Supplemental Figure 2 - Reaction Biologyreactionbiology.com/webapps/largedata/Supplemental Figure...
Transcript of Supplemental Figure 2 - Reaction Biologyreactionbiology.com/webapps/largedata/Supplemental Figure...
Bos
utin
ib
AM
PK
Inhi
bito
r, C
ompo
und
C
Sun
itini
b
Dov
itini
b
Syk
Inhi
bito
r
GS
K−3
Inhi
bito
r IX
Sta
uros
porin
e, N
−ben
zoyl
−
SU
1165
2
Indi
rubi
n D
eriv
ativ
e E
804
SB
218
078
Sta
uros
porin
e, S
trept
omyc
es s
p.
K−2
52a,
Noc
ardi
opsi
s sp
.
Cdk
1/2
Inhi
bito
r III
Gˆ 6
976
PK
R In
hibi
tor
JAK
3 In
hibi
tor V
I
JAK
Inhi
bito
r I
Isog
ranu
latim
ide
Met
Kin
ase
Inhi
bito
r
IKK
−2 In
hibi
tor I
V
VE
GF
Rec
epto
r 2 K
inas
e In
hibi
tor I
II
Auro
ra K
inas
e/C
dk In
hibi
tor
Als
terp
aullo
ne, 2
−Cya
noet
hyl
Cdk
4 In
hibi
tor
Als
terp
aullo
ne
SU
9516
Am
inop
urva
lano
l A
GS
K−3
Inhi
bito
r X
Flt−
3 In
hibi
tor I
I
Indi
rubi
n−3?
−mon
oxim
e
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K−3
Inhi
bito
r XIII
Cdk
2 In
hibi
tor I
V, N
U61
40
SU
6656
GS
K3b
Inhi
bito
r XII,
TW
S11
9
Das
atin
ib
Vand
etan
ib
Lck
Inhi
bito
r
Toza
serti
b
PD
GF
RTK
Inhi
bito
r
Pazo
pani
b
Ro−
32−0
432
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indo
lylm
alei
mid
e IV
PK
Cb
Inhi
bito
r
Bis
indo
lylm
alei
mid
e I
Go
6983
JNK
Inhi
bito
r II
PK
R In
hibi
tor,
Neg
ativ
e C
ontro
l
Alo
isin
e A
, RP
107
Alo
isin
e, R
P10
6
Pur
vala
nol A
Com
poun
d 52
Cdk
1 In
hibi
tor,
CG
P74
514A
Nilo
tinib
PD
GF
Rec
epto
r Tyr
osin
e K
inas
e In
hibi
tor I
V
Sor
afen
ib
PD
K1/
Akt
/Flt
Dua
l Pat
hway
Inhi
bito
r
Syk
Inhi
bito
r II
VE
GF
Rec
epto
r 2 K
inas
e In
hibi
tor I
I
VE
GF
Rec
epto
r 2 K
inas
e In
hibi
tor I
Flt−
3 In
hibi
tor I
II
VE
GF
Rec
epto
r 2 K
inas
e In
hibi
tor I
V
PP
1 A
nalo
g II,
1N
M−P
P1
JAK
3 In
hibi
tor I
I
Src
Kin
ase
Inhi
bito
r I
BP
IQ−I
AG 1
478
Com
poun
d 56
EG
FR/E
rbB
−2/E
rbB
−4 In
hibi
tor
EG
FR/E
rbB
−2 In
hibi
tor
PD
158
780
Erlo
tinib
Gef
itini
b
Kenp
aullo
ne
Cdk
/Crk
Inhi
bito
r
JNK
Inhi
bito
r V
STO
−609
Cas
ein
Kin
ase
II In
hibi
tor I
II, T
BC
A
Cdc
2−Li
ke K
inas
e In
hibi
tor,
TG00
3
p38
MA
P K
inas
e In
hibi
tor I
II
PD
169
316
p38
MA
P K
inas
e In
hibi
tor
SK
F−86
002
SB
2200
25
SB
202
190
SB
203
580
GS
K−3
b In
hibi
tor X
I
H−8
9, D
ihyd
roch
lorid
e
HA
107
7, D
ihyd
roch
lorid
e, F
asud
il
GTP
−145
64
IRA
K−1
/4 In
hibi
tor
Flt−
3 In
hibi
tor
DM
BI
VE
GF
Rec
epto
r Tyr
osin
e K
inas
e In
hibi
tor I
II, K
RN
633
VE
GF
Rec
epto
r Tyr
osin
e K
inas
e In
hibi
tor I
I
Mas
itini
b
Imat
inib
PD
GF
Rec
epto
r Tyr
osin
e K
inas
e In
hibi
tor I
II
Vata
lani
b
AGL
2043
Tand
utin
ib
PI 3
−Kg
Inhi
bito
r
PI 3
−Kg
Inhi
bito
r II
Tpl2
Kin
ase
Inhi
bito
r
PD
174
265
Lapa
tinib
JNK
Inhi
bito
r, N
egat
ive
Con
trol
Rho
Kin
ase
Inhi
bito
r III,
Roc
kout
RO
CK
Inhi
bito
r, Y
−276
32
Rho
Kin
ase
Inhi
bito
r IV
Ros
covi
tine
Cdk
2 In
hibi
tor I
II
Boh
emin
e
VX
−702
MN
K1
Inhi
bito
r
ER
K In
hibi
tor I
I, FR
1802
04
TGF−
b R
I Kin
ase
Inhi
bito
r
TGF−
b R
I Inh
ibito
r III
SC
−683
76
IC26
1
Cas
ein
Kin
ase
I Inh
ibito
r, D
4476
Auro
ra K
inas
e In
hibi
tor I
II
Tofa
citin
ib
Wor
tman
nin
Fasc
aply
sin,
Syn
thet
ic
AG 1
296
AG 1
295
Chk
2 In
hibi
tor I
I
Cdk
4 In
hibi
tor I
II
Cdk
4 In
hibi
tor I
I, N
SC
625
987
Che
lery
thrin
e C
hlor
ide
Cdk
1/5
Inhi
bito
r
Cdk
1 In
hibi
tor
cFM
S R
ecep
tor T
yros
ine
Kin
ase
Inhi
bito
r
PK
CbI
I/EG
FR In
hibi
tor
PD
GF
Rec
epto
r Tyr
osin
e K
inas
e In
hibi
tor I
I
PI−
103
PP
3
PD
980
59
LY 2
9400
2
JNK
Inhi
bito
r VIII
JNK
Inhi
bito
r IX
NF−
kB A
ctiv
atio
n In
hibi
tor
KN
−62
KN
−93
LY 3
0351
1− N
egat
ive
cont
rol
MK
2a In
hibi
tor
ME
K1/
2 In
hibi
tor
JAK
3 In
hibi
tor I
V
ME
K In
hibi
tor I
ME
K In
hibi
tor I
I
AG 1
024
GS
K−3
b In
hibi
tor V
III
GS
K−3
b In
hibi
tor I
I
AG 1
12
Syk
Inhi
bito
r III
AG 9
AG 4
90
Mub
ritin
ib
SB
202
474,
Neg
ativ
e co
ntro
l for
p38
MA
PK
Sph
ingo
sine
Kin
ase
Inhi
bito
r
Rap
amyc
in
EG
FR In
hibi
tor
DN
A−P
K In
hibi
tor I
I
IGF−
1R In
hibi
tor I
I
Her
bim
ycin
A, S
trept
omyc
es s
p.
GS
K−3
b In
hibi
tor I
ER
K In
hibi
tor I
II
DN
A−P
K In
hibi
tor V
DN
A−P
K In
hibi
tor I
II
Dia
cylg
lyce
rol K
inas
e In
hibi
tor I
I
ATM
Kin
ase
Inhi
bito
r
Akt
Inhi
bito
r X
Bcr
−abl
Inhi
bito
r
BAY
11−
7082
Akt
Inhi
bito
r V, T
riciri
bine
ATM
/ATR
Kin
ase
Inhi
bito
r
Akt
Inhi
bito
r IV
Akt
Inhi
bito
r VIII
, Iso
zym
e−S
elec
tive,
Akt
i−1/
2
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