Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug...
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![Page 1: Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development Multiple Sclerosis Rheumatoid Arthritis Neuroinflammation.](https://reader030.fdocuments.net/reader030/viewer/2022032802/56649de75503460f94ae1393/html5/thumbnails/1.jpg)
Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development
Multiple Sclerosis
Rheumatoid Arthritis
Neuroinflammation
Pain
Transplant Rejection
Asthma
Allergy
Atherosclerosis
Cancer Metastasis
Diabetes
HIV
![Page 2: Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development Multiple Sclerosis Rheumatoid Arthritis Neuroinflammation.](https://reader030.fdocuments.net/reader030/viewer/2022032802/56649de75503460f94ae1393/html5/thumbnails/2.jpg)
Core Expertise: Biochemistry, Structural Biology, Cell Biology, Membrane Proteins
Qin et al, Accepted to Science. 2015
Example: CXCR4:vMIP-II
![Page 3: Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development Multiple Sclerosis Rheumatoid Arthritis Neuroinflammation.](https://reader030.fdocuments.net/reader030/viewer/2022032802/56649de75503460f94ae1393/html5/thumbnails/3.jpg)
Core Expertise: Biochemistry, Structural Biology, Biophysics, Cell Biology, Membrane Proteins
CCR2 with Small Molecule Cmpds Low off-rate and allosteric cmpds
decreasing off rate
+ allosteric cmpd
SPR for Interaction Affinities
Cell-Based Assays; e.g. Ligand inducedReceptor Internalization
![Page 4: Structure and Function of Chemokines/Receptors......... with Overall Goal to Contribute to Drug Development Multiple Sclerosis Rheumatoid Arthritis Neuroinflammation.](https://reader030.fdocuments.net/reader030/viewer/2022032802/56649de75503460f94ae1393/html5/thumbnails/4.jpg)
Proposed Collaborations with SSPPS Faculty
Ruben Abagyan: Docking and Structure analysis of chemokine receptors
Dio Siegel: Small molecule compounds for chemokine receptor structures
Bill Gewick: Natural products targeting chemokine receptors
Jim McKerrow and Larissa Podust: membrane protein targets in tropical diseases
Victor Nizet: Chemokines/receptors in microbial pathogenesis
Debbie Spector: Chemokine/receptors and CMV
Pieter Dorrestein: Chemokines/receptor in cell-cell communication by MS
Geoffrey Chang: Nanobodies/antibodies against chemokine receptors
Dong Wang: Stabilization of protein-protein complexes by disulfide locks for structure determination