SURGICAL MANAGEMENT OF LIVER HYDATIDOSIS
Transcript of SURGICAL MANAGEMENT OF LIVER HYDATIDOSIS
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SURGICAL MANAGEMENT OF LIVER
HYDATIDOSIS
Miroslav Milicevic, MD, Ph D., FACS
The First Surgical Clinic, University of Belgrade Clinical Center,
Pavia, September, 2011.
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the disease
Echinococcosis is a zoonosis caused by the larval stage of tenia Echinococcus (class Cestoda) where humans are the accidental intermediate host and animals are both intermediate and definitive hosts
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surgeons and hydatid disease today
Ozdemir Aktan, MD
Marmara University Hospital
Dept. of Surgery
Eur J Surg 165, 2003
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The essential problem – evolution of the disease
A viable liver hydatid cyst is a space-occupying lesion with a tendency to grow, and as a consequence of cyst enlargement, it can rupture – surgery frequently unavoidable.
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Most surgeons even in developed countries will encounter
the disease at some point of their career either in it’s
simple or it’s complicated form
Endemic areas of the disease exist.
the problem for surgeons still exists !
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HC - IHBD communications is a serious complication
of liver hydatidosis, sometimes difficult to manage.
The disease, benign in nature, can cause devastating
damage to the liver and death to the patient.
the problem for the patient - complications
IHBD
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who informal working group on echinococcosis treatment modalities:
SURGERY
PAIR
CHEMOTHERAPY
“WAIT AND OBSERVE
APPROACH “
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indications for surgery in CE
large cysts with multiple daughter cysts
single liver cysts situated superficially that may rupture
infected cysts
cysts communicating with biliary tree
cysts exerting pressure on adjacent organs vital organs
cysts in the lung, brain, bones, kidneys and other organs
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contraindications for surgery in CE
contraindications for surgery in general patients refusing surgery extreme age pregnant women concomitant severe diseases
multiple cysts
cysts difficult to access
dead cysts
cysts partially or totally calcified
very small cysts
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What to expect from chemotherapy in CE
10 – 30% show cyst disappearance (cure)
50 – 70% degeneration or significant size decrease 20 – 30% no morphological changes
relapses sensitive to retreatment in up to 90%
rate of relapse after chemotherapy is high (14 - 25%)
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management algorithms based on natural history of E. granulosus
potential
pathology
management
complete diagnostics
wait and observe
c h e m o t h e r a p y
surgery
PAIR
chemotherapy complete diagnostics
surgery
PAIR
chemotherapy wait and observe
status of parasite
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• No controlled trials comparing radical and conservative surgery ! • Most data anecdotal, not evidence based. • Most operations done in underdeveloped countries, no standardization, no
quality control, missing data and inadequate follow up. • Reporting and terminology not standardized. • Different procedures on single patient with multiple cysts - concept of
“dominant cyst procedure”. • Different protoscolicidal agents. • Frequently unnecessary improvisation and innovation – confusion. • Frequently conflicting opinions! • Majority of publications are not done by surgeons with the largest
experience.
The evaluation of conservative surgery ?
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The rationale for conservative surgery ?
• Majority of operations done by general surgeons in underprivileged areas.
• Conservative surgery is tissue sparing and that is better for a benign disease. H/A complex frequent.
• Recurrence and reinfestation is possible – reoperation feasible. • Other liver disease is possible – frequently young patients. • The majority of cysts, regardless of site and size, can be managed this
way. • Safe surgery - acceptable perioperative mortality and morbidity. • Acceptable recurrence and complication rate. • Extensive worldwide experience.
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Patients 219 /797 HC - BD comm.
Mean age 42,15 yr.
Experience derived from our series – 1016 operated patients
21.5%
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I II III IV V VI VII VIII
6,75%
30,92%
7,23%
27,01%
17,42%
7,23%
4,03%
0,12%
0%
5%
10%
15%
20%
25%
30%
35%
invo
lved
%
Segment involvement
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Largest cyst more than 20 cm
Average number of cysts per pt. with
multiple cysts is 2,9.
Average size of cyst 9,36 cm
Cyst characteristics
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Lobe involvement
71,86%68,94%
14,07%
19,70%
14,07% 11,36%0,00%
10,00%
20,00%
30,00%
40,00%
50,00%
60,00%
70,00%
80,00%
Right lobe Left lobe Both lobes
NO COMMUNICATION
WITH COMMUNICATION
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Infected cysts and sepsis
Massive destruction of liver parenchyma
Cirrhotic livers
Posterior calcified cysts
Multiple organ hydatidosis
Multiple operations for recurrent disease
Central, hilar cysts
Cyst - bile duct communications
The real problems ...
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• Adequate exposure and mobilization
• Safe decompression and evacuation of cyst contents
• Effective cyst sterilization
• Management of bile duct communications
• Management of the residual cavity
• Drainage
The basic surgical procedures in endocystectomy
(conservative surgery)
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Adequate exposure and mobilization
Standard J incision Retractors Extension
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Adequate exposure and mobilization
Topics for discussion:
Midline for left side Degree of mobilization Liberation of diaphragm Same incision for recurrence One cavity at a time Thoraco-phreno incision
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Safe decompression and evacuation of cyst contents
1 2 3
4 5 6
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Safe decompression and evacuation of cyst contents
1 2 3
? ? ?
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The barrier effect of gauze pads soaked with protoscolicidal agents
Two effects of gauze barrier analysed:
Mechanical effect:
filter effect is 99,73% i
PSE effect on protoscolicides that
passed the gauze filter after 15
minutes of exposition
Complete for all tested solutions
except 3 i 5% NaCl.
Gaza - 15 min.
Ž/M
1. 3% NaCl 14/53 19700 ptsc/ml 2. 5% NaCl 7/26 19700 ptsc/ml 3. 20% NaCl 0/28 11200 ptsc/ml 4. 30% NaCl 0/40 19700 ptsc/ml 5. 3% - H2O2, 0/33 11200 ptsc/ml 6. 5% Povidona 0/23 11200 ptsc/ml 7. 10% Povidona 0/25 11200 ptsc/ml 8. Chloramin 0/7 11200 ptsc/ml 9. 70% etanola, 0/23 11200 ptsc/ml 10. 96% etanola 0/17 11200 ptsc/ml 11. 10% Formalin 0/40 11200 ptsc/ml 12. 5% Formalin 0/19 11200 ptsc/ml 13. 0.01% Rivanol 0/18 11200 ptsc/ml 14. 0.005% Rivanol 0/19 11200 ptsc/ml 15. 0.0025% Rivanol 0/33 19700 ptsc/ml
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Safe decompression and evacuation of cyst contents
Topics for discussion:
How to isolate – “ wall of ” High intracystic pressure Double suction devices Lap. troacars Special devices - cones Evacuation of contents
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Effective cyst sterilization - protoscolicides
Univesicular, small volume Multivesicular, large volume
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Effective cyst sterilization – protoscolicidal agents
Topics for discussion:
Injection of protoscolicidal agents Efficacy of protoscolicidal agents Mechanical cleansing Use of two protoscolicidal agents Use of physical methods Adverse effects of cyst sterilization
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Baccelli - mercury compounds - by the end of XIX century
Franke - formalin - 1900..
Deve - routine procedure during hyd. surgery - 1901.
Hicken - 96% etanol - 1966.
Harris - 3% HSS - 1968.
Saidi - diluted silver nitrate - 1977.
Ahrari and Eslami - cetrimide1978.
The history
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The most effective PA
Scolecidal agents Concentration Estimatedefficacy Reported negative effects
Sodium chloride solution 3-20% + Caustic sclerosing cholangitisConcentrated ethanol 75-95% +++ Caustic sclerosing cholangitis
Cetrimide solution 0.1-0.5% + Caustic sclerosing cholangitis,Metabolic acidosis
Povidone 1% +Colors cystic cavity – difficult toidentify bile ductcommunications
Formalin 4-10% +++Caustic sclerosing cholangitis,anaphylactic shock, formalintoxicity
Hydrogen peroxide 1.5-3% ++Bursting, spillage, tearsAir embolismAnaphylactic shock (10%)
Chlorhexidine (Savalon) 10% +++ Metabolic acidosisSilver nitrate 0.5% ++ Caustic sclerosing cholangitisSol. Rivanoli 0.001% ? No data
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Protoscolicidal agents
100% PSE - NaCL
– 10 min. - 15, 20 and 30%
– 30 min. - 10%
– 180 min. - 5% NaCl
– 220 min. - 3% NaCl
PSE 30% NaCl– a) 200x, eozin; b) 400x, eozin
100% PSE - Ethanol
– 10 min. - 96, 70, 48, and 35%.
– 45 min. - 24 and 17,5%
PSE 96% Ethanol– 400x, eozin
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100% PSE Povidone - iodine
– 5 min. - 10% – 0,156125%
Povidon-iodid solution
PSE 10% Povidon– 400x, eozin
100% PSE Formalin
– 5 min. - 10% formalin,
– 10 min. - 5 and 2,5%,
– 15 min, - 1,25% formalin. PSE 10% Formalin – after 15min. of eosin exposure
- “marginal staining” effect, a)200x, eozin; b) 400x, eozin
Protoscolicidal agents
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100% PSE sol. Rivanoli
– 30 min. - 1‰ - 0,125‰ Rivanoli
PSE 1‰ Rivanoli – 200x, eozin
PSE 3% H2O2– 400x, eozin
100% PSE Hydrogen peroxide
– 15 min. - 3% hydrogen peroxide
– 15 min. - 1,5% hydrogen peroxide
Protoscolicidal agents
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100% PSE
Chlorhexidine gluconate 5% - 1:2000 H2O sol.
– 10 min. 2,5‰
PSE Zeneca –200x i 400x, eozin
Cetrimonium bromid (cetyltrimethylammonium bromid)
Cetavlon - (Cetrimide 20% w/v -)
– 5 min. 0,1% - 0,0125% cetrimid
– 15 min. 0,00625% cetrimid
Savlex®
(Cetrimid 1,5% + Chlorhexidine Gluconat 0,15%)
– 5 min 10% - 0,625%
100% PSE AgNO3
– 5 min - 0,5%; - 0,015625%
Protoscolicidal agents
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PA with 100% PSE in 5 min.
0,00%
10,00%
20,00%
30,00%
40,00%
50,00%
60,00%
70,00%
80,00%
90,00%
100,00%
13. 1% Povidon
14. 0,5% Povidon
15. 0,25% Povidon
16. 0,125% Povidon
17. 0,0625% Povidon
18. 0,03125% Povidon
19. 0,0156125% Povidon
24. 10% Formalin
33. Cetrimide 0,1%
34. Cetrimide 0,05%
35. Cetrimide 0,025%
36. Cetrimide 0,0125%
38. Savlex39. Savlex
40. Savlex
41. Savlex
42. Savlex
43. Savlex
44. Savlex
47. AgNO3 0,5%
48. AgNO3 0,25%
49. AgNO3 0,125%
50. AgNO3 0,0625%
51. AgNO3 0,03125%
52. AgNO3 0,015625% 100% PSE u 5 min.
1% Povidon
0,5% Povidon
0,25% Povidon
0,125% Povidon
0,0625% Povidon
0,03125% Povidon
0,0156125% Povidon
10% Formalin
Cetrimide 0,1%
Cetrimide 0,05%
Cetrimide 0,025%
Cetrimide 0,0125%
Savlex 10%
Savlex 5%
Savlex 2,5%
Savlex 1,25%
Savlex 0,625%
Savlex 0,3125%
Savlex 0,15625%
AgNO3 0,5%
AgNO3 0,25%
AgNO3 0,125%
AgNO3 0,0625%
AgNO3 0,03125%
AgNO3 0,015625%
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0,00%
10,00%
20,00%
30,00%
40,00%
50,00%
60,00%
70,00%
80,00%
90,00%
100,00%
4. 15% NaCl
5. 20% NaCl
6. 30% NaCl
7. 96% etanola
8. 70% etanola
9. 48% etanol
10. 35% etanol
25. 5% Formalin
26. 2,5% Formalin
32. Chlorhexidine
100% PSE u 10 min.
15% NaCl
20% NaCl
30% NaCl
96% etanola
70% etanola
48% etanol
35% etanol
5% Formalin
2,5% Formalin
Chlorhexidine
PA with 100% PSE in 100% PSE in 10 min.
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0,00%
10,00%
20,00%
30,00%
40,00%
50,00%
60,00%
70,00%
80,00%
90,00%
100,00%
27. 1,25% Formalin
37. Cetrimide 0,00625%45. Gigasept
1.25% Formalin
Cetrimide 0,00625%
Gigasept
PA with 100% PSE in 100% PSE in 15 min.
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Management of bile duct communications Peroperative cholagiography performed from “above” through the
site of CBC-2
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visualization and verification of the
communication
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Management of bile duct communications Cholangiography through the cystic duct, the site of CBC and
transintestinal catheter
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RHD COMM.
CBD
CBD
CBD
LHD COMM.
LHD COMM.
GB
GB
Management of bile duct communications I.O. Cholangiography
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Suture of the communication
Simple suture
Suture and T-drainage
Interlamelar pericystectomy and capitonage
Internal drainage procedures
Internal transfistulary drainage with/without transduodenal sphincteroplasty
Bilio-digestive derivation
Transduodenal papilotomy
External drainage procedures
Bipolar drainage procedure
Cysto-biliary deconnection procedure
Biliary reconstruction procedures
Intracavitary bilio-digestive reconstruction - Roux-en-Y
Pericysto-jejunostomy - Roux-en-Y
Intracavitary bile dust reconstruction - T-drainage
Management of bile duct communications The procedures
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Management of bile duct communications Bipolar drainage of cysto-biliary communication
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Management of bile duct communications Cysto-biliary deconnection procedure in treatment of CBC-1
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Management of bile duct communications Cysto-biliary deconnection procedure in treatment of CBC-2
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cath. in right h. duct
CBD
sling in l. hepatic duct
Management of bile duct communications Destruction of left hepatic duct
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GB
Central
cyst
CBD
L. hep.
comm
CBD
Central
cyst Orifice of
l. hep. d.
Roux en-Y
Management of bile duct communications Central communicating cyst
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D-OTHER
PROCEDURES
2%
C - 'T' TUBE
5%
2-SUTURE+'T'
TUBE
10%
1-SUTURE
83%
Management of bile duct communications Type of procedure on bile ducts
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with IHBD - HC comm.
55,46% 28,57% 11,77% 3,36% 0,84%
no IHBD - HC comm.
48,91% 34,35 % 7,83% 8,26% 0,65%
Partial pericystectomy
with omentoplasty
Partial pericystectomy
with capitonage
Combine
procedures
I.C.
M
Management of bile duct communications Type of operative procedures performed on the dominant hydatid
cyst-conservative surgery
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Factor incidence ratio stat. signif.
age > 65 1,2 : 1 ns multiple / solitary cysts 1 : 1,2 ns IHBD - HC / no 1,5 : 1 s
Management of bile duct communications Factors affecting incidence of po. complications
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• Small amounts first few days no concern
• Biliary fistula
• Early discharge of large quantity
• Cause:
• overlooked communication
• injury to bile ducts
• inadequate assessment
• inadequate procedure
• obstructed CBD (eg. debris)
• Liver abscess
Management of bile duct communications Postoperative biliary drainage
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external
fistula
Management of bile duct communications Failure of conservative surgery
(calcified cyst) - persistant po. bile fistula
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fully calcified hydatid cyst – status: inactive
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Long-term complications H-A complex, cholangitis
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Management of bile duct communications
Topics for discussion:
Cholecystectomy and io. cholangiography IOUS Injection of dye Role of “T” tube Bilio-digestive anastomosis Management of fistulas
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Management of the residual cavity
Routine procedures
External tube drainage Omentoplasty Capitonnage
Cavity flattened
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Management of the residual cavity
Other procedures
Internal collapse
Introflexion
Introflexion plus omentoplasty
Myeloplasty
Cystojejunostomy
Marsupialization
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Postoperative morbidity
Nonspecific 48 pts. 4.72%
Procedure related 113 pts. 11.12%
Pleural effusion 60 pts. (5.91%)
Liver abscess 31 pts. (3.05%)
Biliary fistula 19 pts. (1.87%)
Bleeding 3 pts. (0.29%)
___________________________________________
T o t a l 161 pts. 15.84%
Re-operation 37 pts. 3.64%
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Recurrence
Second operation for liver hydatid
165 pts. 16,24%
First operation at the Institute
2.86%
frank recurrence 0.68 %
missed cyst 1.18%
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exogenous vesiculation
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extremly thick wall – exogenous vesiculation and engagement of adjacent organs – surgery !
stomach
cyst
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.
Overall
Mortality rate
20 pts. 1.96%
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conclusion: who needs treatment
wise men say – rule of thumb:
1. all symptomatic cysts
2. asymptomatic cysts > 5 cm, especially peripherally located
3. complications of hepatic hydatid disease
4. 95% of all patients are treated when diagnosed
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Conservative, tissue sparing, hydatid cyst surgery, when performed properly, is adequate for the majority of patients.
The detection of a HC-IHBD communication seldom requires more radical surgery.
Conclusion
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