateLoss

2. Ultra-thin Synchrony™ Bioabsorbable Coating Only on abluminal side, bare PtCr surface in the lumen 4 μm thin low polymer load

3. Thin-strut, 74μm PtCr platform highly flexible and conformable high resistance to fracture Exceptional radial strength for good strut apposition*

In preclinical studies Complete endothelialization by 30 days Similar vascular response to SyNERGy™

Stent and OmEGA BmS at 3 months*

3-month DaPT Labeling3

In selected patients, it may be reasonable to interrupt or discontinue P2y12 inhibitor therapy after 3 months.

Easier, More Confident DeliverabilityImPROvED PROCEDURAl PERFORmANCE

The SYNERGY™ Stent offers a new PtCr architecture with thinner struts to improve

endothelialization, deliverability, and conformability while maintaining the strength,

visibility, flexibility and fracture resistance of the current Element™ design.*

Rounder, thinner PtCr struts1

reduce crossing profiles while maintaining strength and radiopacity

additional connectors on the end-most proximal and distal segments increase strength while maintaining flexibility, conformability, and fracture resistance

New stent delivery system with laser-cut hypotube for improved pushability and trackability*

Most extensive size matrixAvailable in 48 monorail sizes

Hypotube with variable pitch Laser-cuts

Laser-cut section

End Tab

1 Synergy Stent strut thickness 2.25 - 3.50 mm: 74 μm, 4.00 mm: 81 μm* Boston Scientific Data on File

PROMUS Element™81 μm

SYNERGY™74 μm

All cited trademarks are the property of their respective owners. CAUTION: The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings and instructions for use can be found in the product labelling supplied with each device. Information for the use only in countries with applicable health authority product registrations.

Information contained herein is for distribution outside the U.S. only. Illustrations for information purposes – not indicative of actual size or clinical outcome.

IC-147814-AB May 2013 Printed in Germany by medicalvision.

www.bostonscientific-international.com

© 2013 Boston Scientific Corporationor its affiliates. All rights reserved.DINCAR2613EB

ømm

Stent Length (mm)

8 12 16 20 24 28 32 38

2.25 H7493919808220 H7493919812220 H7493919816220 H7493919820220 H7493919824220 H7493919828220 H7493919832220 H7493919838220

2.50 H7493919808250 H7493919812250 H7493919816250 H7493919820250 H7493919824250 H7493919828250 H7493919832250 H7493919838250

2.75 H7493919808270 H7493919812270 H7493919816270 H7493919820270 H7493919824270 H7493919828270 H7493919832270 H7493919838270

3.00 H7493919808300 H7493919812300 H7493919816300 H7493919820300 H7493919824300 H7493919828300 H7493919832300 H7493919838300

3.50 H7493919808350 H7493919812350 H7493919816350 H7493919820350 H7493919824350 H7493919828350 H7493919832350 H7493919838350

4.00 H7493919808400 H7493919812400 H7493919816400 H7493919820400 H7493919824400 H7493919828400 H7493919832400 H7493919838400

SYNERGYTM Everolimus–Eluting Coronary Stent System – Product Ordering Information

SYNERGY Stent Monorail® | Available in 48 sizes

SYNERGYTM Stent Delivery System

Dual-Layer PEBAX® Balloon Laser-Cut Hypotube

Platinum Iridium Markerbands PTFE Coated Hypotube

0.018 inch (0.46 mm) Tip Profile