A Al hnRNP protein: nucleic acid

renaturation 181 A5 protein: adhesive domain 40 acetylated low-density lipoprotein

receptors 237 aconitase: iron-sulphur dependent

dehydrations 298 actomyosin molecular motors:

nanomanipulation 319 acute intermittent porphyria (BR)

355 acylation: transducin (l) 164 adhesive domain: MAM 40 I)-adrenergic receptor kinase

coiled-coil domain 315 PH domain 343

affinity binding: immunoglobulin binding protein, BiP 3

aldehyde dehydrogenases: lens constituent 303

alkaline protease: l3-superhelix motif 313

allosteric signal transduction: haemoglobin 385

Alzheimer's disease 480 amino acids: titration curves 69 aminopeptidases

action mechanism 167 methionyl: evolution 403

Amplify program (CC) 448 amyloid plaques: Alzheimer's disease

480 amyloid precursor protein 480 annexins: molecular phylogeny 462 antigens

HPC-l 124 human leucocyte, class II 140

antisense RNA, gene silencing 419

apo-a-Iactalbumin: molten globule state 1

apoptosis mammalian cells 307 neurons 157

ARF proteins: ER-Golgi transport role 3

arginino-succinate lyase: lens constituent 302

association rates: macromolecular 181

AlP hydrolysis 116 AlP-dependent organic anion transporter

(l) 164 autoimmune diseases 140 autophosphorylation: receptor tyrosine

kinases 273 azurin 115

~UBJECT INDEX

Compiled by Diane Albin

B bacteria

cell-surface proteins 136 enzyme sequence similarities 466 genetics (BB) 193 Gram-negative: protein secretion 7 L-serine dehydratases 297 toxins: membrane-insertion domain

391 transmembrane solute transporters

13 bacteriophage plaques: lambda library

contamination (CC) 484 baculovirus expression vectors (BR)

110 l3-barrels: triose phosphate isomerase

313,372 base-pairing: tautomerism 160 bcl-2 gene: apoptosis inhibition 308 bestatin: aminopeptidase inhibition

168 13'1 complexes 292, 315 BIK1, S_ cerevisiae 82 biomolecular processes: computer

288 405

62,354 189

modelling (BR) 311 biochemical equations: K' biochemical organization biochemistry, general (BR) bioenergetics, general (BR) biogenesis (BR) 230 BioGopher servers (CC) 485 bionet (CC) 446 BIOSCI newsgroups (CC) 310 BiP: high-affinity binding 3 botulinum neurotoxin 324 bovine lens leucine aminopeptidase

167 brain-derived neurotrophic factor 49 Brefeldin A 214 bulletin boards (CC) 145

C C-type lectins, animals 224 calcium flux regulation: inositol

phosphates 53 calcium-independent protein kinase Cs

207 calmodulin

a-helices 116 nitric oxide synthases regulation

35 cAMP-dependent protein kinase

I)-adrenergic receptor phosphorylation 276

crystal structure 84, 120 targeting subunits 175

Candida boidinii: PMP47 protein 427 capillary electrophoresis 409

carboxy-terminal domain: RNA polymerase II 117

carnitine palmitoyltransferase I: role in ketogenesis 28

catechols 437 cationic detergents: nucleic acid

renaturation 181 cdc2 gene 195 cdc25: ell00 similarity 377 cell adhesion proteins

MAM: adhesive domain 40 cell cycle

cyclin-dependent kinases 195 differentiation: Ras activation by

receptor tyrosine kinases 273 elongation: lens formation 303 neurons 157 P-domain peptide role 239 proliferation: hypusine role 475 RCel 96

cell death see also apoptosis mammalian cells 307 neurons 157

cell regulation factors 125 cell signalling: inositol phosphate

53 cell-surface proteins: bacteria 136 cereal lectins 223 chaperon ins 81 chloroplast genome introns, E. gracilis

467 chloroplast ribosomal proteins:

molecular genetics 177 chloroplasts: thylakoid membranes

415 chromatin

assembly 90 RCel interaction 99

chromophores: spectroscopy 74 chromophytes: thylakoid membranes

418 chromosome

condensation regulator (RCC1) 96 structure maintenance, lrp 260

chronic granulomatous disease 43 cis-acting elements: tRNA splicing, yeast

33 citrovorum factor: one-carbon

metabolism role 102 CLlDa gene, human 377 class II human leucocyte antigens

140 clinical conditions: human diseases

(BR) 62 Clostridium: neurotoxins 324 co-translational transport

mitochondrial proteins 366 secretory proteins 456

493

coiled-coil domains a-keratin 360 G proteins 315

Cold Spring Harbor (BR) 269 colicin: membrane-insertion domain

391 collision theory: macromolecules 181 complementarity: rRNA-mRNA 406 complex polysaccharides: assembly in

plants 210 computer modelling: biomolecular

processes (BR) 311 computer networks

BIOSCI newsgroups (CC) 310 Internet (CC) 107, (BR)231,

(CC)297, (CC)398, (CC)446, (CC)448, (CC)485

computers for molecular biologists (CC) 57

control analysis 26 cooperativity: haemoglobin 385 creatinase: evolution 403 Crohn's disease 242 crystallins: eye lens 301 cyanobacteria: thylakoid membranes

418 cyclic amplification and selection of

targets 77 cyclin-dependent protein kinases

cell cycle 195 targeting subunits 175

cyclins 195 cyclosporin A: action mechanism 334 cytochromes: flavocytochrome b 44 cytoplasmatic linker protein-170 82 cytoskeleton-associated proteins 82 cytosolic polysomes: mitochondrial

protein import 367

o degenerative diseases: nervous system

157 dehydratases: L-serine/threonine 297 dehydrogenases

flavoprotein 44 lens constituents 301

developmental mechanisms: evolutionary conservation (BR) 401

diazotrophs (BR) 109 dictionary

NMR concepts (BB) 192 science and technology (BR) 190

Dictyostelium discoideum antisense RNA: gene regulation

421 inositol pyrophosphates 55

differential scanning calorimetry: protein folding energetics 2

dihedral angles 317, (l) 464 diphtheria toxin: membrane-insertion

domain 391 DNA

analysis: capillary electrophoresis 412

binding sites: CASTing 77 damage checkpoint mechanism

433 oxidative damage (BR) 486 packaging 202 replication 202

DNA Strider (CC) 187 DNA-activated protein kinase 433

494

DNA-binding proteins low sequence specificity, multimeric

complexes 202 TFlIIA 226

DNASTAR (CC) 187 Drosophila melanogaster: cytoskeleton­

associated protein 82 drug-resistance proteins 13 dynein-associated prote..ir'l .. 82

E electrogenic ion pumps (BR) 63 electrokinetic processes (BR) 64 electron light microscopy (BR) 450 electron transport chain: NADPH oxidase

43 electronic mail (CC) 267, (CC) 398 electrophoresis (BB) 64

capillary 409 elongation factor Tu 155 encounter-limited reactions: rate

constants 181 endocytosis: eukaryotic cells 355 endonuclease

iron-sulphur clusters 153 yeast tRNA splicing 31

endoplasmic reticulum membrane transport 453, 456 protein retention 3

energy-selective optical spectroscopy: proteins 71

energy transduction: haemoglobin 385 engrailed homeodomain proteins:

molecular phylogeny 461 enzymes

as a mechanical device 115, 197 catalytic function diversity 372 evolution 403 immunoassay: genetically prepared

conjugates 279 nomenclature 113, (BR) 192

epidermal growth factor receptors 273

epimorphin 124 equilibrium constant: K' 288 ERD-2 gene, yeast 3 Erwinia chrysanthemi: pectate lyase C

313 Euglena gracilis: chloroplast genome

introns 467 eukaryotes

antisense RNA 419 membrane traffic 395 mRNA transcripts: spliceosomal

system 31 secretory pathway 3

eukaryotic initiation factors 429, 475 even-skipped homeodomain proteins:

molecular phylogeny 460 evolution

bacterial cell-surface proteins 136 chloroplast ribosomes 177 enzymes 372, 403 major facilitator superfamily proteins

13 metazoan 459

exocytosis: control 5 exopolyphosphatase 247 exotoxin 393 eye lens crystallins: gene recruitment

301

F farnesyltransferase

inhibitors 349 sequence repeats 426

fatty acid-binding domain: NMDA receptor 41

fibroblast growth factor receptors 273 fidelity-enhancement: mRNA splicing

381 FITSIM program (CC) 58 FK506: action mechanism 334 flavocytochrome b: electron transport in

NADPH oxidase 44 flavoprotein dehydrogenase 44 fluorescence line narrowing

spectroscopy 74 FMR1 gene: fragile X syndrome 331 folinic acid: one-carbon metabolism role

102 Fourier-transform infrared spectroscopy

198 fragile X syndrome: FMR1 gene 331

G G proteins see GTP-binding and

heterotrimeric G proteins GALl/GALlO genes, S. cerevisiae 90 j3-galactosidase: radiation target size

237 Gcl, G. candidum 20 gene expression

antisense-regulated 419 lens cells 304 translational control 429 translational introns 294

gene fusion: preparation of enzyme conjugates 279

gene recruitment: eye lens Crystallins 301

gene transcription see transcription general regulatory factors 91 genetics, molecular (BR) 451 Geneworks (CC) 188 Geotrichum candidum: Gcl 20 glucocorticoids

apoptosis stimulation 308 nucleosome disruption 90

glued gene product, D. melanogaster 82

glycolytic enzymes: Type I aldolase 36 glycoproteins

plants 210 radiation target size 237

Golgi apparatus KDEl receptor 3 KDEl sequ~nce 395 plants 210 retrieval and retention mechanisms

395 SNAPs 453 SNAREs 453 TGN38 4,397 trans-Golgi network 395

Gopher system (CC) 107, (eC) 485 Gram-negative bacteria: protein

secretion 7 grana stacks, plant chloroplasts 415 growth factors and receptors

apoptosis inhibition 308 nerve growth factor 48 platelet-derived growth factor 49,

273

SH2 domains 273, (L) 464 transforming growth factor fj2 49

GS-X pump (L) 164 GTP-binding proteins 3

ARF 3 rab 3,4 rac 43 rap 46 Ras 43,250,273,349

see a/so p21ras

guanosine penta phosphate phosphatase 247

H H+ symporter proteins 13 haemoglobin

binding energy transduction 385 oxygen affinity 53

Harrington, William Fields (0) 364 HDEL receptor, yeast 3 heat shock proteins 125 helper T lymphocytes 140 heterotrimeric G proteins 275, 315

a-subunit 4, (L) 164, 292 fj-y subunits/complexes 292, 315

HIV1 see human immunodeficiency virus HMG-CoA pathway: ketogenesis role

28 HOM/HOX homeodomain proteins:

molecular phylogeny 460 homeodomain proteins: molecular

phylogeny 459 hormone-sensitive lipase 466 HPC-1 antigen: epimorphin sequence

similarity 124 human

eL1Da gene 377 haemoglobin: binding energy

transduction 385 hormone-sensitive lipase 466 leucocyte antigens, Class II 140 neurotrophins 50 pancreatic lipase (hPL) 20 protein data (SR) 190 WRSgene 263

human diseases autoimmune 140 clinical condition (SR) 62 immunodeficiency virus (HIV-1) 255,

307 human immunodeficiency virus (HIV-1)

apoptotic cell death 307 regulatory proteins 255

hydrogen exchange rates: proteins 359

hydrolysis aminopeptidases 167 ATP 116

hydro peroxides 437 hydrophobicity curvature (L) 81 hyperphosphorylation: carboxy-terminal

domain 117 hypusine: eukaryotic cell proliferation

role 475

immediate-early genes: activation by interferons 338

immune response autoimmune diseases 140 src family tyrosine kinases regulation

215

immunoglobulin heavy chain binding protein: SiP 3

immunosuppressive drugs: action mechanism 334

import: mitochondrial proteins 66 infrared difference spectroscopy:

reaction-induced 197 inositol polyphosphate 5-phosphatase

378 inositol phosphates 53, (SR) 271 insecticidal 8-endotoxin: membrane­

insertion domain 391 integral membrane protein localization:

eukaryotic cells 395 interfacial activation: triacylglyceride

lipases 20 interferons

signalling 338 tryptophanyl-tRNA synthetase

induction 263 intermediate compartment: ER-Golgi 3 intermediate filaments: a-keratin

structure 360 Internet (GG)107, (SR)231, (CC)267,

(CC)398, (CC)446, (CC)448, (CC)485 intramolecular chaperones: protein

folding role 442 intronic snRNA (L) 330 introns

E. graCilis chloroplast genes 467 translational 294

ion channels: NMDA receptor 41 iron metabolism: eukaryotes 432 iron-responsive element binding protein

298 iron-sulphur clusters 153

bacterial L-serine dehydratases 297 isoenzymes: nomenclature 114

Johnson, William Arthur (0) 61

K K', equilibrium constant 288 KDEL

receptor 3 retention mechanisms 395

a-keratin: structure 360 ,B-ketoadipate pathway: evolution 373 ketogenesis: top-down control analysis

28 kinases see a/so specific kinase entries

cAMP dependent 84 hinge motions 116 phosphoglycerate: folding

intermediates 2 kinetic mechanisms: computer

evaluation (CC) 58 kinetic proofreading 381 KINSIM program: reaction mechanism

evaluation (CC) 58 Krebs cycle 61

intermediates 13 Kunitz-type protease inhibitor

superfamily 208, (L) 424, (L) 425

L lac system, E. coli 472 lactate dehydrogenase S: lens

constituent 301 laminin: molecular phylogeny 462 lateral proton conduction: lipid-water

interfaces 243 lectin-like interactions: P-domain

peptides 239 lectins 221 legume lectins 221 lens crystallins: gene recruitment 301 leucine-responsive regulatory protein

(Lrp) 260 leucocytes

antigens, class II human 140 cell-surface receptor-mediated signal

transduction 215 leucovorin: one-carbon metabolism role

102 ligase: yeast tRNA splicing 32 ligation reaction, ultrasonic (CC) 446 limonene: farnesyltransferase inhibition

357 linoleic acid: transducin acylation

precursor (L) 164 lipases

hormone-sensitive 466 triacylglyceride: molecular structure

20 lipid modification, proteins (SR) 400 lipocalins (L) 206 lipoprotein

analysis (SR) 192 low-density: radiation target size

237 Lowe's oculocerebrorenal syndrome

378 lymphocyte

activation: src family tyrosine kinases 215

helper T 140 NADPH oxidase 43

lysozyme: motion 116

M MacDNAsis Pro (GG) 187 macromolecular association: rate 181 MacVector (GG) 187 major facilitator superfamily 13,

(L) 248 MAM: adhesive domain 40 mandelate pathway: evolution 372,

403 Mantoniella: thylakoid membranes

417 manumycin: farnesyltransferase

inhibition 350 MAP kinases

cascade 128 phosphatase: Cll00 377

membrane fusion (L) 81, 453 insertion: bacterial toxins 391 lateral cornrnunlcation 243 surface curvature (L) 81 transport 395, 453, 456

membrane proteins PMP47 427 targeted membrane fusion 324,

327,453 meprin: adhesive domain 40 messenger RNA

antisense: gene silencing 419 splicing: fidelity-enhancement 381 splicing: snRNAs 131 transcripts, eukaryotes: spliceosomal

system 31

495

translation initiation 406, 429 metabolism

control analysis 26 leucovorin role 102

metalloproteases: molecular phylogeny 461

metazoan phylogeny 459 methionyl aminopeptidase: evolution

403 microfibrils: a-keratin structure 360 mimicry, molecular: bacteria cell-surface

proteins 136 mitochondria

ketogenesis: rat liver 28 peptidases: nomenclature (l) 249 protein import and synthesis 366

mitochondrial solute carrier proteins 427

mitogen-activated protein kinases see MAP kinases

molecular biology computers (CC) 57, (6R) 311

molecular genetics (BR) 451 motor proteins: actomyosin 319 mouse

nerve growth factor 48 neurodegenerative disorders 157

mRNA see messenger-RNA msh homeodomain proteins: molecular

phylogeny 461 mucins: P-domain 239 muconate lactonizing enzyme 373,

403 Multalin 4.0 (CC) 106 multimeric complex DNA-binding proteins

202, (l) 424 mutagenesis: tautomerism role 160 myoglobin: folding energetics 1

N N-linked glycans: assembly role of Golgi

apparatus 211 NAD see nicotinamide adenine

dinucleotide NADP see nicotinamide adenine

dinucleotide phosphate nano-manipulation in vitro: actomyosin

molecular motors 319 NEM-sensitive fusion protein: membrane

fusion role 453 nerve growth factor 48 neurofibrillary tangles: Alzheimer's

disease 480 neurodegeneration 157 neuropeptides: molecular phylogeny

461 neurotoxins, clostridial 324 neurotransm itters

blockage by clostridial neurotoxins 325

release inhibition: tetanus toxin 327

neurotrophins 49 neutral lipases: molecular structure

20 Nicotiana

genomic lambda library: contamination (CC) 484

Golgi apparatus 210 nicotinamide adenine dinucleotide

278 nicotinamide adenine dinucleotide

496

phosphate 278 NADPH oxidase 43

nitric oxide synthases 35 nitrogen fixation (BR) 109 nitrogenase iron protein: iron-sulphur

clusters 153 nitrogenase molybdenum-iron protein:

iron-sulphur clusters 153 NK homeodomain proteins: molecular

phylogeny 461 NMDA receptor 41 NMR, dictionary (B6) 192 NOGGIN 208, (l) 424, (l) 425 nomenclature 113

enzymes (66) 192 mitochondrial peptidases (l) 249

nuclear pre-mRNA introns 467 nucleic acid: renaturation 181 nucleolar RNA 131 nucleosomes: transcription regulation

function 90 nucleotides: tautomerism 160

o O-linked glycans: assembly role of Golgi

apparatus 212 oligomeric proteins 65 oncogenes see also proto-oncogenes

acquisition by retroviruses 233 bcl-2, apoptosis inhibition 308

oncogenesis 157 one-carbon metabolism: leucovorin role

102 organic phosphate esters: anti porters

13 organization, biochemical 405 oxidases: NADPH 43 oxidative damage

DNA (BR) 486 proteins and ageing 437

p P-clusters 153 P-domain peptides 239 P-glycoproteins (l) 164 p21 rap protein 46 p21ras protein

activation 273 effector interactions 250

PAC-l gene, human 378 pancreatic lipase (hPl) 20 pathogens: killing and digestion: NADPH

role 43 PCR see polymerase chain reaction pectate lyase C 313 Pep12p: epimorphin sequence similarity

124 peptidases: nomenclature 114 peptide analysis: capillary

electrophoresis 411 peptide bonds: dihedral angles 317 Peptostreptococcus asaccharolyticus:

L-serine dehydratases 297 periplasm: protein secretion, Gram­

negative bacteria 8 peroxisomal membranes: PMP47 protein

427 phagocytes: NADPH oxidase 43 phase III detoxification reaction (l)

164 phosphatases

Cll00 377

E. coli 247 targeting subunits 172 VHl 6

phosphates inositol 53, (BR) 271

phosphatidylinositol 3-kinase 378 phosphoglycerate kinase

folding intermediates 2 hinge motions 116

phospholipases A2 activating protein 292 C 53,403

phosphorylation abnormal: tau protein 480 carboxy-terminal domain 117 DNA-activated protein kinase 433 MAP cascades 128 reversible, proteins 172 rhodopsin 275 tyrosine, leucocyte signal

transduction role 215 phosphotransferase: yeast tRNA splicing

32 photoreceptors: protein kinase C 275 photosystems: thylakoid membrane role

415 phycobilisomes, cyanobacteria 418 phylogeny: metazoan 459 plastic gene transcripts: splicing system

31 platelet-derived growth factors

receptors 273 structure 49

pleckstrin homology: PH domain 343 PlP-dependent L-threonine dehydratases

297 PMP47 protein 427 polyamines: cell growth 477 polygalacturonic

acidjrhamnogalacturonan-I 213 polymerase chain reaction

Amplify program (CC) 448 CASTing 77 contamination (CC) 447

polymeric domains: macromolecular association 181

polymerization: proofreading mechanism 381

post-translational import: mitochondrial proteins 366

poxvirus DNA-dependent ATPases 291 pre-mRNA: splicing 117 pre-tRNA: splicing 31 prenylation: proteins 349 primary biliary cirrhosis 141 programmed cell death see apoptosis prolidases: evolution 405 proofreading, kinetic 381 propeptides: protein folding role 442 protein analysis

capillary electrophoresis 411 e-mail servers (CC) 267 Geneworks (CC) 188

protein data Data Sank 65 human (BR) 190

protein folding SiP-binding role 3 chaperonin 81 energetics 1 pectate lyase C 313 propeptide role 442

slow-exchange core 359 protein kinase Cs

calcium-independent 207 PH domain 343 rhodopsin desensitization 275

protein kinases cAMP-dependent 84, 120 mitogen-activated (MAPK) 128 molecular phylogeny 461 targeting subunits 172

protein phosphatase-l: targeting subunits 172

protein sequence motifs calcium-independent protein kinase

Cs 207 chaperonin 81 eLlOO gene 377 cytoskeleton-associated proteins

82 epimorphin 124 farnesyltransferase 426 FMRl gene 331 hormone-sensitive lipase 466 lipocalins (L) 206 MAM 40 NMDA receptor 41 NOGGIN 208, (L) 424, (L) 425 PMP47 ~27 polyphosphates 247 polyphospholipase A2 activating

protein 292 related GAP domains 378 SNF2 family 291

protein sequences alignment: Multalin 4.0 (CC) 106 Human Protein Data (BR) 190

protein structure (BR) 270 dihedral angles 317, (L) 464 evolution 372 ,6-roll motif 313 secondary structure 120 size, shape and function 65

protein synthesis 155 tRNA function (BR) 356

protein tyrosine kinases see tyrosine kinases

protein-protein interaction (BR) 450 Kunitz domain 208 P-domain peptides 239 p21ras protein 250 PH domain 343 transcription factor 77 tyrosine phosphorylation role 219

proteins bacteria cell-surface 136 chloroplast ribosomal 177 disorder 71 homologous: evolution 403 interaction (BR) 450 iron-sulphur clusters 153 lipid modification (BR) 400 major facilitator superfamily (L) 248 mitochondrial, import and synthesis

366 molecular phylogeny 461 multimeric complex dsDNA binding

202 nomenclature 113 prenylation 349, 426 radical-damaged: accumulation

437 reaction-induced infrared difference

spectroscopy 197 retention in endoplasmic reticulum

3 reversible phosphorylation 172 size, shape and function 65 solute transporters 13 secretion: Gram-negative bacteria 7 targeting (BR) 191 toxins: membrane-insertion domain

391 translocation across ER membrane

456 protonic networks: membranes 243 proto-oncogenes 233 see also

oncogenes trkA 51

pseudomonads exotoxin 393 mandelate pathway evolution 372 Pul protein homologues 9

Pul proteins 8 Purkinje cell, death 157 pyrophosphates: inositol 55

R Rab proteins

ER-Goigi transport role 3 S. pombe 4

rac proteins 43 racemases, mandelate 372, 403 radiation target analysis 236 radical-damaged proteins, accumulation

437 Ran: RCCl interaction 99 rap proteins 46 rapamycin: action mechanism 334 Ras proteins 43, 250 see also p21ras

activation by protein tyrosine kinases 273

farnesyltransferase 349 RCCl protein 96 reaction-induced infrared difference

spectroscopy 197 reaction mechanisms: computer

programs (CC) 58 RecA protein, E. coli (L) 424 receptor kinases

(3-adrenergic 315 receptor protein tyrosine phosphatase

",,: adhesive domain 40 receptors

comn:lOn adhesive domain 40 NMDA 41 protein tyrosine kinase 215, 273

regulatory factors, transcriptional 90 replication, DNA: multimeric complex

binding proteins role 202 restin 82 restriction enzyme mapping, DNA Strider

(CC) 187 retinol G proteins: transducin (L) 164 retroviruses 233 Rev proteins 255 reversible associations: quantitative

characterization 284 reversible transcription: retroviruses

233 Rhizomucor miehei: RmL 20 rhodopsin: desensitization 275 ribonucleoprotein Al 421 ribosomal proteins, chloroplast

177

ribosomal RNA protein synthesis 155 transcription processing, snoRNA

131 translation initiation role 406

RmL, R. meihei 20 RNA see also messenger, pre-,

ribosomal and transfer RNA antisense: gene silencing 419

binding: TFlIlA 227 metabolism: FMRl gene 331 processing: carboxy-terminal domain

role 117 recognition: HIV-l regulatory proteins

255 RNA helicases 125 RNA polymerase II 90

carboxy-terminal domain 117 rRNA see ribosomal RNA (3-roll motif. 313

S Saccharomyces cerevisiae

cytoskeleton-associated proteins 82

GALl/GALlO genes 90 immunosuppressive drugs 334 MAP kinase cascade homologues

129 SH2 domain (L) 464 snRNAs 131 tRNA splicing pathway 31 yeast VHl (YVH1) 6

a-sarcin loop, translocation 155 Schiff base-forming Lys 37 Schizosaccharomyces pombe

cdc2 gene 195 cdc25 protein 6 MAP kinase cascade homologues

129 membrane traffic model 4

science and technology, dictionary (BR) 190

secretory pathway eukaryotic cells 3, 395 proteins: Gram-negative bacteria 7

secretory proteins P-domain peptides 239

sedimentation equilibrium measurement and analysis 284

self-splicing RNA systems 31 sequence alignment: Multalin 4.0 (CC)

106 sequence analysis

bye-mail (CC) 267 computer programs (CC) 187

sequence homology calcium-independent protein kinase

Cs 207 cytoskeleton-associated proteins

82 epimorphin 124

serine dehydratases 297 SH2 domain, yeast (L) 464 signal transduction pathways

endoplasmic reticulum membrane translocation 456

effector-protein activation 292 haemoglobin 385 inositol phosphates 53 interferons 338 leucocytes, cell-surface receptor

497

mediated 215 MAP kinase cascade 128 p21ras 250 phototransduction 275 Ras activation by receptor tyrosine

kinases 273 RCCl 100 T cell receptor 334 tools for elucidating 334

slow-exchange core: protein folding 359

small nuclear RNA (snRNA) 131, (l) 330

SNAPs 453 SNAREs 453 SNF2 family proteins 291 snoRNA see nucleolar snRNA snRNA see small nuclear RNA soluble proteins 65, 453 solute transporter proteins 13 Southern blots (CC) 484 spectrin: molecular phylogeny 462 spectroscopy

energy-selective 71 Fourier transform 198 reaction-induced infrared 197

spliceosomal snRNA 131 spliceosomal system: eukaryotic mRNA

transcripts 31 splicing

introns: E. gracilis chloroplast genes 467

pre-mRNA 117 RNA 31 snRNAs 131

splicing factors 117 src family tyrosine kinases 215 Staphylococcus: cell-surface proteins

136 statistical thermodynamics: protein

folding energetics 1 Streptococcus: cell-surface proteins

136 Strider, DNA (CC) 187 subtilisin: intramolecular chaperones

443 sugar-facilitator proteins 13 ~-superhelix motif 313 surface curvature: membranes (l) 81 synapsin I 327 synaptobrevin 325, 329, 453 syntaxins 124, 329, 453 synthetase, tRNA 362

T T cell

blockage by immunosuppressive drugs 334

src family tyrosine kinases 215 T lymphocytes 140 targeting, proteins (BR) 191 targeting membrane fusion: membrane

proteins 453 targeting subunits: protein

phosphorylation regulation 172 Tat proteins 255 tau protein: Alzheimer's disease marker

480

498

tautomerism, nucleotides 160 tear-specific prealbumin (l) 206 technology and science, dictionary

(BR) 190 tetanus neurotoxin 324, 327 TFIlIA 226 TGN see trans-Golgi network TGN38 4, 397 thanatogenesis 157 thermodynamics, statistical: protein

folding energetics 1 threonine dehydratases 297 thylakoid membranes, plants 415 thymocytes: apoptosis 307 titration curves: amino acids 69 top-down control analySis 26 toxins: membrane-insertion domain

391 trans-acting factor: yeast tRNA splicing

31 trans-activation see transcription trans-Golgi network (TGN) 210

eukaryotic cells 395 vesicle budding 4

transcription artificial regulatory systems 471 initiation 90, 117 multimeric complex dsDNA binding

proteins 202 TFlIIA 226

transcriptional regulatory factors 90, 459

transducin 275, 293 acylation (l) 164

transfer RNA protein synthesis (BR) 356 splicing 31 tertiary structure 362

transforming growth factor ~2: structure 49

transglutaminase: activation by tetanus toxin 327

transition mutation 160 transition state theory 181 translation

bypassing in mRNA 294 initiation, rRNA-mRNA

complementarity 406 initiation regulation 429

translational introns: gene expression regulation 294

translocation a-sarcin loop role 155 Gram-negative bacteria 7 protein 456

transport ER-Golgi 3 G proteins role 4 major facilitator superfamily proteins

13 transversion mutations 160 trefoil motif proteins 239 triacylglyceride ester hydrolases:

molecular structure 20 triose phosphate isomerase 313, 372 trkA gene 51 tRNA see transfer RNA tryptophanyl-tRNA synthetase 263

tumour necrosis factor: apoptotic cell death 308

twintrons: E. gracilis chloroplast genes 467

type I fructose biphosphate aldolase 36

tyrosine kinases

U

activation of Ras 273 src family 215

UhpC 13 ultracentrifugation: biomolecular

associations 284 ultrasonic DNA ligation (eC) 446 unstructured polymeric domains 181 Usenet (CC) 398

V vaccinia virus

NTPl protein 291 VHl phosphatase 6 WHl 377

vesicle-associated membrane proteins 453 cleavage by neurotoxins 324 cleavage by tetanus toxins 327

vesicular transport G proteins role 4 proteins (l) 248, 453 Rab6 protein 4

vibrational energy: proteins 71 viruses: fusion mechanisms (BR)

355 visual transduction: protein kinase C

role 275 Von Ebner's gland protein (l) 206

W wheat germ agglutinin 223 wobble base pairing 160 WRS gene, human 263

X Xenopus

MAP kinase cascade 128 NOGGIN gene 208, (l) 424,

(l) 425 TFIIIA 226

xyloglucan 213

y yeast

ERD-2gene 3 HDEl receptor 3 Pep12p protein 124 PMP47 protein 427 SH2 domain (l) 464 tRNA splicing 31

Yersinia enterocolitica: Yop proteins 10

Yop proteins, Y. enterocolitica 10 Ypt proteins, S. pombe 4

Z zinc endopeptidases

clostridial neurotoxins 324 tetanus toxins 327