Stroke telemedicine Ryan Heyborne, MD
Transcript of Stroke telemedicine Ryan Heyborne, MD
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STROKE TELEMEDICINERyan Heyborne, MDIdaho Emergency Physicians – June 2009
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“Telemedicine can be an effective method to
provide expert stroke care to patients located in rural
areas.”
- 2007 AHA/ASA Stroke Guidelines
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Stroke Telemedicine
Stroke Centers limited in Idaho Time critical Many facilities not comfortable with
diagnosis and/or treatment without support
Visual diagnosis helpful Guidance in treatment
Thrombolytics
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Stroke Telemedicine (cont)
Stroke Telemedicine. Mayo Clin Proc. 2009;84 ~20 telestroke networks worldwide – CA,
NY, GA, AZ, MI, MA, MD, TX, PA, UT, NV, CO, Canada, Europe
Hub and spoke hospitals Communication established within 40 min of
arrival (initial assessment begun and tests ordered)
Treatments recommended and started within 60 min.
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Primary Stroke Center
~200 Hospitals in US
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Overview
Tools to provide direction Not meant to be an esoteric lecture
TIA’s Stroke Protocol Thrombolytics Interventional Radiology
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TIA’s
TIA defined AHA: “A TIA is a "warning stroke" or "mini-
stroke" that produces stroke-like symptoms but no lasting damage.”
Some controversy regarding “duration” Most < 30 min. Many over 60 min. (never more than 24 h) Practical purposes – only having this discussion
if already resolved.
Kimura K. The duration of symptoms in transient ischemic attack. Neurology 1999
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TIA Workup
Predictor of Stroke Angina of the Brain Risk Stratification
Inpatient v. Outpatient Risk Factor Based – ABCD2 Resource Based – Many hospitals can’t do
workup
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ABCD2
A (Age); 1 point for age >60 years,
B (Blood pressure > 140/90 mmHg); 1 point for hypertension at the acute evaluation,
C (Clinical features); 2 points for unilateral weakness, 1 for speech
disturbance without weakness, and
D (symptom Duration); 1 point for 10–59
minutes, 2 points for >60 minutes.
D (Diabetes); 1 point
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ABCD2 (cont)
ABCD2 Score Guideline only – Clinical Judgment Trumps Validated in Multiple Studies – “Best” for ED Use
Recent Study – Neurology; June 2009 (half in first 24 h)
Stroke risk at 2 days, 7 days, 30 days, and 90 days: Scores 0-3: low risk (1-4%) Scores 4-5: moderate risk (4-14%) Scores 6-7: high risk (8-23%) Admit Moderate/High risk – Low risk MAY be worked
up as outpatient and started on antiplatelet therapy.Johnston SC. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007.
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TIA Workup
Cardiac Monitoring, EKG Head CT Physical Examination Labs, Consider Hypercoag. Carotid Duplex US Consider MRI/MRA Consider Echocardiogram
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Treatment
AHA/ASA 2006 – Guidelines for Prevention of Stroke in TIA/Ischemic Stroke Risk Factor Modification: DM/HTN/Tob/etc. Non-cardiogenic ischemic stroke or TIA:
Aspirin Alone – Low dose (81-325 mg/day) adequate Aspirin and Dipyridamole Plavix Alone – increased bleeding risk with Aspirin and
Plavix Cardiogenic – arrhythmia, vascular disease, PFO
Consider Coumadin, referral for cardiology intervention
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TIA Summary
Decision of inpatient v. outpatient Resource-based May need stroke center, may not
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Stroke
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Stroke Protocol
Preparation Maintain patient safety (escort/fall
precautions) Obtain VS, Pulse-ox Monitor, O2 @ 2L (Sat 95%)
History Event History – Time of Onset, affected
function PMH – Recent Trauma or Procedures
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Stroke Protocol (cont)
Assessment Respiratory Status – patent airway,
secretions Neurological Status
LOC Speech Clarity and Pattern Facial Symmetry Hand Grip, foot push/pull Paresthesia/Paralysis Blood Glucose Check
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NIH Stroke Scale
Within 10 minutes Level of Consciousness Visual – Gaze/Fields Motor –
Facial/Extremities/Ataxia
Sensory – Pinprick Speech Neglect
http://www.ninds.nih.gov/doctors/NIH_Stroke_Scale.pdf
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Stroke Protocol (cont)
Brain Attack Team Activate if symptoms < 3 hours Includes
Emergency Physician Emergency Nurse Phlebotomist CT Tech ED Tech Brain Attack Radiologist Stroke Service
The telemedicine Emergency Physician
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Stroke Protocol (cont)
2 IV Sites Labs – Cardiac Panel,
Coags EKG CXR? (2007) Brain Attack Protocol
Head CT Noncontrast Head CT CT angiogram of
carotid artery and Circle of Willis
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Intervention
IV t-PA IA t-PA Clot retrieval Admission
ICU if Thrombolytics Telemetry if not
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IV t-PA
Studies NEJM 1995 – National Institute of Neurological
Disorders and Stroke (NINDS) Overall, for every 100 patients treated within the first 3
hours, 32 had a better outcome as a result and 3 a worse outcome.
Lancet 2004 – Pooled analysis of multiple studies (ATLANTIS, ECASS, NINDS) 2775 Patients Favorable 3-month outcome
Multiple measures – common - Modified Rankin Scale: Shifting a grade compared to placebo
Odds Ratio 2.81 if < 90 min. Odds Ratio 1.55 90-180 min. Odds Ratio 1.40 180-270 min.
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Improved Outcomes
Modified Rankin Score 0 - No symptoms at all 1 - No significant disability despite symptoms; able to
carry out all usual duties and activities 2 - Slight disability; unable to carry out all previous
activities, but able to look after own affairs without assistance 3 - Moderate disability; requiring some help, but able to
walk without assistance 4 - Moderately severe disability; unable to walk without
assistance and unable to attend to own bodily needs without assistance
5 - Severe disability; bedridden, incontinent and requiring constant nursing care and attention
6 - Dead
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IV t-PA continued
From St. Al’s t-PA Information sheet: “1 out of 9 received benefit and 1 out of 16 had a
serious bleeding complication…” ECASS 3 (NEJM 2008) - consider out to 4.5 hours
– need more data, may consider in some cases – discuss with neurologist. Risk of Hemorrhage increases from 1.1% to 5.9%
with no significant difference in mortality rate Not FDA Approved – Recommended by ASA with
qualifications Stroke Scale < 25, age <80, anticoagulation, H/O CVA
and DM
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Sorting through the Criteria…
Evolving Always at
your fingertips online.
Clinical judgment and open discussion…
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IV t-PA Inclusion Criteria
Stroke onset less than 3 hours Age > 18 Informed Consent Neurologic deficit measurable on NIH
stroke scale No specific cut off (around 5 to 22)
CT scan of the brain showing no evidence of intracranial hemorrhage
Labs Reviewed
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IV t-PA Exclusion
Evidence of intracranial hemorrhage, mass-efffect or edema on noncontrast head CT, or history of ICH
High suspicion of subarachnoid hemorrhage (if CT nl)
History of intracranial neoplasm, arteriovenous malformation, or aneurysm
Active internal bleeding (e.g., GI or urinary bleed-21d) Asymptomatic, non-anemic guiac + not absolute
contraindication Within 3 months of previous stroke, intracranial
surgery, serious head trauma Recent acute myocardial infarction (around a
week)
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IV t-PA Exclusion (cont)
SBP > 185 or DBP > 110 repeatedly or requiring agrressive Tx to keep below Labetalol 10 mg repeated x 1 OR Nitropaste 1-2” OR Nicardipine infusion 5-15 mg/hr
Major Surgery within 14 days Known bleeding diathesis such as (not limited to)
Platelet count <100,000/mm Heparin/Lovenox within 48 hours and had an elevated
pTT Recent use (48 h) of anticoagulant (e.g., warfarin sodium)
and elevated PT (INR > 1.5) Glucose is <50 mg/dL or >400 Witnessed seizure at stroke onset
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IV t-PA Exclusion (cont)
Only minor (sensory loss, ataxia, dysarthria alone) or rapidly improving stroke symptoms
Patient has a large stroke/MCA Infarct In consultation with Neurologist NIHSS 22-25 or more
Recent arterial puncture at non-compressible site
Severe complicated condition that may confound treatment (Neuro, Psych, Cancer, AIDS, etc)
Pregnant
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IV t-PA Criteria (cont)
Relative Contraindications Age > 80 Pericarditis/Endocarditis Liver/Kydney Dysfunction Diabetic Hemorrhagic Retinopathy Occluded/Infected AV cannula
(hemodialysis) Lumbar puncture within 7 days Within 14 days of serious trauma
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IV t-PA Criteria (cont)
Summary of Indications/Contraindications Requires an open, in-depth discussion with the
patient and family members IF you’re going to do it, do it right… ED “Stroke Packet”
ED orders Thrombolytic Checklist for stroke / Order Sheet
Risk and benefits information sheet Admission Order Sheet So you don’t have to commit it all to memory…
All available on telemedicine web-site
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Safe in a Telemedicine Setting
Telemedicine for Safe and Extended Use of Thrombolysis in Stroke: The Telemedic Pilot
Project for Integrative Stroke Care (TEMPiS) in Bavaria
Stroke 2005;36;287-291
“The present data suggest that systemic thrombolysis indicated via stroke experts in the setting of teleconsultation exhibits similar complication rates to those reported in the NINDS and Stroke trial. Therefore, tPA treatment is also safe in this context and can be extended to nonurban areas.”
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Giving IV t-PA
“Alteplase” 0.9 mg /kg up to 90 mg 10% as a bolus and the rest to be infused
over one hour. Start at Outside Facility During Transport
Need Paramedic Lifeflight
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Giving t-PA (cont)
Q 15 min. BP measurements No Heparin, aspirin, clopidogrel, etc. for
24 hours Standard treatments if having seizure
but prophylaxis not routinely given ICU monitoring Monitor for Bleeding
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Post t-PA Blood Pressure Mgmt. 2007 AHA/ASA Stroke Guidelines
Measure Q 15 minutes Don’t treat below ~180/105 Systolic 180-230; Diastolic 105-120
Labetalol – boluses to max of 300 mg v. infusion 2-8 mg/hr
Systolic >230; Diastolic >120 Labetalol as above Nicardipine 5-15 mg/hr (titrate by 2.5 every 5
minutes) Consider nitroprusside
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t-PA Reversal
Intracranial Hemorrhage Acute neurologic deterioration, new headache, BP
spike, nausea/vomiting Stop t-PA infusion Stat Head CT Stat Pt, PTT, fibrinogen, Platelet count Prepare for administration of
6-8 units of cryoprecipitated fibrinogen Platelets Factor VII
Neurosurgical consultation Don’t need to have this all available to start
infusion
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t-PA Summary
Risk/Benefit Discussion Blood pressure management to 180/110
Labatelol first line 0.9 mg /kg up to 90 mg ICU Admission Follow closely for deterioration
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Intra Arterial Thrombolytics
Interventional Radiology Direct Injection Similar Exclusion Criteria
Dissection/Stenosis/Poor Visualization PROACT II (JAMA 1999)
Acute strokes less than 6 hours duration caused by middle cerebral artery occlusion.
180 patients in 54 centers Patients given 9 mg of IA r-proUK PLUS IV
heparin VS IV heparin alone
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IA Thrombolytics (cont)
Results Positive
Treatment group – 40% Rankin score of 2 or less Control group – 25% Rankin score of 2 or less
Negative Increase in intracranial hemorrhage with
neurologic deterioration within 24 hours 10% of IA r-proUK vs 2% of control
Overall mortality at 90 days was 25% for IA r-proUK vs 27% of control
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IA Thrombolytics Summary
IA t-PA considered equivalent to r-proUK Consider if < 6 hours and lesion
amenable on CTA Decision in consultation with
Neuroradiologist/ Neurologist
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Mechanical Retreival
MERCI Retriever (Mechanical Embolus Removal in Cerebral Ischemia)
Consideration up to 6-8 hours
Can be safely combined with IV-tPA – Am J Neuroradiol 2006
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Mechanical (cont)
Inclusion Acute large vessel stroke NIHSS ≥ 8 8 hours of symptom onset for MERCI and
Penumbra devices 6 hours of symptom onset for IA tPA
Exclusions Significant cytotoxic edema Blood on Head CT
Allow consideration of the post trauma, post partum, and post surgical patient.
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Summary
TIA Risk Factor Stratification Risk management
Stroke Time sensitive treatments St. Al’s is Stroke Center NIH Stroke Scale Appropriate Initial Work-up/Evaluation prior
to transfer/Stroke Team Activation
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Summary (cont)
Stroke Treatments IV Thrombolytics
Symptoms less than 3 hours Careful discussion of
indications/contraindications IA Thrombolytics
Symptoms less than 6 hours with favorable lesion
Mechanical Retreival Symptoms less than 8 hours with favorable
lesion
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Discussion / Questions