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Supplemental figures
Phosphosulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: Enhanced efficacy and mitochondria targeting by its formulation in solid lipid
nanoparticles
0
200
400
PS PS sulfone Sulindac S. sulfone S. sulfide
Tu
mo
r d
rug
lev
el
pm
ole
/mg
pro
tein
Xenograft
Lung
Liver
Small intestine
Suppl.Fig.1 Drug level of PS and its metabolites in four organs after treated with PS via po.
S. sulfide
P=0.038
0%
15%
30%
45%
0 20 40 60 80 100
S. sulfideP=0.009
0%
20%
40%
60%
0 20 40 60 80 100
Sulindac
P = 0.041
0%
15%
30%
45%
0 100 200 300 400 500
Sulindac
P = 0.0001
0%
20%
40%
60%
0 100 200 300 400 500
S. sulfone
P=0.129
0%
15%
30%
45%
0 50 100 150 200
S. sulfone
P=0.017
0%
20%
40%
60%
0 50 100 150 200
TU
NE
L (
+)%
C
ell
Ki-
67
(+
)% C
ell
Drug level, pmole/mg protein
Suppl.Fig.2 Correlation between tumor drug level and Ki-67 or TUNEL positive cell ratio.