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Syllabus for CSIR Examination June 2013

Jan 2: Composition, structure and function of carbohydrates

3: metabolism of carbohydrates

4: composition, structure and function of proteins (Ramachandran plot ,sec structures,domains,motifs)

5: metabolism of amino acids6: Nucleic acids

7: metabolism of nucleic acids

8: vitamins, enzymes, enzyme kinetics, mechanism of enzyme catalysis

9: stabilizing interactions (vanderwalls, electrostatic, hydrogen bonding , hydrophobic

interactions), glycolysis

10: TCA, Oxidative phosphorylation, Photophosphorylation, PPP(including inhibitors)

11: DNA replication

12: Chromosomes: deletion, insertion, transition, transversion, translocation( include types of

chromosomes )

13 :Mutagens (include disorders &ploidies)

14: DNA damage and repair mechanisms15: Recombination (homologous, site specific recombination),transposons

16: Transcription(include difft RNA pol, types of RNA)

17& 18: capping, elongation, termination, RNA processing, RNA editing, Splicing,

polyadenylation, RNA transport

19: Translation(include aminoacyl tRNA synthetase)

20: genetic code

21:transcriptional and translational inhibitors

22:post translational modification of proteins

23 : regulation of prokaryotic gene expression(Operon)

24: Virus and phages including lytic and lysogeny)

25 &26: regulation of eukaryotic gene expression

27: gene silencing (nucleosomes,heterochromatin ,euchromatin)

28:structure of membrane(lipid bilayer),lipids(glycerophospholipids,spingolipids etc)

29 &30: membrane transport(diffusion,osmosis,ion channels,pumps,carriers,active & passive

transporters)

31: all organelles

Feb 1:Cytoskeleton

2: cellular communication: ECM, collagen, integrin, gap and tight junctions etc (including

disorders)

3: cell division and cell cycle4 & 5: Cancer ( oncogenes.tumor suppressor genes, cancer and cell cycle, virus induced

cancer,apoptosis,therapeutic interventions of uncontrolled cell growth)

6: Innate & adaptive immunology,antigens,antibodies,Ag-Ab complex

7 &8: antibody diversity,monoclonal antibodies,antibody engineering

9 &10: MHC ,antigen processing and presentation,activation and differentiation of B & T cells,

BCR & TCR

11 & 12:Complement system,Toll like receptors,cytokines

13:Hypersensitivity,Autoimmune disorders,immune deficiencies

14: Photosynthesis ( C3,C4,CAM),ETC

15: Respiration and photorespiration ( include alternative oxidase,inhibitors of pathways)

16:Nitrogen metabolism, plant hormones

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17 & 18: sensory photobiology: phytochromes,cytochromes,stomatal

movements,photoperiodism and biological clocks

19: solute transport( through xylem & phloem)

20:sec metabolites( biosynthesis of terpnes,phenols and other nitrogenous compoundsMEP

pathway,mevalomic acid pathway,shikimic acid pathway)

21 & 22: Floral system(ABC model-genes involved etc-chapter 24 Taiz & Zieger)23: Stress physiology

24: Mendelian principles,concept of gene( pseudoallele,complementation test)

25: codominance,incomplete dominance,gene interactions,pliotropy,genomic

imprinting,penetrance & expressivity,phenocopy

26: linkage & crossing over,sex linkage,sex limited & sex influenced characters

27: linkage maps,tetrad analysis,mapping with molecular markers

28: microbial genetics(transformation,transduction,sexduction

March1: human genetics: pedigree analysis, genetic disorders, Quantitative genetics

( polygenic inheritance, heritability, QTL mapping)

2: Ecology: Environment, habitat, niche, resource partitioning, character displacement,population growth curves, r &K selection, demes and dispersal

3: species interactions: competition, herbivory, carnivory, symbiosis, community ecology

4: ecological succession, energy flow(GNP,NNP)

5: Evolution: Oparin & Haldane concept, evolution of prok & euk, evolutionary time scale,

eras, periods & epoch, Neutral evolution

6:population genetics-Hardy Weinberg law, migration & random genetic drift,adaptive

radiation, allopatric & sympatric, convergent evolution, sexual selection, co-evolution,

Altruism, Kin selection, reciprocal altruism

7: Blood and circulation, Cardiovascular system(heart structure, ECG, Cardiac cycle)

8: Respiratory system, Digestive system

9: Nervous system

10: endocrinology (basic mechanisms of hormone action, hormones and diseases)

11: Bioremediation and phytoremediation, Biosensors

12: Vaccines, gene therapy

13: rDNA tech: analysis of RNA, DNA and proteins, gel electrophoresis, isoelectric

focusing gels

14: molecular cloning of RNA & DNA in bacterial & euk systems, DNA fragments in plasmid,

phage, cosmid, BAC,YAC vectors

15: protein sequencing, DNA sequencing, in vitro mutagenesis and deletion techniques,

detection of post translational modification of proteins

16: analysis of gene expression at RNA & protein level, microarray based tech, RFLP, RAPD&AFLP tech

17: ELISA, RIA, Western blot, Fluocytometry, microscopy (from Prescott),FISH, GISH

18: Difft spectroscopy, Circular dichroism, NMR,ESR, mass speck, X 2 test

19: Taxonomy (+2 NCERT, Campbell biology)

20: biogeography

21-31: +2 NCERT, Campbell biology

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