Supplemental material Daniel A. Rossignol Hugo …...CDK7 Cyclin-dependent kinase 7 (MO15 homolog,...

1

Supplemental material

Environmental toxicants and autism spectrum disorders: A systematic review

Daniel A. Rossignol

Stephen Genuis

Richard E. Frye

Institute of Environmental Health Sciences Environmental Genome Project (Phase 1 finished genes, http://egp.gs.washington.edu/finished_genes.html)

http://egp.gs.washington.edu/finished_genes.html

Hugo Gene

Name Gene Description

ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1

ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4

ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1

ABL1 V-abl Abelson murine leukemia viral oncogene homolog 1

ABL2 V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

ABP1 Amiloride binding protein 1 (amine oxidase (copper-containing))

ACTB Actin, beta

ADAM33 ADAM metallopeptidase domain 33

ADH1A Alcohol dehydrogenase 1A (class I), alpha polypeptide

ADH1B Alcohol dehydrogenase IB (class I), beta polypeptide

ADH1C Alcohol dehydrogenase 1C (class I), gamma polypeptide

ADH4 Alcohol dehydrogenase 4 (class II), pi polypeptide

ADH5 Alcohol dehydrogenase 5 (class III), chi polypeptide

ADH6 Alcohol dehydrogenase 6 (class V)

ADM Adrenomedullin

ADPRT ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)

ADPRTL2 ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2

AHR Aryl hydrocarbon receptor

AKT2 V-akt murine thymoma viral oncogene homolog 2

ALAD Aminolevulinate, delta-, dehydratase

ALDH1A1 Aldehyde dehydrogenase 1 family, member A1

2

ALDH1A2 Aldehyde dehydrogenase 1 family, member A2

ANAPC10 Anaphase promoting complex subunit 10

ANGPTL7 Angiopoietin-like 7

AOC2 Amine oxidase, copper containing 2 (retina-specific)

AOC3 Amine oxidase, copper containing 3 (vascular adhesion protein 1)

APEX APEX nuclease (multifunctional DNA repair enzyme)

APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2

API5 Apoptosis inhibitor 5

APP Amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)

APRT Adenine phosphoribosyltransferase

AREG Amphiregulin (schwannoma-derived growth factor)

ARNT Aryl hydrocarbon receptor nuclear translocator

ARSA Arylsulfatase A

ASNA1 ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

ATF3 Activating transcription factor 3

ATM Ataxia telangiectasia mutated (includes complementation groups A, C and D)

ATOX1 ATX1 antioxidant protein 1 homolog (yeast)

ATRX Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)

ATXN3 Ataxin 3

BACE1 Beta-site APP-cleaving enzyme 1

BAK1 BCL2-antagonist/killer 1

BAX BCL2-associated X protein

BCL2 B-cell CLL/lymphoma 2

BID BH3 interacting domain death agonist

BIK BCL2-interacting killer (apoptosis-inducing)

BIRC2 Baculoviral IAP repeat-containing 2



BIRC5 Baculoviral IAP repeat-containing 5 (survivin)

BLM Bloom syndrome

BLVRA Biliverdin reductase A

3

BLVRB Biliverdin reductase B (flavin reductase (NADPH))

BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1



BRAF V-raf murine sarcoma viral oncogene homolog B1

BRCA1 Breast cancer 1, early onset

BRCA2 Breast cancer 2, early onset

BTG1 B-cell translocation gene 1, anti-proliferative

BZRP Benzodiazapine receptor (peripheral)

CALCA Calcitonin/calcitonin-related polypeptide, alpha

CAPN1 Calpain 1, (mu/I) large subunit

CAPN2 Calpain 2, (m/II) large subunit

CAPN3 Calpain 3, (p94)

CAPN6 Calpain 6

CAPN9 Calpain 9 (nCL-4)

CAPNS1 Calpain, small subunit 1

CASP10 Caspase 10, apoptosis-related cysteine peptidase

CASP2 Caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2)

CASP3 Caspase 3, apoptosis-related cysteine protease






CCK Cholecystokinin

CCL5 Chemokine (C-C motif) ligand 5

CCNA2 Cyclin A2

CCNB1 Cyclin B1

CCNB2 Cyclin B2

CCND1 Cyclin D1 (PRAD1

CCND2 Cyclin D2

4

CCND3 Cyclin D3

CCNE1 Cyclin E1

CCNE2 Cyclin E2

CCNG1 Cyclin G1

CCNG2 Cyclin G2

CCNH Cyclin H

CCNI Cyclin I

CCNK Cyclin K

CCNT2 Cyclin T2

CCRK Cell cycle related kinase

CD3Z CD3Z antigen, zeta polypeptide (TiT3 complex)

CD4 CD4 antigen (p55)

CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)

CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)

CDC16 CDC16 cell division cycle 16 homolog (S. cerevisiae)

CDC2 Cell division cycle 2, G1 to S and G2 to M


CDC23 CDC23 (cell division cycle 23, yeast, homolog)

CDC25A Cell division cycle 25A

CDC25B Cell division cycle 25B

CDC25C Cell division cycle 25C

CDC27 Cell division cycle 27

CDC2L5 Cell division cycle 2-like 5 (cholinesterase-related cell division controller)

CDC34 Cell division cycle 34


CDC42 Cell division cycle 42 (GTP binding protein, 25kDa)

CDC42BPB CDC42 binding protein kinase beta (DMPK-like)

CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2

CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)

CDC5L CDC5 cell division cycle 5-like (S. pombe)


5

CDC7 CDC7 cell division cycle 7 (S. cerevisiae)

CDH1 Cadherin 1, type 1, E-cadherin (epithelial)

CDK2 Cyclin-dependent kinase 2



CDK5R1 Cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R2 Cyclin-dependent kinase 5, regulatory subunit 2 (p39)


CDK7 Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

CDK9 Cyclin-dependent kinase 9 (CDC2-related kinase)

CDKL1 Cyclin-dependent kinase-like 1 (CDC2-related kinase)

CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

CDKN2A Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

CDKN2B Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

CDKN2C Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

CDKN2D Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

CES2 Carboxylesterase 2 (intestine, liver)

CES3 Carboxylesterase 3 (brain)

CETN2 Centrin, EF-hand protein, 2

CHC1L Chromosome condensation 1-like

CHEK1 CHK1 checkpoint homolog (S. pombe)

CHEK2 CHK2 checkpoint homolog (S. pombe)

CHRNA4 Cholinergic receptor, nicotinic, alpha polypeptide 4

CHST1 Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

CIZ1 CDKN1A interacting zinc finger protein 1

CKB Creatine kinase, brain

CKN1 Cockayne syndrome 1 (classical)

CKS2 CDC28 protein kinase 2

CLU Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

6

COMT Catechol-O-methyltransferase

CP Ceruloplasmin (ferroxidase)

CSK C-src tyrosine kinase

CTNNA1 Catenin (cadherin-associated protein), alpha 1, 102kDa

CTNNAL1 Catenin (cadherin-associated protein), alpha-like 1

CTNNB1 Catenin (cadherin-associated protein), beta 1, 88kDa

CTNND1 Catenin (cadherin-associated protein), delta 1

CTNND2 Catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

CX3CR1 Chemokine (C-X3-C motif) receptor 1

CXCR6 Chemokine (C-X-C motif) receptor 6

CYC1 Cytochrome c-1

CYP17A1 Cytochrome P450, family 17, subfamily A, polypeptide 1




CYP1B1 Cytochrome P450, family 1, subfamily B, polypeptide 1




CYP2C19 Cytochrome P450, family 2, subfamily C, polypeptide 19



CYP2E1 Cytochrome P450, family 2, subfamily E, polypeptide 1

CYP2J2 Cytochrome P450, family 2, subfamily J, polypeptide 2




CYP4V2 Cytochrome P450, family 4, subfamily V, polypeptide 2

CYR61 Cysteine-rich, angiogenic inducer, 61

DAD1 Defender against cell death 1

DAP Death-associated protein

7

DAPK1 Death-associated protein kinase 1

DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)

DCLRE1B DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)

DCLRE1C DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)

DDB1 Damage-specific DNA binding protein 1, 127kDa

DDB2 Damage-specific DNA binding protein 2, 48kDa

DDC Dopa decarboxylase (aromatic L-amino acid decarboxylase)

DDIT3 DNA-damage-inducible transcript 3

DEPC1 Prostate cancer antigen-1

DIA1 Diaphorase (NADH) (cytochrome b-5 reductase)

DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)

DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3

DNCH1 Dynein, cytoplasmic, heavy polypeptide 1

DTR Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)

DUSP1 Dual specificity phosphatase 1

DUT DUTP pyrophosphatase

E2F1 E2F transcription factor 1



E2F4 E2F transcription factor 4, p107/p130-binding

E2F5 E2F transcription factor 5, p130-binding

ECE1 Endothelin converting enzyme 1

EDN1 Endothelin 1

EDN2 Endothelin 2

EDN3 Endothelin 3

EDNRA Endothelin receptor type A

EDNRB Endothelin receptor type B

EEF1A1 Eukaryotic translation elongation factor 1 alpha 1

EGF Epidermal growth factor (beta-urogastrone)

EGFR Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

ELA1 Elastase 1, pancreatic

8

ELA2 Elastase 2, neutrophil

ENO1 Enolase 1, (alpha)

EPHX1 Epoxide hydrolase 1, microsomal (xenobiotic)

EPHX2 Epoxide hydrolase 2, cytoplasmic

EPX Eosinophil peroxidase

ERBB2 V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

ERCC1 Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

ERCC2 Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)

ERCC3 Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)

ERCC4 Excision repair cross-complementing rodent repair deficiency, complementation group 4

ERCC5 Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syn

ERCC6 Excision repair cross-complementing rodent repair deficiency, complementation group 6

ESR1 Estrogen receptor 1

ESRRA Estrogen-related receptor alpha

ESRRG Estrogen-related receptor gamma

EXO1 Exonuclease 1

FAAH Fatty acid amide hydrolase

FADD Fas (TNFRSF6)-associated via death domain

FANCA Fanconi anemia, complementation group A

FANCC Fanconi anemia, complementation group C

FANCD2 Fanconi anemia, complementation group D2

FANCE Fanconi anemia, complementation group E

FANCF Fanconi anemia, complementation group F

FANCG Fanconi anemia, complementation group G

FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30

FBP1 Fructose-1,6-bisphosphatase 1

FDXR Ferredoxin reductase

FEN1 Flap structure-specific endonuclease 1

FGF1 Fibroblast growth factor 1 (acidic)

FGF10 Fibroblast growth factor 10


9



FGF2 Fibroblast growth factor 2 (basic)







FGF8 Fibroblast growth factor 8 (androgen-induced)

FGF9 Fibroblast growth factor 9 (glia-activating factor)

FGFR1 Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)

FGFR2 Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackso

FGFR3 Fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

FGFR4 Fibroblast growth factor receptor 4

FIBP Fibroblast growth factor (acidic) intracellular binding protein

FLJ35220 Hypothetical protein FLJ35220

FMO1 Flavin containing monooxygenase 1





FOS V-fos FBJ murine osteosarcoma viral oncogene homolog

FOSB FBJ murine osteosarcoma viral oncogene homolog B

FOXC1 Forkhead box C1

FOXC2 Forkhead box C2 (MFH-1, mesenchyme forkhead 1)

FOXM1 Forkhead box M1

G22P1 Thyroid autoantigen 70kDa (Ku antigen)

GAB1 GRB2-associated binding protein 1

GABPA GA binding protein transcription factor, alpha subunit 60kDa

GAD1 Glutamate decarboxylase 1 (brain, 67kDa)

10

GAD2 Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

GADD45A Growth arrest and DNA-damage-inducible, alpha

GADD45B Growth arrest and DNA-damage-inducible, beta

GADD45G Growth arrest and DNA-damage-inducible, gamma

GAP43 Growth associated protein 43

GAPD Glyceraldehyde-3-phosphate dehydrogenase

GCKR Glucokinase (hexokinase 4) regulatory protein

GCLC Glutamate-cysteine ligase, catalytic subunit

GCLM Glutamate-cysteine ligase, modifier subunit

GCSH Glycine cleavage system protein H (aminomethyl carrier)

GLP1R Glucagon-like peptide 1 receptor

GLRX Glutaredoxin (thioltransferase)

GLRX2 Glutaredoxin 2

GPI Glucose phosphate isomerase

GPX1 Glutathione peroxidase 1

GPX2 Glutathione peroxidase 2 (gastrointestinal)

GPX3 Glutathione peroxidase 3 (plasma)

GPX4 Glutathione peroxidase 4 (phospholipid hydroperoxidase)

GPX5 Glutathione peroxidase 5 (epididymal androgen-related protein)

GPX6 Glutathione peroxidase 6 (olfactory)

GPX7 Glutathione peroxidase 7

GRM8 Glutamate receptor, metabotropic 8

GSR Glutathione reductase

GSS Glutathione synthetase

GSTA3 Glutathione S-transferase A3

GSTA4 Glutathione S-transferase A4

GSTM2 Glutathione S-transferase M2 (muscle)

GSTM3 Glutathione S-transferase M3 (brain)

GSTP1 Glutathione S-transferase pi

GSTZ1 Glutathione transferase zeta 1 (maleylacetoacetate isomerase)

GTF2H1 General transcription factor IIH, polypeptide 1, 62kDa

11

GTF2H3 General transcription factor IIH, polypeptide 3 (34kD subunit)

GTF2H4 General transcription factor IIH, polypeptide 4 (52kD subunit)

H2AFX H2A histone family, member X

HCNP HCNP protein; XPA-binding protein 2

HFE Hemochromatosis

HGF Hepatocyte growth factor (hepapoietin A; scatter factor)

HK2 Hexokinase 2

HMOX2 Heme oxygenase (decycling) 2

HPRT1 Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)

HRAS V-Ha-ras Harvey rat sarcoma viral oncogene homolog

HSD17B2 Hydroxysteroid (17-beta) dehydrogenase 2


HSF2 Heat shock transcription factor 2

HSPA1A Heat shock 70kDa protein 1A

HSPA1B Heat shock 70kDa protein 1B

HSPA1L Heat shock 70kDa protein 1-like

HSPA2 Heat shock 70kDa protein 2

HSPA5 Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

HSPA6 Heat shock 70kDa protein 6 (HSP70B')

HSPA9B Heat shock 70kDa protein 9B (mortalin-2)

HSPB1 Heat shock 27kDa protein 1

HSPB2 Heat shock 27kDa protein 2

HSU24186 Replication protein A complex 34 kd subunit homolog Rpa4

HTATIP HIV-1 Tat interactive protein, 60kDa

HUS1 HUS1 checkpoint homolog (S. pombe)

IFNA1 Interferon, alpha 1

IGF1 Insulin-like growth factor 1 (somatomedin C)

IGF1R Insulin-like growth factor 1 receptor

IGF2R Insulin-like growth factor 2 receptor

IGFBP1 Insulin-like growth factor binding protein 1

IGFBP2 Insulin-like growth factor binding protein 2, 36kDa

12






ITGAL Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

ITM2B Integral membrane protein 2B

JUN V-jun sarcoma virus 17 oncogene homolog (avian)

JUNB Jun B proto-oncogene

JUND Jun D proto-oncogene

LCMT2 Leucine carboxyl methyltransferase 2

LIG1 Ligase I, DNA, ATP-dependent

LIG3 Ligase III, DNA, ATP-dependent

LIG4 Ligase IV, DNA, ATP-dependent

LIPF Lipase, gastric

LPO Lactoperoxidase

LTA Lymphotoxin alpha (TNF superfamily, member 1)

LTB Lymphotoxin beta (TNF superfamily, member 3)

MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)

MAP2K4 Mitogen-activated protein kinase kinase 4

MAPK1 Mitogen-activated protein kinase 1



MARCKS Myristoylated alanine-rich protein kinase C substrate

MB Myoglobin

MBD4 Methyl-CpG binding domain protein 4

MCL1 Myeloid cell leukemia sequence 1 (BCL2-related)

MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)

MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)

MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein

MCM4 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)

13

MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)

MCM6 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)

MDM2 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)

MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)

MGST1 Microsomal glutathione S-transferase 1



MIF Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

MLH1 MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

MLH3 MutL homolog 3 (E. coli)

MLL Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

MLP MARCKS-like protein

MMP1 Matrix metalloproteinase 1 (interstitial collagenase)

MMP10 Matrix metalloproteinase 10 (stromelysin 2)

MMP11 Matrix metalloproteinase 11 (stromelysin 3)

MMP12 Matrix metalloproteinase 12 (macrophage elastase)

MMP13 Matrix metalloproteinase 13 (collagenase 3)

MMP14 Matrix metalloproteinase 14 (membrane-inserted)

MMP15 Matrix metallopeptidase 15 (membrane-inserted)

MMP16 Matrix metalloproteinase 16 (membrane-inserted)

MMP19 Matrix metalloproteinase 19

MMP2 Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

MMP20 Matrix metalloproteinase 20 (enamelysin)

MMP21 Matrix metalloproteinase 21

MMP7 Matrix metalloproteinase 7 (matrilysin, uterine)

MMP8 Matrix metalloproteinase 8 (neutrophil collagenase)

MMP9 Matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

MMS19L MMS19-like (MET18 homolog, S. cerevisiae)

MN1 Meningioma (disrupted in balanced translocation) 1

MNAT1 Menage a trois 1 (CAK assembly factor)

MOSC1 MOCO sulphurase C-terminal domain containing 1

14

MOSC2 MOCO sulphurase C-terminal domain containing 2

MPG N-methylpurine-DNA glycosylase

MPO Myeloperoxidase

MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

MRPL37 MARCKS-like 1

MSH2 MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

MSH3 MutS homolog 3 (E. coli)




MSR1 Macrophage scavenger receptor 1

MT2A Metallothionein 2A

MT3 Metallothionein 3 (growth inhibitory factor (neurotrophic))

MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH)

MUC1 Mucin 1, transmembrane

MUC2 Mucin 2, oligomeric mucus/gel-forming

MUC5AC Mucin 5AC, oligomeric mucus/gel-forming

MUTYH MutY homolog (E. coli)

MYBPC3 Myosin binding protein C, cardiac

MYC V-myc myelocytomatosis viral oncogene homolog (avian)

NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)

NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)

NBS1 Nijmegen breakage syndrome 1 (nibrin)

NCOA3 Nuclear receptor coactivator 3

NEIL1 Nei endonuclease VIII-like 1 (E. coli)

NEIL2 Nei like 2 (E. coli)

NEIL3 Nei endonuclease VIII-like 3 (E. coli)

NELL1 NEL-like 1 (chicken)

NF1 Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)

NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NFKB2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

15

NGB Neuroglobin

NOS1 Nitric oxide synthase 1 (neuronal)

NOS2A Nitric oxide synthase 2A (inducible, hepatocytes)

NQO1 NAD(P)H dehydrogenase, quinone 1

NQO2 NAD(P)H dehydrogenase, quinone 2

NR3C1 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NRAS Neuroblastoma RAS viral (v-ras) oncogene homolog

NTHL1 Nth endonuclease III-like 1 (E. coli)

NUDT1 Nudix (nucleoside diphosphate linked moiety X)-type motif 1

OAZ1 Ornithine decarboxylase antizyme 1

ODC1 Ornithine decarboxylase 1

OGG1 8-oxoguanine DNA glycosylase

OPRM1 Opioid receptor, mu 1

ORC2L Origin recognition complex, subunit 2-like (yeast)



OSR1 Odd-skipped related 1 (Drosophila)

OXR1 Oxidation resistance 1

OXSR1 Oxidative-stress responsive 1

PANK2 Pantothenate kinase 2 (Hallervorden-Spatz syndrome)

PAWR PRKC, apoptosis, WT1, regulator

PAX1 Paired box gene 1

PAX3 Paired box gene 3 (Waardenburg syndrome 1)

PCK1 Phosphoenolpyruvate carboxykinase 1 (soluble)

PCNA Proliferating cell nuclear antigen

PDLIM1 PDZ and LIM domain 1 (elfin)

PEMT Phosphatidylethanolamine N-methyltransferase

PEO1 Progressive external ophthalmoplegia 1

PGR Progesterone receptor

PKLR Pyruvate kinase, liver and RBC

PKM2 Pyruvate kinase, muscle

16

PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

PLA2G1B Phospholipase A2, group IB (pancreas)

PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)

PLA2G2D Phospholipase A2, group IID

PLA2G4A Phospholipase A2, group IVA (cytosolic, calcium-dependent)

PLA2G4C Phospholipase A2, group IVC (cytosolic, calcium-independent)

PLA2G5 Phospholipase A2, group V

PLA2G6 Phospholipase A2, group VI (cytosolic, calcium-independent)

PLCG1 Phospholipase C, gamma 1

PLK3 Polo-like kinase 3 (Drosophila)

PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)

PNKP Polynucleotide kinase 3'-phosphatase

POLA Polymerase (DNA directed), alpha

POLB Polymerase (DNA directed), beta

POLD1 Polymerase (DNA directed), delta 1, catalytic subunit (125kD)

POLD2 Polymerase (DNA directed), delta 2, regulatory subunit (50kD)

POLD4 Polymerase (DNA-directed), delta 4

POLE Polymerase (DNA directed), epsilon

POLE2 Polymerase (DNA directed), epsilon 2 (p59 subunit)

POLE3 Polymerase (DNA directed), epsilon 3 (p17 subunit)

POLG Polymerase (DNA directed), gamma

POLH Polymerase (DNA directed), eta

POLI Polymerase (DNA directed) iota

POLK Polymerase (DNA directed) kappa

POLL Polymerase (DNA directed), lambda

POLM Polymerase (DNA directed), mu

POLN Polymerase (DNA directed) nu

POLS Polymerase (DNA directed) sigma

POR P450 (cytochrome) oxidoreductase

PPARD Peroxisome proliferative activated receptor, delta

PPIA Peptidylprolyl isomerase A (cyclophilin A)

17

PPIB Peptidylprolyl isomerase B (cyclophilin B)

PPIC Peptidylprolyl isomerase C (cyclophilin C)

PPID Peptidylprolyl isomerase D (cyclophilin D)

PRDX1 Peroxiredoxin 1





PRKCB1 Protein kinase C, beta 1

PRKD1 Protein kinase D1

PRKDC Protein kinase, DNA-activated, catalytic polypeptide

PRKR Protein kinase, interferon-inducible double stranded RNA dependent

PTCH Patched homolog (Drosophila)

PTCH2 Patched homolog 2 (Drosophila)

PTEN Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)

PTGS2 Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

RAD1 RAD1 homolog (S. pombe)


RAD18 RAD18 homolog (S. cerevisiae)


RAD23A RAD23 homolog A (S. cerevisiae)

RAD23B RAD23 homolog B (S. cerevisiae)

RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)

RAD51C RAD51 homolog C (S. cerevisiae)

RAD51L1 RAD51-like 1 (S. cerevisiae)

RAD51L3 RAD51-like 3 (S. cerevisiae)

RAD52 RAD52 homolog (S. cerevisiae)

RAD54L RAD54-like (S. cerevisiae)

RAD9A RAD9 homolog A (S. pombe)

RAF1 V-raf-1 murine leukemia viral oncogene homolog 1

18

RAG1 Recombination activating gene 1

RB1 Retinoblastoma 1 (including osteosarcoma)

RECQL4 RecQ protein-like 4

REQ Requiem, apoptosis response zinc finger gene

RETN Resistin

REV1L REV1-like (yeast)

REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast)

RFC1 Replication factor C (activator 1) 1, 145kDa

RFC2 Replication factor C (activator 1) 2 (40kD)

RFC3 Replication factor C (activator 1) 3, 38kDa

RFC4 Replication factor C (activator 1) 4 (37kD)

RFC5 Replication factor C (activator 1) 5, 36.5kDa

RPA1 Replication protein A1, 70kDa



RPS3 Ribosomal protein S3

RRM2B Ribonucleotide reductase M2 B (TP53 inducible)

RUNX2 Runt-related transcription factor 2

RXRA Retinoid X receptor, alpha

SCARA3 Scavenger receptor class A, member 3

SEI1 CDK4-binding protein p34SEI1

SEPP1 Selenoprotein P, plasma, 1

SHH Sonic hedgehog homolog (Drosophila)

SIRT1 Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

SLC22A6 Solute carrier family 22 (organic anion transporter), member 6

SLC22A7 Solute carrier family 22 (organic anion transporter), member 7

SLC4A2 Solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)

SLC6A3 Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

SLC6A4 Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

SMUG1 Single-strand selective monofunctional uracil DNA glycosylase

19

SNCA Synuclein, alpha (non A4 component of amyloid precursor)

SNN Stannin

SOD1 Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))

SOD2 Superoxide dismutase 2, mitochondrial

SOD3 Superoxide dismutase 3, extracellular

SPHAR S-phase response (cyclin-related)

SPO11 SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae)

SPRR1A Small proline-rich protein 1A

SPRR1B Small proline-rich protein 1B (cornifin)

SPRR3 Small proline-rich protein 3

SRD5A1 Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

SRD5A2 Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

STAT1 Signal transducer and activator of transcription 1, 91kDa

STAT2 Signal transducer and activator of transcription 2, 113kDa

STE Sulfotransferase, estrogen-preferring

STK25 Serine/threonine kinase 25 (STE20 homolog, yeast)

SULT1C2 Sulfotransferase family, cytosolic, 1C, member 2

SULT2A1 Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kD




TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD


TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kD



TBX1 T-box 1

TBXA2R Thromboxane A2 receptor

TCF15 Transcription factor 15 (basic helix-loop-helix)

20

TDG Thymine-DNA glycosylase

TDP1 Tyrosyl-DNA phosphodiesterase 1

TERF1 Telomeric repeat binding factor (NIMA-interacting) 1

TERT Telomerase reverse transcriptase

TFDP1 Transcription factor Dp-1

TFDP2 Transcription factor Dp-2 (E2F dimerization partner 2)

TGFB1I1 Transforming growth factor beta 1 induced transcript 1

TGFB2 Transforming growth factor, beta 2


TGFBI Transforming growth factor, beta-induced, 68kD

TGFBR1 Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)

TGFBR2 Transforming growth factor, beta receptor II (70/80kDa)

TGFBR3 Transforming growth factor, beta receptor III (betaglycan, 300kDa)

TGM1 Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)

TGM2 Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

TGM3 Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)

TIMELESS Timeless homolog (Drosophila)

TIPIN TIMELESS interacting protein

TJP1 Tight junction protein 1 (zona occludens 1)

TNF Tumor necrosis factor (TNF superfamily, member 2)

TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

TNFRSF14 Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

TNFRSF17 Tumor necrosis factor receptor superfamily, member 17

TNFRSF1B Tumor necrosis factor receptor superfamily, member 1B








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TP53 Tumor protein p53 (Li-Fraumeni syndrome)

TP53BP1 Tumor protein p53 binding protein, 1

TP53I3 Tumor protein p53 inducible protein 3

TPO Thyroid peroxidase

TRAF4 TNF receptor-associated factor 4

TREX1 Three prime repair exonuclease 1

TREX2 Three prime repair exonuclease 2

TRIM5 Tripartite motif-containing 5

TRPM2 Transient receptor potential cation channel, subfamily M, member 2

TUBA1 Tubulin, alpha 1 (testis specific)

TUBA2 Tubulin, alpha 2

TXN Thioredoxin

TXNRD1 Thioredoxin reductase 1

UBA52 Ubiquitin A-52 residue ribosomal protein fusion product 1

UBE2A Ubiquitin-conjugating enzyme E2A (RAD6 homolog)

UBE2B Ubiquitin-conjugating enzyme E2B (RAD6 homolog)

UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2

UCP2 Uncoupling protein 2 (mitochondrial, proton carrier)

UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1

UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4

UHRF1 Ubiquitin-like, containing PHD and RING finger domains, 1

UMPS Uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)

UNG Uracil-DNA glycosylase

VDR Vitamin D (1,25- dihydroxyvitamin D3) receptor

VNN1 Vanin 1

VNN2 Vanin 2

VNN3 Vanin 3

WRN Werner syndrome

WT1 Wilms tumor 1

XDH Xanthine dehydrogenase

XPA Xeroderma pigmentosum, complementation group A

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XPC Xeroderma pigmentosum, complementation group C

XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1




XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)

ZFP36 Zinc finger protein 36, C3H type, homolog (mouse)

SeattleSNPs (http://pga.gs.washington.edu/finished_genes.html)

http://pga.gs.washington.edu/finished_genes.html

HUGO NAME GENE DESCRIPTION

A4GALT Alpha 1,4-galactosyltransferase

ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3

ABCE1 ATP-binding cassette, sub-family E (OABP), member 1

ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2

ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

ACE2 Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

ACHE Acetylcholinesterase (YT blood group)

ADAMTS13 A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13

ADRA2A Adrenergic, alpha-2A-, receptor

ADRA2B Adrenergic, alpha-2B-, receptor

ADRB1 Adrenergic, beta-1-, receptor

ADRB2 Adrenergic, beta-2-, receptor, surface

ADRB3 Adrenergic, beta-3-, receptor

AGRP Agouti related protein homolog (mouse)

AGTRAP Angiotensin II receptor-associated protein

ALB Albumin

ALOX12 Arachidonate 12-lipoxygenase

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ALOX15 Arachidonate 15-lipoxygenase

ALOX5AP Arachidonate 5-lipoxygenase-activating protein

APOBEC3F Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

APOBEC3G Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

APOH Apolipoprotein H (beta-2-glycoprotein I)

AQP1 Aquaporin 1 (channel-forming integral protein, 28kDa)

AQP3 Aquaporin 3

AVPR1B Arginine vasopressin receptor 1B

B3GALT3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3

B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

BDKRB2 Bradykinin receptor B2

BF B-factor, properdin

BGLAP Bone gamma-carboxyglutamate (gla) protein (osteocalcin)

BSG Basigin (OK blood group)

C1QA Complement component 1, q subcomponent, alpha polypeptide

C1QBP Complement component 1, q subcomponent binding protein

C2 Complement component 2


C3AR1 Complement component 3a receptor 1

C4BPB Complement component 4 binding protein, beta


CASR Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)

CAT Catalase

CBR1 Carbonyl reductase 1

CBR3 Carbonyl reductase 3

CCR2 Chemokine (C-C motif) receptor 2

CD151 CD151 antigen

CD36 CD36 antigen (collagen type I receptor, thrombospondin receptor)

CD9 CD9 antigen (p24)

CEACAM1 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

CEACAM8 Carcinoembryonic antigen-related cell adhesion molecule 8

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CEBPA CCAAT/enhancer binding protein (C/EBP), alpha

CEBPB CCAAT/enhancer binding protein (C/EBP), beta

CFH Complement factor H

CHUK Conserved helix-loop-helix ubiquitous kinase

CKLF Chemokine-like factor

CKM Creatine kinase, muscle

CLSPN Claspin homolog (Xenopus laevis)

COCH Coagulation factor C homolog, cochlin (Limulus polyphemus)

CPB2 Carboxypeptidase B2 (plasma, carboxypeptidase U)

CPSF4 Cleavage and polyadenylation specific factor 4, 30kDa

CRF C1q-related factor

CRP C-reactive protein, pentraxin-related

CSF2 Colony stimulating factor 2 (granulocyte-macrophage)

CSF3 Colony stimulating factor 3 (granulocyte)

CSF3R Colony stimulating factor 3 receptor (granulocyte)

CXCL12 Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

CXCR4 Chemokine (C-X-C motif) receptor 4

CYB5R4 Cytochrome b5 reductase 4



CYP4F2 Cytochrome P450, subfamily IVF, polypeptide 2

CYP4F3 Cytochrome P450, family 4, subfamily F, polypeptide 3

DAF Decay accelerating factor for complement (CD55, Cromer blood group system)

DCN Decorin

DO Dombrock blood group

EDAR Ectodysplasin A receptor

ELN Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)

ENG Endoglin (Osler-Rendu-Weber syndrome 1)

EPHB6 EphB6

EPPB9 B9 protein

ERMAP Erythroblast membrane-associated protein

25

F10 Coagulation factor X

F11 Coagulation factor XI (plasma thromboplastin antecedent)

F12 Coagulation factor XII (Hageman factor)

F13A1 Coagulation factor XIII, A1 polypeptide

F13B Coagulation factor XIII, B polypeptide

F2 Coagulation factor II (thrombin)

F2R Coagulation factor II (thrombin) receptor

F2RL1 Coagulation factor II (thrombin) receptor-like 1



F3 Coagulation factor III (thromboplastin, tissue factor)

F5 Coagulation factor V (proaccelerin, labile factor)

F7 Coagulation factor VII (serum prothrombin conversion accelerator)

F8 Coagulation factor VIII, procoagulant component (hemophilia A)

F9 Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)

FCN3 Ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

FGA Fibrinogen, A alpha polypeptide

FGB Fibrinogen, B beta polypeptide

FGG Fibrinogen, gamma polypeptide

FGL1 Fibrinogen-like 1

FGL2 Fibrinogen-like 2

FLJ23878 Hypothetical protein FLJ23878

FOXA2 Forkhead box A2

FOXA3 Forkhead box A3

FSBP Fibrinogen silencer binding protein

FUK Fucokinase

FUT1 Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)

FUT2 Fucosyltransferase 2 (secretor status included)

FUT3 Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included)

GAS6 Growth arrest-specific 6

GATA3 GATA binding protein 3

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GBGT1 Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

GP1BA Glycoprotein Ib (platelet), alpha polypeptide

GPR109A G protein-coupled receptor 109A

GPR109B G protein-coupled receptor 109B

GPR154 G protein-coupled receptor 154

GPR81 G protein-coupled receptor 81

GYPC Glycophorin C (Gerbich blood group)

HABP2 Hyaluronan binding protein 2

HMGB1 High-mobility group box 1

HMOX1 Heme oxygenase (decycling) 1

HNF4A Hepatocyte nuclear factor 4, alpha

HPGD Hydroxyprostaglandin dehydrogenase 15-(NAD)


ICAM1 Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

ICAM4 Intercellular adhesion molecule 4, Landsteiner-Wiener blood group

IFNAR1 Interferon (alpha, beta and omega) receptor 1

IFNAR2 Interferon (alpha, beta and omega) receptor 2

IFNG Interferon, gamma

IFNGR1 Interferon gamma receptor 1

IFNGR2 Interferon gamma receptor 2 (interferon gamma transducer 1)

IGF1 Insulin-like growth factor 1 (somatomedin C)

IGF2 Insulin-like growth factor 2 (somatomedin A)

IGF2AS Insulin-like growth factor 2, antisense

IKBKB Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IKBKE Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IL10 Interleukin 10

IL10RA Interleukin 10 receptor, alpha

IL10RB Interleukin 10 receptor, beta

IL11 Interleukin 11


IL12A Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

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IL12B Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

IL12RB1 Interleukin 12 receptor, beta 1

IL12RB2 Interleukin 12 receptor, beta 2

IL13 Interleukin 13

IL13RA2 Interleukin 13 receptor, alpha 2


IL16 Interleukin 16 (lymphocyte chemoattractant factor)

IL17 Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17B Interleukin 17B

IL17RB Interleukin 17 receptor B

IL19 Interleukin 19

IL1A Interleukin 1, alpha

IL1B Interleukin 1, beta

IL1F10 Interleukin 1 family, member 10 (theta)

IL1F5 Interleukin 1 family, member 5 (delta)

IL1F6 Interleukin 1 family, member 6 (epsilon)

IL1F7 Interleukin 1 family, member 7 (zeta)

IL1F8 Interleukin 1 family, member 8 (eta)

IL1F9 Interleukin 1 family, member 9

IL1R1 Interleukin 1 receptor, type I

IL1R2 Interleukin 1 receptor, type II

IL1RL2 Interleukin 1 receptor-like 2

IL1RN Interleukin 1 receptor antagonist

IL2 Interleukin 2

IL20 Interleukin 20

IL21 Interleukin 21

IL21R Interleukin 21 receptor

IL22 Interleukin 22

IL22RA2 Interleukin 22 receptor, alpha 2

IL24 Interleukin 24

IL26 Interleukin 26

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IL2RG Interleukin 2 receptor, gamma (severe combined immunodeficiency)

IL3 Interleukin 3 (colony-stimulating factor, multiple)

IL3RA Interleukin 3 receptor, alpha (low affinity)

IL4 Interleukin 4

IL4R ILK4R

IL5 Interleukin 5 (colony-stimulating factor, eosinophil)


IL6 Interleukin 6 (interferon, beta 2)


IL8 Interleukin 8



IL9 Interleukin 9


IRAK4 Interleukin-1 receptor-associated kinase 4

ITGA2 Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

ITGA8 Integrin, alpha 8

JAK3 Janus kinase 3 (a protein tyrosine kinase, leukocyte)

KEL Kell blood group

KLF2 Kruppel-like factor 2 (lung)

KLF4 Kruppel-like factor 4 (gut)

KLK1 Kallikrein 1, renal/pancreas/salivary

KLKB1 Kallikrein B, plasma (Fletcher factor) 1

KNG Kininogen

LDHB Lactate dehydrogenase B

LEP Leptin (obesity homolog, mouse)

LIPE Lipase, hormone-sensitive

LOC284100 Hypothetical protein LOC284100

LPA Lipoprotein, Lp(a)

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LTA Lymphotoxin alpha (TNF superfamily, member 1)

LTB Lymphotoxin beta (TNF superfamily, member 3)

LU Lutheran blood group (Auberger b antigen included)

MAP3K8 Mitogen-activated protein kinase kinase kinase 8

MAPT Microtubule-associated protein tau

MC1R Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

MCP Membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)

MGP Matrix Gla protein

MMP3 Matrix metalloproteinase 3 (stromelysin 1, progelatinase)

MMP9 Matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase)

NCOA1 Nuclear receptor coactivator 1

NFE2 Nuclear factor (erythroid-derived 2), 45kDa

NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NFKBIB Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

NFKBIE Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

NOS3 Nitric oxide synthase 3 (endothelial cell)

NR1I2 Nuclear receptor subfamily 1, group I, member 2

OPN4 Opsin 4 (melanopsin)

OTUD4 HIV-1 induced protein HIN-1

OTUD4 HIV-1 induced protein HIN-1

PAN3 PABP1-dependent poly A-specific ribonuclease subunit PAN3

PCSK9 Proprotein convertase subtilisin/kexin type 9

PCYT1A Phosphate cytidylyltransferase 1, choline, alpha

PCYT1B Phosphate cytidylyltransferase 1, choline, beta

PDIA2 Protein disulfide isomerase family A, member 2

PFC Properdin P factor, complement

PLA2G7 Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

PLAT Plasminogen activator, tissue

PLAU Plasminogen activator, urokinase

PLAUR Plasminogen activator, urokinase receptor

PLG Plasminogen

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PLTP Phospholipid transfer protein

POLG2 Polymerase (DNA directed), gamma 2, accessory subunit

PON1 Paraoxonase 1

PON2 Paraoxonase 2

PON3 Paraoxonase 3

PPARA Peroxisome proliferative activated receptor, alpha

PPARG Peroxisome proliferative activated receptor, gamma

PPARGC1A Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

PPM1D Protein phosphatase 1D magnesium-dependent, delta isoform

PRKACA Protein kinase, cAMP-dependent, catalytic, alpha

PRKACB Protein kinase, cAMP-dependent, catalytic, beta

PRKACG Protein kinase, cAMP-dependent, catalytic, gamma

PROC Protein C (inactivator of coagulation factors Va and VIIIa)

PROCR Protein C receptor, endothelial (EPCR)

PROS1 Protein S (alpha)

PROZ Protein Z, vitamin K-dependent plasma glycoprotein

PSD4 Pleckstrin and Sec7 domain containing 4

PTGDR Prostaglandin D2 receptor (DP)

PTGDS Prostaglandin D2 synthase 21kDa (brain)

PTGER2 Prostaglandin E receptor 2 (subtype EP2), 53kDa

PTGER4 Prostaglandin E receptor 4 (subtype EP4)

PTGES Prostaglandin E synthase



RAB38 RAB38, member RAS oncogene family

RAP1B RAP1B, member of RAS oncogene family

RELA V-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)

RIPK1 Receptor (TNFRSF)-interacting serine-threonine kinase 1

SCMH1 Sex comb on midleg homolog 1 (Drosophila)

SCYA2 Small inducible cytokine A2 (monocyte chemotactic protein 1)

SEC15L2 SEC15-like 2 (S. cerevisiae)

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SELE Selectin E (endothelial adhesion molecule 1)

SELL Selectin L (lymphocyte adhesion molecule 1)

SELP Selectin P (granule membrane protein 140kD, antigen CD62)

SELPLG Selectin P ligand

SEMA7A Sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

SERPINA10 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

SERPINA5 Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

SERPINC1 Serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

SERPINE1 Serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPING1 Serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)

SFTPA1 Surfactant, pulmonary-associated protein A1

SFTPA2 Surfactant, pulmonary-associated protein A2

SFTPB Surfactant, pulmonary-associated protein B

SFTPC Surfactant, pulmonary-associated protein C

SFTPD Surfactant, pulmonary-associated protein D

SLC14A1 Solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

SLC20A1 Solute carrier family 20 (phosphate transporter), member 1

SLC4A1 Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

SLCO1B1 Solute carrier organic anion transporter family, member 1B1

SMP1 Small membrane protein 1

STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor)

STAT4 Signal transducer and activator of transcription 4

STAT6 Signal transducer and activator of transcription 6, interleukin-4 induced

TCF1 Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor

TF Transferrin

TFPI Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)


THBD Thrombomodulin

THBS4 Thrombospondin 4

TIRAP Toll-interleukin 1 receptor (TIR) domain-containing adapter protein

TNF Tumor necrosis factor (TNF superfamily, member 2)

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TNFAIP1 Tumor necrosis factor, alpha-induced protein 1 (endothelial)

TNFAIP2 Tumor necrosis factor, alpha-induced protein 2

TNFAIP3 Tumor necrosis factor, alpha-induced protein 3

TNFRSF1A Tumor necrosis factor receptor superfamily, member 1A

TNFRSF1B Tumor necrosis factor receptor superfamily, member 1B

TNNI3K TNNI3 interacting kinase

TRADD TNFRSF1A-associated via death domain



TRPV5 Transient receptor potential cation channel, subfamily V, member 5

TRPV6 Transient receptor potential cation channel, subfamily V, member 6

TTRAP TRAF and TNF receptor associated protein

TYK2 Tyrosine kinase 2

USF1 Upstream transcription factor 1

VCAM1 Vascular cell adhesion molecule 1

VEGF Vascular endothelial growth factor

VKORC1 Vitamin K epoxide reductase complex, subunit 1

VKORC1L1 Vitamin K epoxide reductase complex, subunit 1-like 1

VLDLR Very low density lipoprotein receptor

VTN Vitronectin (serum spreading factor, somatomedin B, complement S-protein)

VWF Von Willebrand factor

XK Kell blood group precursor (McLeod phenotype)

ZNF202 Zinc finger protein 202

Supplemental material Daniel A. Rossignol Hugo …...CDK7 Cyclin-dependent kinase 7 (MO15 homolog,...

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Transcript of Supplemental material Daniel A. Rossignol Hugo …...CDK7 Cyclin-dependent kinase 7 (MO15 homolog,...