Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 1...

Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 1

PopMedNet in the pSCANNER Network

PMN User Meeting


pSCANNER Network – 16M patients

• 5 University of California Medical Centers• Cedar’s Sinai Hospital • Pacific NW Rural Health Practice-Based Research

Network• Los Angeles Department of Health Services• Intermountain Health Care• 5 multi-site FQHCs• Children’s Hospital of Los Angeles• Keck Medicine of USC


Service Oriented Architecture for privacy-preserving analytics in distributed research networks› Focus on map-reduce, iterative algorithms based on

parallel-distributed processing algorithms Role based access control De-centralized study administration Menu-driven queries for multiple activities › Proposing collaboration partners, data sets, and

protocols› Specifying regression analytics › Data set extractions› Cohort discovery

Methods repository for contributing analytic methods

SCANNER Network Software (AHRQ 2010-2014)


2015


Traditional 3-tier Architecture


Data Tier

Local Logic Tier

Code & Specification Repository(1) PRESENTATION(2) TRANSLATION(3) AGGREGATION(4) STORED SPECIFICATIONS

Aggregation Logic Tier

This layer coordinates across results produced by multiple sites. (1)Aggregate for Display(2)Aggregate for Iteration

Translation Logic Tier (DAN)TBD whether this happens locally or as a service (OR BOTH). This layer reads metadata from each site and translates platform independent specifications into platform-specific executables

ASSEMBLEPROGRAMS

STANDARDIZE OUTPUT

Authorization TierLocal authorities verify (may be automated, pre-authorized, or manual)(1) Validity of Localization(2) Access Permission(3) Verity of Results

AuthorizeVerify

Authorize Verify

AuthorizeVerifyAuthorizeVerify

Authorize Verify

Authorize Verify

GLOBAL

LOCAL

New in pSCANNER-PMN


Replace pSCANNER role-based access controls with PopMedNet API

Replace pSCANNER methods repository with GitHub for open source analytics› Collaboration with CEILO social code-sharing platform

Platform-independent, ISO & HL7 standards-based query formats

Replaces pSCANNER nodes’ web API with modified PopMedNet DataMartClient & pSCANNER Request Types

Adding features to PopMedNet› New PMN permission type – any investigator can

propose a study to any site, any site can decline or agree to participate

› New PMN node that aggregates results and re-issues requests

New in pSCANNER Software


• Menu-driven Queries for Compatible Analytic Libraries• Data Visualization (Observational Health

Data Science & Informatics) • Electronic Clinical Quality Measures (NQF

Library)• Privacy-preserving Multivariate Map-

Reduce (One Model Per Network)• Independently Estimated Multi-Variate

(One model per site)

• Model Transformation Libraries• OMOP CDM to PCORnet CDM• OMOP CDM to CMS Quality Data Model• Version control of local EHR DBs to CDMs• Study-Specific Dataset ETLs

Open Source Code Repository

Code & Specification Repository(1) PRESENTATION(2) TRANSLATION(3) AGGREGATION(4) STORED SPECIFICATIONS


2016 - Stakeholders & Partners

CIELO: “Towards a research analysis

commons”

OHDSI: “To transform medical decision making …health databases for

population-level estimation and patient-level predictions”

PCORNet: “fosters a range of observational and interventional

research that harnesses the power of clinical data gathered at the point of

care in health systems across the country.”

National Quality Forum: “…National collaboration

to improve health and healthcare quality

through measurement”

Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 1...

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