Surgical Nutrition M. Sayal, MD FRCSC September 17, 2008.
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Transcript of Surgical Nutrition M. Sayal, MD FRCSC September 17, 2008.
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Surgical NutritionSurgical Nutrition
M. Sayal, MD FRCSCM. Sayal, MD FRCSC
September 17, 2008September 17, 2008
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ObjectivesObjectives
1.1. Review the current concepts of Review the current concepts of nutritional assessmentnutritional assessment
2.2. Review perioperative nutritional issuesReview perioperative nutritional issues
3.3. Review routes and methods of Review routes and methods of perioperative nutritional perioperative nutritional supplementationsupplementation
4.4. Review basic aspects of nutritional Review basic aspects of nutritional support in the critically illsupport in the critically ill
5.5. The TPN sheetThe TPN sheet
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CasesCases
1. 55yo male with Crohn’s disease—1. 55yo male with Crohn’s disease—failure on Remicade and needs an failure on Remicade and needs an ileocolic resectionileocolic resection
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CasesCases
2. 55yo male, otherwise healthy has a 2. 55yo male, otherwise healthy has a right hip fracture, needing a repairright hip fracture, needing a repair
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CasesCases
3. 55yo male, otherwise healthy, just 3. 55yo male, otherwise healthy, just diagnosed with sigmoid cancer on diagnosed with sigmoid cancer on routine screening. For sigmoid routine screening. For sigmoid resectionresection
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CasesCases
4. 55yo male, healthy, involved in an 4. 55yo male, healthy, involved in an industrial accident. Has 40% BSA industrial accident. Has 40% BSA burns and is vented in the ICU in burns and is vented in the ICU in shockshock
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This is not so much a talk on nutrition This is not so much a talk on nutrition as it is on malnutritionas it is on malnutrition
We are trying to minimize or prevent We are trying to minimize or prevent malnutrition (and its complications) malnutrition (and its complications) in our patientsin our patients
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The BasicsThe Basics
The principal components of a normal diet The principal components of a normal diet are energy (carbohydrate and lipid), are energy (carbohydrate and lipid), nitrogen, trace elements, minerals and nitrogen, trace elements, minerals and vitaminsvitamins
A healthy adult requires 20-25kcal per kilo A healthy adult requires 20-25kcal per kilo per day (20-30% from fat), 1gm/kg of per day (20-30% from fat), 1gm/kg of protein per dayprotein per day
Metabolic stress associated with sepsis, Metabolic stress associated with sepsis, trauma, surgery, ventilation, increases trauma, surgery, ventilation, increases energy requirements to 35-40kcal/kg/denergy requirements to 35-40kcal/kg/d
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The BasicsThe Basics
The notion that malnutrition affects The notion that malnutrition affects surgical outcomes was first reported surgical outcomes was first reported in 1936 in a study that showed that in 1936 in a study that showed that malnourished patients undergoing malnourished patients undergoing ulcer surgery had a 33% mortality ulcer surgery had a 33% mortality rate compared to 3.5% in well rate compared to 3.5% in well nourished individuals (Studley, HO, nourished individuals (Studley, HO, JAMA 1936; 106:458)JAMA 1936; 106:458)
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The BasicsThe Basics
The stress of surgery or trauma increases The stress of surgery or trauma increases protein and energy requirements by protein and energy requirements by creating a hypermetabolic and catabolic creating a hypermetabolic and catabolic statestate
A redistribution of macronutrients (fat, A redistribution of macronutrients (fat, protein, glycogen) from the labile reserves protein, glycogen) from the labile reserves of adipose tissue and skeletal muscle to of adipose tissue and skeletal muscle to more metabolically active tissues such as more metabolically active tissues such as liver, bone, and visceral organs occurs and liver, bone, and visceral organs occurs and this leads to protein-calorie malnutritionthis leads to protein-calorie malnutrition
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The BasicsThe Basics
This leads to impaired complement This leads to impaired complement activation and production, bacterial activation and production, bacterial opsonization, impaired function of opsonization, impaired function of neutrophils, macrophages and neutrophils, macrophages and lymphocyteslymphocytes
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The BasicsThe Basics
These factors result in:These factors result in: Increased susceptibility to infectionIncreased susceptibility to infection Poor wound healing (including Poor wound healing (including
anastomotic breakdown/leakage, poor anastomotic breakdown/leakage, poor graft adherence etc)graft adherence etc)
Increased frequency of decubitus ulcersIncreased frequency of decubitus ulcers Bacterial overgrowth in the bowelBacterial overgrowth in the bowel Abnormal nutrient losses in the stoolAbnormal nutrient losses in the stool
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The BasicsThe Basics
Therefore, in our surgical patients, Therefore, in our surgical patients, malnutrition results in:malnutrition results in: Disturbed cellular and organ function Disturbed cellular and organ function
resulting in impaired cardiac and respiratory resulting in impaired cardiac and respiratory muscle function, atrophy of smooth muscle muscle function, atrophy of smooth muscle in the GI tract, impaired immune function in the GI tract, impaired immune function
This leads to loss of fat, muscle, skin and This leads to loss of fat, muscle, skin and ultimately bone and viscera with consequent ultimately bone and viscera with consequent weight loss and increases in ECFweight loss and increases in ECF
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The BasicsThe Basics
Nutritional requirements decrease as Nutritional requirements decrease as an individual’s BMI decreases, an individual’s BMI decreases, probably reflecting more efficient probably reflecting more efficient utilization of ingested food and a utilization of ingested food and a reduction in the work capacity at the reduction in the work capacity at the cellular level….cellular level….
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The BasicsThe Basics
However, this combination of However, this combination of decreased tissue mass and reduction decreased tissue mass and reduction in work capacity impedes in work capacity impedes homeostatic responses to stressors homeostatic responses to stressors such as critical illness or surgerysuch as critical illness or surgery
This dysregulatory mechanism This dysregulatory mechanism worsens as the malnourishment worsens as the malnourishment worsensworsens
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Case 1Case 1
55yo male with Crohn’s disease has 55yo male with Crohn’s disease has failed Remicade and needs an failed Remicade and needs an ileocolic resection.ileocolic resection. What are the surgical nutritional issues?What are the surgical nutritional issues?
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Case 1Case 1
Pre-op Nutritional AssessmentPre-op Nutritional Assessment Pre-op nutritional assessment is a key element Pre-op nutritional assessment is a key element
of the surgical history in non-emergent surgery; of the surgical history in non-emergent surgery; however, there is no one single, simple and however, there is no one single, simple and reliable technique for assessing nutritional reliable technique for assessing nutritional statusstatus
On history, ask about chronic medical or On history, ask about chronic medical or comorbid conditions (DM, IBD, CV disease, EtOH comorbid conditions (DM, IBD, CV disease, EtOH abuse etc), recent hospitalizations or current abuse etc), recent hospitalizations or current hospitalization, past surgery (esp GI surgery) hospitalization, past surgery (esp GI surgery) that may contribute to malnourishmentthat may contribute to malnourishment
Vitamin or mineral useVitamin or mineral use Wt loss or gain, N+V+D, diet historyWt loss or gain, N+V+D, diet history
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Case 1Case 1
Physical ExamPhysical Exam Head and Neck: hair loss, bitemporal wasting, Head and Neck: hair loss, bitemporal wasting,
conjunctival pallor, xerosis, glossitis, conjunctival pallor, xerosis, glossitis, bleeding/sore gums, angular cheliosis, bleeding/sore gums, angular cheliosis, stomatitis, poor dentition, thyromegalystomatitis, poor dentition, thyromegaly
Extremities: edema, muscle wasting, loss of sq Extremities: edema, muscle wasting, loss of sq fatfat
Neurologic: evidence of peripheral neuropathy, Neurologic: evidence of peripheral neuropathy, reflexes, tetany, decreased mental statusreflexes, tetany, decreased mental status
Skin: ecchymosis, petechie, pallor, pressure Skin: ecchymosis, petechie, pallor, pressure ulcers, wound problems/infectionulcers, wound problems/infection
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Case 1Case 1
Anthropometric measurementsAnthropometric measurements BMI: body mass index BMI: body mass index
(weight(kg)/height(m) squared)(weight(kg)/height(m) squared) BMI<18.5 implies nutritional impairment BMI<18.5 implies nutritional impairment
and a BMI<15 is associated with and a BMI<15 is associated with significant mortalitysignificant mortality
Unplanned weight loss of >10% over a Unplanned weight loss of >10% over a six month period is a good prognostic six month period is a good prognostic indicator of a poor clinical outcomeindicator of a poor clinical outcome
Others: triceps skinfold thickness and Others: triceps skinfold thickness and mid-arm muscle circumferencemid-arm muscle circumference
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Case 1Case 1
Labs:Labs: Protein status—affected by previous Protein status—affected by previous
intake, muscle mass, duration of current intake, muscle mass, duration of current illness, blood loss, wound healing, illness, blood loss, wound healing, infection, GI absorptioninfection, GI absorption
Serum albumin—half life 18-20d; low levels are Serum albumin—half life 18-20d; low levels are markers of a negative catabolic state and a markers of a negative catabolic state and a predictor of poor outcome; levels are predictor of poor outcome; levels are depressed in surgery, hepatic and renal depressed in surgery, hepatic and renal disease, critically illdisease, critically ill
Mild (28-35), moderate (21-27), severe (<21)Mild (28-35), moderate (21-27), severe (<21)
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Case 1Case 1
Labs:Labs: Serum transferrin: half-life 8-9d; reflects protein Serum transferrin: half-life 8-9d; reflects protein
status over last 2-4wks; also reflects iron status status over last 2-4wks; also reflects iron status (therefore low value reflects decreased protein status (therefore low value reflects decreased protein status only in the setting of normal iron)only in the setting of normal iron)
Normal 200-400mg/dL; mild (150-200), moderate Normal 200-400mg/dL; mild (150-200), moderate (100-150), severe (<100)(100-150), severe (<100)
Serum prealbumin (transthyretin): short half-life; Serum prealbumin (transthyretin): short half-life; influenced by renal/hepatic diseaseinfluenced by renal/hepatic disease
Normal 17-42mg/dL; moderate (11-17), severe (<10)Normal 17-42mg/dL; moderate (11-17), severe (<10) Other tests: retinol-binding protein, BUN/creatinine, Other tests: retinol-binding protein, BUN/creatinine,
Fe/vitamin levels (if indicated), Ca, Mg, PO4, Mg, TSHFe/vitamin levels (if indicated), Ca, Mg, PO4, Mg, TSH
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MalnourismentMalnourisment
Weight loss (%):Weight loss (%): Mild (80-90), moderate (70-80), severe Mild (80-90), moderate (70-80), severe
(<70)(<70) Recent weight change:Recent weight change:
>5% over 1 month or >10% over 6 >5% over 1 month or >10% over 6 months signifies mod-severe months signifies mod-severe malnutritionmalnutrition
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Case 1Case 1
What does he need and how?What does he need and how? Would you do anything pre-op and Would you do anything pre-op and
why?why?
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Case 1Case 1
If he’s malnourished there is some If he’s malnourished there is some evidence to support pre-op evidence to support pre-op nutritional supplementation nutritional supplementation decreases post-op complicationsdecreases post-op complications
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Case 1Case 1
Once you’ve decided to supplement Once you’ve decided to supplement the patient, estimate the patient’s the patient, estimate the patient’s energy requirement using the REE energy requirement using the REE (calculated by the Harris-Benedict (calculated by the Harris-Benedict equation). Similarly, calculate equation). Similarly, calculate protein and fluid requirements, and protein and fluid requirements, and add trace elements, minerals and add trace elements, minerals and vitaminsvitamins
2 routes of delivery: enteral and 2 routes of delivery: enteral and parenteral parenteral
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Case 1Case 1
You can also just use oral You can also just use oral supplements (Boost, ensure etc)supplements (Boost, ensure etc)
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Case 2Case 2
55 yo healthy male has fractured hip 55 yo healthy male has fractured hip and needs surgeryand needs surgery
When can you safely feed him?When can you safely feed him?
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Case 2Case 2
Even though the stress of the Even though the stress of the surgery results in a net catabolic surgery results in a net catabolic state, the body is able to adapt for 5-state, the body is able to adapt for 5-7d7d
Supplemental feeding can wait that Supplemental feeding can wait that long if the patient is not long if the patient is not malnourished previouslymalnourished previously
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Routes of FeedingRoutes of Feeding
Enteral vs ParenteralEnteral vs Parenteral If you can use the gut, use itIf you can use the gut, use it Entereal is much more cost effective Entereal is much more cost effective
with fewer complications than with fewer complications than parenteral—it is also thought to parenteral—it is also thought to preserve gut barrier functionpreserve gut barrier function
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Enteral FeedingEnteral Feeding
NasogastricNasogastric Short term, requires fully functional GI tract, Short term, requires fully functional GI tract,
can be inserted orallycan be inserted orally Insertion method: blindly at bedside; by Insertion method: blindly at bedside; by
radiology or endoscopicallyradiology or endoscopically Benefits: easily inserted and replaced; can use Benefits: easily inserted and replaced; can use
bolus feedsbolus feeds Complications: sinusitis, aspiration, airway Complications: sinusitis, aspiration, airway
obstruction (postcricoid ulceration), nasal obstruction (postcricoid ulceration), nasal neucrosis, pneumothorax, displacement, neucrosis, pneumothorax, displacement, occlusionocclusion
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Enteral FeedingEnteral Feeding NasoentericNasoenteric
Short term; used in patients with aspiration risk Short term; used in patients with aspiration risk or poor gastric emptying; requires continuous or poor gastric emptying; requires continuous infusioninfusion
Insertion methods: blindly at bedside, in OR, Insertion methods: blindly at bedside, in OR, endoscopically, radiologicallyendoscopically, radiologically
Benefits: reduces aspiration risk; some tubes Benefits: reduces aspiration risk; some tubes allow suction of stomach while simultaneously allow suction of stomach while simultaneously feeding small bowelfeeding small bowel
Complications: sinusitis, aspiration, airway Complications: sinusitis, aspiration, airway obstruction (postcricoid ulceration), nasal obstruction (postcricoid ulceration), nasal neucrosis, pneumothorax, displacement (esp neucrosis, pneumothorax, displacement (esp into stomach), occlusion, pneumotosis, intestinal into stomach), occlusion, pneumotosis, intestinal ischemia/infarction, blockage, unable to check ischemia/infarction, blockage, unable to check residualsresiduals
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Enteral FeedingEnteral Feeding GastrostomyGastrostomy
Long term tube; requires well emptying Long term tube; requires well emptying stomach; not a good choice for patients with stomach; not a good choice for patients with significant reflux and aspirationsignificant reflux and aspiration
Insertion methods: surgically, endoscopically, Insertion methods: surgically, endoscopically, radiologicallyradiologically
Benefits: allows bolus feeding, can be placed at Benefits: allows bolus feeding, can be placed at bedside, low profile tubes may decrease bedside, low profile tubes may decrease dislodgementdislodgement
Complications: bleeding, retching, abdominal Complications: bleeding, retching, abdominal wall infection, perforation of other abdominal wall infection, perforation of other abdominal organs, migration of parts of the tube, organs, migration of parts of the tube, aspiration, dislodgement, occlusion, bowel aspiration, dislodgement, occlusion, bowel obstruction, pneoumoperitoneum, obstruction, pneoumoperitoneum, dislodgment/malpositiondislodgment/malposition
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Enteral FeedingEnteral Feeding
Transgastric jejunostomyTransgastric jejunostomy Long term; requires continuous infusion; use in Long term; requires continuous infusion; use in
patients with aspiration risk or poor gastric patients with aspiration risk or poor gastric emptyingemptying
Insertion: surgically, radiologically, Insertion: surgically, radiologically, endoscopicallyendoscopically
Benefits: reduces aspiration risk, allows Benefits: reduces aspiration risk, allows suction of stomach while feeding small bowel; suction of stomach while feeding small bowel; may be used immediately after placement; may be used immediately after placement; may be converted to g-tubemay be converted to g-tube
Complications: same as gastrostomyComplications: same as gastrostomy
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Enteral FeedingEnteral Feeding
JejunostomyJejunostomy Short or long term; requires continuous Short or long term; requires continuous
infusion;use in patients with aspiration infusion;use in patients with aspiration risk or poor gastric emptying; difficult to risk or poor gastric emptying; difficult to replacereplace
Insertion: surgically, endoscopically, Insertion: surgically, endoscopically, radiologicallyradiologically
Benefits: reduces aspiration risk, may be Benefits: reduces aspiration risk, may be used immediately after insertionused immediately after insertion
Complications: same as g-tube but also Complications: same as g-tube but also higher obstruction riskhigher obstruction risk
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Case 3Case 3
55yo male for elective sigmoid 55yo male for elective sigmoid resectionresection
When do you feed post-op and how?When do you feed post-op and how?
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Case 3Case 3
NPO until co-ordinated bowel NPO until co-ordinated bowel function?function?
Cochrane reivew 2008Cochrane reivew 2008
Others: ambulation, gum chewing, Others: ambulation, gum chewing, fluids to DAT progressionfluids to DAT progression
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Case 4Case 4
55yo male, severe burns (>40% BSA)55yo male, severe burns (>40% BSA)—admitted to ICU; intubated and —admitted to ICU; intubated and ventilatedventilated
What is the best way to provide What is the best way to provide nutritional support?nutritional support?
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Case 4Case 4
Canadian Clinical Guidelines for Canadian Clinical Guidelines for Nutritional Support in Mechanically Nutritional Support in Mechanically Ventilated, Critically Ill Adult PatientsVentilated, Critically Ill Adult Patients Heyland, DK et alHeyland, DK et al Journal of Parenteral and Enteral Journal of Parenteral and Enteral
Nutrition, 2003Nutrition, 2003
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Strongly recommend enteral over Strongly recommend enteral over parenteral nutritionparenteral nutrition
Start nutrition early (within 24-48h) of Start nutrition early (within 24-48h) of admission to ICU (enteral)admission to ICU (enteral)
There is no benefit for arginine as a There is no benefit for arginine as a supplement in diets in the critically ill supplement in diets in the critically ill yetyet
Fish oils, borage oils, and antioxidants Fish oils, borage oils, and antioxidants may be of benefit in ARDSmay be of benefit in ARDS
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Glutamine supplementation should be Glutamine supplementation should be used in trauma, bone marrow used in trauma, bone marrow transplant and burn patients transplant and burn patients
Consider prokinetics early with Consider prokinetics early with initiation of enteral feedsinitiation of enteral feeds
Small bowel feeding may be Small bowel feeding may be associated with a reduction in associated with a reduction in pneumonia in the critically ill being pneumonia in the critically ill being enterally fedenterally fed
Keep HOB at 45 degreesKeep HOB at 45 degrees
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In patients requiring short term TPN In patients requiring short term TPN or supplemental TPN, consider or supplemental TPN, consider withholding lipidswithholding lipids
Keep blood sugar levels tightly Keep blood sugar levels tightly controlledcontrolled
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Parenteral NutritionParenteral Nutrition
Should be considered when enteral is Should be considered when enteral is not an option or is providing not an option or is providing incomplete nutritional support (eg. incomplete nutritional support (eg. Mechanical obstruction, acute GI Mechanical obstruction, acute GI bleeding, ileus, high output fistulas, bleeding, ileus, high output fistulas, severe intractable diarrhea, short severe intractable diarrhea, short bowel syndrome, severe bowel syndrome, severe hemodynamic instabilityhemodynamic instability
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Parenteral NutritionParenteral Nutrition
Routes: Peripheral vs CentralRoutes: Peripheral vs Central Consider withholding if BS Consider withholding if BS
excessively high, BUN >100, excessively high, BUN >100, significant hemodynamic instabilitysignificant hemodynamic instability
Consists of glucose, fat, proteins, Consists of glucose, fat, proteins, vitamins and trace vitamins and trace minerals/elementsminerals/elements
2 in 1 or 3 in 1 solutions2 in 1 or 3 in 1 solutions
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Parenteral NutritionParenteral Nutrition
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Parenteral NutritionParenteral Nutrition
How to OrderHow to Order First calculate the total caloric need of First calculate the total caloric need of
the patient (25-35kcal/kg/day)the patient (25-35kcal/kg/day) Then determine protein needs Then determine protein needs
(1-2gm/kg/day)—each gm of protein has (1-2gm/kg/day)—each gm of protein has 4.3kcal4.3kcal
Generally 30% of calories should be via Generally 30% of calories should be via lipid (fat) and the rest by glucose lipid (fat) and the rest by glucose (carbohydrates)(carbohydrates)
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Parenteral NutritionParenteral Nutrition
Remember:Remember:1.1. 1mL 20% lipid gives 2 kcal1mL 20% lipid gives 2 kcal
2.2. 1g dextrose gives 3.4 kcal1g dextrose gives 3.4 kcal
3.3. 1g protein gives 4.3 kcal1g protein gives 4.3 kcal
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Parenteral NutritionParenteral Nutrition
To each bag is added necessary To each bag is added necessary vitamins, minerals, trace elements vitamins, minerals, trace elements etcetc
Bloodwork is done regularily looking Bloodwork is done regularily looking at extended lytes, transaminases, at extended lytes, transaminases, cholesterol profile, coagulation cholesterol profile, coagulation parameters, CBCparameters, CBC
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Parenteral NutritionParenteral Nutrition
Complications:Complications: Line related (mechanical or septic), Line related (mechanical or septic),
hyperglycemia (or hypoglycemia), hyperglycemia (or hypoglycemia), cholestasis, hepatic steatosis, biliary cholestasis, hepatic steatosis, biliary sludge, aluminum toxicity, possible sludge, aluminum toxicity, possible increased rates of bacterial translocation, increased rates of bacterial translocation, elevation of BUN (hyperosmolar elevation of BUN (hyperosmolar dehydration), hyperlipidemia, refeeding dehydration), hyperlipidemia, refeeding syndrome, electrolyte abnormalities, syndrome, electrolyte abnormalities, metabolic acidosis, EFA deficiency, CO2 metabolic acidosis, EFA deficiency, CO2 retention, hyperammonemiaretention, hyperammonemia
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Questions???Questions???