Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG...

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Supplementary Information

Transcript of Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG...

Page 1: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Supplementary Information

Page 2: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Figure S1. DCE MRI modelling for Ktrans maps generation in U87 mouse model. L-R: T1-CE, T1-CE

with defined CE tumor VOI (red), Ktrans map generated from kinetic modelling of DCE MRI data and

arterial input function (AIF) selected for the generation for the K trans map.

Page 3: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005
Page 4: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005
Page 5: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Figure S2. DCE MRI modelling for Ktrans maps generation in WK1 mouse model. L-R: T1-CE, T1-CE

with defined CE tumor VOI (red), Ktrans map generated from kinetic modelling of DCE MRI data and

arterial input function (AIF) selected for the generation for the K trans map.

Page 6: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005
Page 7: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005
Page 8: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Figure S3. DCE MRI modelling for Ktrans maps generation in patient rHGG. L-R: T1-CE, T1-CE with

defined CE tumor VOI (red), Ktrans map generated from kinetic modelling of DCE MRI data and arterial

input function (AIF) selected for the generation for the K trans map.

Page 9: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Figure S4. Additional images of H&E and immunofluorescence stained brain sections. The images show A. H&E,

B. CD31/PLVAP/DAPI and C. GFAP staining of whole brain sections, and magnification of two areas (close-up 1 -

yellow rectangle, close-up 2 - blue rectangle) of the U87 and WK1 mouse models.

Page 10: Supplementary Information - TheranosticsWK1_016 0.01 0.13 WK1_017 0.02 0.10 WK1_018 0.03 0.19 rHGG RIDER_001 0.03 0.35 RIDER_002 0.01 0.22 RIDER_003 0.05 0.24 RIDER_004 0.04 0.23 RIDER_005

Table S1. Values of mean Ktrans and mean Kep in the CE tumor VOI for each subject in the study.

Group Subject ID Ktrans [min-1] Kep [min-1]

U87

U87_001 0.05 0.24

U87_002 0.07 0.30

U87_003 0.06 0.24

U87_004 0.03 0.26

U87_005 0.05 0.22

U87_006 0.03 0.38

U87_007 0.03 0.27

U87_008 0.03 0.23

U87_009 0.03 0.29

U87_010 0.06 0.33

U87_011 0.08 0.29

U87_012 0.06 0.25

WK1

WK1_001 0.01 0.26

WK1_002 0.05 0.16

WK1_003 0.05 0.15

WK1_004 0.03 0.16

WK1_005 0.02 0.15

WK1_006 0.02 0.20

WK1_007 0.03 0.24

WK1_008 0.04 0.12

WK1_009 0.02 0.11

WK1_010 0.05 0.27

WK1_011 0.08 0.28

WK1_012 0.03 0.15

WK1_013 0.03 0.13

WK1_014 0.03 0.23

WK1_015 0.01 0.23

WK1_016 0.01 0.13

WK1_017 0.02 0.10

WK1_018 0.03 0.19

rHGG

RIDER_001 0.03 0.35

RIDER_002 0.01 0.22

RIDER_003 0.05 0.24

RIDER_004 0.04 0.23

RIDER_005 0.02 0.29

RIDER_006 0.03 0.30

RIDER_007 0.02 0.25

RIDER_008 0.02 0.20

RIDER_009 0.03 0.27

RIDER_010 0.02 0.17

RIDER_011 0.02 0.30

RIDER_012 0.02 0.18

RIDER_013 0.03 0.38

RIDER_014 0.02 0.32

RIDER_015 0.02 0.18

RIDER_016 0.03 0.20


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