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Transcript of summer project on mkt. research hyperuricemia & allopurinol molecule
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SSCMR 1 2009-11
Index
Objective of Study…………………………………………………
Scope of Study……………………………………………………
Research Methodology……………………………………………
Introduction to Wockhardt Limited………………………………
Hyperuricemia……………………………………………………
Drugs………………………………………………………….........
Data Analysis………………………………………………………
Recommendations and Suggestions ………………………………..
Conclusion …………………………………………………………
Limitations of Study………………………………………………
Learning Experience……………………………………………….
Questioner……………………………………………………….. ..
Bibliography……………………………………………………… .
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SSCMR 2 2009-11
Objective of Study
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SSCMR 3 2009-11
Objective of the study was to Estimate How many patients suffering from
Hyperuricemia per week in three different cities in Maharashtra and alsoestimate how many patients will be suffering from the same condition as in year,
And in five year and also which drugs doctors use to treat these Conditions.
Also find out the brands of Allopurinol available in market and potentiality
Of Allopurinol molecule near future as per Doctors survey and Chemist survey
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SSCMR 4 2009-11
Scope of Study
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SSCMR 5 2009-11
Scope was limited to Doctors [Nephrologist] and Chemist. And Doctors
Personal experiences with patients of Hyperuricemia and their views on drugs
Especially on Allopurinol was considered. This study has taken the entire question
felt necessary for information regarding Market Research on Hyperuricemia and
Allopurinol.
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SSCMR 6 2009-11
Research Methodology
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SSCMR 7 2009-11
Research methodology is considered as the nerve of the project. Without a proper
Organized research plan, it is impossible to complete the project and reach to
Any conclusion. The main objective of survey was to collect appropriate data
Which work as a base for drawing conclusion and getting result?
Therefore, research methodology is the way to systematically solve the research
Problem. Research methodology not only talks of the methods but also logic
behind The methods used in the context of research study and it explains why a
particular method has been used in the preference of the other method A
pharmaceutical company, or drug company, is a commercial business whose focus
is to research, develop, market and/or distribute drugs, most commonly in the
context of healthcare. They can deal in generic and/or brand Medications. They
are subject to a variety of laws and regulations regarding the Patenting, testing and
marketing of drugs, particularly prescription drugs. From Its beginnings at the
start of the 19th Century, the pharmaceutical industry is now one of the most
successful and influential industries, attracting both praise and Controversy, and
its activity are subject of much market research.
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SSCMR 8 2009-11
Research Design
Research design is important primarily because of the increased complexity in the
market as well as marketing approaches available to the researchers. In fact, it is
the key to the evolution of successful marketing strategies and programmers. It is
an important tool to study buyers behavior, consumption pattern, brand loyalty,
and focus market changes. A research design specifies the methods and
procedures for conducting a particular study. According to Kerlinger,
“Research design is a plan, conceptual structure, and strategy of investigation conceived as to obtain answers to research question answers to
research questions and to control variance.
Types of Research
Descriptive Research
The type of research adopted for study is descriptive. Descriptive studies are
undertaken in many circumstances when the researches is interested to know the
characteristic of certain group such as age, sex, education level, occupation or
income. A descriptive study may be necessary in cases when a researcher is
interested in knowing the proportion of people in a given population who have in
particular manner, manner making projections of a certain thing or determining
the relationship between two or more variables. The objective of such study is to
answer the “who, when where and how” of the subject under investigation, there
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SSCMR 9 2009-11
is a general feeling that descriptive studies are factual and very simple. This is not
necessarily true. Descriptive study can be complex, demanding a high degree of
scientific skill on part of the researcher.
Descriptive studies are well structured. An exploratory study needs to be flexible
in its approach, but a descriptive study in contract tends to be rigid and its
approach cannot be changed every now and then. It is therefore necessary, the
researcher give sufficient thought to framing research.
Questions and deciding the types of data to be collected and the procedures to be
used in this purpose. Descriptive studies can be divided in two brand categories: -
cross sectional and longitudinal sectional. A cross sectional studies are concerned
with sample of element from a given population. Thus, it may be deal with
household’s dealers, retail stores or other entities. Data on number of
characteristics from sample elements are collected and analyzed. Cross sectional
studies are two types: fields study and survey. Although the dictation between
them is not clear cut there are some practical differences, which need to be
different techniques and skills. Field studies are ex-post- factor scientific inquiries
that aim at finding the relations and interrelations among variables in a real
setting. Such studies are done in live situations like communities, schools,
factories and organizations. Another type of cross fuctional study is survey result,
which has been taken by me; a major strength of survey research is its wide scope.
Detail information can be obtained from a sample of large population. Besides it is
economical as more information can be collected per unit of cost. In addition it is
obvious that a sample survey needs less time than a census inquiry. Descriptive
research includes
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SSCMR 10 2009-11
Data collection method
Primary Data collection method
For primary data collection, we have to plan the following important aspects.
Sample survey – Nephrologist and chemist Survey with the help of
Questioner
Secondary data :- The company’s profile, with the help of internet
Data analysis and interpretation
1. Questionnaires
2. Pie chart and bar chart
3. Bar Chart
This is another way of representing data graphically. As the name findings and
suggestions. The sample of the questionnaire is attached with the report itself
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SSCMR 11 2009-11
Preparation of report
The report was based on the analysis and all detail information given on XL.
Sheet and presented with the findings and suggestions. Length of the bards are
proportional to the value they represent the report was based on the analysis and
presented with the findings and suggestions. The sample of the questioner is
attached with the report itself.
Sampling Methodology
Details of the sampling methodology, I have made 2 questionnaires. The one is
made for doctors and other for chemist
Sample unit
Doctors [Nephrologist]:- 50 =30 [Mumbai] + 9 [Nagpur] + 11 [Pune]
Chemist: - 15
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SSCMR 12 2009-11
About Company profile
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SSCMR 13 2009-11
Wockhardt is a global, pharmaceutical and biotechnology company that has
grown by leveraging two powerful trends impacting the world of medicine -
Globalization and biotechnology. The Company has a market capitalization of over US$ 1 billion and an annual turnover of US$ 650 million. Wockhardt’s Pace
of growth and momentum permeates every mindset, system and technology within
the organization.
.
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SSCMR 14 2009-11
Head Office Location
Wockhardt Limited
Wockhardt Towers
Brandra Kurla Complex Brandra [East], Mumbai-400051.India
Phone : +91-22-2653 4444Fax : +91-22-2653 4242
Website: www.wockhardt.com
Chairman
Mr.Habil F Khorakiwala
Foundation
Early 1960
Annual Turn Over*
Capitalization of over US$ 1 billion and an annual turnover of US$ 650
Million.
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SSCMR 15 2009-11
Products
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SSCMR 16 2009-11
Recombinant Biopharmaceuticals
Generic
In recent years, Wockhardt’s growth has been propelled by consistent expansion in
the global generics market. Wockhardt has an aggressive programme targetingthree strategic platforms for launching generic products in the advanced markets.
These are
Biovac-B is a WHO GMP certified hepatitis B vaccine.Wepox, Wockhardt’s recombinant erythropoietin, is for the treatment of
Anemia
Wosulin is the first r-DNA insulin developed and manufactured outside
the US and Europe.
A recent addition to the Company’s product basket is Wosulin Pen &
Cartridge, an automatic insulin delivery device - for the convenience
of diabetic patients.
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SSCMR 17 2009-11
Some of Wockhardt Power Brands include:
Diabetology
Wosulin (Recombinant Insulin)Mopaday (Oral Antidiabetic)Glimaday (Oral Antidiabetic)
Nephrology Wepox (Recombinant Erythropoietin)
Pain Management ProxyvonSpasmo-Proxyvon
Nutrition MethycobalDexolacDecdan
Neuro-Psychiatry
LibotrypTryptomer
Cough Therapy ZedexBro-ZedexViscodyne
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SSCMR 18 2009-11
Hyperuricemia
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SSCMR 19 2009-11
Hyperuricemia (British English: hyperuricaemia) is a level of uric acid in the
blood that is abnormally high. In humans, the upper end of the normal range is
360 µmol/L (6 mg/dL) for women and 400 µmol/L (6.8 mg/dL) for men.
Causes
Many factors contribute to Hyperuricemia, including: genetics, insulin resistance,
hypertension, renal insufficiency, obesity, diet, use of diuretics, and consumption
of alcoholic beverages. Of these, alcohol consumption is the most important.
Causes of Hyperuricemia can be classified into three functional types:
increased production of uric acid, decreased excretion of uric acid, and mixed type
A purine-rich diet is a common but minor cause of Hyperuricemia. Diet alone
generally is not sufficient to cause Hyperuricemia. Purine content of foods varies.
Foods high in the purines adenine and hypoxanthine may be more potent in
exacerbating Hyperuricemia.
The principal drugs that contribute to Hyperuricemia by decreased excretion are
the primary antiuricosurics. A ketogenic diet impairs the ability of the kidney to
excrete uric acid, due to competition for transport between uric acid and ketones.
Causes of Hyperuricemia that are of "mixed" also ("double whammy")
type have a dual action, both increasing production and decreasing excretion of
uric acid.
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SSCMR 20 2009-11
Drugs
Allopurinol
Allopurinol is a drug used primarily to treat Hyperuricemia (excess uric acid in
blood plasma) and its complications, including chronic gout.[1]
Allopurinol has been marketed in the United States since 1964. Allopurinol
is marketed by Prometheus in the United States as Zyloprim, while in other
countries it continues to be marketed by GlaxoSmithKline. Other brand names are
Allohexal, Allosig, Milurit, Alloril, Progout, and Zyloric.
Febuxostat
Febuxostat (INN; brand names Adenuric (EU) and Uloric (US)) is an
inhibitor of xanthine oxidase that is indicated for use in the treatment of
Hyperuricemia and gout. The drug is marketed by Menarini.
NSAID
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or
NAIDs, are drugs with analgesic and antipyretic (fever-reducing) effects and which
have, in higher doses, anti-inflammatory effects (reducing inflammation).
Narcotic.
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SSCMR 21 2009-11
Data Analysis
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SSCMR 22 2009-11
Q 1] On an average how many patients suffering from the following conditions doyou treat per week?
Cities Hyperuricemia Kidney Stones
Mumbai 190 91
Nagpur 42 39
Pune 70 19
Total 302 149
Percentage 66% 34%
Inference:-
Above 66% hyperuricemic patients, doctors treat per week and 34%
kidney stone patients treat per week.
These Shows that Nephrologist have high number of hyperuricemic
patient than kidney stone [with uric acid}
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SSCMR 23 2009-11
Q 2} in what percentage of hyperurecemic patients do you prescribe drug therapy?
Inference:-
This shows that Higher percentage of doctors prescribe 90-100% drug therapy
% Mumbai Nagpur Pune Total
0-10 4 1 0 5
11-20 1 1 0 2
21-30 0 0 1 1
31-40 1 0 0 1
41-50 6 1 1 7
51-60 0 0 0 0
61-70 1 0 1 2
71-80 3 1 1 5
81-90 3 4 0 7
91-100 11 1 7 19
Total 30 9 11 50
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SSCMR 24 2009-11
Q 3} which of the following drugs do you prescribe for hyperuricemia
NSAID Allopurinol Febuxostat Probenecid
Others {Please Mention}
Inference :-
As per data analysis Allopurinol prescribe by all the doctors then
febuxostat and NSAID but febuxostat is emerging drug for hyperuricemia
This shows that Allopurinol is most prescribed molecule
Sr. No. Drugs Mumbai Nagpur Pune Total
1 Allopurinol 30 9 11 50
2 Febuxostat 9 7 5 21
3 NSAID 1 0 0 1
4 Probenecid 1 0 0 1
5 Others 4 2 2 8
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SSCMR 25 2009-11
Q4}:- In what percent of hyperuricemic patients,
A} Do you prescribe Allopurinol?
% Mumbai Nagpur Pune Total
0-20 1 1 0 220-40 2 1 0 3
40-60 2 1 2 560-80 5 1 2 8
80-100 19 5 0 24
AS per Conditions 1 0 7 8Total 30 9 11 50
Inference :-
As per data analysis most of the Nephrologist prescribe 80-100%
Allopurinol
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SSCMR 26 2009-11
B} Dosage mg/day
Dosage mg/day Mumbai Nagpur Pune Total
100-200 18 7 4 20
200-300 8 1 5 4100-300 1 1 1 9
As per Conditions 3 0 1 5
Total 30 9 11 50
Inference :-
As per Data Analysis most doctors prescribe 100-200 dosage mg/day of
Allopurinol
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SSCMR 27 2009-11
C] Duration
Duration Mumbai Nagpur Pune Total
1-2 month 1 1 0 2
2-3month 1 1 0 24-8month 2 3 4 9
Long duration 5 1 2 8
Depend on patient 2 3 3 8Not mention 18 0 2 20
Total 30 9 11 50
Inference :-
As per data Analysis Duration for Allopunol in Hyperuricemia is varies as per
patients some Nephrologist given 1-2 months , 2-3 months ,4-8 months many
Nephrologist given long duration It was shows that Duration for Allopurinol is
varies as per patiens
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SSCMR 28 2009-11
Q5 a} Do you prescribe Allopurinol in,
Ans:-
Patients with kidney stones {with uric acid component}
Cities Yes No
Not
ans. Total
Mumbai 19 9 2 30Nagpur 5 3 1 9
Pune 5 5 1 11
Total 29 17 4 50
Inference :-
Data Analysis shows that highest numbers of Nephrologist says No for about
prescription of Allopurinol in patients with kidney stones but some Nephrologist
prescribe Allopurinol in ptients with kidney disease
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SSCMR 29 2009-11
If yes, kindly mention the dosage and duration of therapy prescribed
Dosage mg/day Mumbai Nagpur Pune Total100-200 8 3 3 14200-300 4 2 1 7100-300 1 1 1 3
As per cond. 4 0 0 4Not prescribe 13 3 6 22
Total 30 9 11 50
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SSCMR 30 2009-11
Duration Mumbai Nagpur Pune Total1-2 Month 2 0 0 32-3 month 2 1 0 36-8month 2 1 2 5
Long duration 5 1 0 6Depend on patient 2 2 2 6
Not mention 17 4 6 27Total 30 9 11 50
Inference :-
Data Analysis shows that most of the Nephrologist does not prescribe
Allopunol in patients with kidney stones and did not mentien dosage mg/day and
duration but some Nephrologist prescribe Allopurinol in patients with kidney
stones which is varies as per Hyperuricemic patients
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SSCMR 31 2009-11
Q6Are there any limitations of Allopurinol?
Cities Yes No Notmention Total
Mumbai 25 3 2 30
Nagpur 8 0 1 9Pune 10 0 1 11Total 43 3 4 50
Inference :-
As per data analysis Maximum Number of Nephrologist says that there are
some Limitations of Allopurinol
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SSCMR 32 2009-11
If yes, kindly mention…
Drug interaction, allergic rash, Leucopenia, Nephrotoxicity, decrease the
dose decrease the kidney function, Post-transplant, Interaction with
antimetabolites, Inability to use with Azithroprime, Conphenstate, mofetil,
Side effect like WBC interaction etc.
Inference:-
As per experts comments there are many side effects of Allopurinol so
because of that many doctors prescribe Febuxostat as a substitute of
Allopurinol
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SSCMR 33 2009-11
Market Potentiality
Mumbai Nagpur Pune Total
Total no. of Doc's, surveyed 30 9 11 50Total no.of patients treated per week for Hyperuricemia 190 42 70 302
Total no. of patients treated per 1yearfor Hyperuricemia 9880 2184 3640 15704Total no. of patients treated per 5 yr.for Hyperuricemia 49400 10920 18200 78520
Avg. no. of patients per doctor in aweek 6.33 4.66 6.36
Inference:-
As per data analysis of No. of patients for Hyperuricemia in Mumbai is more
than the Nagpur and Pune and also it consistently increases per year so Market
Potentiality of Hyperuricemia is more then Kidney Stone and
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SSCMR 34 2009-11
Inference:-As per Data Analysis it was shows that All Nephrologist Prescribe Allopunol drug
And also Market potentiality of Allopurinol is higher than any other drug for
Hyperuricemia like Febuxostat NSAID etc.
Total no. Doc's.
Prescribe
Mumbai Nagpur Pune Total %
Allopurinol 30 9 11 50 100%
Febuxostat 9 7 5 21 42%
NSAID 1 0 0 1 2%
Probenecid 1 0 0 1 2%
Others 4 2 2 8 16%
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SSCMR 35 2009-11
As per Chemist Survey
Total No. of Chemist
Allopurinol
Brand Strength MRP
Avg.Qty.
sold/ week
15 Zyloric 100mg*10 29 10Strip
Inference:-
As per sample survey and Data Analysis it was observed that Zyluric is only
brand that contain Allopurinol which treat Hyperuricemia and the market
potentiality of zyloric is higher that febuxostat containing brand.almost All
Nephrologist prescribe zyloric to treat Hyperuricemic patient
Total Zyloric strips sold { as per
surveyed chemist } QTY
Rs.{ As per 29
Rs/strip}
Week 142 4118
1 year 7384 214136
5 year 36920 1070680
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SSCMR 36 2009-11
After Whole Market survey on Nephrologist and chemist About Hyperuricemia
and Allopurinol it was observed that 66% hyperuricemic patients treated per week
and 100% doctors prescribe Allopurinol ie Zyloric so the whole market capture byzyloric so as per mkt.scenario If Company wants to lounch Allopurinol it will be
more successful But becouse of Limitaions of Allopurinol Febuxostat will be the
better option and Also Febuxostat is a Emerging leader in Hyperuricemia Market
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SSCMR 37 2009-11
Recommendations and Suggestion
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SSCMR 38 2009-11
Hyperuricemia is lab abnormality find out Couse asymptomatic Hyperuricemia
may not require treatment
Drugs which are safe for liver & renal disease to treat Couse of HyperuricemiaFebuxostat if allergic to Allopurinol
Febuxostat has lower price
Low Purine Diet [LPD] or dietary support that help to normalized Hyperuricemia
Depend on clinical situation eg. Hydration in case of tunolysis leading to
Hyperuricemia
Improving therapy on drug interaction
Drug interaction with Azithroprime
New drugs require
Alkalization of urine, Allopurinol which could be given in appropriate dosage
depending upon renal function
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SSCMR 39 2009-11
Conclusion
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SSCMR 40 2009-11
As per market survey on Hyperuricemia and related drugs therapy, on three
major cities of Maharashtra [ Mumbai , Nagpur, Pune] of 50 Doctors
[Nephrologist] and 15 chemist
Mumbai has highest number of Nephrologist in comparisons to Nagpur and
Pune so respectively highest number hyperurecemic patients treated in Mumbai
so it clearly signifies that Mumbai has highest potentiality than Pune and Nagpur
In all 3 Major cities in Maharashtra, all doctors prescribe Allopurinol then any
other drugs for treatment of Hyperuricemia.
As per chemist survey Zyloric [ Allopurinol] made by GSK is most prescribe
brand
Market potentiality of Allopurinol for treatment of Hyperuricemia is higher than
any other drugs
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SSCMR 41 2009-11
Limitations of Study
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SSCMR 42 2009-11
Every study has a certain limitations. In my study, also there were certain
limitations which I could not able to solve.
The Research was conducted in very small area i.e. limited to only 3 major
cities of Maharashtra.
During the research period many other companies also doing same research
with the help of summer trainee that was the biggest drawback for me doctors
and chemist were not able to respond effectively
Some doctors and chemist were not supported to this kind of market research so
they fill questionnaire more careless manner so it was difficult to hold for time
The call timing of doctors was not proper and also all doctors clinics and
hospitals were scattered in different areas so travelling problem I had faced
during market research
My study is not recognizable for whole India as well as outside Maharashtra due
to the limitations
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Learning Experience
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SSCMR 44 2009-11
Market research is one of the part of marketing process to know market behavior ,
market capabilities, potentiality and to check what will be the future prospect of
newly enter product or about market behavior . Market research is not bound foronly one field or one area it applies to all fields and area.
Now a days pharmaceuticals company do that kind of project to know the
market better before launching the particular drugs or to check potentiality and
limitations so it saves money and time and prevent to trap in loss
I also did such kind of market research in Wockhardt Ltd. That was my best
learning experience
Made questioner for market survey of Hyperuricemia and related drugs to treat
Hyperuricemia like Allopurinol
Made strategy to meet doctors[ Nephrologist] for that purpose I made doctor list
and call planner for 3 major cities
I learn How to talk with doctors for that purpose I communicated with them veryeffectively for survey purpose
The most Important during project I applied marketing tool like , I gave gifts to
doctors and chemist like siddhivinayak photos , chocolates, sweets for getting
excellent response from doctors and it was really benefited because of that
technique I got excellent response from doctors and successfully completed my
project
I also made Data Analysis of market survey and find potentiality of market
I learn how to behave in corporates how to communicate with doctors corporate
employees and how to solve the problems and each doctors behavior is different
and response is also different so I learn and handle them accordingly
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SSCMR 45 2009-11
The time management is important thing that I learn from this learning process
and also how to work in corporate environment that i know because of that I
successfully completed my project once again I thankful to my external projectguide and company employees that support me help me a lot for this project
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SSCMR 46 2009-11
Questionnaire
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SSCMR 47 2009-11
DOCTORS
Doctor Name:-
1) On an average how many patients suffering from the following conditions do youtreat per week?
a. Hyperuricemia: Patients Per week
b. Kidney stones (with uric acid component): Patients Per week
2) In what percentage of hyperurecemic patients do you prescribe drug therapy?
A. %
3) Which of the following drugs do you prescribe for Hyperuricemia
NSAID Allopurinol Febuxostat Probenecid
Others (Please Mention)
4) In what percent of hyperurecemic patients,
a) Do you prescribe Allopurinol?
%
b) Kindly mention the most commonly required dosage and duration requiredtreating them?
Dosage: mg per day
Duration:
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SSCMR 48 2009-11
5} Do you prescribe allopurinol in,
a) patients with kidney stones (with uric acid component)
Yes No
b) If Yes, Kindly mention the dosage and duration of therapy prescribed
Dosage: mg per day
Duration:
6} are there any limitations of Allopurinol?
Yes No
If yes, kindly mention …
1.
2.
7} any other recommendations for improving therapy for Hyperuricemia:
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SSCMR 49 2009-11
PHARMACIST
Kindly provide information with respect to following allopurinol brands:
Brand Company Strength MRP Qty sold
per week
Also tried to find out the name of doctors prescribing the same and their
speciality
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SSCMR 50 2009-11
Bibliography
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www.google.com
www.wikipedia.com
www.wockhadtin.com Wockhardt magazine