Summary SSN Meeting, Zürich, February 9, 2018

A. Development and Stem Cells

Lesion-dependent plasticity of spinal cord circuits in vitro with and without stem cell insertionA1

Samuel Buntschu, Jürg Streit

Wharton’s jelly stem cell-derived exosomes induce neural progenitors towards oligodendroglialcell fate

A2

Marianne Joerger-Messerli, Marialuigia Spinelli, Byron Oppliger, Gierin Thomi, Valérie Haesler, Daniel V. Surbek,Andreina Schoeberlein

Anti-Inflammatory Effects of Exosomes Derived from Wharton’s Jelly Mesenchymal Stem/StromalCells on Neuroglia in an In Vitro Model of Perinatal Brain Damage

A3

Gierin Thomi, Valérie Haesler, Marianne Joerger-Messerli, Daniel V. Surbek, Andreina Schoeberlein

Erythropoietin promotes neural differentiation in vitro and in vivoA4Kasifa Khalid, Giovanna Bosshard, Christina Köster-Hegmann, Tatjana Hänggi, Jean-Marc Fritschy, Max Gassmann,Edith M. Schneider Gasser

Endoglycan is involved in neural development by fine-tuning cell adhesionA5Georgia Tsapara, Thomas Baeriswyl, Esther T. Stoeckli

Loss of C5orf42 mimics Joubert syndrome pathology in the chickA6Justin E. Strauss, Reza Asadollahi, Anita Rauch, Esther T. Stoeckli

Characterization of the endothelial progenitor cells secretome on cultured striatal neuronal stemcells.

A7

Stefano Di Santo, Stefanie Seiler, Hans R. Widmer

Development of sensory-driven cortical inhibition in mouse barrel cortexA8Alexander van der Bourg, Rahel Kästli, Rasmus Vighagen, Fabian Voigt, Ali Argunsah, Daniel Kirschenbaum, AdrianoAguzzi, Fritjof Helmchen, Theofanis Karayannis

Quantitative analysis of the structural development of the monkey entorhinal cortexA9

Olivia Piguet, Loïc J. Chareyron, Pamela Banta Lavenex, David G. Amaral, Pierre Lavenex

Imaging Extracellular Potassium Dynamics in the Brain Using a Potassium-Sensitive NanosensorA10

Joel Wellbourne-Wood, Guillaume Azarias, Theresa Rimelle, Bruno Weber, Jean-Yves Chatton

Excessive generation of NMDA receptor-dependent early network oscillations in a human stemcell-derived model of autism

A11

Katharina Behr, Philippe Valmaggia, Ravi Jagasia, Josef Bischofberger

B. Synaptic Plasticity, Neurons and Glia

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Structural correlates of neuroprosthetic learningB1Antoine Philippides, Gregorio Galinanes, Mario Prsa, Daniel Huber

Experience-dependent synaptic plasticity in the lateral habenulaB2Massimo Trusel, Salvatore Lecca, Manuel Mameli

Optogenetic Control Of Sleep Slow Waves To Improve Recovery After Ischemic StrokeB3

Laura Facchin, Cornelia Schöne, Armand Mensen, Mojtaba Bandarabadi, Kaspar Schindler, Antoine Adamantidis,Claudio Bassetti

3D calcium imaging provides a novel view on astrocyte biologyB4Erika Bindocci, Iaroslav Savtchouk, Nicolas Liaudet, Denise Becker, Giovanni Carriero, Andrea Volterra

Resolving accumbal projections to lateral hypothalamusB5Sarah Thoeni, Eoin O'Connor, Christian Lüscher

Rapid astrocyte calcium signals are evoked by cortical circuit activity in vivoB6Jillian Stobart, Kim David Ferrari, Matthew Barrett, Chaim Glück, Michael Stobart, Marc Zünd, Bruno Weber

Combining high-pressure freezing and optogenetics to evaluate synaptic transmission athippocampal mossy fiber synapses

B7

Carolina Borges-Merjane, Olena Kim, Walter Kaufmann, Daniel Gütl, Peter Jonas

Neuropathic Pain Impairs Spike-Timing Dependent Long-Term Depression in Layer 5 PyramidalNeurons of the Anterior Cingulate Cortex

B8

Norbert Krebs, Sigrid M. Blom, Thomas Nevian

The impact of astrocytic gap junction coupling on neuronal function and energy metabolismB9

Ladina Hösli, Zoe Looser, Michael J. Stobart, Christian Giaume, Bruno Weber, Aiman S. Saab

Differences in astrocytic glutamate uptake between cortical regions impact neuronal NMDAreceptor activation

B10

Jennifer Romanos, Dietmar Benke, Hanns Ulrich Zeilhofer, Mirko Santello

Activity-Dependent Metabolic Support to Myelinated AxonsB11Zoe J. Looser, Matthew J. Barret, Michael J. Stobart, Johannes Hirrlinger, Felipe Barros, Klaus-Armin Nave, BrunoWeber, Aiman S. Saab

Evaluation of the receptor-mediated function of lactate in neuronal activityB12Haissa De Castro Abrantes, Marc Briquet, Stefan Offermanns, Jean-Yves Chatton

Studying the impact of astrocytic glucose metabolism on brain function in vivo B13

Laetitia V. Thieren, Ladina Hoesli, Zoe J. Looser, ED Abel, Bruno Weber, Aiman S. Saab

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Stimulation of cultured astrocytes with glutamate decreases the variability of energy metabolismB14

Guillaume Azarias, Haissa de Castro Abrantes, Jean-Yves Chatton, Bruno Weber

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmentalorigin

B15

Alexandre Bacq, Simone Astori, Elias Gebara, Wei Tang, Bianca Silva, Jose Sanchez-Mut, Jocelyn Grosse, IsabelleGuillot de Suduiraut, Olivia Zanoletti, Carmen Sandi

Glia facilitate hippocampal synchrony and sharp wave generationB16Stewart Berry, Christopher Lewis, Fabian Voigt, Fritjof Helmchen, Urs Gerber

SOM and NOS interneurons activate nonlinear GABA receptors that effectively regulate dendriticNMDA receptor recruitment

B17

Jan Michael Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger

Behavioral phenotypes and input-specific synaptic plasticity in the Sapap3-/- mouse model ofobsessive-compulsive disorder

B18

Linda Simmler, Meaghan Creed, Vincent Pascoli, Christian Lüscher

In vivo real-time two-photon laser-scanning imaging of the cellular energy metabolism inastrocytes and glioblastoma cells

B19

Pascal Imseng, Guillaume Azarias, Bruno Weber

Using uncoupling in mitochondria of astrocytes to promote neuroprotection in Alzheimer's diseaseB20

Nadia Rosenberg, Anne-Bérengère Rocher, Yann Bernardinelli, Leonardo Restivo, Marc Briquet, Jean-Yves Chatton

C. Molecular and Subcellular Mechanisms

A catalytic domain mutation causing SCA14 confers increased catalytic activity and implies thePKC and calcium signaling pathways as targets of mutations causing ataxia

C1

Etsuko Shimobayashi, Josef P. Kapfhammer

Distinct transcriptomic, proteomic and epigenetic stress-responses in dorsal and ventralhippocampus

C2

Amalia Floriou-Servou, Lukas von Ziegler, Luzia Stadler, Oliver Sturman, Johannes Bohacek

Hippocampal single-nucleus sequencing identifies a unique transcriptional signature that ispredictive of reactivity in dentate granule neurons

C3

Baptiste Jaeger, Sara Linker, Sarah Parylak, Jerika Barron, Iryna Gallina, Christian Saavedra, Benjamin Lacar, ConorFitzpatrick, Sebastian Jessberger, Fred Gage

Phosphorylation of GABAB1 by CaMKIIbeta triggers lysosomal degradation of GABAB receptorsby regulating MIB2-mediated Lys63-linked ubiquitination

C4

Karthik Balakrishnan, Khaled Zemoura, Thomas Grampp, Dietmar Benke

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Calcium Signaling in PericytesC5Chaim Gluck, Jill Stobart, Annika Keller, Bruno Weber

Musashi RNA binding protein regulates synaptic specificity in the Drosophila CNSC6Maria Landinez Macias, Martin Müller, Olivier Urwyler

D. Circuits and Systems Neuroscience

Engineering functional brain connectivity patterns by neuromodulator clustering and polytherapyD1

Mostafa Rezaie, Peter Eimon, Yuelong Wu, Mehmet Fatih Yanik

Local, spindle-enriched non-REM sleep in mouse somatosensory cortex enabled throughheterogeneous thalamic burst propensity

D2

Laura M.J. Fernandez, Gil Vantomme, Elidie Béard, Anita Lüthi

Glutamatergic recruitment of thalamic reticular nucleus by postsubiculum projections: role inhead-direction system?

D3

Gil Vantomme, Zita Rovó, Georgia Katsioudi, Laura MJ Fernandez, Anita Lüthi

The nucleus reuniens of the thalamus mediates remote fear memory attenuationD4Bianca Ambrogina Silva, Johannes Gräff

Comparator circuits in layer 2/3 of mouse visual cortexD5Alexander Attinger, Pawel Zmarz, Georg Keller

The Key Role of Layer 6 in Translaminar Circuits of Cat Primary Visual Cortex (V1)D6Franziska Sägesser, Kevan Martin

Frequency selective encoding of substrate vibrations in the somatosensory cortexD7Mario Prsa, Daniel Huber

Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behaviorD8

Salvatore Lecca, Frank Julius Meye, Massimo Trusel, Anna Tchenio, Julia Harris, Denis Burdakov, Martin KarlSchwartz, Francois Georges, Manuel Mameli

Disinhibitory amygdala microcircuits for aversive learningD9Sabine Krabbe, Enrica Paradiso, Simon D'Aquin, Chun Xu, Milica Markovic, Jan Gründemann, Francesco Ferraguti,Andreas Lüthi

The Swiss mesoSPIM initiative – open-source light-sheet microscopes for imaging in cleared tissueD10

Fabian F. Voigt, Daniel Kirschenbaum, Stéphane Pagès, Ladan Egolf, Rahel Kästli, Alexander van der Bourg, AndreasFrick, Theofanis Karayannis, Adriano Aguzzi, Fritjof Helmchen

Directional reaching in miceD11Claudia Bonardi, Gregorio Galinanes

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Correlating Structure and Function of Single Excitatory Synapses in Mouse Barrel CortexD12

Gregor F.P. Schuhknecht, Simone Holler-Rickauer, German Köstinger, Kevan A.C. Martin

Limbic control of reinforced learning via striatal cholinergic interneuronsD13Giorgio Rizzi, Zhuoliang Li, Alberto Merli, Kelly R Tan

GABAergic organization in the striatumD14Leonardo Cristiá Lara, Ida Luisa Boccalaro, Jean-Marc Fritschy, Lena Rubi

Distinctive roles of primary auditory regions in sound processingD15Magdalena Solyga, Tania Rinaldi Barkat

Basal Forebrain circuits contribute to memory consolidationD16Marta Dimanico, Reza Mazloum, Wenxue Li, Jayakrishnan Nair, Michael Harvey, Gregor Rainer

Introducing the CHAIN initiative: Clustering the Heterogeneity of Autism wIth NeuroimagingD17

Valerio Zerbi, Marija Markicevic, Markus Rudin, CHAIN team, Alessandro Gozzi, Nicole Wenderoth

Brain modules for visuomotor integration revealed by whole-brain functional ultrasound imagingD18

Emilie Mace, Gabriel Montaldo, Stuart Trenholm, Cameron Cowan, Alex Brignall, Alan Urban, Botond Roska

Pharmacogenetic activation of somatosensory cortex by DREADDs modulates brain-widefunctional connectivity in wildtype mice

D19

Marija Markicevic, Johannes Bohacek, Markus Rudin, Nicole Wenderoth, Valerio Zerbi

Task-dependent integration of visual and somatosensory stimuli in mouse cortexD20Moritz Buchholz, Yaroslav Sych, Fritjof Helmchen, Asli Ayaz

Inhibition as an effector of learning in the zebrafish homolog of olfactory cortexD21Thomas Frank, Nila Moenig, Shin-ichi Higashijima, Rainer W Friedrich

Optical monitoring and perturbation of behavior-related mesoscale brain activity using a novelmulti-fiber array

D22

Yaroslav Sych, Fritjof Helmchen

Optical monitoring and perturbation of behavior-related mesoscale brain activity using a novelmulti-fiber array

D23

Yaroslav Sych, Fritjof Helmchen

Converging neural dynamics during short-term memory in tactile and auditory discrimination tasksD24

Yasir Gallero-Salas, Ariel Gilad, Balazs Laurenczy, Fritjof Helmchen

5 / 10

The role of GABAergic Basal Forebrain projections in processing of complex sounds in ratauditory thalamus and cortex

D25

Arndt-Lukas Klaassen, Laura Lozano, Michael Harvey, Gregor Rainer

Functional Organization of Primary Visual Cortex of Microcebus MurinusD26Chun Lum Andy Ho, Robert Zimmermann, Banty Tia, Juan Weidinger, Fabien Pifferi, Fred Wolf, Fabienne Aujard,Daniel Huber

Activation of cortical GABAergic interneurons in primary somatosensory cortex in head-restrainedmice during locomotion and whisking

D27

Andreas Stäuble, Asli Ayaz, Fritjof Helmchen

Dissecting local sleep spindles in the thalamocortical systemD28Mojtaba Bandarabadi, Carolina Gutierrez Herrera, Thomas Gent, Claudio Bassetti, Kaspar Schindler, AntoineAdamantidis

Genetic and Functional Characterization of Rubral PathwaysD29Maria del Angel Ocaña Fernandez, Giorgio Rizzi, Mustafa Coban, Alberto Merli, Kelly Tan

Motor Thalamus Supports Striatum-Driven ReinforcementD30Arnaud Lalive, Anatol Kreitzer

MRI-Guided Targeting of Deep Brain CircuitsD31Horea-Ioan Ioanas, Markus Rudin

Neuronal circuits for the interoceptive regulation of behaviorD32Isabel De Araujo Salgado, Naila BenFredj, Christophe Lamy

E. Cognitive and Behavioral Neuroscience

Visuo-acoustic cognitive stimulation for critically ill patients in the intensive care unit: A virtualreality setup

E1

Stephan M. Gerber, Marie-Madlen Jeitziner, Patric Wyss, Alvin Chesham, Prabitha Urwyler, Urs P. Mosimann, RenéMüri, Stephan M. Jakob, Tobias Nef

The 0.02 Hz-oscillation in sigma power times spontaneous transitions out of undisturbed non-REMsleep in mouse

E2

Sandro Lecci, Romain Cardis, Anita Lüthi

Competitive interaction between spatial memory systems in Williams syndromeE3Emilie Fragnière, Mathilde Bostelmann, Floriana Costanzo, Silvia Diavara, Deny Menghini, Stefano Vicari, PierreLavenex, Pamela Banta La

Competitive interaction between spatial memory systems in Down syndromeE4Mathilde Bostelmann, Floriana Costanzo, Deny Menghini, Lorelay Martorana, Paolo Ruggeri, Stefano Vicari, PierreLavenex, Pamela Banta Lavenex

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Contextual effects on the neural encoding of speech in the auditory cortexE5Sanne Rutten, Roberta Santoro, Alexis Hervais-Adelman, Elia Formisano, Narly Golestani

The bright side of training in the dark: audio-visual spatial reorganization in Swiss firefightersE6

Isabel Tissieres, Gérard Loquet, Jacques Anken, Christophe Windler, Stephanie Clarke, Sonia Crottaz-Herbette

Improving attention through network-based neurofeedback trainingE7Gustavo Pamplona, Yury Koush, Robert Langner, Jennifer Langner, Frank Scharnowski, Carlos Salmon

Dynamic visual stimulation elicits neuronal response reflected in LFP, single-unit activity andBOLD in human amygdala

E8

Tommaso Fedele, Bettina Steiger, Athina Tzovara, Peter Hilfiker, Thomas Grunwald, Dominik Bach, Lennart Stieglitz,Hennric Jokeit, Johannes Sarnthein

Acute physical exercise improves memory consolidation in humans via BDNF andendocannabinoid signaling

E9

Kinga Igloi, Blanca Marin Bosch, Aurélien Bringard, Estelle Lauer, Aurélien Thomas, Guido Ferretti, Sophie Schwartz

Prior expectation sharpens bottom-up somatosensory representationsE10Pegah Kassraian Fard, Daniel Woolley, Nicole Wenderoth

Functional imaging of CA3 pyramidal cell populations in the adult mouse hippocampus duringanesthesia and wakefulness

E11

Gwendolin and Stefano Schoenfeld and Carta, Asli Ayaz, Urs Gerber, Fritjof Helmchen

Tutor preference in juvenile zebra finchesE12Diana Rodrigues, Juneseung Lee, Joerg Rychen, Richard Hahnloser

Reactivation of hypothalamic inhibitory neurons during REM sleep consolidates appetite.E13

Lukas Oesch, Mary Gazea, Carolina Gutierrez Herrera, Antoine Adamantidis

F. Computational and Theoretical Neuroscience

Towards Multiscale Modeling of Transcranial Focused Ultrasound NeurostimulationF1Hazael Montanaro, Esra Neufeld, Mehmet Sirin Özdas, Théo Yanik, Silvestro Micera, Mehmet Fatih Yanik, NielsKuster

Investigation of Pulse-shape Effects in TES and TMS Using Neurofunctionalized AnatomicalModels and Coupled Electromagnetic-Electrophysiological Simulations

F2

Antonino Mario Cassara', Esra Neufeld, Manuel Guidon, Wolfgang Kainz, Niels Kuster

Exploring Brain-wide Development of Inhibition through Deep LearningF3Asim Iqbal, Muhammad Asfandyar Sheikh, Ali Özgür Argunsah, Theofanis Karayannis

7 / 10

G. Human Brain Imaging and Recording

Brain oxygenation in preterm neonates measured non-invasively with a novel near-infraredspectroscopy (NIRS) based oximeter: Preliminary findings of a new study

G1

Felix Scholkmann, Tanja Karen, Stefan Kleiser, Daniel Ostojic, Helene Isler, Dirk Basler, Martin Wolf

MANIPULATION OF EEG MICROSTATES & fMRI RESTING STATE NETWORKS BY INSTRUCTEDSPONTANEOUS MENTATION

G2

Lucie Bréchet, Denis Brunet, Gwénaël Birot, Rolf Gruetter, Christoph M. Michel, João Jorge

Differences in click and speech ABR and cortical response patterns: a pilot study.G3Jean-François Knebel, Arnaud Jeanvoine, Fabian Guignard, Jean-Marc Vesin, Céline Richard

Persistently active neurons in human hippocampus support verbal working memory network.G4

Ece Boran, Tommaso Fedele, Lennart Stieglitz, Peter Hilfiker, Thomas Grunwald, Johannes Sarnthein

Disentangling cue-induced wanting and liking in tobacco use disorder with parametric functionalmagnetic resonance imaging

G5

Amelie Haugg, Andrei Manoliu, Ronald Sladky, Lea M. Hulka, Matthias Kirschner, Annette B. Brühl, Erich Seifritz,Boris B. Quednow, Marcus Herdener, Frank Scharnowski

Reward decreases motor fatigability by increasing neural activity within the motor networkG6

Rea Lehner, Marc Bächinger, Samira Hanimann, Joshua Balsters, Nicole Wenderoth

How increased craving changes functional brain connectivity during restG7Cindy Lor, Amelie Haugg, Andrei Manoliu, Ronald Sladky, Lea Hulka, Matthias Kirschner, Erich Seifritz, BorisQuednow, Marcus Herdener, Frank Scharnowski

Dynamics of neuronal activity in the cerebral neocortex during human epileptic seizures revealedby microelectrode recordings

G8

Jonas B. Zimmermann, Pierre Mégevand, Aude Yulzari, Alain Woodtli, Laurent Spinelli, Shahan Momjian, MarcoCorniola, G. Rees Cosgrove, John P. Donoghue, Margitta Seeck

Closed-loop amygdala neurofeedback using emotional facesG9Ronald Sladky, Nada Frei, Amelie Haugg, Yury Koush, David Willinger, Gustavo Pamplona, Annette Brühl, PhilippStämpfli, Frank Scharnowski

Neural mechanisms of audiovisual integration in beginning readers at-risk for developmentaldyslexia with varying reading outcomes

G10

Fang Wang, Iliana I. Karipidis, Georgette Pleisch, Silvia Brem

Age-related changes in resting-state EEG microstates and memoryG11Adeline Jabès, Giuliana Klencklen, Paolo Ruggeri, Pamela Banta Lavenex, Christoph Michel, Pierre Lavenex

Processing dynamic emotional faces: preliminary results of an fMRI studyG12David Willinger, Iliana Karipidis, Selina Beltrani, Ronald Sladky, Silvia Brem

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H. Disorders of the Nervous System: Basic mechanisms

Split GFP technologies to study structural and functional biomolecular interactions in cells:analysis of TDP-43 physiological oligomers

H1

Chiara Foglieni, Stéphanie Papin, Tariq Afroz, Sandra Pinton, Giona Pedrioli, Agnese Salvadè, Giorgio Ulrich,Magdalini Polymenidou, Paolo Paganetti

Searching for molecules contributing to the PKC-mediated reduction of dendritic growth incerebellar Purkinje cells

H2

Sabine Winkler, Josef Kapfhammer

Elucidating the role of chaperones in prion biosynthesis and replication by siRNA mediated high-throughput screening

H3

Valeria Eckhardt, Bei Li, Elke Schaper, Jérôme Dauvillier, Pierre Goloubinoff, Adriano Aguzzi

Effects of chronic social stress on parvalbumin GABA interneurons in the amygdalaH4Giorgio Bergamini, Hannes Sigrist, Damaris Holder, Agata Panek, Diana Kukelova, Christopher Pryce

Tau Modifications Associated to Specific Subcellular LocationsH5Giorgio Ulrich, Paul Boersema, Chiara Foglieni, Stéphanie Papin, Sandra Pinton, Agnese Salvadè, Paola Picotti,Paolo Paganetti

PM20D1 methylation quantitative trait locus is associated with Alzheimer’s diseaseH6Jose V. Sanchez-Mut, Holger , Bianca Ambrogina , Lucie Dixsaut, Enrique Vidal, Liliane Glauser, Isidre Ferrer, DaveMonk, Manel Esteller, Johannes Gräff

Acute and chronic dopamine depletion differently affect thalamic and cortical beta bandH7

Laura Clara Grandi, Alessandro Stefani, Alain Kaelin-Lang, Salvatore Galati

Interacting with spike-wave activity by closed-loop acoustic stimulation during sleep? A pilot studyin patients with childhood epilepsies

H8

Sara Fattinger, Bigna Bölsterli Heinzle, Georgia Ramantani, Lucia Abela, Bernhard Schmitt, Reto Huber

Studies on transcellular communication in neurodegenerationH9Giona Pedrioli, Paolo Paganetti

I. Disorders of the Nervous System: Clinical Neuroscience

Effect of APOE*4 status on cortical thickness co-variance networks in Mild Cognitive ImpairmentI1

Gretel Sanabria Diaz, Lester Melie Garcia, Bodgan Draganski, Ferath Kherif

Phosphorylated and oligomeric alpha-synuclein in skin nerve fibers discriminate ParkinsonDisease from Atypical Parkinsonism

I2

Elena Vacchi, Sandra Pinton, Vanessa Biemmi, Salvatore Galati, Claudio Staedler, Giorgia Melli, Alain Kaelin-Lang

9 / 10

Non-invasive brain stimulation relieves phantom limb pain in amputees; an fMRI studyI3

Sanne Kikkert, Melvin Mezue, Jacinta O'Shea, David Henderson-Slater, Heidi Johansen-Berg, Irene Tracey, TamarMakin

10 / 10