Course SyllabusBIOS E-162a

HUMAN PATHOPHYSIOLOGY IMONDAY 5:30-7:30 FALL 2015

HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH677 Huntington Ave., Boston 02115 Kresge 502

~ July 16, 2015 DRAFT~

Course Directors:

Nancy Long Sieber, Ph.D.Adjunct Lecturer, MIPS ProgramDepartment of Environmental Health, Harvard School of Public HealthOffice: HSPH 1 - Room 1308BTel: (617) 432-3484 (office) (781) 391-1118 (home; please don’t call after 9 pm) Fax: (617) 432-3468Email: nlong@hsph.harvard.edu

Stephanie Shore, Ph.D.Senior Lecturer, MIPS Program Department of Environmental Health, Harvard School of Public HealthOffice: Building 1, Room 309Tel: (617) 432-0199 (Office) (617) 432-3470 (Laboratory):  Fax:  (617) 432-4710Email: sshore@hsph.harvard.edu

Teaching Assistants: TBD

Course Description: This course focuses on the pathophysiology of the human cardiovascular, respiratory, and renal systems, and on how these systems are altered by various physiologic challenges. The concept of homeostasis is integrated with general disease processes such as injury, inflammation, fibrosis, and neoplasia to demonstrate ways in which perturbations in physiological regulatory mechanisms and anatomy result in pathophysiology. We particularly focus on the effects of stress and obesity on these systems, and on differences between men and women in the manifestation of diseases of these systems. Please note that Human Pathophysiology II is offered in alternate years. Prerequisites: BIOS E-65c and E-65d, or the equivalent. (4 credits)

Course Website: https://canvas.harvard.edu/courses/4061

Course Texts: Electronic versions of the required texts are available for free through Countway Digital Library. Hard copies are available at the Harvard COOP

Pathophysiology of Heart Disease 5 rd Edition . by Leonard Lilly. Lippincott, Williams and Wilkins, Baltimore, 2010. Note: 3rd or 4th editions would be fine

Renal Pathophysiology   The Essentials, 4th Edition by Helmut G Rennke MD; Bradley M Denker MD. Lippincott, Williams and Wilkins. Baltimore, 2013. Note: The 3rd edition would be fine.

Pulmonary Pathophysiology. The Essentials 8th Edition by John B. West. Lippincott, Williams andWilkins. Philadelphia, 2012. Note: An earlier edition would be fine.

It is also recommended that students have a basic physiology text. Copies of Vander, Sherman, and Luciano’s, Human Physiology: The mechanisms of body function, 13th edition, by Widmaier, Raff and Strang, 2013 McGraw Hill, are available at the COOP in Cambridge. An earlier edition of this text, or another similar text would also be fine. I’ll gladly help you find the relevant readings in whichever book you choose.

Grading:Undergraduate Students: Problem Sets (4 @ 5% each) 20%

Midterm Exam 40%Final Exam 40%

Graduate Students: Problem Sets (4 @ 5% each) 20%Term Paper 10%Midterm Exam 35%Final Exam 35%

The problem sets and exams will be different for graduate and undergraduate students. Make sure you do the right ones. Also, the graduate students' exams will contain questions from the material in the assigned readings as well as the material covered in class. Unless specified, I will not test directly on material from the Vander textbook, since it is used to support the lecture material, not as a source of new information.

Problem sets Problem sets will be posted on the website in a folder named, “Assignments and Exams”. The graders prefer to work with paper copies of the assignments, so please submit a hard copy of your paper in class. However, if you are away or are unable to print, there will be a dropbox on the website for each assignment. Even if you hand in a paper copy, you are welcome (but not required) to submit an electronic copy, to give you a record that it has been received. Problem sets must be submitted by 7:30 PM on the day that they are due.

Grading of problem sets: The purpose of the problem sets is for you to grapple with new concepts and to stretch your understanding of the material presented in class. Therefore, we are more concerned about your putting thought and effort into your work than whether your answers are completely correct. To this end, we will give only 4 grades for problem sets: 100, 90, 80, 70 or 0. Most students who understand the material and who have put a good effort into the problem set will get a 90. Exceptional papers will get a 100. If you do not understand the concepts, or have not put sufficient time or effort into your work, you will get an 80, or maybe a 70. If you don’t turn it in at all, or if you really don’t get it, you will get a 0. Please don’t grumble if you get a 70 or 80 – it is just a reminder to do better next time. And especially don’t grumble if you get a 90 – we grade on a curve, so don’t sweat it. You may discuss the questions with your classmates or others, but you need to compose your own answers independently. If you do work with others, please include their names on your problem set. You must cite any references that you use (other than the lecture notes and the assigned course texts), and, whenever possible, draw your own diagrams. Failure to submit your own original answers and to cite your sources will result in academic discipline.

Policy with respect to late problem sets: Problem sets will be accepted up to four days (i.e. by Friday at 7:30 PM) after the due date, with a penalty of 1% of the final grade (i.e. 20% of the value of that assignment). Problem sets will not be accepted if submitted more than four days after they are due. Late problem sets should be emailed to Nancy.

Note: Many students in this course travel on business during the semester. Travel and the various electronic glitches that can occur when away from home are not acceptable excuses for late submission of problem sets. If you are concerned about being able to submit your assignment, send it before you leave town. If you do submit your problem set electronically or by fax, it must arrive before 7:30 PM on the day that it is due.

Exams The midterm will be given on October 26 and the final will be given on December 21. Make sure you arrive promptly on these days! The final exam will focus on material given after the midterm, but will integrate concepts from the entire semester. You will have 2 hours for each of these exams.

Make-up exam policy: Students unable to take the scheduled midterm due to illness or unavoidable business travel must contact Nancy Long Sieber PRIOR to the exam to arrange for a make-up. Students who need a make-up on the final exam must contact Academic Services at the Extension School (617 495-0977). The faculty cannot schedule a make-up for the final, and the Extension School is very strict about approving makeups.

** Fairness in grading : Many students who take this class are applying to highly competitive professional and graduate school programs. Therefore, I place a high priority on grading fairly and consistently. As a result, I am unable to make exceptions for students who fail to take exams on time, or who pass in their assignments late. Any questions concerning grading should be brought to Nancy Sieber.

Date Lecturer TopicMay be changed slightly

Reading Assignments Will be updated

Problem sets and ExamsWill not change

Aug. 31 Sieber Introduction, Course RequirementsChronic Disease and the Challenge of Maintaining Homeostasis

Background reading: Vander Ch. 1

Sept. 7 Labor Day HOLIDAY Go to the beach!Sept. 14 Sieber Inflammatory Processes Underlying

Chronic Disease Introduction of Course Themes.

Background reading: Lightly review Vander Ch. 18

First problem set posted

Sept. 21 Sieber Cardiovascular Pathophysiology IDesign and Function of the Cardiovascular System, Maintenance of Blood Pressure,

Lilly Ch. 1 & Ch 2 Background reading:Vander Ch 12 Sections A-D Also read:Coronary heart disease in women: a challenge for the 21st century http://dx.doi.org/10.1590/S1807-59322010000100015 

Sept. 28 Sieber Cardiovascular Pathophysiology II Hypertension and Atherosclerosis

Lilly Chapters 13 and 5Background reading: Vander: Chapter 12 ,Section E

First problem set due, second PS posted

Oct 5 Sieber Cardiovascular Pathophysiology IIIMyocardial Infarction, Heart Failure, and Sudden Cardiac Death

Lilly Chapters 7 and 9

Oct. 12 Columbus Day HOLIDAYOct 19 Sieber Nutrition, Exercise and

Cardiovascular Risk Second problem set due

Oct. 26 EXAM MIDTERM EXAMBe sure to arrive on time!!!

MIDTERM EXAM

Nov. 2 Shore Respiratory Pathophysiology ICauses of Hypoxemia and Hypercarbia

TBA Third problem set posted

Nov. 9 Shore Respiration Pathophysiology IIObstructive Diseases: Chronic Obstructive Lung Disease and Asthma

TBA

Nov. 16 Shore Respiratory Pathophysiology IIIRestrictive Diseases: Pulmonary Edema, Vascular Diseases: Pulmonary Embolism, Respiratory Failure

TBA Third Problem set due / Fourthproblem setposted

Nov. 23 Sieber Renal Pathophysiology IPathophysiology of Water and Sodium Regulation

Rennke Chapters 1 and 2 Background Reading: Review Vander Chapter 14

Nov. 30 Sieber Renal Pathophysiology IIRegulation of plasma osmolarity, volume, sodium and potassium

Rennke Chapters 3, 4 and 7

Term papers due (grad students only)

Dec. 7 Sieber Renal Pathophysiology IIIRenal Disease

RennkeChapters 8, 9, and 12

Fourth Problem Set Due

Dec. 14 Sieber Ageing and Death TBADec. 21 EXAM FINAL EXAM

Be sure to arrive on time!!!FINAL EXAM