Subject index

Abetalipoproteinemia 41Acid fastness 25, 26, 47, 48Acid hydroxylase 1Acidic groups, acidophilic 24-26, 28Aging 1, 2, 30-38Alcoholic live~disease 48Aldrich W!scott syndrome 50Alkylperoxy radical 8, 9Alphatocopherol4, 11-13, 37-43- deficiency 12, 13Anionic groups, see acidic groupsAntioxidant-deficient diet 4Antioxidants 4, 8, 10-13, 36-40Aplysia limancina 2Argentophilic granules 14Ascorbic acid 8Autocatalytic reactions, see chain reactionsAutofluorescence 1, 17, 20-22, 25, 42, 45, 47,

51,52 'Avitaminosis E 5, 38-43, 45

Basophilia, amphiphilia 14, 25, 28, 46, 51Batten disease 28, 36, 51- dolichol in 51- retinoyl complexes in 51Bile duct 4Bleaching 22, 52Brown bowel syndrome 5, 41Brown fat 39Bulla gouldiana 2

Carbonyl groups 14,22-25Carboxyls 1,25Cat 5Central nervous system (CNS) 2, 6Ceroid storage disease 50Ceroids 1Cervical carcinoma 48Chain- initiation 9- propagation 9, 10- reactions 9-13, 38- termination 9, 11-13, 15Choline 40

Chromolipids 1, 7Chronic- childhood cholestasis 41- inflammation 48- pancreatitis 41Cock 2Copolymerization 12Copper 45, 51Creatinuria 38Cystic fibrosis 41Cytochemistry 16Cytochrome C 12

Dialdehydes and malonyldialdehyde 9, 20, 23Double bond, see polyunsaturated fatty acidsDrosophila melanogaster 2 'Ductuli efferentes 5

Electron- donors 8- microscopy 1- transferers 8Elephant 5Endocardium 2Encephalopathy 39Endocytosis 15Endoplasmic reticulum 14, 16- rough 14- smooth 13, 16Enzyme activities 29-31, also see lysosomal en-

zymesEpidemic hepatitis 47Epithelium 4, 5-acinar cells 6- intercalated duct cells 6- interlobular duct cells 6- intralobular duct cells 6- photoreceptor dells of retina 6- prostate 5- retinal 6- testes 4, 5Erythrocytes 43, 44Esters 7- of sterols 7

76 . Subject index

Ethoxyquin 13Ethylenic links, see unsaturated fatty acidExudative diathesis 39

Familial LCAT deficiency 51Ferritin-like granules 16Fish 2Fixation 19Follicular cells 5Free fatty acids 7Free ;:.adicals 7-13, 36, 38Frogs 2, 6Function and functional activity 30-38

Gallus G, see cockGastropods 2 'Gaucher disease 48Giant cells 39Glutathione, see reducing groups- hydroxylase 13- peroxidase 49Glycerides 7Glycolipids 7Golgi apparatus 14, 15, 52Grafts, see transplantationsGranulomata 39, 48Granulomatous disease of childhood 49, 50Guinea pig 4

Hallervorden-Spatz disease 42Hamazaki-Wesenberg bodies 48Hamster 3, 16Heart 2,3Heme 13Hemoceroid 44Hemoproteins 13Hemorrhagic-thrombotic phenomena 39Hemosiderin, see ironHemosiderosis and hemochromatosis 45Hepatic necrocis and cirrhosis 40Hepatocytes 4, 13, 14- fat vacuoles in 14Hepatopancreas 2Heterogeneity of pigment granules 16, 17Histochemistry 1Hormones 4Housefly 2Hydrolytic enzymes, see lysosomal enzymesHydroperoxides 9-11

Hydroxyls 1, 7Hyperlipoproteinemia 49, 50Hyperoxia 48

Infants 4Interstitial cells 4Intralobular duct cells 5Intranuclear inclusions 45Iron 7, 16, 17,22,28,43,44,48, 51-, compounds 7Irondextran 45Isolated vitamin E deficiency 41

Ketosteroids 23, 25

Lead 45 .Leydig cells 4, 5Lipid- animal kingdom of 2- electron microscopy of 1- fetal 2- free radicals 7, 9-11- occurrence 1, 2- oxidation 8- peroxidation 1, 7-9, 13 .- pigments 1, 13-15, 17- vertebrates 2Lipid peroxides and peroxidation 7-14, 22, 29,

30,36-41,44,48,49Lipids- ingested 14Lipochromes 2Lipofuscins- cardiac 2, 14, 15- intrinsic of larynx 3- limb 3- limb (rats) 3- lip 3- muscle fibers 1, 2, 5, 14-16- orbicularis oculi 3- perioral muscles 3, 31, 35- skeletal 3- soleus 3- tongue muscle (human) 3, 31, 35- tongue muscle (rat) 3- uterus 5Lipomelanins and melanins 11, 22, 28, 29, 36,

51,52Lipophilia 1

Liver 3Luminal colloid 5Lysosomal enzymes 15, 16, 29, 30, 51Lysosomes 15, 16, 30

Macaca fuscata, see monkeysMalabsorption 41Malignancies 48Malnutrition 41Malonyldialdehyde (MDA) 9Mammals 2Maturation, s& polymerizationMelanization of lipid pigments 52Metallo enzymes 16Metals 9Mice 4- aging 5Microsomes 13Minocycline 47Minor salivary glands 6Mitochondria 12, 13, 15, 16Mollusca 2Monkeys 6- cynomolgus 2- Formosan rock (Macaca cyclopsis) 7- Japanese 2- rhesus 7, 15- squirrel 4, 15Musca domestica, see houseflyMuscular dystrophy 38Myocardium 2, 3, 16Myoepithelial cells 6

NADH 12NADPH oxidase 49Necrotic processes 44, 47, 48Nerve cells 2, 6- choroid plexus 7- dentrites 6- ependymal cells 6- glial cells 6, 7- human cerebellum 6- lipophilic 6, 7- lipophobic 6, 7- microglia 7- neuroglia 6, 7- neurons 2, 15- oligodendroglia 7- perikarya 6

Subject index . 77

- Purkinje neurons 7- subependymal cells 6Neuroaxonal dystrophy 40,42Neuroblastoma cells 37Neuromelanins, see lipomelaninsNewborns 45Niemann-Pick disease 20, 49Nodular synovitis 48Nutritive emulsions 14

Odontogenic cysts 48Oral mucosa 6Organelles 13-15Osmiophilia 1, 14,15Oxidation 7, 8- catalysts 7-9, 38, 43, 45Oxygen 7- radicals 13Oxodonta africana, see elephant

Parafollicular cells 5Parenteral nutrition 41Parotid gland 6PAS stain 26-28Peroxidation- in detoxification 13- in phagocytosis 13- in thyroxin formation 13Peroxides 1, 7, 9, 10Phospholipids 7Pigment- bile 2- color of 1, 17- deposition, inhibition of 36, 37- deposition, rate of 34, 35- distribution in 1-7, 15, 16, 30, 31, 33, 34, 38,

39,45,47, 51, 52- formation of 7-13- granules 1, 3, 5, 7, 13-15, 17- insolubility of 1, 17, 19,29- in vitro formation of 1, 7, 17,20, 38, 43-45- lipophilia of, sudanophilia of 1, 14, 15, 17,

18,19,52- proteins in 11, 15, 17- wear and tear 1Pigmentation- adipose tissue 39- adrenal 29, 30, 33, 41, 47- age-associated 2, 3, 5, 6, 15

78 . Subject index

- apparent increase of 32- bone marrow 51- cardiac 2, 3, 15, 16, 28, 30-38, 47- epididymis 5, 33- glia cells, see nervous system- intestine 38, 41- liver 3, 4, 30, 35, 47, 48- lymph node 42, 50- mammary·30- muscle 3, 16, 30-32, 35, 36, 38, 39, 47- ne;:>:ous system 2, 6,7, 14-16,25,27,28,30,

31, 33, 34, 36, 3~ 42, 48, 51, 52-' ovarian and changes 30, 33, 41- placenta 5, 36- prostate 5, 33, 36- prostatic carcinoma 5- renal 46, 47- retinal 6, 19, 34-37- salivary glands 5, 6, 34, 48- seminal vesicle 5, 33, 41- skin 47- spleen 42, 48, 50- testis 4, 5, 30, 33, 41, 47- thyroid 5, 34, 47- uterus 5, 40, 41Pigmentogenesis 3, 7, 14, 15Plasmal reaction and pseudoplasmal 22, 23, 25Polymerization 10-12, 16,17, 29, 30, 38, 40,

45,49Polyunsaturated fatty acids (PUFA) 7-9,

22-25, 38, 38-41Porphyria 13Pre-ceroid 19Prematurity 41Pro-oxidants, see oxidation catalystsProteins and peptides 11, 17, 19, 20, 24-26, 28

Quenching of fluorescence 22, 45, 52

Racial factors 35Rana esculenta, see frogsRana temporaria, see frogs

Rat 3, 5, 6, 13, 14Reducing groups 13, 23, 24, 28, 45, 46Rheomelanins 29RNA 14

Salivary glands 5, 48Sarcoidosis, see granulomataSchiff base 2- conjugated 17, 20, 22Sea blue histiocytes 50, 51Selenium 40, 41Seminal vesicle 5Sepia officina/is 2SertoIi cells 4, .5SH groups, see.reducing groupsShort bowel syndrome 41Steroids 29, 33, 47Submandibular gland 5, 6Sudanophilia 14, 15

Tay-Sachs disease 48Testis 4, 5Thiobarbituric acid (TBA) 9Thrombocytopenic purpura 49, 50Tissue culture, see pigment, in vitro formationToad 2, see fishTorpedo 3Transplantations 47

Ubiquinone 12Ultracentrifugation of granules 21Ultraviolet absorption and excitation 9, 20Unsaturated fatty acids (UFA) 7, 10, 14

Vertebrates 2Vitamin A 39, 40, 45Vitamin E, see alphatocopherol

Wilson's disease 45Wolman disease 20, 40

Xanthomata 48, 49