SUNDAY 28 SEPTEMBER 2014 - ASBMB · Management, Australian Centre for International Agricultural...

SUNDAY 28 SEPTEMBER 2014

15:00 – 19:00

REGISTRATION

Location: Main Foyer

16:00 – 19:30

CAREER DEVELOPMENT FORUM

Convenors: Dr Jean Finnegan, CSIRO, ACTDr Ulrike Mathesius, Australian National University,ACT

Location: Finkel Theatre, JCSMR, Australian National University

16:00 Dr Sharath SriramDeputy Chair, Australian Early/Mid Career ResearcherForum, Australian Academy of Science School ofElectrical and Computer Engineering, RMIT University

‘EMCR Challenges: Minimising setbacks andmaximising professional development’

16:20 Dr Maude BernouxCSIRO, Agriculture Flagship

‘Being a French woman and making a scientific careerat CSIRO’

16:40 Dr Rowena MartinDivision of Biomedical Science and BiochemistryResearch School of Biology, ANU

‘A how-to guide for CVs, fellowships, and prizeapplications’

SUNDAY 28 SEPTEMBER 2014

17:00 Dr Eric HuttnerProgram Manager for Crop Improvement andManagement, Australian Centre for InternationalAgricultural Research (ACIAR)

‘A career in science and its applications’

17:20 Break

17:35 A/Prof Susan HowittDivision of Biomedical Science and BiochemistryResearch School of Biology, ANU

‘Science, teaching and scientific teaching’

17:55 Professor Harvey MillarARC Centre of Excellence in Plant Energy Biology,The University of Western Australia

‘In 2 A4 pages explain why it matters so much’

18:15 Professor Hans LambersSchool of Plant Biology, The University of WesternAustralia

‘Preparing your results for publication - maximisingyour chances to get your manuscript rapidly accepted’

18:35 Discussion and drinks

MONDAY 29 SEPTEMBER 2014

07:30 - 08:30

REGISTRATION

Location: Main Foyer

08:30 – 08:45CONFERENCE OPENING

Chair: Professor Edna Hardeman, University of New SouthWales, NSWChair, ComBio2014 Local Organizing Committee

Location: Royal Theatre

Professor Peter Gunning, ASBMB PresidentProfessor Tim Colmer, ASPS PresidentA/Prof Carol Wicking, ANZSCDB President


08:45 – 09:30

PLENARY 1

PLENARY LECTURE

Chair: Professor Richard Harvey, Victor Chang Cardiac ResearchInstitute, NSW


PLE-MON-01The stability and reversal of cell differentiationGurdon, J.B. (United Kingdom)

Dr John Gurdon

John Gurdon was a Zoology undergraduate at OxfordUniversity and returned, after a postdoctoral year atCalTech, as Lecturer in Embryology. In 1971, he joinedthe MRC molecular biology lab in Cambridge tocontinue his work on Amphibian developmental biology.In 1983, as John Humphrey Plummer Professor of CellBiology at the University of Cambridge, he co-founded aresearch institute of developmental and cancer biology

(now named the Gurdon Institute) with Professor Laskey, acting as Chairmanuntil 2002. His career has concentrated on nuclear transplantation in the frogand experiments to discover the value of mRNA microinjection, mechanismsof response to morphogen gradients, and recently, mechanisms of nuclearreprogramming by Xenopus oocytes and eggs. Master of Magdalene CollegeCambridge from 1995–2002, he has received various recognitions, includingthe 2009 Lasker Award for Basic Medical Science and the Nobel Prize forPhysiology or Medicine in 2012.


08:50 - 09:30

PLENARY 2

ANNALS OF BOTANY LECTURE

Chair: Professor Hans Lambers, The University of WesternAustralia, WA

Location: Bradman Theatrette

PLE-MON-02Plant responses to global climate changes, how plants copewith heat, drought and viral infectionsPrasch, C., Ott, O., Hirschmueller, H., Zhang, Z. andSonnewald, U. (Germany)

Professor Uwe Sonnewald

Uwe Sonnewald received his PhD in 1989 from the FreeUniversity of Berlin. From 1989 to 1992, he was a postdocat the Institute for Genbiologische Forschung in Berlin. In1992, he became group leader at the Institut fürPflanzengenetik und Kulturpflanzenforschung (IPK) inGatersleben. In the same year he was honored with anaward from the Federation of European Societies of PlantPhysiology for his work in the field of Molecular Plant

Physiology. In 1998, he became head of the Department Molecular CellBiology at the IPK and full professor at the University Halle-Wittenberg. SinceDecember 2004, he has been a full professor of Biochemistry at the Friedrich-Alexander University Erlangen-Nürnberg. He is member of the selectioncommittee of the Alexander von Humboldt Foundation and has published morethan 200 publications in peer-reviewed scientific journals, including NatureBiotechnology and The Plant Cell, plus more than 30 issued patents and patentapplications.


09:35 - 10:15

PLENARY 3

PLENARY LECTURE

Chair: Professor Peter Gunning, University of New South Wales,NSW


PLE-MON-03Navigating the cellular landscape with new optical probes,imaging strategies and technical innovationsLippincott-Schwartz, J. (USA)

Dr Jennifer Lippincott-Schwartz

Dr Jennifer Lippincott-Schwartz is Section Chief of the CellBiology and Metabolism Branch, National Institute of ChildHealth and Human Development at the National Institutesof Health (NIH) and is an NIH Distinguished Investigator.Dr Lippincott-Schwartz’s lab develops and applies lightmicroscopy approaches, such as photoactivatablefluorescence imaging and super-resolution lightmicroscopy, to study biological systems quantitatively. Shehas pioneered the use of photoactivatable green fluorescent

protein (GFP) to visualise the dynamic activity of discrete protein populationsin live cells. With Dr Eric Betzig, she developed the super-resolutionfluorescence microscopy method of PALM, which breaks the diffraction limitand allows fluorescence imaging with nanometer-scale resolution. Her labapplies this high resolution imaging method to investigate the nanoscaledistribution and activity of single molecules in their native cellularenvironment. Dr Lippincott-Schwartz received her BA from SwarthmoreCollege and her PhD from the Johns Hopkins University. She is a member ofthe National Academy of Sciences (NAS) and also a member of the Institute ofMedicine of the NAS. She has received numerous honors for her pioneeringwork. She is President of the American Society of Cell Biology for 2014


09:35 - 10:15

PLENARY 4

PLENARY LECTURE

Chair: Dr Elizabeth Dennis, CSIRO Plant Industry, ACTLocation: Bradman Theatrette

PLE-MON-04The plant vascular system: An RNA and protein informationsuperhighwayLucas, W.J. (USA)

Professor William (Bill) Lucas

William (Bill) Lucas is Distinguished Professor and Chairof the Department of Plant Biology at the University ofCalifornia, Davis. After receiving his PhD in 1975 from theUniversity of Adelaide in the laboratory of Andrew Smith,he moved to Canada, where he worked as a postdoctoralfellow and then Research Fellow with Jack Dainty at theUniversity of Toronto. He was appointed AssistantProfessor at the University of California in 1977, advanced

to Associate Professor in 1980 and promoted to Professor in 1983. Bill’s mainresearch interests center on the role of plasmodesmata and the phloem aspathways for local and long-distance trafficking of informationmacromolecules in the orchestration of physiological and developmentalevents, at both the tissue and whole-plant levels.

10:15 – 10:45 MORNING TEA / EXHIBITION / POSTERSLocation: Exhibition Hall


10:45 - 12:15

SYMPOSIUM 1

PLANT DEVELOPMENT

Chairs: A/Prof Jim Weller, University of Tasmania, TASDr Michelle Watt, CSIRO Plant Industry, ACT


10:45 SYM-01-01Hormonal regulation of differential cell growthBenkova, E. (Austria)

11:05 SYM-01-02ASPS 2014 Functional Plant Biology Best PaperAward LectureAuxins or ethylene - who controls grape berry ripening?Boettcher, C., Boss, P.K. and Davies, C. (Australia)

11:25 SYM-01-03Apical dominance, the powerful role of sugar demand and thesecond fiddle role of hormonesBeveridge, C.A., Mason, M.G., Ross, J.J., Babst, B.A., Kerr,S., Gui, R. and Weinclaw, B. (Australia, USA and China)

11:45 SYM-01-04Spatial metabolic profiling of the barley root in response to saltstressShelden, M.C., Bacic, A., Dias, D.A., Tyerman, S.D. andRoessner, U. (Australia)

12:00 SYM-01-05New Functions for flavonoids in legume nodule developmentHassan, A., Ng, J.L.P., Wasson, A.P., Frugier, F., Truong, T.,Hocart, C.H. and Mathesius, U. (Australia and France)


10:45 - 12:15

SYMPOSIUM 2

ECOSYSTEM ADAPTATION TO CLIMATE VARIABILITY

Chair: A/Prof Justin Borevitz, Australian National University,ACT

Location: Menzies Theatrette

10:45 SYM-02-01Using community and ecosystem genetics to develop genetics-based solutions to climate change and other global challengesWhitham, T.G. (USA)

11:05 SYM-02-02Eucalyptus landscape genomicsBragg, J.G. (Australia)

11:25 SYM-02-03Evolution of a iconic wide spread eucalypt, the river red gum,in response to climateDillon, S., Bragg, J., Rees, G., Baldwin, D., McEvoy, R. andSoutherton, S. (Australia)

11:45 SYM-02-04Global patterns of heat-wave risks to higher plantsAtkin, O.K., O'Sullivan, O.S., Heskel, M.A., Reich, P.B.,Tjoelker, M.G. Weerasinghe, K.W.L.K., Egerton, J.J.G.,Bloomfield, K.J., Creek, D. and Meir, P. (Australia)

12:00 SYM-02-05Identifying genetic architecture of adaptive traits inBrachypodium in variable climatesWilson, P.B., Streich, J.C., Brown, T.B., Cheng, R., Murray,K.D. and Borevitz, J.O. (Australia)


10:45 - 12:15

SYMPOSIUM 3

BLOOD DEVELOPMENTAL BIOLOGY

Chairs: Dr Samir Taoudi, Walter & Eliza Hall Institute of MedicalResearch, VICA/Prof John Pimanda, University of New South Wales,NSW

Location: Sutherland Theatrette

10:45 SYM-03-01Identification of hemogenic precursor cells in vivoMoore, K. (USA)

11:05 SYM-03-02Dissecting pathways of human hematopoietic developmentusing pluripotent stem cellsElefanty, A.G. (Australia)

11:25 SYM-03-03Genetic fate mapping of mesenchymal stem-like cells and theircontribution to developmental hematopoiesisChandrakanthan, V., Knezevic, K., Qiao, Q., Kang, Y.C. andPimanda, J. (Australia)

11:45 SYM-03-04Analysis of human globin gene switching during embryonicstem cell differentiationDiepstraten, S., Vadolas, J., McColl, B., Chan, C.K. and Hart,A. (Australia)

12:00 SYM-03-05MiR-155 reduces colony formation and proliferation of AML invitro, but does it delay disease onset in vivo?Narayan, N., Brumatti, G., Goodall, G.J., Jabbour, A.M. andEkert, P.G. (Australia)


10:45 - 12:15

SYMPOSIUM 4

GENE REGULATION

Chairs: Professor Merlin Crossley, University of New SouthWales, NSWProfessor Melissa Brown, University of Queensland, QLD

Location: Swan Room

10:45 SYM-04-01 LabGear Australia Discovery ScienceAward LectureTherapeutic alternative splicing: opportunities and challengesWilton, S.D. and Fletcher, S. (Australia)

11:05 SYM-04-02Identification of 2500 novel protein isoforms arising from anunusual outcome of alternative splicingFahrer, A.M. and Wilson, L.O.W. (Australia)

11:25 SYM-04-03Epigenome profiling of primary human subcutaneous andfisceral adipocytes reveals differences in potential regulation ofdevelopmental and metabolism genesBradford, S.T., Van Dijk, S., Nair, S.S., Statham, A.L.,French, H.J., Peters, T.J., Lord, R.V., Samaras, K., Molloy, P.L.and Clark, S.J. (Australia)

11:45 SYM-04-04ATRX dependent deposition of H3.3 at heterochromatin isnecessary for the maintenance of chromatin statesVoon, H.P.J., Hughes, J., Rode, C., Jenuwein, T., Feil, R.,Higgs, D.R. and Gibbons, R.J. (UK, Australia, Germany andFrance)

12:00 SYM-04-05Creating and characterizing epialleles in wheatFinnegan, E.J., Boden, S., Cavanagh, C., Swain, S. andTrevaskis, B. (Australia)


10:45 - 12:15

SYMPOSIUM 5

TISSUE ARCHITECTURE, SIGNALLING AND GROWTH

Chairs: A/Prof Helena Richardson, Peter MacCallum CancerCentre, VICA/Prof Kieran Harvey, Peter MacCallum Cancer Centre,VIC


10:45 SYM-05-01The two faces of Hippo: the Hippo signaling pathway inmammalian development, regeneration and diseaseJohnson, R.L. (USA)

11:05 SYM-05-02Lgl regulates notch signaling via endocytosis in the developingdrosophila eyePortela, M., Parsons, L.M. Grzeschik, N.A. and Richardson,H.E. (Australia and The Netherlands)

11:25 SYM-05-03Defining the role of innate immunity and nerve signalling in theregulation of adult salamander limb regenerationGodwin, J.W. and Rosenthal, N. (Australia and UnitedKingdom)

11:45 SYM-05-04Polarity protein control of epithelial plasticityShewan, A.M. (Australia)

12:00 SYM-05-05Tropomyosin based regulation of actin dynamics at the leadingedge of migrating cellsBrayford, S., Schevzov, G. and Gunning, P (Australia)


10:45 - 12:15

SYMPOSIUM 6

CANCER SIGNALLING

Chairs: Professor Rick Pearson, Peter MacCallum Cancer Centre,VICProfessor Kum Kum Khanna, Queensland Institute ofMedical Research, QLD

Location: Nicholls Theatrette

10:45 SYM-06-01The Ras-ERK-RSK pathway & regulation of cell fate decisionsBlenis, J. (USA)

11:05 SYM-06-02Novel roles for the pseudokinases SgK223 and SgK269 incancer progressionLiu, L., Tactacan, C.M., Lee, R., Humphrey, E.S., Chan, H.,Phua, Y., Zhang, L. and Daly, R.J. (Australia)

11:25 SYM-06-03Resistance to MAPK inhibitors in melanoma: insights for futuretherapiesRizos, H., Menzies, A.M., Pupo, G.M., Carlino, M.S., Fung, C.,Johansson, P., Hayward, N.K., Scolyer, R.A., Kefford, R.F. andLong G.V. (Australia)

11:45 SYM-06-04The Bromodomain, BRD4, is an RNA Pol II CTD kinase thatlinks transcription and cell cycleSinger, D.S., Devaiah, B.N., Gegonne, A. and Case Borden, C.(USA)


12:00 SYM-06-05Flicking the switch on cancer cell signalling - targeting proteinphosphatase 2A in breast cancerWatt, L.F., Copeland, B., Panicka, N., Kahl, R.G.S., Dun,M.D., Young, B., Roselli, S., Skelding, K. and Verrills, N.M.(Australia)

12:15 – 13:15 LUNCH / EXHIBITION / POSTERSLocation: Exhibition Hall


12:30 – 14:00

SYMPOSIUM 7

MAKING CELL AND DEVELOPMENTAL BIOLOGYATTRACTIVE IN THE CURRENT FUNDING CLIMATE

Chair: A/Prof Carol Wicking, University of Queensland, QLDLocation: Nicholls Theatrette

This lunchtime symposium is a discussion session with a panel of seniorcell and developmental biologists.


12:30 – 13:55

SYMPOSIUM 8

MACROMOLECULAR CRYSTALLAGRAPHY SYMPOSIUM(International Year of Crystallography)

Chair: A/Prof Aaron Oakley, University of Wollongong, NSWLocation: Menzies Theatrette

12:30 SYM-08-01Protein crystallography downunderGuss, J.M. (Australia)

13:00 SYM-08-02Crystal structures of Acinetobacter baumannii chi:SSB-Ct andchi:psi complexes reveal conserved protein-protein interactionsLi, N., Robinson, A., Oakley, A. and Dixon, N. (Australia)

13:20 SYM-08-03A molecular basis for the association of the HLA-DRB1 locus,citrullination and rheumatoid arthritisScally, S.W., Petersen, J., Law, S.C., Dudek, N.L., Nel, H.,Loh, K.L., Purcell, A.W., Reid, H.H., Thomas, R. andRossjohn, J. (Australia)

13:40 SYM-08-04Exploring CMP-sialic acid transporter structure/function usingsurface plasmon resonance and 2D electron crystallographyHadley, B., Maggioni, A., Day, C. and Tiralongo, J. (Australia)

13:15 – 14:15 POSTER SESSION ALocation: Exhibition Hall


14:15 - 14:55

PLENARY 5

PLENARY LECTURE

Chair: Dr Megan Maher, La Trobe University, VICLocation: Royal Theatre

PLE-MON-05Structural insight into the biogenesis of -barrel membraneproteinsBuchanan, S. (USA)

Dr Susan Buchanan

Dr Susan Buchanan is Chief of the Section on StructuralBiology of Membrane Proteins in the National Institute forDiabetes and Digestive and Kidney Diseases (NIDDK), atthe National Institutes of Health. She received her PhDfrom the Johann-Wolfgang-Goethe Universität in Frankfurt,Germany, in 1990. She completed postdoctoral fellowshipsat the MRC Laboratory of Molecular Biology, Cambridge,UK, and at UT Southwestern Medical Center, Dallas,

before returning to the UK to establish a research group at Birkbeck College,London, in 1998. She joined the NIDDK as a tenure track investigator in 2001and is currently a senior investigator in the Laboratory of Molecular Biology,NIDDK. Research in Dr Buchanan’s laboratory focuses on the structuredetermination of integral membrane proteins by X-ray crystallography andfunctional analysis of these proteins using biophysical, biochemical and cellbiological techniques. Current topics include small molecule and proteinimport across the bacterial outer membrane, protein secretion by pathogenicbacteria and protein import across mitochondrial outer membranes.


14:15 - 14:55

PLENARY 6

ANZSCDB PRESIDENT’S MEDAL LECTURE(Including presentation of Medal)

Sponsored by Sigma-Aldrich

Chair: A/Prof Carol Wicking, University of Queensland, QLDLocation: Bradman Theatrette

PLE-MON-06From cell biology to systems biologyJames, D.E. (Australia)

Professor David James

David James was awarded a PhD in 1985 in Physiology andBiochemistry. During this period, together with Ted Kraegenand colleagues at the Garvan Institute, he developed novelmethodologies for studying in vivo glucose metabolism insmall animals leading to a number of important discoveriesabout the role of tissue specificity of insulin action at thewhole body level. In 1985 he was awarded a FogartyFellowship and later a Juvenile Diabetes Foundation

fellowship to undertake postdoctoral training at Boston University with PaulPilch and subsequently at Washington University in St Louis. During thisperiod he provided cellular and molecular evidence to document the identityand behaviour of the insulin responsive glucose transporter GLUT4. In 1989he established his own independent career as Assist/Professor at WashingtonUniversity in St Louis funded by a Career Development Award from theJuvenile Diabetes Foundation. During this period he mapped many of themolecules and pathways that are known to be involved in the cell biology ofinsulin regulated glucose transport in muscle and fat cells. In 1993 he returnedto Australia on a Wellcome Trust Senior Research Fellowship taking up aposition at the IMB in Brisbane. In 2001 he moved to Sydney to head up theDiabetes and Obesity Research Program at the Garvan Institute. He is currentlyan NHMRC Senior Principal Research Fellow. Since returning to Australia hehas won several awards including the Glaxo Wellcome Medal for MedicalResearch and the Kellion medal for outstanding contributions to Diabetesresearch. In 2007 he was elected as a fellow of the Australian Academy ofScience. He has joined the University of Sydney as the Leonard P UllmannChair in Metabolic Science and the Domain Leader for Biology in the CharlesPerkins Centre.


15:00 - 15:40

PLENARY 7

PLENARY LECTURE

Chair: Professor Greg Goodall, Centre for Cancer Biology, SAPathology, SA


PLE-MON-07Biogenesis of PIWI-interacting RNAs in drosophila germlineSiomi, M. (Japan)

Professor Mikiko Siomi

Mikiko Siomi is a Professor in the Graduate School ofScience at the University of Tokyo, Japan. She wasawarded her PhDs from Kyoto University in 1994 and theUniversity of Tokushima in 2003. In 1999, together withHaruhiko Siomi, she founded a laboratory at theUniversity of Tokushima to study the molecular functionof Drosophila FMR1 (dFMR1). Later, her researchfocused on small RNA-mediated gene silencing pathways

in Drosophila. In 2012, she moved to her present position at the University ofTokyo, where her study of small RNA-mediated gene silencing continues


15:00 - 15:40

PLENARY 8

PLENARY LECTURE

Chair: A/Prof Nicole La Gruta, University of Melbourne, VICLocation: Bradman Theatrette

PLE-MON-08Molecular basis for thymic selection of an MHC restrictedTCR repertoireVan Laethem, F., Saba, I., Tikhonova, A. and Singer, A.(USA)

Dr Alfred Singer

Dr Alfred Singer received his BS from MIT and his MDfrom Columbia University. Alfred heads the ExperimentalImmunology Branch of the National Cancer Institute at theNational Institutes of Health. His research is focused onidentifying and characterising the signalling events thatdrive T cell differentiation in the thymus, especially thesignaling events known as ‘positive selection’ that result inthe exclusive generation of functionally mature T cells with

specificity for peptide-MHC complexes. His laboratory identified themolecular basis for thymic selection of an MHC-restricted T cell repertoire andidentified the mechanism by which developing T cells determine theirappropriate lineage fate.

15:40 – 16:15 AFTERNOON TEA / EXHIBITION / POSTERSLocation: Exhibition Hall


16:15 - 17:45

SYMPOSIUM 9

SIGNALING AND TRANSPORT IN PLANTS

Chairs: Dr Rosemary White, CSIRO Plant Industry, ACTDr Matthew Gilliham, University of Adelaide, SA


16:15 SYM-09-01Plasmodesmata: Portals controlling delivery of nutrients andsignaling agentsLucas, W.J. (USA)

16:35 SYM-09-02Vegetative bud outgrowth in pea: regulation by hormonal andflowering pathwaysDun, E.A., Beveridge, C.A. and Rameau, C. (Australia andFrance)

16:55 SYM-09-03Networks regulating hormone-mediated plant growthLewsey, M.G., Huang, C.S., Zander, M., Song, L., Xie, M.,Wise, A., Weirauch, M.T., Hughes, T.R., Bar-Joseph, Z. andEcker, J.R. (USA, Spain and Canada)

17:15 SYM-09-04The Arabidopsis phosphate exporter PH01: 3 distinct domainsinvolved in subcellular localization, phosphate transport andphosphate deficiency responseWege, S., Khan, G.A., Vogiatzaki, E., Jung, J.Y., Aller, I.,Meyeer, A.J. and Poirier, Y. (Switzerland, Germany andAustralia)

17:30 SYM-09-05Epistatic regulation of cis-carotenoid signaling metabolitesaffects chloroplast differentiation, nuclear gene expression andplant developmentCazzonelli, C.I., Hou, X., Watkins, J., Holland, S.,Shashikanth, M., Nisar, N. and Pogson, B.J. (Australia)


16:15 - 17:45

SYMPOSIUM 10

GENE REGULATORY NETWORKS, EPIGENETICS ANDNON-CODING RNAs IN DEVELOPMENT

Chairs: Dr Tim Thomas, Walter & Eliza Hall Institute of MedicalResearch, VICDr Romaric Bouveret, Victor Chang Cardiac ResearchInstitute, NSW


16:15 SYM-10-01Pluripotency and beyondLemischka, I. (USA)

16:35 SYM-10-02L1 retrotransposition and genomic mosaicism in mammaliandevelopmentFaulkner, G.J. (Australia)

16:55 SYM-10-03Drosha-mediated messenger RNA cleavage is necessary forstem cell functionChong, M. (Australia)

17:15 SYM-10-04Unravelling epigenetic complexes associated with GTF2IRD1to understand the cognitive features of Williams-BeurensyndromeCarmona-Mora, P., Tomasetig, F., Canales, C.P., Alshawaf,A., Dottori, M., Hardeman, E.C. and Palmer, S.J. (Australia)

17:30 SYM-10-05microRNA and mRNA processing variations in cardiac biologySoetanto, R., Hynes, C.J., Patel, H., Duan, G.W., Humphreys,D.T., Smith, N.J., Parker, B.J., Archer, S.K., Beilharz, T.,Graham, R.M., Clancy, J.L. and Preiss, T. (Australia)


16:15 - 17:45

SYMPOSIUM 11

PROTEIN STRUCTURE AND FUNCTION(INCLUDING ENZYMES)

Chairs: Dr Colin Jackson, Australian National University, ACTDr Travis Beddoe, La Trobe University, VIC


16:15 SYM-11-01Not different, just better: The adaptive evolution of a glycolyticenzymeDobson, R.C.J. (Australia)

16:35 SYM-11-02The link to defining the allosteric mechanism of an oligomericbacterial and plant enzymeGupta, R., Hogan, C., Burgess, B.R., Dogovski, C., Panjikar, S.and Perugini, M.A. (Australia)

16:55 SYM-11-03Structure-function analysis of plant immune receptorsBernoux, M., Williams, S.J., Burdett, H., Chen, C., Anderson,P.A., Kobe, B., Ellis, J.G. and Dodds, P.N. (Australia)

17:15 SYM-11-04The promoter search of RNA polymerase: the importance ofprotein flexibilityMurchland, I., Dodd, I.B., Shearwin, K.E. and Sneppen, K.(Australia and Denmark)

17:30 SYM-11-05Improving the workhorse: metabolic engineering of thenitrogen cycle in E.coliHartley, C.J., Dorrian, S.J., French, N., Liu, J.-W., Easton,C.J., Oakeshott, J.G. and Scott, C. (Australia)


16:15 - 17:45

SYMPOSIUM 12

HUMAN GENOMICS

Chairs: A/Prof Marcel Dinger, Garvan Institute of MedicalResearch, NSW

Location: Swan Room

16:15 SYM-12-01Mapping human history: from our earliest ancestors to complexadmixtureChan, E.K.F., Petersen, D.C. and Hayes, V.M. (Australia)

16:35 SYM-12-02The success of whole exome sequencing diagnosis in a largecohort of patients with Mendelian disordersRoscioli, T., Ewans, L.J., Cowley, M.J., Ying, K., Zhu, Y.,Walsh, C., Lee, E., Field, M., Buckley, M. and Dinger, M.E.(Australia)

16:55 SYM-12-03Targeted sequencing reveals fine details of the human genomeMercer, T.R. (Australia)

17:15 SYM-12-04Ubiquitous LINE-1 somatic mosaicism in hippocampal neuronsrevealed by single cell sequencingUpton, K.R., Gerhardt, D.J., Jesuadian, J.S., Brennan, P.M. andFaulkner, G.J. (Australia and UK)

17:30 SYM-12-05Chromatinized PKC-theta directly regulates inducible genes inepithelial to mesenchymal transition and breast cancer stemcellsZafar, A., Wu, F., Hardy, K. and Rao, S. (Australia)


16:15 - 17:45

SYMPOSIUM 13

LIPIDS AND MEMBRANES

Chairs: Professor Andrew Brown, University of New South Wales,NSWDr Michelle Hill, University of Queensland, QLD


16:15 SYM-13-01Dynamic monomer-dimer equilibrium of G-protein-coupledreceptors as detected by single-molecule trackingKasai, R.S., Fujiwara, T.K. and Kusumi, A. (Japan)

16:35 SYM-13-02One E3 ligase targets two key control points in cholesterolsynthesisSharpe, L.J., Zelcer, N., Loregger, A., Kristiana, I., Cook,E.C.L., Phan, L., Stevenson, J. and Brown, A.J. (Australia andThe Netherlands)

16:55 SYM-13-03PTRF/cavin-1 neutralises caveolin-1 in prostate cancermediated by extracellular vesicle contentMoon, H. and Hill, M. (Australia)

17:15 SYM-13-04A female-gametocyte-specific ABC transporter plays a role inlipid metabolism in the malaria parasiteTran, P.N., Brown, S.H.J., Mitchell, T.W., Matuschewski, K.,McMillan, P.J., Kirk, K., Dixon, M.W.A. and Maier, A.G.(Australia and Germany)

17:30 SYM-13-05Calpain: an overdrive switch for dysferlin membrane repairRedpath, G.M.I., Woolger, N., Piper, A.K., Lemckert, F.A.,Lek, A., North, K.N. and Cooper, S.T. (Australia)


16:15 - 17:45

SYMPOSIUM 14

NEURONAL SIGNALLING

Chair: Professor Seong-Seng Tan, University of Melbourne, VICLocation: Nicholls Theatrette

16:15 SYM-14-01Rho regulators in synapse development and diseaseNakano-Kobayashi, A., Tai, Y., Nadif Kasri, N. and Van Aelst,L. (USA)

16:35 SYM-14-02Ubiquitination and endosomal trafficking of the tumorsuppressor Pten during brain developmentHowitt, J., Li, Y., Low, L.-H., Putz, U. and Tan, S.-S. (Australia)

16:55 SYM-14-03Synaptic activity controls the flux of axonal retrograde carriersin peripheral and central neuronsMartin, S., Tong, W., Harper, C.B., Nguyen, T.H., Rogers, T.,Lavidis, N.A., Karunanithi, S., van Swinderen, B. and Meunier,F.A. (Australia)

17:15 SYM-14-04Neural cell adhesion molecule 2 guides neuronal developmentby inducing submembrane calcium spikesSheng, L., Leshchyns'ka, I. and Sytnyk, V. (Australia)

17:30 SYM-14-05Endosomal sorting of the Alzheimer's disease β-secretase,BACE1Toh, W.H., Chia, P.Z.C. and Gleeson, P.A. (Australia)

17:45 – 19:45 WELCOME MIXER / EXHIBITION / POSTERSLocation: Exhibition Hall

TUESDAY 30 SEPTEMBER 2014

08:30 – 09:15

PLENARY 9

ASBMB MERCK MILLIPORE MEDAL LECTURE(Including presentation of Award)

Chair: Professor Peter Gunning, University of New South Wales,NSWASBMB President


PLE-TUE-09Mitochondrial DNA: vestigial genome or master regulator ofmetabolism?Filipovska, A. (Australia)

Professor Aleksandra Filipovska

Aleksandra Filipovska is an NHMRC Senior ResearchFellow at the Harry Perkins Institute of Medical Researchand the School of Chemistry and Biochemistry at theUniversity of Western Australia in Perth. Aleksandrareceived her BSc (Hons) and PhD from the University ofOtago, New Zealand. In 2003, she was awarded a NewZealand Foundation for Research, Science and TechnologyFellowship to carry out postdoctoral work at the MRC

Mitochondrial Biology Unit in Cambridge in the United Kingdom. Aleksandrawas awarded an NHMRC Howard Florey Fellowship that enabled her torelocate in 2006 and establish her research group at the University of WesternAustralia. Her research efforts have been recognised with the award of theAustralian Academy of Sciences Ruth Stephens Gani Medal, the ANZSCDBYoung Investigator Award and the WA Tall Poppy Award. Her currentresearch focuses on the regulation of mitochondrial gene expression by RNA-binding proteins and the development therapeutics for inherited mitochondrialdiseases. Her research group uses functional genomics to identify andcharacterise pathogenic mutations in mitochondrial genes that cause disease.


08:30 - 09:15

PLENARY 10

ASPS PETER GOLDACRE LECTURE(Including presentation of Award)

Chair: Professor Tim Colmer, The University of WesternAustralia, WAASPS President


PLE-TUE-10Discovery of new factors involved in the development andautoregulation of legume nodulesFerguson, B.J., Hastwell, A.H., Li, D., Mirzaei, S., VanHameren, B., Reid, D.E., Hayashi, S., Batley, J. andGresshoff, P.M. (Australia)

Dr Brett Ferguson

Dr Brett Ferguson is a member of the Centre for IntegrativeLegume Research (CILR), in the School of Agriculture andFood Sciences (SAFS), at the University of Queensland(UQ). His research focuses on the identification andcharacterisation of the signals and signalling interactionsinvolved in legume nodulation. Legumes can enter into asymbiotic relationship with bacteria, called rhizobia, that fixatmospheric nitrogen for their host plant in specialised

nodule structures. This gives legumes a competitive advantage and makes themdesirable for agriculture as they require less chemical nitrogen fertiliser, whichis expensive and often pollutes. Dr Ferguson's work has contributed to thediscovery of many new genes and signals, particularly in soybean, includingnovel CLE peptide hormones that act to regulate nodule numbers. He has alsocontributed to the identification of other genes involved in the control ofnodule numbers, as well as nodule formation and nitrogen signalling, inaddition to identifying key roles for various phytohormones during thenodulation process. Collectively, these discoveries are helping to shape thecomplex molecular mechanisms that drive legume nodulation.


09:15 - 09:20LABGEAR AUSTRALIA DISCOVERY SCIENCE AWARD

PRESENTATION

To: Professor Steve Wilton, Murdoch University, WAChair: Professor Peter Gunning, University of New South Wales,

NSW / ASBMB PresidentLocation: Royal Theatre

09:20 – 09:25

EPPENDORF EDMAN AWARD PRESENTATION &BIOPLATFORMS AUSTRALIA AWARD PRESENTATION

To: Dr Suresh Mathivanan, La Trobe Institute for MolecularSciences, VIC

Chair: Professor Peter Gunning, University of New South Wales,NSW / ASBMB President


09:25 – 09:30

BECKMAN COULTEREDUCATION AWARD PRESENTATION

To: Dr Susan Rowland, University of Queensland, QLDChair: Professor Peter Gunning, University of New South Wales,

NSW / ASBMB PresidentLocation: Royal Theatre

09:25 – 09:30

ASPS 2014 FUNCTIONAL PLANT BIOLOGYBEST PAPER AWARD PRESENTATION

To: Dr Christine Böttcher, CSIRO, SAChair: Professor Tim Colmer, The University of Western Australia,

WA / ASPS PresidentLocation: Bradman Theatrette


09:30 - 10:15

PLENARY 11

ASBMB LEMBERG LECTURE(Including presentation of Award)

Chair: Professor Peter Gunning, University of New South Wales,NSWASBMB President


PLE-TUE-11Antifungal proteins-mechanism, function and applicationsAnderson, M.A. (Australia)

Professor Marilyn Anderson

Professor Marilyn Anderson FAA FTSE is a Professor ofBiochemistry at La Trobe University and is Chief ScienceOfficer of Hexima, an agribiotechnology company that shefounded with Professor Adrienne Clarke in 1998. Sheobtained her PhD at La Trobe University and then undertookthree postdoctoral placements in the US. In 1982, shereturned to Australia to join Professor Clarke and set upmolecular biology at the newly formed Plant Cell Biology

Research Centre at the University of Melbourne. The work in the Centre led tothe discovery of the genes that control self-incompatibility in flowering plants.In 1995, Marilyn returned to the Department of Biochemistry at La TrobeUniversity. Her current research is focussed on defence molecules produced byplants for protection against insect pests and fungal pathogens. It spans thespectrum from basic work on the structure and mechanism of action of thesemolecules, to the practical application of creating crop plants that are protectedfrom losses in the field due to predation and fungal disease.


09:30 - 10:15

PLENARY 12

ASPS R.N. ROBERTSON LECTURE(Including presentation of Award)

Chair: Professor Tim Colmer, The University of WesternAustralia, WAASPS President


PLE-TUE-12A salty tale: the ups and downs of water use in mangrovesBall, M.C. (Australia)

Professor Marilyn Ball

Marilyn Ball received a PhD in Environmental Biologyfrom the Australian National University in 1982. Sheheld postdoctoral positions at the University ofCalifornia, Berkeley (1981-1984) and the ANU NorthAustralia Research Unit in Darwin (1985-1988), and anARC National Research Fellowship in 1989. Since1990, she has led an eco-physiological research group atthe ANU in studies aimed at linking physiological

mechanisms of stress tolerance with larger scale patterns in whole plantstructure and function along complex environmental gradients. She worksmainly on field-based studies of salinity and freezing tolerance in mangrove,temperate sclerophyll, and alpine/sub-Antarctic systems. In 2007, she becamethe first woman to receive the lifetime Honorary Member Award from theEcological Society of America for distinguished achievement in ecologicalresearch, and was elected to the Australian Academy of Science in 2009.



10:45 – 12:15

SYMPOSIUM 15

PHOTOSYNTHESIS AND RESPIRATION

Chairs: Dr Kristine Crous, University of Western Sydney, NSWProfessor Murray Badger, Australian National University,ACT


10:45 SYM-15-01Glycine metabolism in photorespirationAbadie, C., Boex-Fontvieille, E.R.A., Mahe, A., Gilard, F.,Hodges, M. and Tcherkez, G.G.B. (France)

11:05 SYM-15-02The heat is on: temperature trumps CO2 in a boreal coniferWay, D.A. and Kroner, Y. (Canada and USA)

11:25 SYM-15-03Advances in modifying leaf CO2-fixation ratesWhitney, S.M. (Australia)

11:45 SYM-15-04The neurachninae: a new paradigm to investigate the evolutionof C4 photosynthesisClayton, H., Saladie, M., Sharwood, R. and Ludwig, M.(Australia)

12:00 SYM-15-05Seasonal changes in the temperature-dependency of thephotosynthetic response to CO2 of apple leavesGreer, D.H. (Australia)


10:45 – 12:15

SYMPOSIUM 16

MODELLING CLIMATE CHANGE IMPACTS

Chairs: Professor Graham Farquhar, Australian NationalUniversity, ACTDr Libby Pinkard, CSIRO, TAS

Location: Swan Room

10:45 SYM-16-01Delineating the roles of Rising [CO2] and Temperature onFlowering Time in Arabidopsis thaliana GenotypesWard, J.K. and Walker, S.M. (USA)

11:05 SYM-16-02Global patterns in biomass allocation in woody plants: thebiomass and allometry database (BAAD)Duursma, R.A., Falster, D.S., Barneche, D.R. and Fitzjohn,R.G. (Australia)

11:25 SYM-16-03Not including stress and damage in vegetation climate changeassessments leads to underestimate of impactsBattaglia, M., Bruce, J. and Pinkard, E.A. (Australia)

11:45 SYM-16-04Experimental manipulation of temperature, salinity and osmoticstress to determine germination thresholds of coastal plantseedsGuja, L.K., Wardell-Johnson, G., Dixon, K.W. and Merritt,D.J. (Australia)

12:00 SYM-16-05Genetic variation in water use efficiency (WUE) and responseto drought in selected wheat landracesChemayek, B., Bariana, H.S., Bansal, U.K. and Barbour, M.M.(Australia)


10:45 – 12:15

SYMPOSIUM 17

PLURIPOTENT STEM CELL DIFFERENTIATION ANDEPIGENETICS, AND CELLULAR REPROGRAMMING

Chairs: A/Prof Jose Polo, Monash University, VICProfessor Melissa Little, University of Queensland, QLD


10:45 SYM-17-01Epigenetic memoryGurdon, J.B. (United Kingdom)

11:05 SYM-17-02Reconfiguration of the DNA methylome during cellularreprogrammingLister, R. (Australia)

11:25 SYM-17-03Directed differentiation of human pluripotent cells to form aself-organising kidneyLittle, M.H., Takasato, M., Er, P., Becroft, M.,Vanslambrouck, J., Stanley, E. and Elefanty, A. (Australia)

11:45 SYM-17-04Generating cell lineages during human cardiovasculardevelopmentSkelton, R.J.P., Anderson, D.A., Karavendzas, K.,Arasaratnam, D., Qian, L., Elefanty, A.G., Stanley, E.G.,Murrery, C.L. and Elliott, D.A. (Australia and TheNetherlands)

12:00 SYM-17-05The Mixl1 transcriptional network in cell priming andmorphogenetic cell movementsLange, K.K., Chan, C.K. and Hart, A.H. (Australia)


10:45 – 12:15

SYMPOSIUM 18

DRUG-DESIGN, DYNAMICS AND COMPUTATIONALMODELLING

Chairs: Dr Haibo Yu, University of Wollongong, NSWDr Megan O’Mara, University of Queensland, QLD


10:45 SYM-18-01The identification and validation of protein: ligand complexes:reconciling theory and experimentMark, A.E. (Australia)

11:05 SYM-18-02Ligand discovery by target similarity searchYang, Y. and Zhou, Y. (Australia)

11:25 SYM-18-03DNA clamps: structure, dynamics and drug discoveryOakley, A.J., McGrath, A.E., Yin, Z., Whittell, L.R., Dawes,F.E., Beck, J.L., Kelso, M.J. and Dixon, N.E. (Australia)

11:45 SYM-18-04Inhibitor peptide design - improving affinity without losingspecificityGunzburg, M.J., Kulkarni, K., Watson, G., Brandt, R., Lim,R.C.C., Payne, R., DelBorgo, M., Perlmutter, P., Wilce, M.C.and Wilce, J.A. (Australia)

12:00 SYM-18-05Targeting cell death pathways to treat parasitic infectionsLee, E.F., Feng, Z., Speed, T.P., Gasser, R., Young, N.,Strasser, A., Colman, P.M., Grevelding, C. and Fairlie, W.D.(Australia and Germany)


10:45 – 12:15

SYMPOSIUM 19

MATRIX, MIGRATION AND MECHANOBIOLOGY

Chairs: A/Prof Melissa Knothe-Tate, University of New SouthWales, NSWA/Prof Michael Samuel, Centre for Cancer Biology, SAPathology, SA


10:45 SYM-19-01The lamellipodium requires two different types of actinfilamentsBrayford, S., Schevzov, G., Bear, J., Hardeman, E. andGunning, P. (Australia and USA)

11:05 SYM-19-02Regulation of the 3D shape of crawling cells by a contractileand counterbalancing adhesion systemLippincott-Schwartz, J. (USA)

11:25 SYM-19-03Manipulating ECM to improve anti-invasive drug responseusing biosensor imagingTimpson, P. (Australia)

11:45 SYM-19-04Stem cell mechanomics as a cellular integrator of matrix,migration and mechanobiology?Knothe Tate, M.L. (Australia)

12:00 SYM-19-05Generation of polarized pressure by a nuclear piston governs3D cell motilityPetrie, R.J., Koo, H. and Yamada, K.M. (USA)


10:45 – 12:15

SYMPOSIUM 20

SIGNALLING ENZYMES

Chairs: A/Prof Nikki, Verrills, University of Newcastle, NSWProfessor Stuart Pitson, University of South Australia, SA


10:45 SYM-20-01Cytoskeletal signalling in wound healing and skin cancerSamuel, M.S. (Australia)

11:05 SYM-20-02Boosting the power of endogenous phosphatases to reduceinflammation in asthmaRahman, M.M., Rumzhum, N.N., Verrills, N.M. and Ammit,A.J. (Australia)

11:25 SYM-20-03Signal transduction by PP2A: regulating the regulatorSontag, E., Hoffman, A., Bottiglieri, T. and Sontag, J.M.(Australia and USA)

11:45 SYM-20-04Oxygen-dependent hydroxylation by factor inhibiting HIF(FIH) regulates the TRPV3 ion channelKartunnen, S., Duffield, M., Scrimgeour, N.R., Lim, W.L.,Chicher, J., David, K.A., Gorman, J.J., Gleadle, J.M., Rychkov,G.Y. and Peet, D.J. (Australia)

12:00 SYM-20-05Src kinase determines the dynamic exchange of the dockingprotein NEDD9 at focal adhesionsBradbury, P., Bach, C., Paul, A. and O'Neill, G. (Australia)

12:15 – 13:15 LUNCH / EXHIBITION / POSTERSLocation: Exhibition Hall

12:15 – 13:15 STUDENT LUNCH WITH OVERSEAS SPEAKERSLocation: First Floor Foyer, National Convention Centre


12:30 – 14:00

SYMPOSIUM 21

EDUCATION I

Chairs: A/Prof Janet Macaulay, Monash University, VICDr Alex Johnson, University of Melbourne, VIC


12:30 SYM-21-01The current state of science in higher educationChubb, I. (Australia)

13:00 SYM-21-02Learning from productive failureKapur, M. (Singapore)

13:30 SYM-21-03 Beckman Coulter Education Award LectureFree energy radio: interviews with scientists develop a pictureof scientists' personal and career motivationsRowland, S. (Australia)

13:15 – 14:15 POSTER SESSION BLocation: Exhibition Hall


14:15 – 15:45

COLLOQUIUM 1

PLANT BIOLOGY

Chairs: Dr Chris Cazzonelli, University of Western Sydney, NSWDr Andrew Eamens, University of Newcastle, NSW


14:15 COL-01-01The role of plant phenomics in building a C4 riceCoe, R.A., Sirault, X.R.R., Furbank, R.T. and Quick, W.P.(Philippines and Australia)

14:30 COL-01-02Secondary structure of target mRNAS influences microRNAregulation in ArabidopsisReichel, M., Zheng, Z., Li, J. and Millar, A.A. (Australia)

14:45 COL-01-03PEA-CLARITY: 3D immunohistochemistry of whole mountplant tissuesPalmer, W.M., Martin, A.P., Furbank, R.T. and Grof, C.P.(Australia)

15:00 COL-01-04Understanding the role of organic nitrogen in the nutrition ofEucalyptus speciesSimpson, J.E. and Warren, C.R. (Australia)

15:15 COL-01-05Physiological insights into heat- and drought- regulated leafmembrane ion transport in Eucalyptus grandisHuang, G., Rymer, P., Chen, Z., Smith, R. and Tissue, D.(Australia)

15:30 COL-01-06CEP regulatory peptides control Arabidopsis root developmentDelay, C., Imin, N. and Djordjevic, M.A. (Australia)


14:15 – 15:45

COLLOQUIUM 2

DEVELOPMENTAL, STEM CELL AND REGENERATIVEBIOLOGY

Chairs: Dr Mirana Ramialison, Monash University, VICDr Jatin Patel, University of Queensland, QLD


14:15 COL-02-01Localised control of growth factor activation in Drosophilaterminal patterningHenstridge, M.A., Johnson, T.K., Whisstock, J.C. and Warr,C.G. (Australia)

14:30 COL-02-02The role of GTF2IRD1 in the facial abnormalities of Williams-Beuren syndrome patientsCanales, C.P., Corley, S., Beverdam, A., Kaur, P., Smyth, I.,Wilkins, M., Hardeman, H.C. and Palmer, S.J. (Australia)

14:45 COL-02-03Primary cilia function regulates the length of the embryonictrunk axis and urogenital field in miceWainwright, E.N., Svingen, T., Ng, E.T., Wicking, C. andKoopman, P. (Australia)

15:00 COL-02-04Identification and characterisation of jam packed (jam), a novelregulator of stem cell development in the Drosophila testisLa Marca, J.E., Hodge, A., Wang, H. and Somers, W.G.(Australia and Singapore)

15:15 COL-02-05Control of cell proliferation by the Brahma chromatin-remodelling complexRoesley, S.N.A., Yasuhide, Y., Richardson, H., Sarcevic, B.and Bernard, O. (Australia)


15:30 COL-02-06The Zic2 gene directs the formation and function of node ciliato control cardiac situsBarratt, K.S., Glanville-Jones, H.C. and Arkell, R.M.(Australia)


14:15 – 15:45

COLLOQUIUM 3

PROTEINS

Chairs: Dr Denisse Leyton, Monash University, VICDr Nan Li, University of Wollongong, NSW


14:15 COL-03-01Acinetobacter DNA replicationDawes, F., Robinson, A., Li, N., McGrath, A., Keep, G., Jergic, S.and Dixon, N. (Australia)

14:30 COL-03-02 Adelaide Protein Group LectureShigella flexneri IcsA contains a conserved autotransportermotif with roles in polar targeting and passenger domainsecretion efficiencyDoyle, M.T., Grabowicz, M. and Morona, R. (Australia andUSA)

14:45 COL-03-03 Queensland Protein Group LectureDirect interaction of Rab8a with PI3Kin innate immunesignallingLuo, L., Wall, A.A., Collins, B.M., Sweet, M.J. and Stow, J.L.(Australia)

15:00 COL-03-04MG53/TRIM72 - a novel biomarker of cardiac ischaemic injuryLemckert, F., Bournazos, A., Hawkes, J., Butler, T., Winlaw,D., North, K., Egan, J. and Cooper, S. (Australia)

15:15 COL-03-05Identifying novel transaminases for industrial applicationsWilding, M.A. and Scott, C. (Australia)

15:30 COL-03-06Two-step mechanism regulates human telomerase DNAbinding


Tomlinson, C.G., Moye, A.L., Holien, J.K., Parker, M.W.,Cohen, S.B. and Bryan, T.M. (Australia)


14:15 – 15:45

COLLOQUIUM 4

GENOME BIOLOGY AND BIOINFORMATICS

Chairs: Dr Cameron Bracken, Centre for Cancer Biology, SAPathology, SADr Tim Mercer, Garvan Institute of Medical Research,NSW

Location: Swan Room

14:15 COL-04-01Uncovering functional mechanisms of Junk DNA in the brainand psychiatric diseaseBarry, G., Briggs, J.A., Poth, E.M., Nayler, S.P., Blackshaw,S., Wolvetang, E.J. and Mattick, J.S. (Australia and USA)

14:30 COL-04-02Different strategies of chromatin remodelling at thetranscription start siteNekrasov, M., Soboleva, T., Amrichova, J., Jack, C., Parker,B., Williams, R., Huttley, G.A. and Tremethick, D.J. (Australiaand Singapore)

14:45 COL-04-03Environmental risk factors for schizophrenia alter miRNAexpression in the enthorhinal cortexHollins, S.L, Zavitsanou, K., Walker, F.R. and Cairns, M.J.(Australia)

15:00 COL-04-04Finding off-targets & biological pathways for human chymaseinhibitors via structure-based systems biologyArooj, M. (Australia)


15:15 COL-04-05Cytidine to uridine RNA editing: new player and new targetsFossat, N., Tourle, K., Humphreys, D. Wilkie, E., Radziewic,T., Barratt, K., Liebhold, D., Studdert, J.B., Power, M., Jones,V., Loebel, D.A.F., Arthur, J., Preiss, T. and Tam, P.P.L.(Australia)

15:30 COL-04-06miR-17 family regulation of uncharacterised splice variant ofBDNF receptor NTRK2 during neuronal differentiationSherwin, S.K., Goldie, B.J. and Cairns, M.J. (Australia)


14:15 – 15:45

COLLOQUIUM 5

CELL BIOLOGY

Chairs: Dr Danny Hatters, University of Melbourne, VICDr Till Boecking, University of New South Wales, NSW


14:15 COL-05-01Vps26B-retromer negatively regulates plasma membraneresensitisation of PAR-2Bugarcic, A., Vetter, I., Chalmers, S., Kinna, G., Stow, J.L.,Collins, B.M. and Teasdale, R.D. (Australia)

14:30 COL-05-02Mechanism of Protocadherin 19 (PCDH19) female epilepsy,cell adhesion converging on transcriptional regulation byestrogen receptorPham, D., Tan, C., Kumar, R., McAninch, D., Thomas, P. andGecz, J. (Australia)

14:45 COL-05-03The tomato defensin TPP3 induces tumour cell lysis through aconserved mechanism involving PIP2 binding andoligomerisationBaxter, A.A., Richter, V., Poon, I.K.H., Lay, F.T., Adda, C.,Kvansakul, M. and Hulett, M.D. (Australia)

15:00 COL-05-04Diverse mutational pathways converge on saturablechloroquine transport via the malaria parasite's 'chloroquineresistance transporter'Summers, R.L., Dave, A., Dolstra, T.J., Bellanca, S.,Marchetti, R.V., Nash, M.N., Richards, S.N., Sachez, C.P.,Lanzer, M. and Martin. R.E. (Australia and Germany)


15:15 COL-05-05Molecular basis for interaction and stabilisation of themammalian amino acid transporters B0AT1 and B0AT3 by theirancillary protein collectrinFairweather, S.J., Broer, A., OMara, M.L., Subramanian, N.and Broer, S. (Australia)

15:30 COL-05-06Parkinson's disease linked mutation alters the function ofretromerFollett, J., Yang, Z., Bugarcic, A. and Teasdale, R.D.(Australia)


14:15 – 15:45

COLLOQUIUM 6

SIGNALLING

Chairs: Dr Michaela Waibel, Peter MacCallum Cancer Centre,VICMr Yogesh Jeelall, Australian National University, ACT


14:15 COL-06-01Investigating the role of transcription factors HIF-1 comparedto HIF2 and its relevance in multiple myeloma diseaseprogressionMartin, N.M., Hewett, D., Zannettino, A.C.W. and Peet, D.J.(Australia)

14:30 COL-06-02 Sydney Protein Group LectureTargeting the CHK1-CIP2A axis to treat glioblastoma (GBM)Khanna, A., Stringer, B., Day, B., Ensbey, K., Shen, H.,McDonald, K., Boyd, A. and Pimanda, J. (Australia)

14:45 COL-06-03Distinct actin filament networks modulate different cellsignalling pathways involved in cell proliferation andsenescenceSchevzov, G., Wang, B., Hook, J., Tonthat, C., Pleines, I., Kile,B., Hardeman, E. and Gunning, P. (Australia)

15:00 COL-06-04Regulation of WD40-repeat protein 62 by aurora A-insightsinto the maintenance of the mitotic spindle during neurogenesisLim, N.R., Bogoyevitch, M.A., Quinn, L.M. and Ng, D.C.(Australia)

15:15 COL-06-05Isolating the bulk endosome from nerve terminalsMiller, L.C., Hains, P., Kettle, E., Boadle, R.A. and Robinson,P.J. (Australia)


15:30 COL-06-06Depolarization-dependent syndapin 1 phosphorylation in nerveterminalsQuan, A., Graham, M.E., Anggono, V., Rao, S., Larsen, M.R.and Robinson, P.J. (Australia and Denmark)

15:45 – 16:15 AFTERNOON TEA / EXHIBITION / POSTERSLocation: Exhibition Hall


16:15 – 18:05

SYMPOSIUM 22

PLANT (epi) GENOMICS AND PHENOMICS(Including the Farrer Memorial Oration and Award)

Sponsored by the Farrer Memorial Trust

Chairs: Dr Jean Finnegan, CSIRO Plant Industry, ACTDr Iain Searle, University of Adelaide, SA


16:15 SYM-22-01Hybrid Mimic and the mechanism of hybrid vigorWang, L., Groszmann, M., Greaves, I.K., Wu, L., Peacock,W.J. and Dennis, E.S. (Australia)

16:35 SYM-22-02Metabolic pathways required for pollen exine formation inplantsZhang, D. (China)

16:55 SYM-22-03Identification and classification of DNA methylation variationacross maizeEichten, S.R., Springer, N.M. and Borevitz, J.O. (Australia andUSA)

17:15 Five minute break for the Farrer Memorial Trust guests to maketheir way into the auditorium.

17:20 SYM-22-04 Farrer Oration and AwardArabidopsis and Agriculture - what can we learn from a weed?Dennis, E.S. (Australia)


16:15 – 17:45

SYMPOSIUM 23

DEVELOPMENTAL GENETICS OF HUMAN DISEASE

Chairs: Professor Sally Dunwoodie, Victor Chang CardiacResearch Institute, NSWA/Prof Carol Wicking, University of Queensland, QLD


16:15 SYM-23-01 ANZSCDB Young Investigator AwardPresentation and Lecture (Sponsored by Carl Zeiss)The importance of "normal": Global quantification of tissuedynamics in the developing mouse kidneySmyth, I.M. (Australia)

16:35 SYM-23-02The histone acetyltransferase MOZ in cardiovascular andcraniofacial developmentVanyai, H.K., Sheikh, B.S., Thomas, T. and Voss, A.K.(Australia)

16:55 SYM-23-03The ADPKD gene PKD1 regulates lymphatic vascularmorphogenesis during developmentHogan, B.M. (Australia)

17:15 SYM-23-04Gene discovery and functional analysis for ciliopathiesCortes, C., McInerney-Leo, A.M., Schmidts, M., Leon, P.,Beales, P., Brown, M.A., Zankl, A., Mitchison, H., Duncan,E.L. and Wicking, C. (Australia and United Kingdom)

17:30 SYM-23-05New insights for XBP-related cancer predispositionMitchell, N.C., Lee, S., Chahal, A., Poortinga, G., Levens,D.L., Hannan, R.D. and Quinn, L.M. (Australia)


16:15 – 17:45

SYMPOSIUM 24

MACROMOLECULAR INTERACTIONS(INCLUDING PROTEIN-NUCLEIC ACID)

Chairs: A/Prof Jackie Wilce, Monash University, VICProfessor Joel Mackay, University of Sydney, NSW


16:15 SYM-24-01Discovery of a neuroprotective chemicalMcKnight, S.L. (USA)

16:35 SYM-24-02Cet-Z tubulin-like proteins in Archaea: structure, function, andinsights into cellular diversity and evolutionDuggin, I.G. (Australia)

16:55 SYM-24-03Chasing the structural diversity of autotransporter proteinsPaxman, J.J., Totsika, M., Peters, K.M., Schembri, M.A. andHeras, B. (Australia)

17:15 SYM-24-04Can we design PPR protein to bind user-defined RNA targets?Kindgren, P., Yap, A., Shearston, K., Bond, C. and Small, I(Australia)

17:30 SYM-24-05Designed cyclic peptide targeting SPSB proteins as a potentialnew class of anti-infective agentLleung, E.W.W., Yap, B.K., Yagi, H., Chhabra, S., Chalmers,D.K., Nicholson, S.E. Thompson, P.E. and Norton R.S.(Australia)


16:15 – 17:45

SYMPOSIUM 25

NEW CONCEPTS IN TRAFFICKING AND TRANSPORT

Chairs: Professor Jenny Stow, University of Queensland, QLDProfessor David Jans, Monash University, VIC


16:15 SYM-25-01Endosome biogenesis and the regulation of signallingVillasenor, R., Zeigerer, A., Nonaka, H., Meyer, K., Marsico,G., Seifert, S., Kalaidzidis, Y. and Zerial, M. (Germany)

16:35 SYM-25-02The role of Rabs, RabGAPs and RabGEFs in insulin action inadipocytesStoeckli, J., Murrow, B., D'Souza, R. and James, D.E.(Australia)

16:55 SYM-25-03The P53-induced factor E124 inhibits nuclear import through animportin β-binding-like domainLieu, K.G., Shim, E.-H., Wang, J., Lokareddy, R.K., Tao, T.,Cingolani, G., Zambetti, G.P. and Jans, D.A. (Australia, USAand China)

17:15 SYM-25-04Ferl-in or Ferl-out? Characterising the subcellular localisationof the ferlin protein familySophocleous, R.A., Redpath, G.M.I. and Cooper, S.T.(Australia)

17:30 SYM-25-05Sheer stress triggers translocation of TRPV4 channels to thecell surfaceBaratchi, S., Darby, B., Al Mazi, T., Khoshmanesh, K.,Tovarlopez, F., Mitchell, A. and McIntyre,P. (Australia)


16:15 – 17:45

SYMPOSIUM 26

IMMUNE CELL SIGNALLING

Chair: Professor Brendan Jenkins, MIMR-PHI Institute ofMedical Research, VIC


16:15 SYM-26-01Effect of MHC-I TCR signal strength on lineage uncertaintyand the time required for CD8 T cell positive selection in thethymusKimura, M.Y. and Singer, A. (USA and Japan)

16:35 SYM-26-02A two-site interaction underpins TRIM25 activation of the RIG-1 anti-viral responseD'Cruz, A.A., Kershaw, N.J., Linossi, E., Dagley, LF., Chiang,J.J., Wang, M.K., Hayman, T.J., Zhang, J.G., Gack, M.U.,Nicola, N.A., Babon, J.J. and Nicholson, S.E. (Australia andUSA)

16:55 SYM-26-03Defects in cytokine signaling pathways manifesting as humanimmune deficient diseasesTangye, S.G. (Australia)

17:15 SYM-26-04The hidden guanylate cyclase function of IRAK3: a new trickfrom an immune proteinFreihat, L.A., Manallack, D.T., Wheeler, J.I. and Irving, H.R.(Australia)

17:30 SYM-26-05Soluble heparan sulfate fragments generated by heparanasetrigger the release of proinflammatory cytokines through TLR-4Goodall, K.J., Poon, I.K., Phipps, S. and Hulett, M.D.(Australia)


16:15 – 17:45

SYMPOSIUM 27

APOPTOSIS AND AUTOPHAGY

Chairs: Professor Sharad Kumar, University of South Australia, SAA/Prof Marie Bogoyevitch, University of Melbourne, VIC

Location: Swan Room

16:15 SYM-27-01 Melbourne Protein Group LecturePannexin 1 channels regulate cell disassembly during apoptosisPoon, I.K.H., Chiu, Y.-H., Armstrong, A.J., Kinchen, J.M.,Juncadella, I.J., Bayliss, D.A. and Ravichandran, K.S.(Australia and USA)

16:35 SYM-27-02A novel mouse model to dissect the mechanisms of Bcl-2regulated cell death in vivoLee, E.F., Grabow, S., Gray, D.H., Witkowski, M.T.,Hockings, C., Kluck, R.M., Cory, S., Kile, B.T. and Fairlie,W.D. (Australia)

16:55 SYM-27-03Novel signals regulating autophagy and cell deathDenton, D., Xu, T., Nicolson, N., Dayan, S., Aung-Htut, M.and Kumar, S. (Australia)

17:15 SYM-27-04The protonophore CCCP interferes with lysosomal degradationof autophagic cargo in yeast and mammalian cellsPadman, B.S., Bach, M., Lucarelli, G., Prescott, M. andRamm, G. (Australia)

17:30 SYM-27-05Examining the role of MLKL in necroptotic cell deathHildebrand, J.M., Tanzer, M.C.., Lucet, I.S., Spall, S.K.,Alexander, W.S., Czabotar, P.E., Lessene, G., Murphy, J.M.and Silke, J. (Australia)

17:45 – 19:15 COCKTAIL PARTY / EXHIBITION / POSTERSLocation: Exhibition Hall

WEDNESDAY 1 OCTOBER 2014

08:30 – 09:10

PLENARY 13

PLENARY LECTURE

Chair: Professor Joel Mackay, University of Sydney, NSWLocation: Royal Theatre

PLE-WED-13Test tube reconstitution of neuronal granulesMcKnight, S.L. (USA)

Professor Steve McKnight

Steve McKnight received his BSc from the University ofTexas in 1974 and his PhD from the University of Virginiain 1977. He conducted postdoctoral research at theCarnegie Institution of Washington and was appointed as astaff member in 1983. He was appointed as a HowardHughes Medical Institute investigator in 1988. In 1991,McKnight left academia to co-found Tularik, abiotechnology company devoted to the discovery of ethical

drugs acting to treat disease state via the regulation of gene expression. In1995, McKnight moved to UT Southwestern Medical Center and in 1996, hewas appointed as chairman of the Department of Biochemistry. McKnight hasdirected an active research laboratory and has guided the Department ofBiochemistry to substantial growth in the disciplines of chemistry,biochemistry and biophysics. His research is focused on dynamic regulation ofmetabolic state in cell types ranging from budding yeast to mouse embryonicstem cells; efforts to discover novel chemicals capable of fostering the birth orsurvival of neurons in the hippocampus of the mammalian brain; andexperiments facilitating the test tube reconstitution of RNA granules importantfor spatially localised regulation of translation. McKnight is a member of theNational Academy of Sciences, the Institute of Medicine of the NationalAcademy of Sciences, the American Academy of Arts and Sciences and theAmerican Association for the Advancement of Science.


08:30 – 09:10

PLENARY 14

PLENARY LECTURE

Chair: Professor Rick Pearson, Peter MacCallum Cancer Centre,NSW


PLE-WED-14TOR complex 1: signal integrator and regulator of cell growthBlenis, J. (USA)

Professor John Blenis

Professor John Blenis’ research is defining how alteredcellular signaling promotes carcinogenesis. He discoveredthat Ras connected tyrosine kinases to the serine/threoninekinases Raf, ERK and RSK, and that activated ERK andRSK translocate to the nucleus to alter gene expression. Hethen identified several molecular sensors that convert subtledifferences in ERK activity into specific biologicalresponses such as EMT and metastasis. Dr Blenis alsodiscovered the link between tyrosine kinases, PI3-kinases

and serine/threonine S6 kinase (S6K), and that S6K activation is blocked bythe mTOR inhibitor rapamycin, now in several clinical trials. His lab isdefining how mTOR/S6K regulates cell metabolism and growth. His honorsinclude ACS Junior Faculty award, AHA Established Investigator award, theLAM Foundation Established Investigator award and the NIH/NCI MERITaward. Dr Blenis is the newly appointed Kellen Professor of Cancer Researchand Pharmacology at the Meyer Cancer Center at Weill Cornell MedicalCollege.


09:15 – 09:30

ASBMB FRED COLLINS FELLOWSHIP,ASBMB FELLOWSHIP AWARD PRESENTATIONS AND

PRESENTATIONS OF CERTIFICATES TOLONG STANDING MEMBERS OF THE ASBMB

To: Fred Collins FellowshipDr Annie Quan, Childrens Medical Research Institute,NSW

ASBMB FellowshipsMiss Victoria Hewitt, Monash University, VICMr Kim Gia Lieu, Monash University, VICMr Iain Murchland, University of Adelaide, SAMs Maya Olshina, Walter & Eliza Hall Institute, VICMr Stephen Scally, Monash University, VIC

Long Standing Members of the ASBMBDr Cyril CravenDr Ron HillDr Edith LeesDr Peter NixonProfessor Ken Scott

Chair: Professor Peter GunningUniversity of New South Wales, NSWASBMB President



09:15 – 10:00

PLENARY 15

PLENARY LECTURE

Chair: Dr Yong-Ling Ruan, University of Newcastle, NSWLocation: Bradman Theatrette

PLE-WED-15Identification of a key regulator of cotton fiber elongationShan, C.M., Chao, L.M., Zhao, B., Shangguan, X.X., Wang,L.J. and Chen, X.Y. (P.R. China)

Professor Xiao-Ya Chen

Xiao-Ya Chen is Professor at the Institute of PlantPhysiology and Ecology, Shanghai Institutes for BiologicalSciences (SIBS), Chinese Academy of Sciences. Hecurrently serves as Vice President of Chinese Society ofPlant Biology and Director of the Shanghai ChenshanBotanical Garden. He obtained his BSc in 1982 fromNanjing University, China, and his PhD in 1985 fromReading University, UK. Dr Chen is interested in plant

secondary metabolism, cotton biology and biotechnology. He has madecontributions in the areas of regulation of sesquiterpene biosynthesis in plants,gossypol biosynthesis pathway, the role of plant secondary metabolites inplant-insect interactions, plant-mediated RNAi technology for insect pestcontrol and cotton fibre development with an emphasis on key transcriptionfactors. In recent years, he has led a project to genome sequencing of theallotetraploid extra-long staple cotton, Gossypium barbadense. Dr Chen waselected a member of Chinese Academy of Sciences in 2005, a member of TheWorld Academy of Sciences in 2008 and received the HLHL Foundation Prizefor Scientific and Technological Progress in 2008. He currently serves as CoEditor-in-Chief for Molecular Plant and Associate Editor for PlantBiotechnology Journal.



10:30 – 12:00

SYMPOSIUM 28

PLANT-MICROBE AND ANIMAL INTERACTIONS

Chairs: Professor Karam Singh, CSIRO Plant Industry, WAA/Prof Ulrike Mathesius, Australian National University,ACT


10:30 SYM-28-01Response of cotton bollworm to gossypolMao, Y.B., Chen, D.Y., Liu, Y.Q., Yang, C.Q. and Chen, X.Y.(P.R. China)

10:50 SYM-28-02The multinucleate genome of a single Rhizoctonia solani AG8isolate possesses a higher level of variation than populations ofhaploid pathogensAnderson, J.P., Hane, J.K., Foley, R., Williams, A.H.,Sperschneider, J. and Singh, K.B. (Australia)

11:10 SYM-28-03Fungal cell walls are dynamic structures that can enhance cellsurvival in the presence of antifungal moleculesAnderson, M.A., Payne, J.A.E., Hayes, B.M., Friendship, D.T.,Bleackley, M.R. and Van Der Weerden, N.L. (Australia)

11:30 SYM-28-04MtCEP1 peptide regulates root architecture and nodulation inthe model legume Medicago truncatulaMohd-Radzman, N.A., Imin, N. and Djordjevic, M.A.(Australia)

11:45 SYM-28-05Proteomic analysis of the soybean symbiosome identifies newsymbiotic proteinsClarke, V.C., Loughlin, P.C., Day, D.A. and Smith, P.M.C.(Australia)


10:30 – 12:00

SYMPOSIUM 29

CROP YIELD AND FOOD SECURITY

Chairs: Professor Harvey Millar, The University of WesternAustralia, WAProfessor Barry Pogson, Australian National University,ACT


10:30 SYM-29-01DELLA mutants of wheat and barley, and their potentialapplication in cereal breedingChandler, P.M., Miraghazadeh, A., Harding, C.A., Derkx,A.P. and Brooks, B.J. (Australia)

10:50 SYM-29-02Improving the salt tolerance of bread and durum wheatMunns, R., James, R.A., Byrt, C.S. and Gilliham, M.(Australia)

11:10 SYM-29-03Molecular breeding for abiotic stress tolerance and improvednutrient-use efficiencyHeuer, S.H. (Australia)

11:30 SYM-29-04Investigation of the regulatory mechanisms controllingcyanogensis in forage sorghumBlomstedt, C., Fromhold, S., Quinn, A., Neale, A., LindbergMoller, B. and Gleadow, R. (Australia and Denmark)

11:45 SYM-29-05Grain yield of salt stressed chickpea is improved by sugarsupply at the reproductive stageKhan, H.A., Siddique, K.H.M. and Colmer, T.D. (Australia)


10:30 – 12:00

SYMPOSIUM 30

POSTNATAL/ADULT STEM CELLS AND ORGANREGENERATION

Chairs: Dr Enzo Porrello, University of Queensland, QLDA/Prof James Bourne, Monash University, VIC


10:30 SYM-30-01Molecular regulation of stem cell quiescenceRando, T.A. (USA)

10:50 SYM 30-02Metabolic reprogramming in skeletal muscle stem cellsRyall, J.G., Ly, C.H. and Lynch, G.S. (Australia)

11:10 SYM-30-03Myelin regeneration by precursor cells in the adult centralnervous systemXing, Y.L., Roth, P.T., Stratton, J.A.S., Ellis, S.L., Chuang,B.H.A., Ng, S.W., Kilpatrick, T.J. and Merson, T.D.(Australia)

11:30 SYM-30-04Yap activates beta-catenin in murine epidermal stem/progenitorcell proliferationAkladios, B., Eeles, J., Lambie, D., Soyer, H.P., Khosrotehrani,K., Key, B., Hardeman, E. and Beverdam, A. (Australia)

11:45 SYM-30-05The ubiqutin specific protease, USP9x, is required for thecellular proliferation and stabilisation of mTORC1 componentsp-mTOR(ser2448), in neural stem cell (ReNcells VM) in vitroand in vivoBridges, C.R.F., Tan, M., Premarathne, S., Jolly, L., Bellette,B., Zencak, D., Murtaza, M. and Wood, S.A. (Australia)


10:30 – 12:00

SYMPOSIUM 31

AT AND ACROSS THE MEMBRANE

Chairs: Dr Megan Maher, La Trobe University, VICDr Chris McDevitt, University of Adelaide, SA


10:30 SYM-31-01Structural basis for iron piracy by pathogenic NeisseriaBuchanan, S. (USA)

10:50 SYM-31-02A receptor for human haemoglobin on the surface of pathogenicStaphylococcus aureusDickson, C.F., Krishna Kumar, K., Jacques, D.A.,Malmirchegini, G.R., Spirig, T., Mackay, J.P., Clubb, R.T.,Guss, J.M. and Gell, D.A. (Australia and USA)

11:10 SYM-31-03A novel 'nucleotide-bound outward-occluded' conformation ofan antibacterial peptide ABC transporterChoudhury, H.G., Iwata, S., Rebuffat, S. and Beis, K.(Australia and United Kingdom)

11:30 SYM-31-04Characterising the structural dynamics of pneumococcal surfaceadhesin A by MD simulations and SPR spectroscopyDepaizes, E., Begg, S., Campbell, R., Van Wonderen, J.,Macmillan, F., McDevitt, C.A. and O'Mara, M.L. (Australiaand UK)

11:45 SYM-31-05A mortise tenon joint in the transmembrane domain modulatesautotransporter assembly into bacterial outer membranesLeyton, D.L. and Lithgow, T. (Australia)


10:30 – 12:00

SYMPOSIUM 32

INTEGRATIVE BIOLOGY

Chairs: Dr Michael Inouye, University of Melbourne, VICDr Melissa Davis, University of Melbourne, VIC

Location: Swan Room

10:30 SYM-32-01Integrative genomics applied to human complex diseases: astudy of coronary artery diseaseMakinen, V.-P. (Australia)

10:50 SYM-32-02Symbiotic cnidaria and meta-organism responses toenvironmental changeAinsworth, T.D. (Australia)

11:10 SYM-32-03Population metagenomics of a developing infant gutmicrobiomeChan, E.K.F., Nelson, T., Zhang, Q., Brown, M., Michel, M.,Larsen, D., Facciotti, M. and Darling, A.E. (Australia)

11:30 SYM-32-04Genomic strategies and functional insights to novel eye diseasegenesJamieson, R.V., Greenlees, R., Prokudin, I., Yousoof, S.,Loebel, D., Becker, T., Tam, P., Semina, E. and Davila, S.(Australia, USA and Singapore)

11:45 SYM-32-05RBP atlas: an exploration of interactions between mRNA andproteins and their impact on cardiomyocyte biologyLiao, Y., Fischer, B., Castello, A., Yang, H., Foehr, S., Leicht,S., Rastislav, H., Jeroen, K., Hentze, M. and Preiss, T.(Australia)


10:30 – 12:00

SYMPOSIUM 33

SIGNALLING IN SPACE AND TIME

Chairs: Professor Alpha Yap, University of Queensland, QLDProfessor Sarah Russell, Peter MacCallum Cancer Centre,VIC


10:30 SYM-33-01Regulation of signal transduction by caveolaeParton, R.G. (Australia)

10:50 SYM-33-02Genetic and environmental factors affect signal transductionduring mouse embryogenesisDunwoodie, S.L. (Australia)

11:10 SYM-33-03Reconstruction of protein clusters that organize T cell receptorphosphorylation signaling network regulated both positivelyand negatively by phosphatase CD45Kaizuka, Y. (Japan)

11:30 SYM-33-04Plasticity in the functional networks that comprise and controlcell migrationLock, J.G., Berge, U., Gong, X., Hernandez-Varas, P., Kiss,A., Kowalewski, J., Mamaghani, M.J., Shafqat, H. andStrombald, S. (Sweden)

11:45 SYM-33-05Multiple roles for the Drosophila netrin receptor, Frazzled, inEpithelial Mesenchymal transitionsGolenkina, S., Manhire-Heath, R., Saint, R. and Murray, M.J.(Australia)

12:00 – 13:00 LUNCH / EXHIBITION / POSTERSLocation: Exhibition Hall13:00 – 14:00 POSTER SESSION CLocation: Exhibition Hall


14:00 – 14:40

PLENARY 16

PLENARY LECTURE

Chair: Professor Rob Parton, University of Queensland, QLDLocation: Royal Theatre

PLE-WED-16Organizing principles of the plasma membrane for signaltransduction as revealed by single-molecule trackingKusumi, A. (Japan)

Professor Aki Kusumi

My love of membranes was accidentally initiated when I, asenior majoring in physics at that time, went to the wronglecture room. There, Professor Shun-ichi Ohnishi of KyotoUniversity happened to be lecturing about the Singer andNicolson’s fluid mosaic model in his membrane course in1974, just two years after the publication of this model.Professor Ohnishi became my PhD advisor, with whom Istudied the rotational diffusion of rhodopsin in reconstituted

membranes using saturation transfer EPR, which had just been invented byProfessor Jim Hyde of the Medical College of Wisconsin. I did mypostdoctoral research with Jim, who is responsible for developing my patiencefor the signal-to-noise ratios of less than three (nonlinear EPR of membranes,1980–2) and then with Professor Malcolm Steinberg (Princeton University,1982–4), who is responsible for my experience with cellular anddevelopmental biology (cell adhesion and desmosomes). Through these foggyperiods, I somehow developed my love of time-resolved fluorescencemeasurements under the microscope (1984) and single-molecule imaging(1989). Like molecules in the plasma membrane, I underwent hop diffusionfrom Kyoto (Assistant Professor), Tokyo (Associate Professor), Nagoya(Professor 1997), and then Kyoto again (Professor 2005), and sometimesbecame trapped in smaller domains within a compartment, carrying outprojects called ‘Membrane Organizers’, ‘Membrane Mechanisms’ and‘Hierarchical Meso-Scale Domains’.


14:00 – 14:40

PLENARY 17

PLENARY LECTURE

Chair: Professor Christine Beveridge, University of Queensland,QLD


PLE-WED-17Hormonal cross-talk regulating plant organogenesis anddevelopmentBenkova, E. (Austria)

Professor Eva Benková

Eva Benková obtained her PhD in Biophysics in 1998from the Institute of Biophysics, Czech Academy ofSciences. Currently, she is the head of a research group atthe Institute of Science and Technology in Austria . Sheis a plant developmental biologist and her researchfocuses on molecular mechanisms and principlesunderlying hormonal interactions in plants and theidentification of key points in which hormonal signalingpathways converge to control plant growth and

development. Benková’s earlier developmental biology studies identified acommon module for the formation of plant organs. She showed that all organssuch as leaves, flowers and lateral roots in all plant species are formed by thesame mechanism involving asymmetric activity of the plant hormone auxin.More recently, Benková’s research focus is on hormonal crosstalk. Togetherwith her team, she contributed to the understanding of molecular mechanismsunderlying the establishment of complex hormonal networks directing plantdevelopment.


14:45 – 15:25

PLENARY 18

PLENARY LECTURE

Chair: Dr Jason Howitt, University of Melbourne, VICLocation: Royal Theatre

PLE-WED-18Rho regulators in neuronal development and associateddisordersYang, Y.-T., Wang, C.-L., Tai, Y., Elmer, B., Wang, M. andVan Aelst, L. (USA)

Professor Linda Van Aelst

Linda Van Aelst is a Professor and Leader of the SignalTransduction Program at Cold Spring Harbor Laboratory.Research in her laboratory focuses on understanding howdefects in Ras- and Rho-linked proteins contribute to bothcancer and brain disorders, at a molecular and cellular level.Her laboratory has made seminal contributions towardsunraveling downstream effector pathways of oncogenic Ras

proteins, mediating their effects on cellular transformation. More recently, herlaboratory has concentrated in particular on the functional characterisation ofdistinctive Rho regulators in neurodevelopment and associated disorders,including mental retardation, schizophrenia and autism. Their studies haverevealed novel functions for distinctive Rho regulators in the development,maturation and physiology of different neuronal cell types. Their future studieswill continue to investigate how defects in Rho-linked proteins contribute tothe pathophysiology/development of common brain disorders. Professor VanAelst has been recognised with several honours, including the V Foundationand Sidney Kimmel Research Award, the Dana Foundation Award and theNAAR Foundation Award.


14:45 – 15:25

PLENARY 19

PLENARY LECTURE

Chair: Professor Edna Hardeman, University of New SouthWales, NSW


PLE-WED-19Posttranscriptional control of stem cell functionRando, T.A. (USA)

Professor Thomas Rando

Thomas Rando is Professor of Neurology and NeurologicalSciences and Director of the Glenn Laboratories for theBiology of Aging at Stanford University School ofMedicine. He is also Chief of Neurology at the Palo AltoVA Medical Center where he is Director of theRehabilitation Research and Development Center ofExcellence whose focus is the emerging field ofregenerative medicine. Research in the Rando laboratoryconcerns the basic biology of stem cells, how stem cells

function in adult tissue homeostasis, and how their function is altered indegenerative diseases and during aging. Groundbreaking work showed that theage-related decline in stem cell function is due primarily to influences of theaged environment rather than to intrinsic aging of stem cell themselves. Randohas received numerous awards, including a Paul Beeson Physician FacultyScholar in Aging, a Senior Scholar Award from the Ellison MedicalFoundation and a Breakthroughs in Gerontology Award from the AmericanFederation for Aging Research. In 2005, he received the prestigious NIHDirector’s Pioneer Award, and he was recently awarded a TransformativeResearch Award from the NIH.

15:25 – 16:00 AFTERNOON TEA / EXHIBITION / POSTERS15:35 PASSPORT DRAWLocation: Exhibition Hall


16:00 – 17:30

SYMPOSIUM 34

EDUCATION II

Chairs: Dr Gonzalo M. Estavillo, CSIRO, ACTA/Prof Susan Howitt, Australian National University, ACT


16:00 SYM-34-01Development of a 'Learning and Teaching Academic Standardsstatement' for agricultureAcuna, T., Kelder, J., Able, A., McDonald, G., Guisard, Y.,Bellotti, B., Wormell, P., Doyle, R. and Meinkie, H. (Australia)

16:20 SYM-34-02Mapping Assessment practices to provide insight into learningand teachingSimpson, C.M., Speed, C.J. and Macaulay, J.O. (Australia)

16:40 SYM-34-03The development of undergraduate science students' scientificargument skills in oral presentationsBugarcic, A., Colthorpe, K., Zimardi, K., Su, H.W. andJackson, K. (Australia)

17:00 SYM-34-04Developing students' scientific writing skills through embeddedwriting activities in bioscience undergraduate laboratory andhonours coursesTonissen, K.F., Lee, S.E., Woods, K.J. and Osborne, S.A.(Australia)

17:15 SYM-34-05Beyond memorising facts: developing critical thinking andscientific reasoning skills in biology undergraduatesCossetto, S.B. and Gniel, H. (Australia)


16:00 – 17:30

SYMPOSIUM 35

PLANT ECOPHYSIOLOGY

Chairs: Professor David Tissue, University of Western Sydney,NSWProfessor Marilyn Ball, Australian National University,ACT


16:00 SYM-35-01Live fast, die young? Plant traits associated with recovery fromdrought-induced xylem embolism across contrasting biomesZeppel, M.J.B., Adams, H.D., Anderegg, W.L., Cook, A.,Hudson, P., Eamus, D.G., Pacala, S. and Tissue, D.T.(Australia, New Mexico and USA)

16:20 SYM-35-02Comparative ecophysiology of acacia hybrid clones, doespolyploidy infer incrased drought tolerance?O'Grady, A.P., Mitchell, P.J., Pinkard, E.A., Harbard, J.,Griffith, R. and Ottenschlaeger, M. (Australia)

16:40 SYM-35-03Testing the limits of photosynthetic plasticity in tropical andtemperate provenances of two widespread eucalyptus speciesSharwood, R.E., Crous, K., Drake, J., Aspinwall, M., Whitney,S.M., Tjoelker, M. and Ghannoum, O. (Australia)

17:00 SYM-35-04Short-term and long-term effects of CO2 on mesophyllconductance in wheat (Triticum aestivum L.)Jahan, E., Farquhar, G.D. and Barbour, M.M. (Australia)

17:15 SYM-35-05Assessing the coordination of leaf hydraulic supply and demandwith gas exchange in response to elevated CO2 acrossgenotypes of Eucalyptus camaldulensis seedlingsBlackman, C.J., Smith, R., Pinkard, L., O'Grady, t., Farquahar,G. and Tissue, D.T. (Australia)


16:00 – 17:30

SYMPOSIUM 36

BIOMIMETIC MATERIALS AND BIODEVICE PLATFORMSFOR REGENERATION

Chairs: Professor Justin Cooper-White, CSIRO and University ofQueensland, QLDDr Keith McLean, CSIRO, VIC


16:00 SYM-36-01From biochemistry to biomaterials: building and repairingtissue in 3DWeiss, A.S. (Australia)

16:20 SYM-36-02Harnessing the regenerative power of the brain usingbiomaterialsFon, D., Crack, P.J., Finkelstein, D.I., Zhou, K. and Forsythe,J.S. (Australia)

16:40 SYM-36-03Optimisation of stem cell expansion, maintenance anddifferentiation using multiplexed microbioreactor arraysCooper-White, J.J. (Australia)

17:00 SYM-36-04Biomimetic macroporous hydrogels for cell culture and softtissue engineeringO'Connor, A.J. (Australia)

17:15 SYM-36-05Using pancreatic cell biology to inform the design of abiosynthetic hydrogel microencapsulation systemMartens, P.J., Cheng, J., Young, C.J. and Poole-Warren, L.A.(Australia)


16:00 – 17:30

SYMPOSIUM 37

PROTEOMICS (AND LIPIDOMICS)

Chairs: A/Prof Todd Mitchell, University of Wollongong, NSWA/Prof Mark Raftery, University of New South Wales,NSW


16:00 SYM-37-01 Eppendorf Edman Award LectureA bubble ride for the oncogenes: exosomes in the tumormicroenvironmentLiem, M., Kaira, H., Ang, C. and Mathivanan, S. (Australia)

16:20 SYM-37-02Comprehensive lipidome profiling to identify functionalbiomarkers of colorectal cancer malignancy and metastaticprogressionReid, G.E. (Australia)

16:40 SYM-37-03Quantitative phosphotyrosine profiling to identify noveltherapeutic targets in high-risk pediatric leukemiaDolai, S., Sia, K.C., Mendomo, A., Robbins, A., Zhong, L.,Hochgrafe, F., Daly, R.J., Raftery, M.J. and Lock, R.B.(Australia and Germany)

17:00 SYM-37-04Multiphase on-chip peptide separation enables improvedidentification and quantitation in targeted and discoveryproteomicsKrisp, C., Yang, M., Van Soest, R., Parker, R., Pascovici, D.and Molloy, M.P. (Australia and USA)

17:15 SYM-37-05The discovery and characterisation of novel peptides encodedby upstream open reading framesNouwens, A.S., Feng, C., Andrews, S.J., Yeoh, J., Friend, L.,Smith, R. and Rothnagel, J.A. (Australia)


16:00 – 17:30

SYMPOSIUM 38

TRANSCRIPTION AND REGULATORY PROGRAMS

Chairs: Professor Ross Hannan, Peter MacCallum Cancer Centre,VICDr Leonie Quinn, University of Melbourne, VIC

Location: Swan Room

16:00 SYM-38-01Caging the beast: How FBP, FIR and DNA supercoilingconstrain MYC expression and functionLevens, D. (USA)

16:20 SYM-38-02Transcription factors: choosing the right target geneCrossley, M. (Australia)

16:40 SYM-38-03Activator protein-1: a hub for epithelial-mesenchymal plasticitycontrol in cancer cellsDiesch, J., Gilan, O., Perreira, L., Hannan, R. and Dhillon, A.(Australia)

17:00 SYM-38-04Histone variant H3.3 provides the heterochromatic H3K9trimethylation mark at telomeresUdugama, M., Chan, F.L., Chang, F.T.M., Mcghie, J.D., Tang,M., Mann, J.R. and Wong, L.H. (Australia)

17:15 SYM-38-05Crosstalk between Single-minded 2 and Hypoxia InducibleFactors in cancer developmentSullivan, A.E., Lee, K.-L., Farrall, A.L., Peet, D.J., Poellinger,L. and Whitelaw, M. (Australia and Singapore)


16:00 – 17:30

SYMPOSIUM 39

RECEPTORS AND RECEPTOR SIGNALLING

Chairs: Professor Tony Tiganis, Monash University, VICProfessor Fiona Pixley, University of Western Australia,WA


16:00 SYM-39-01The structural biology of the insulin/insulin receptor interaction- new insights at the limits of resolutionMenting, J.G., Yang, Y., Phillips, N.B., Smith, B.J., Yadav,S.P., Ward, C.W., Weiss, M.A. and Lawrence, M.C. (Australiaand USA)

16:20 SYM-39-02Mechanism of activation of JAK2 by the growth hormonereceptorWaters, M.J. and Brooks, A.J. (Australia)

16:40 SYM-39-03Exploiting GP130 signaling for the treatment of gastrointestinalcancerPutoczki, T., Wilson, N., Boussioutas, A. and Ernst, M. (Australia)

17:00 SYM-39-04A unique insight into the mechanism of insulin receptor bindingand activation using dicarba insulin peptidesOng, S.-C., Belgi, A., Van Lierop, B., Lawrence, M.,Andrikopoulos, S., Robinson, A. and Forbes, B. (Australia)

17:15 SYM-39-05The phospholipid flippase dATP8B is required for odorantreceptor function in DrosophilaLiu, Y.-C., Pearce, M., Herr, A., Prescott, M., De Bruyne, M.and Warr, C.G. (Australia)


17:30 – 18:30

ANNUAL GENERAL MEETINGS

Locations: ASBMB Royal TheatreASPS BradmanTheatretteANZSCDB Sutherland Theatrette

19:30 – 23:30 CONFERENCE DINNERLocation: National Arboretum

Buses will depart from the front of the National Convention Centreat 7.00pm.

THURSDAY 2 OCTOBER 2014

09:00 – 10:30

SYMPOSIUM 40

PLANT METABOLISM AND NUTRITION

Chairs: A/Prof Yong-Ling Ruan, University of Newcastle, NSWDr Steve Jobling, CSIRO, ACT


09:00 SYM-40-01Molecular responses of maize plants to nitrogen or phosphatestarvationSchlueter, U. and Sonnewald, U. (Germany)

09:20 SYM-40-02Alleviating micronutrient deficiencies through biofortificedbananasDale, J.L., Paul, J.Y., Khanna, H., Kleidon, J., Mlalazi, B.,Hoang, P., Daniels, J., James, A., Tushemereirwe, W. andHarding, R.M. (Australia and Uganda)

09:40 - SYM-40-03Oilseed TAG yields from plant leavesVanhercke, T., Petrie, J., El Tahchy, A., Liu, Q., Zhou, X.-R.,Shrestha, P., Reynolds, K. and Singh, S. (Australia)

10:00 SYM-40-04A vacuolar invertase GhVIN1, controls cotton fibre initiationprobably by modulating a set of regulatory genes via sugarsignallingWang, L., Cook A., Patrick. J.W., Chen, X.Y. and Ruan, Y.L.(Australia and China)

10:15 SYM-40-05Small change in seed, big benefits to nutrition: nutritionalenhancement of rice by thick aleurone phenotypeYu, C.W., Wu, X.B., Howitt, C.A., Bird, A.R., Pogson, B.J.,Liu, C.M. and Larkin, P.J. (Australia and China)


09:00 – 10:30

SYMPOSIUM 41

IMPROVING ABIOTIC STRESS TOLERANCE

Chairs: Dr Peter Ryan, CSIRO, ACTProfessor Sergey Shabala, University of Tasmania, TAS


09:00 SYM-41-01Ethylene priming: a new mechanism that confers floodingtoleranceVoesenek, L.A.C.J. (The Netherlands)

09:20 SYM-41-02Identifying novel salinity and drought tolerance mechanisms incerealsHill, C.B., Natera, S.H., Boughton, B.A., Mather, D., Taylor, J.,Langridge, P., Bacic, A., Roy, S. and Roessner, U. (Australia)

09:40 SYM-41-03Reproductive stage abiotic stress tolerance in wheatDolferus, R., Edlington, J., Staniford, H. and Rebetzke, G.(Australia)

10:00 SYM-41-04Evaluating contribution of ionic, osmotic and oxidative stresscomponents towards salinity tolerance in barleyAdem, G., Roy, S., Zhou, M., Bowman, J. and Shabala, S.Australia)

10:15 SYM-41-05Climate-induced manganese toxicity stress vs evolvedtolerance: a study of two contrasting plant ecosystemsFermando, D.R.M., Marshall, A.T., Forster, P.I. and Lynch,J.P. (Australia and USA)


09:00 – 10:30

SYMPOSIUM 42

EMBRYONIC PATTERNING AND ORGANOGENESIS

Chairs: Professor Christophe Marcelle, Monash University, VICA/Prof Joan Heath, Walter & Eliza Hall Institute ofMedical Research, VIC


09:00 SYM-42-01Immune regulation of zebrafish heart regenerationSheng, D.Z., Gonzalez-Rajar, A. and Kikuchi, K. (Australia)

09:20 SYM-42-02Control of tissue growth via the hippo pathwayHarvey, K.F., Dent, L.G., Zhang, X., Degoutin, J.L., Poon,C.L.C., Milton, S. and Yu, E. (Australia)

09:40 SYM-42-03In situ identification of bipotent stem cells in the mammaryglandRios, A., Fu, N.Y., Lindeman, G.J. and Visvader, J. (Australia)

10:00 SYM-42-04The ZIC2 gene mediates correct migration of anterior notochordprecursors to prevent holoprosencephalyGlanville-Jones, H.C., Chappel, A., Gibson, P. and Arkell,R.M. (Australia)

10:15 SYM-42-05RNA-squ identifies the zinc finger gene, ZNF385B, as a novelplayer in chicken gonadal sex differentiationSmith, C.A., Ayers, K.L. and Lambeth, S.L. (Australia)


09:00 – 10:30

SYMPOSIUM 43

CHROMATIN STRUCTURE AND EPIGENOMICS

Chairs: A/Prof Sudha Rao, University of Canberra, ACTDr Adele Holloway, University of Tasmania, TAS

Location: Swan Room

09:00 SYM-43-01The prenucleosome, a novel non-nucleosomal histone-DNAparticleKhoung, M.T., Fei, J., Torigoe, S.E, Brown, C.R., Boeger, H.and Kadonaga, J.T. (USA)

09:20 SYM-43-02Linking epigenomics to biology: insights from developmentalcanalisation in honey beesMaleszka, R. (Australia)

09:40 SYM-43-03Epigenome engineering in cancerBloj, B.G., Flahi, F., Viklova, V. and Blancafort, P. (Australia)

10:00 SYM-43-04Changes in DNA accessibility occur in putative enhancerregions of a subset of T cell memory responsive genesHardy, K., Tu, W., Sutton, C., Li, J., Morris, M. and Rao, S.(Australia)

10:15 SYM-43-05Probing the structure and function of a 1-MDA chromatinremodeling complexWebb, S.R., Low, J.K., Landsberg, M.J., Shepherd, N.E., Silva,A. and Mackay, J.P. (Australia)


09:00 – 10:30

SYMPOSIUM 44

MOLECULAR IMAGING AND SINGLE MOLECULEBIOCHEMISTRY

Chairs: Dr Elizabeth Hinde, University of New South Wales, NSWProfessor Katharina Gaus, University of New South Wales,NSW


09:00 SYM-44-01Single-molecular imaging of cellular assembly and disassemblyprocessesBowden, Q., Rosenkranz, T., Hatters, D. and Boecking, T.(Australia)

09:20 SYM-44-02Prions here, prions there, prions everywhereGambin, Y., Giles, N., Polinkovsky, M.E., Moustaqil, M.,Bhumkar, A. and Sierecki, E. (Australia)

09:40 SYM-44-03Malaria virulence: A super resolution solutionDixon, M.W.A., McHugh, E., Batinovic, S., Looker, O.,Dearnely, M.K., Kenny, S., Hanssen, E., McMillan, P. andTilley, L. (Australia)

10:00 SYM-44-04Elucidation of T cell fate control by time lapse imaging andquantitative microscopyYassin, M., Shimoni, R., Ludford-Menting, M., Gu, M. andRussell, S.M. (Australia)

10:15 SYM-44-05Structural rearrangement of HIV-1 prior to uncoating revealedby single-molecule localisation microscopyTabarin, T., Pham, S., Mak, J. and Gaus, K. (Australia)


09:00 – 10:30

SYMPOSIUM 45

PROTEIN MODIFICATION AND TURNOVER

Chairs: Professor Wally Langdon, The University of WesternAustralia, WADr Justine Mintern, Unversity of Melbourne, VIC


09:00 SYM-45-01A non-canonical N-end rule pathway of protein degradation inmitochondriaSaiyed, T., Faou, P., Dougan, D.A. and Truscott, K.N.(Australia)

09:20 SYM-45-02Defining the role of E3 ubiquitin ligase UBR5 in cancerthrough substrate identificationIconomou, M., Shearer, R., McKenna, J., Uhl, F. andSaunders, D. (Australia)

09:40 SYM-45-03Regulating iron transport through ubiquitinationKumar, S., Mackenzie, K., Foot, N., Collins, B., Hiwase, D.and Dalton, H. (Australia)

10:00 SYM-45-04Epithelial cell movement and the nuclear and cytoplasmicforms of the essential protease dipeptidyl peptidase-9Zhang, H., Keane, F.M., Stephens, A.N., Gall, M.G.,McCaughan, G.W., Geiss-Friedlander, R., Justa-Such, D.,Maqsudi, S., Chen, Y. and Gorrell, M.D. (Australia andGermany)


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10:15 SYM-45-05Fibroblast activation protein (FAP) degradomics highlights therole of FAP in extracellular matrixHamson, E.J., Keane, F., Koczorowska, M., Tholen, S.,Schilling, O. and Gorrell, M. (Australia and Germany)

10:30 – 11:00 MORNING TEALocation: Main Foyer


11:00 – 12:30

SYMPOSIUM 46

PLANT-WATER RELATIONS

Chairs: Professor Steve Tyerman, University of Adelaide, SAProfessor Tim Colmer, The University of WesternAustralia, WA


11:00 SYM-46-01Estimating turnover time of leaf water pools using stableisotopesSong, X., Simonin, K.A., Loucos, K.E. and Barbour, M.M.(Australia)

11:20 SYM-46-02Osmotic adjustment and turgor maintenance in salt-stressedwheat and barleyJames, R.A., Blake, C. and Munns, R. (Australia)

11:40 SYM-46-03Constitutive overexpression of soybean plasma membraneintrinsic protein GmPIP1;6, GMPIP2;9 confers drought and salttoleranceShou, H.X., Zhou, L., Liu, R., Wang, C., Han, Q., Duan, J.,Vandeleur, R.K. and Tyerman, S. (China and Australia)

12:00 SYM-46-04A shift of driving force for water uptake into grape berriesduring the course of ripeningScharwies, J.D. and Tyerman, S.D. (Australia)

12:15 SYM-46-05The complete set of maize CV B73 aquaporins and a subsetexpressed in roots with water permeabilityWignes, J.A., Dechorgnat, J., Kaiser, B.N. and Tyerman, S.D.(Australia)


11:00 – 12:30

SYMPOSIUM 47

NEURAL DEVELOPMENT

Chairs: A/Prof Helen Cooper, University of Queensland, QLDProfessor Paul Thomas, University of Adelaide, SA


11:00 SYM-47-01Sonic hedgehog and primary cilia regulate a switch in axonguidance responses in the spinal cordWilson, N.H. (Switzerland and Australia)

11:20 SYM-47-02Exploring the role of the oligodendrocyte progenitor cellprocess in synaptogenesis and activity-dependent myelinationGasperini, R., Cobden-Watts, F., O'Rourke, M., Cullen, C.,Hogarth, S., Foa, L. and Young, K.M. (Australia)

11:40 SYM-47-03Mutations in USP9X cause intellectual disability and effectneuronal migration and axon growthJolly, L.A., Homan, C.C., Wood, S.A. and Gecz, J. (Australia)

12:00 SYM-47-04Sumoylation of Zic5 exerts multiple effects on transcription topromote neural crest cell developmentAli, R.G., Bellchambers, H.M., Warr, N., Ahmed, J.N., Barratt,K., Neill, K. and Arkell, R.M. (Australia and UK)

12:15 SYM-47-05The role of the neural cell adhersion molecule in maturation ofsynaptic contactsLeshchynska, I. and Sytnyk, V. (Australia)


11:00 – 12:30

SYMPOSIUM 48

PROTEIN FOLDING AND MISFOLDING

Chairs: A/Prof Margaret Sunde, University of Sydney, NSWProfessor Andrew Hill, University of Melbourne, VIC


11:00 SYM-48-01Altered proteostasis during aging in C. elegans revealed byproteomic analysisLiang, V., Ullrich, M., Lam, H., Chew, Y.L., Banister, S., Song,X., Zaw, T., Kassiou, M., Gotz, J. and Nicholas, H. (Australia)

11:20 SYM-48-02Protein disulphide isomerase is protective against the pathologyinduced by mutant forms of SOD1, TDP-43 and FUS inamyotrophic lateral sclerosisParakh, S., Spencer, D., Sultana, J., Billa, N., Al Helwani, N.,Turner, B., Aumann, T. and Atkin, J.D. (Australia)

11:40 SYM-48-03Tau nitration modulates -synuclein secretion through anexosome dependent pathwayHung, L.W., Jacobson, L.H., Gunn, A.P., Coleman, B.,Scicluna, B.J., Ugalde, C., Donnelly, P.S., Adlard, P.A.,Finkelstein, D., Hill, A.F. and Barnham, K.J. (Australia)

12:00 SYM-48-04Functional amyloid from fungal hydrophobins: structure,assembly and applicationsMorris, V.K., Ren, Q., Pham, C., Lo, V., Liner, R., Knight,M.J., Pintacuda, G., Sunde, M. and Kwan, A.H. (Australia,Germany and France)

12:15 SYM-48-05Deciphering the "aggregation kinetics" of misfolded proteins inthe cellHatters, D.M., Polling, S., Mok, Y.F., Ramdzan, Y.M., Turner,B.J., Yerbury, J.J. and Hill, A.F. (Australia)


11:00 – 12:30

SYMPOSIUM 49

RNA BIOLOGY

Chairs: Professor Greg Goodall, Centre for Cancer Biology,SA Pathology, SAProfessor Thomas Preiss, Australian National University,ACT

Location: Swan Room

11:00 SYM-49-01piRNAs in the adult testes in the common marmosetSiomi, H., Hirano, T., Iwasaki, Y.W. and Siomi, M.C. (Japan)

11:20 SYM-49-02MicroRNA replacement therapy in cancer - are we there yet?Kalinowski, F.C., Brown, R.A.M., Giles, K.M., Candy, P.,Epis, M.R. and Leedman, P.J. (Australia)

11:40 SYM-49-03A microRNA-Quaking regulatory pathway controls alternativesplicing associated with epithelial cell plasticityGregory, P.A., Phillips, C.A., Roslan, S., Pillman, K.A.,Toubia, J., Conn, S.J., Selth, L.A., Lawrence, D.M. andGoodall, G.J. (Australia)

12:00 SYM-49-04Depolarisation-associated miRNA redistribution in humanneurons occurs primarily in the neurite fraction and involves therelease of exosomesGoldie, B.J., Dun, M.D., Lin, M. and Cairns, M.J. (Australia)

12:15 SYM-49-05Exploring the role of RNA cytosine methylation in post-transcriptional gene regulation and cancerSibbritt, T., Parker, B.J., Humphreys, D.T., Squires, J.E.,Beveridge, N.J., Shafik, A., Statham, A.L., Patel, H.R., Clark,S.J. and Preiss, T. (Australia)


11:00 – 12:30

SYMPOSIUM 50

CELL BIOLOGY IN VIVO

Chairs: Dr Scott Mueller, University of Melbourne, VICA/Prof Nicolas Plachta, Monash University, VIC


11:00 SYM-50-01Intravital two-photon photoconversion and single cell geneexpression analysis to map the origin and fate of follicular Bhelper T cellsSuan, D., Nguyen, A., Moran, I., Hampton, H.R., Bourne, K.,Hermes, J., Arshi, M., Brink, R., Chtanova, T. and Phan, T.G.(Australia)

11:20 SYM-50-02Surveillance and protective responses by skin tissue-residentmemory T cellsZaid, A., Mackay, L.M., Hor, J.L., Heath, W.R. and Mueller,S.N. (Australia)

11:40 SYM-50-03Revealing how the first tissue-like structure forms in themammalian embryoWhite, M.D. (Australia)

12:00 SYM-50-04Rho GTPase functions in early postimplantation mousedevelopmentLoebel, D.A.F., Tang, T.L., Chung, H.C., Power, M.,Greenlees, R. and Tam, P.P.L. (Australia)

12:15 SYM-50-05Intravital imaging at subcellular resolution reveals multipleactin filament populations involved in exocytosis of secretorygranulesMasedunskas, A., Appaduray, M., Hardeman, E. and Gunning,P. (Australia)


11:00 – 12:30

SYMPOSIUM 51

SIGNALLING NETWORKS

Chairs: Professor Roger Daly, Monash University, VICA/Prof Yeesim Khew-Goodall, Centre for Cancer Biology,SA Pathology, SA


11:00 SYM-51-01Characterising novel signaling axes in the interferon systemDe Weerd, N., Mangan, N., Gould, J., Zaker-Tabriz, L., Fung,K.Y., Forstser, S., Reid, H., Vivian, J.P., Rossjohn, J. andHertzog, P.J. (Australia)

11:20 SYM-51-02ID4 controls mammary stem cells and marks breast cancerswith a stem cell-like phenotypeJunankar, S., Baker, L., Roden, D.L., Nair, R., Elsworth, B.,Lakhani, S., Simpson, P.T., Ormandy, C., O'Toole, S. andSwarbrick, A. (Australia and USA)

11:40 SYM-51-03Pathway and network analysis of molecular interactions andsignalling networks implicated in epithelial-mesenchymalplasticityDavis, M.J. (Australia)

12:00 SYM-51-04Beta2-adrenergic signalling regulates invadopodia formationand invasion in breast cancerCreed, S.J., Hassan, M., Chan, K.T., Albold, S., Berginski,M.E., Bear, J.E., Nowell, C.J. and Sloan, E.K. (Australia andUSA)


12:15 SYM-51-05The actin associated protein tropomyosin 5NM1 participates inMAPK/ERK-mediated cell proliferation by regulating pERKnuclear transportWang, B., Schevzov, G., Hook, J., Kee, A., Lucas, C., Seger,R., Hardeman, E. and Gunning P. (Australia and Israel)

12:30 – 13:30 LUNCH BREAK (lunch may be purchased at nearby cafés)


13:00 – 13:50

SYMPOSIUM 52

WARWICK HILLIER MEMORIAL SYMPOSIUM ONPHOTOSYNTHETIC LIGHT REACTIONS

Chairs: Professor Barry Pogson, Australian National University,ACTProfessor Murray Badger, Australian National University,ACT


13:00 SYM-52-01Introduction to the life and work of Warwick HillierBadger, M. (Australia)

13:05 SYM-52-02Studies of photosystem II at the Hillier lab: mechanism of PSIIphotodamage & mechanism of water oxidation by PSIICheah, M. (Australia)

13:20 SYM-52-03Monitoring photosystem II function in leavesChow, W.S. (Australia)

13:35 SYM-52-04High level computational chemical studies of substrate waterbinding to the oxygen evolving centre (OEC) in Photosystem IIPetrie, S., Terrett, R., Stranger, R. and Pace, R.J. (Australia)


13:30 – 14:10

PLENARY 20

PLENARY LECTURE

Chair: Professor Katharina Gaus, University of New South Wales,NSW


PLE-THU-20Multi-scale analysis of cell and tissue organizationVillasenor, R., Zeigerer, A., Nonaka, H., Meyer, K., Marsico,G., Seifert, S., Kalaidzidis, Y. and Zerial, M. (Germany)

Professor Marino Zerial

Marino Zerial has made major contributions towards theunderstanding of the molecular mechanisms of endocytosis.With the characterization of the role of Rab GTPases asintracellular trafficking regulators, Zerial’s work hasestablished key principles that are now textbook knowledge.He has shown that Rab5 is a master regulator of endosomebiogenesis. In the past few years, Zerial’s group hasperformed a systems analysis of endocytosis using acombination of genome-wide RNAi screening and

quantitative multiparametric image analysis. Zerial and colleagues have beendeveloping methods for a multiscale analysis of tissue organisation andfunction, using the mouse liver as model system. For his scientificcontributions, he has been awarded international research prizes including the1994 FEBS Anniversary Prize, the 1999 Chiara D’Onofrio Prize and theprestigious Gottfried Wilhelm Leibniz Prize in 2006. Zerial was elected EMBOMember in 1996, became Director at the Max Planck Institute of MolecularCell Biology and Genetics in 1998 and is Honorary Professor at the MedicalFaculty, University of Technology, Dresden.


13:30 – 14:10

PLENARY 21

PLENARY LECTURE

Chair: A/Prof Sudha Rao, University of Canberra, ACTLocation: Bradman Theatrette

PLE-THU-21Operating systems and "apps" for the regulation of our genesWang, Y.L., Duttke, S.H.C., Chen, K., Johnston, J.,Kassavetis, G.A., Gucwa, J., Zeitlinger, J., Doolittle, R.F. andKadonaga, J.T. (USA)

Professor Jim Kadonaga

Jim Kadonaga was an undergraduate in Chemistry at theMassachusetts Institute of Technology, where he receivedthe Alpha Chi Sigma Prize as well as the American Instituteof Chemists Certificate. He then carried out his graduatestudies with Jeremy R. Knowles in the Department ofChemistry at Harvard University, where he was a DuPontFellow. Jim was a postdoctoral associate with Robert Tjianat UC Berkeley as a Fellow of the Miller Institute for Basic

Research in Science, American Cancer Society, and Lucille P. MarkeyCharitable Trust. He joined the faculty at the University of California, SanDiego (UCSD) in 1988 and served as the Chair of the Section of MolecularBiology (2003–2007). In 2012, he received the UCSD Chancellor’s AssociatesAward for Excellence in Research in Science and Engineering. Jim is presentlythe Amylin Endowed Chair and a Distinguished Professor. His researchinterests include chromatin dynamics as well as the regulation of transcriptionby RNA polymerase II.


14:15 – 14:55

PLENARY 22

PLENARY LECTURE

Chair: Professor Owen Atkin, Australian National University,ACT


PLE-THU-22Physiological responses of trees to rising carbon dioxide sincethe last glacial period: synchronous responses on bothhemispheresWard, J. (USA)

A/Prof Joy Ward

Joy Ward is an Associate Professor in the Department ofEcology and Evolutionary Biology and is the WohlgemuthFaculty Scholar at the University of Kansas. She receivedher PhD from Duke University with Boyd Strain in 1997,and she was a postdoctoral fellow at the University of Utahwith James Ehleringer from 1998–2003. Joy’s researchfocuses on the effects of changing atmospheric CO2 on thephysiology, growth and development of plants. Her work

incorporates broad time scales ranging from the last glacial period throughpredicted future conditions. Her early work showed through selection studiesthat changing atmospheric CO2 over contemporary time scales can alter theevolutionary trajectories of model plants, and she later demonstrated thatglacial plants were likely limited in carbon during the last glacial period. Joyreceived a CAREER Award from the US National Science Foundation in 2008,as well as the 2009 Presidential Early Career Award for Scientists andEngineers from President Obama.


14:15 – 14:55

PLENARY 23

PLENARY LECTURE

Chair: A/Prof John Pimanda, University of New South Wales,NSW


PLE-THU-23Induction of hematopoiesis in mouse and human fibroblastsMoore, K. (USA)

A/Prof Kateri Moore

Kateri Moore is an Associate Professor in theDevelopmental and Regenerative Biology Department anda member of the Black Family Stem Cell Institute at theIcahn School of Medicine at Mount Sinai, New York City.She received her Doctor of Veterinary Medicine in 1987from Kansas State University, where she also was aResearch Associate for many years. Her postdoctoraltraining was with John Belmont, in the Institute for

Molecular Genetics at Baylor College of Medicine in Houston, Texas. In 1992,she moved to the Department of Molecular Biology at Princeton University towork with Ihor Lemischka as a Senior Research Scholar in Molecular Biology.In 2007, she moved to Mount Sinai, where she has continued to develop herstudies of hematopoietic stem cells and their niche interactions and to expandinto research that involves the direct reprogramming of somatic cells intohemogenic cells and the mechanisms that mediate this process.


15:05 – 15:30

CLOSING CEREMONY, COMBIO2015 PRESENTATION ANDSOCIETY AWARD PRESENTATIONS


Professor Edna Hardeman, University of New South Wales, NSWChair, ComBio2014

A/Prof Marie Bogoyevitch, University of Melbourne, VICCo-Chair, ComBio2015

Professor Peter Gunning, University of New South Wales, NSWASBMB President

Professor Tim Colmer, The University of Western Australia, WAASPS President

A/Prof Carol Wicking, University of Queensland, QLDANZSCDB President

15:30 – 16:30 CLOSING DRINKSLocation: Main Foyer

SUNDAY 28 SEPTEMBER 2014 - ASBMB · Management, Australian Centre for International Agricultural...

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