Strategy July 06

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    1JCB 30June 20, 2007Vision and Strategy

    Robert Ridley

    TDR Business Plan2008-2013

    Fostering an effective global research efforton infectious diseases of poverty in whichdisease endemic countries play a pivotal role

    Stewardship

    Empowerment

    Research on Neglected PriorityNeeds

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    2JCB 30June 20, 2007Vision and Strategy

    Fourth External Review and JCB 29

    TDR to change, evolve and grow

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    3JCB 30June 20, 2007Vision and Strategy

    Need for new TDR vision/strategy triggered by criticaltrends in global research environment

    DEC's leftbehind in

    priority setting

    Growing regionalvariation

    Enhancedresearch

    capabilities inDEC's

    Global researchenvironment fortropical diseases

    EpidemiologicalChanges

    Momentumthrough new

    players / initiatives

    Infectiousdisease burdenremains high

    Rise inpharmaceutical

    product

    developmentComplexity andfragmentation

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    What is Needed?

    An effective global research effort

    on infectious diseases of poverty

    in which disease endemic

    countries play a pivotal role

    Extension of TDR Mandate to cover'infectious diseases of needypopulations'

    Greater social contextualisationof research (including gender issues)bringing closer to control needs

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    Implications for TDR

    To foster the vision

    To focus activity where there is need andwhere TDR has a comparative advantage

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    6JCB 30June 20, 2007Vision and Strategy

    New andimprovedtools

    New andimprovedstrategies

    Newknowledge /discoveries

    New andimprovedinterventions

    Modelling the system to address TDR's role

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    7JCB 30June 20, 2007Vision and Strategy

    Newknowledge /discoveries

    New andimprovedtools

    New andimprovedinterventions

    Responding to needs

    New andimprovedstrategies

    GAELF

    Trachoma

    RBM

    StopTB

    Global Fund

    APOC

    New andimprovedtools

    EDCTP

    New andimprovedtools

    MMV

    Microbicides

    DNDi

    GATB

    IAVI

    FIND

    NIH, Trust,Research

    councils, etc

    Grand Challenges

    Empowerment, pivotal role

    Stewardship, effective global effort

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    Implications

    Newknowledge /discoveries

    New andimprovedtools

    New andimprovedinterventions

    New andimprovedstrategies

    Foster innovation for

    products,emphasizing DECengagement

    Foster research to

    develop and evaluateinterventions inreal-life settings

    Foster researchfor access tointerventions

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    What we want to achieve

    InnovationInterventions

    Access

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    Stewardship

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    Stewardship

    Vision To help focus global efforts on priority needs in infectious

    diseases research in disease endemic countries

    Overall objective To facilitate and foster knowledge management, needs

    assessment, priority setting and progress analysis forhealth research on infectious diseases of poverty, and to

    provide a neutral platform for stakeholders to discuss andharmonize their activities with disease endemic countriesplaying a pivotal role in the agenda setting.

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    12JCB 30June 20, 2007Vision and Strategy

    Research capacity

    Research Utilisation

    Empowerment

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    13JCB 30June 20, 2007Vision and Strategy

    Individual

    Institution

    National

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    14JCB 30June 20, 2007Vision and Strategy

    Mainstream Capacity Building

    RCS

    R&D

    RCSR&D

    RCS

    Scientific

    capacity at

    country

    level

    +-

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    15JCB 30June 20, 2007Vision and Strategy

    Empowerment

    Vision DEC Leadership in health research, training and

    partnerships within sound scientific, ethical and qualityframeworks

    Overall objective

    To develop excellence and leadership in health research

    and decision making so that high quality institutional andnational systems can identify and manage researchpriorities.

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    Capacity, Empowerment, led by

    Effective global effort, Stewardship

    Empowerment

    Stewardship

    BL 4: Innovationfor PD in DEC

    Research Business Lines and Gaps

    BL 3: Discovery

    BL 5: Innovative vector control

    BL 11: Integrateddelivery strategies

    BL 9: Malaria/fever treatment policy

    BL 8: Treatment for HIV/TB

    BL 7: Drugs for helminths

    BL 6: Diagnostics

    BL 10: VL elimination

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    Planned activities across research continuum

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    Business Lines

    Greater clarity of activity Easier to justify funding

    Easier to define interactions

    External partners

    Internal within WHO

    Closer cooperation and easier collaboration with WHO controldepartments and regional offices

    Form follows function leading to:

    Transparency of portfolio

    Easier review and evaluation

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    Business Lines can enter / exit / change over time

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    Determinants of BL entry / exit

    Entry / exit criteria based on comparative addedvalue, needs and cost

    STAC to validate entry / exit

    Comparative added value and new opportunitiesinformed by:

    stewardship analysis and consultation on priority needs

    empowerment and capacity needs innovation fund driven opportunities

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    Innovation Fund

    Fund @ $1M per year

    Open to applications on any topic relevant to TDR'sresearch, empowerment and stewardship mission

    No limit to request, may be for limited funding at project level(rapid response) or larger funding for major initiative(detailed negotiation)

    Goal to initiate and stimulate sustainable activity that will

    have impact Interface with stewardship for topics to be addressed

    Possible incubation of future business lines

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    Issues associated with management of BL's

    Entry / exit DEC's play pivotal role

    Synergies across functions and business lines

    Mainstreaming cross-cutting issues e.g. gender

    Overall balance e.g. disease scope expansion conservative and meets

    JCB mandate

    Stewardship has broad scope

    BL 6 (helminths) BL 11 (integrated CDI)

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    Delivering Impactmaking a difference

    Innovation

    Interventions

    Access

    Monitoring and Evaluation against indicators and deliverables

    STRATEGIC OBJECTIVES INTERIM IMPACT DIMENSIONS INTERIM MONITORING METRICS/INDICATORS

    TARGET FOR2008 2009

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    INDICATORS 2008-2009

    1. Global consensus on priorityresearch needs

    # of quality consultations/reports forconsensus facilitated by TDR

    12

    2. Equitable access to healthresearch information

    Surveyed user satisfaction levels withknowledge platform

    65 %

    1. Stewardship

    3. Greater engagement of keyinstitutions/networks

    % of key institutions/networksactively involved in TDR forums

    60 %

    4. Quality research led by DECscientists and institutions

    # of publications with DEC

    researchers as lead authors 175

    5. Sustainable regional research andknowledge networks

    # of DEC research institutions/networks improved towards

    international standards

    40

    2. Empowerment

    6. DEC effectively negotiatingresearch partnerships

    # of partnerships with DECresearchers as leads

    5

    7. Promising leads identified &transferred to partnerships

    % of lead development/transfers atplanned milestones

    80 %

    8. Effective north-south innovationnetworks established

    # of innovation networks established/expanded/strengthened 2

    3. Research on NeglectedPriorities

    3a. Innovation for

    product discovery anddevelopment

    9. Product R&D managed by DECinstitutions

    # of key R&D projects managed byDEC institutions

    1

    10. Evidence on real-life safety andeffectiveness of tools

    % of real-life safety/effectivenessevaluations at planned milestones

    80 %

    11. Effective intervention tools andstrategies

    % of intervention tools and strategiesat planned milestones

    80 %

    3b. Development and

    evaluation of

    interventions inreal-life settings

    12. Cost-effective elimination andsurveillance strategies

    % elimination/surveillance strategiesat planned milestones

    80 %

    13. Integrated strategies for largescale intervention delivery

    % integrated intervention deliverystrategies at planned milestones

    80 %

    14. Cost-effective strategies for scale-up of interventions

    % cost-effective scale-up strategies atplanned milestones

    80 %

    3c. Implementation

    research for access tointerventions

    15. Research culture within controlprogrammes

    # of control programmes activelyinvolved in research projects

    24

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    Dashboards linking BL performance to strategic

    indicators

    C i

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    Committees central to strategy development

    plus monitoring and evaluation

    STAC

    BL5BL4BL3 BL6 BL10 BL11BL 1(Stew) BL9BL7 BL8BL 2(Emp)

    SPT SPT SPT SPT SPTMIM SPT

    STAC

    BL5BL4BL3 BL6 BL10 BL11BL 1(Stew) BL9BL7 BL8BL 2(Emp)

    SatelliteBL

    DRG's

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    Portfolio review links STAC, SAC's

    and secretariat

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    Timing of reviews to ensure strategic impact

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    Role of governance

    JCBCo-sponsors, Resource Contributors

    Regional Representatives, Others

    Special ProgrammeCoordinator

    Standing Committee STAC

    Director and Secretariat

    JCBCo-sponsors, Resource Contributors

    Regional Representatives, Others

    Special ProgrammeCoordinator

    Standing Committee STAC

    Director and Secretariat

    WHOExecuting Agency

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    Regional emphasis and leverage

    TDR Governance systems reinforced Links to co-sponsor regional offices and ACHR's

    Stewardship and empowerment activities will link toregional partners

    Concept of regional associations of tropical diseases and co-hosted meetings (stewardship)

    Concept of 'satellite' business lines (empowerment)

    Research BL's strongly link to regions VL elimination

    Diagnostics specimen bank management and operation

    General emphasis on DEC led management of projects

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    More frequent revisiting of strategy for better

    planning (e.g. regular review of portfolio)

    Stronger element of coordination (e.g.linking Business Lines and TDR advisory

    committees)

    Greater monitoring (e.g. indicator

    dashboards, periodic reviews)

    Emphasis on resource optimization (e.g.

    more dynamic budget allocation)

    Delegation of responsibilities (e.g. budget

    implementation / approvals at BL level)

    Simplification of processes (e.g. elimination

    of large numbers of allotments)

    Lesser reliance on ad hocmechanisms

    Better supporting HR and IT systems (e.g.

    more effective recruitment)

    Stronger emphasis on strategy and accountability

    Greater delegation and simpler administration

    Operationalising the Strategy

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    Operational Processes

    4. Externalinterface

    4A.resourcemobilization

    4B.Commun-

    ications

    1. Strategy

    1A.IndividualBL Review

    1B. BLPortfolioreview

    1C.

    Budget

    2. Operations

    2A.Activity/Projectapproval

    2B.

    Contractapproval

    2C.

    Paymentapproval

    3A. HR

    3B. IT

    3. Support

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    TDR proposed structure

    Links to:NTD / BL 6GMP/ BL 9STB / BL 8

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    3844 45 48 50 51 49

    49

    87

    2007

    55

    100

    2008

    58

    104

    2009

    65

    114

    2010

    68

    119

    2011

    71

    123

    2012

    72

    123

    2013

    Professional

    Support

    +6%

    TDR PERSONNEL REQUIREMENTS, (2007-2013)

    6%6%

    CAGR(2007-2013)

    4%4%

    515251494645

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    2007 TDR TRANSITION PLAN

    Apr

    2007

    MarFebJan DecAugMay Jun Jul Sep Oct Nov

    Define external interface processes*** Define support processes (IT)

    Performance management

    Define support processes (HR)

    Match current personnel

    Individual BL transition

    Preparation of BL work plan for 2008

    Define operations processes**

    Setting up of supporting committees

    Description

    Define strategy processesProcesses in revised operating model

    Prioritize and select new personnel

    Write job descriptions Outline level 2&3 organogram & responsibilities Determine personnel requirements

    Business plan

    Select level 1* personnel Outline level 1* structureOrganization structure and personnel selection

    Determine Budget

    Prepare TDR Business plan

    Draft Business Line (BL) plan

    Cascade TDR metrics to BL level dashboard Determine TDR level impact dashboard

    STACStanding CommitteeJCB

    * Level 1 positions report to Director** Operations processes include approvals for projects / activities (meetings, travel), contracts and payments

    *** External interface processes refer to fund-raising, communications

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    10 11 11 11 12 1414

    10 1212 14

    15 1515

    30

    50

    2007

    34

    57

    2008

    40

    64

    2009

    44

    70

    2010

    48

    76

    2011

    51

    81

    2012

    49

    80

    2013

    +8%

    9%

    CAGR(2007-2013)

    9%

    7%

    TDR OVERALL BUDGET (2007-2013), $ MILLION

    BL Operations BL Personnel Overhead and others

    9%9%

    CAGR(2007-2013)

    9%9%

    7%7%

    TDR OVERALL BUDGET (2007-2013), $ MILLION

    BL Operations BL Personnel Overhead and others

    171616151312

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    Justification for increase

    1. Stewardship role is new and requires new resources

    2. Empowerment BL to grow by 30% over 6 years and is further manifest withinresearch activity

    3. Proposed objectives and deliverables meet needs of a balanced portfolio.

    Inability to reach budget targets clearly associated with corresponding lack of endproducts

    Research now better served globally, but more complex with more (focused) issuesneeding to be professionally covered

    1990 20071990

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    2008-2009 budgets

    Budget 1 (aligned to business plan) $120 M

    Budget 2 (back-up)

    $ 98 M

    1 business line not initiated

    several business lines with reduced number of

    objectives

    Slower scale up of stewardship role

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    Resource mobilisation targets

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    What's New?

    Addresses MDG's and health research interface with development

    Stewardship goals fostering

    Capacity strengthening to empowerment goals

    Focus on leadership

    Research goals more strategically focused

    Re-emphasise committees and networks

    Regional focus / devolved activities

    Better cohesion and coherence with external partners, and WHO Link to control departments Link to regions

    Link to primary health care (IR community emphasis) Link to innovation (IGWG)

    Professionalised processes incl. STAC portfolio review

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    Comparison between 2006/7 and 2008/9

    budget

    8% 3% 7% 12% 22% 8% 15% 20%

    2 % 9 %

    17% 14%

    11% 18%

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    Some final thoughts

    On the right track, but not there yet Responsiveness to country needs who sets the agenda?

    Stewardship and empowerment will take time

    Looking to cultural shifts in emphasis

    Fostering, outreach, facilitation, networks

    Mainstreaming capacity building for empowerment

    Focused professionalism of operation with transparency andopenness to review

    Recognising and building on unique nature of the 'SpecialProgramme'

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    Assistance for Discussion1. Top level endorsement of vision and strategy

    2. Guidance sought on whether previous concerns adequately addressed

    Objectives and outputs of Stewardship function incl. outreach Objectives and outputs of Empowerment function incl. partnerships / networks

    Objectives and outputs of Research on Neglected Priorities function

    Business lines: focus, entry / exit and management

    Cross-cutting issues: e.g. gender

    Mechanisms for DEC's to play a pivotal role

    Regionalisation / decentralisation and interfaces with co-sponsoring agencies

    Priority setting criteria and processes e.g. through committees

    Monitoring and evaluation

    Prospective 5th external review

    Implementation plan incl. human resources

    Role of STAC3. Approve budget with / without amendment

    4. Agree TDR to follow WHO practice on reporting by activity and personnel

    5. Agree to 10% flexibility in budget allocation