Structure Skeletal Muscle

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    Structure and Function of

    Skeletal Muscle

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    Skeletal MuscleHuman body contains over 400skeletal muscles

    40-50% of total body weightFunctions of skeletal muscle

    Force roduction for locomotion and

    breathingForce roduction for ostural su ortHeat roduction during cold stress

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    Structure of SkeletalMuscle!Connective Tissue

    Covering

    " imysiumSurrounds entire muscle

    #erimysiumSurrounds bundles of muscle $bers

    Fascicles

    "ndomysiumSurrounds individual muscle $bers

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    Structure of SkeletalMuscle!MicrostructureSarcolemma

    Muscle cell membrane

    Myo$brils hreadlike strands within muscle $bers&ctin 'thin $lament(

    ro onin ro omyosin

    Myosin 'thick $lament(

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    Structure of SkeletalMuscle!The SarcomereFurther divisions of myo$brils

    )-line

    &-band*-band

    +ithin the sarco lasmSarco lasmic reticulum

    Storage sites for calcium

    ransverse tubules erminal cisternae

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    he ,euromuscular unction

    Site where motor neuron meets the muscle$ber

    Se arated by ga called the neuromuscular cleftMotor end late

    #ocket formed around motor neuron bysarcolemma

    &cetylcholine is released from the motorneuron

    .auses an end- late otential '"##(/e olari ation of muscle $ber

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    *llustration of the,euromuscular unction

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    Motor 1nitSingle motorneuron 2 muscle$bers it innervates"ye muscles 3 ! muscle nerveratioHamstrings 3 600! muscle nerveratio

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    Muscular .ontraction he sliding $lament model

    Muscle shortening occurs due to themovement of the actin $lament overthe myosin $lamentFormation of cross-bridges between

    actin and myosin $laments7eduction in the distance between )-lines of the sarcomere

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    he Sliding Filament Modelof Muscle .ontraction

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    .ross-8ridge Formation inMuscle .ontraction

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    Sliding Filament heory7est 3 uncharged & # cross-bridgecom le9

    "9citation-cou ling 3 charged & # cross-bridge com le9: ;turned on<.ontraction 3 actomyosin 3 & # = &/# 2#i > energy7echarging 3 reload cross-bridge with & #7ela9ation 3 cross-bridges ;turned o?<

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    Muscle Function&ll or none law 3 $ber contractscom letely or not at allMuscle strength gradation

    Multi le motor unit summation 3 moremotor units er unit of time

    +ave summation 3 vary fre@uency ofcontraction of individual motor units

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    "nergy for Muscle.ontraction

    & # is re@uired for musclecontraction

    Myosin & #ase breaks down & # as$ber contracts

    Sources of & #

    #hos hocreatine '#.(AlycolysisB9idative hos horylation

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    Sources of & # for Muscle.ontraction

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    #ro erties of Muscle Fibers8iochemical ro erties

    B9idative ca acity y e of & #ase

    .ontractile ro ertiesMa9imal force roductionS eed of contractionMuscle $ber eCciency

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    *ndividual Fiber y esFast $bers

    y e **b $bers

    Fast-twitch $bersFast-glycolytic$bers

    y e **a $bers*ntermediate $bersFast-o9idativeglycolytic $bers

    Slow $bers y e * $bers

    Slow-twitch $bersSlow-o9idative$bers

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    .om arison of Ma9imalShortening Delocities8etween Fiber y es

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    Histochemical Staining ofFiber y e

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    Fiber y es and#erformance

    #ower athletesS rinters

    #ossess high ercentage of fast $bers"ndurance athletes/istance runnersHave high ercentage of slow $bers

    Bthers+eight lifters and nonathletesHave about 50% slow and 50% fast $bers

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    raining-*nduced .hangesin Muscle Fiber y e

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    Hy ertro hy andHy er lasia

    *ncrease in si e *ncrease innumber

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    &ge-7elated .hanges inSkeletal Muscle

    &ging is associated with a loss ofmuscle mass

    7ate increases after 50 years of age7egular e9ercise training canim rove strength and endurance

    .annot com letely eliminate the age-related loss in muscle mass

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    y es of Muscle

    .ontraction*sometric

    Muscle e9erts force without changing length

    #ulling against immovable obEect#ostural muscles

    *sotonic 'dynamic(.oncentric

    Muscle shortens during force roduction

    "ccentricMuscle roduces force but length increases

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    *sotonic and *sometric

    .ontractions

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    *llustration of a Sim le

    witch

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    Force 7egulation in Muscle y es and number of motor units recruited

    More motor units greater force

    Fast motor units greater force*nitial muscle length

    ;*deal< length for force generation

    ,ature of the motor units neural

    stimulationFre@uency of stimulation

    Sim le twitch: summation: and tetanus

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    7elationshi 8etween

    Stimulus Fre@uency andForce Aeneration

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    Gength- ension

    7elationshi in SkeletalMuscle

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    Force-Delocity 7elationshi&t any absolute force the s eed ofmovement is greater in muscle with

    higher ercent of fast-twitch $bers he ma9imum velocity of shorteningis greatest at the lowest force

    rue for both slow and fast-twitch $bers

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    Force-Delocity 7elationshi

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    Force-#ower 7elationshi&t any given velocity of movementthe ower generated is greater in a

    muscle with a higher ercent offast-twitch $bers he eak ower increases withvelocity u to movement s eed of

    00-600 degreesIsecond -Force decreases with increasingmovement s eed beyond this velocity

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    Force-#ower 7elationshi

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    7ece tors in MuscleMuscle s indle

    /etect dynamic and static changes inmuscle lengthStretch reJe9

    Stretch on muscle causes reJe9 contraction

    Aolgi tendon organ 'A B(Monitor tension develo ed in muscle#revents damage during e9cessive forcegeneration

    Stimulation results in reJe9 rela9ation of muscle

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    Muscle S indle

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    Aolgi endon Brgan

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