Standardized Automation for Vaccine Production at the NVI

StrategicPharma Project

Systems and Solutions for the Process Industry

processnews

3rd edition March 1|2004

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Trends in Process Instrumentation

Compact Process Cntro:Simatic PCS 7 Box

Trends in Process Instrumentation

Compact Process Control: Simatic PCS 7 Box

Standardized Automation for Vaccine Production at the NVI

StrategicPharma Project

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Sensors are the eyes and ears of productionand form the basis for every process controlsystem. Siemens uses its extensive automationknow-how to turn new technologicaldevelopments into innovative solutions for the process industry

At present, virtually every new bioreactor isinstrumented and automated device-specifically. The NVI was looking for analternative and, together with Siemens, createda detailed and comprehensive user requirementspecification that will form the basis for allfuture bioreactor projects at NVI

At Reckitt Benckiser in Ladenburg,Germany, Simatic PCS 7 hasconsiderably inreased productivity,while Simatic IT ensures greatertransparency and availability

CONTENT2

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3 EDITORIAL

4 NEWS

Modernization of the world’slargest phenol plant at INEOS Phenol

Siemens wins contract for processanalysis at Linde-KCA-Dresden

Process analysis has a firm grip on a complex application

Tailor-made Simatic PCS 7 coursefor bulldozer drivers

Siemens outfits a sugar refinery in Turkey

Siemens automates LIFE at B. Braun in Melsungen

TECHNOLOGY

Process Instrumentation6 Portfolio for the Future

Current trends and developments inprocess instrumentation

Process Control Technology9 Magic Box

Control System on a PC: Simatic PCS 7 Box

CASE STUDIES

Batch Production10 Problem Solved

Flexible Processing with Simatic PCS 7

Biotechnology12 Long-term Cooperation

NVI and Siemens develop a standard for bioreactor instrumentation, analysis and automation

Research Project Pharma16 Parametric Release

Totally integrated quality assurance for vaccine production

Supply Chain Management18 Managing Process Information

Simatic IT improves supply chain visibility and turnaround times

Fail-safe Control20 Fail-Safe Pharma Expertise

Largest ever fail-safe project in Denmark

Power Supply22 Energy? Sure

Reliable power supply at AstraZeneca

Waste Incineration23 Strategic Project

Simatic PCS 7 control system for Incinerator in Taiwan

process news 1/2004

Cover: Vaccineresearch at the NVI

Photo by Peter Koerber

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Dear Readers!Setting new standards and “knowing what’spossible tomorrow” –that’s the slogan ofHanover Fair 2004. An important milestone in this respect is the inte-

gration of Interkama+, the leading international fair for process automation, which is being heldtogether with the Factory Automation fair inHanover from April 19 to 24. This means thatprocess and factory automation are beingpresented together for the first time on a singleinternational platform.

Siemens will be presenting its extensive andintegrated portfolio of solutions, systems, andproducts for the process and manufacturingindustries together on one stand. With the uniformTotally Integrated Automation platform and theintegrated interfaces to the IT world, solutions andsystems from Siemens provide the ideal technologyenvironment for creating genuinely integratedautomation solutions and the optimization ofindustrial processes – across all industries andprocesses. As a result, manufacturers can moreeasily identify and exploit potential forrationalization and increase the productivity of theentire production chain. This is in keeping withSiemens’ declared goal for its customers – theslogan of the company’s exhibition stand is“Increase your productivity.” Using the chemical andpharmaceutical industries as two examples, thestand offers demonstrations of how innovativeproducts and solutions contribute to an increase inprocess and plant productivity.

Productivity and quality are critical, especially inthe pharmaceutical industry. Siemens not onlyprovides products and solutions for the pharma-ceutical industry but is also actively involved in thedevelopment of new technologies. Two currentprojects in the Netherlands, which we present inthis issue of Process News, provide evidence of thatcommitment. I hope that these and the many otherprojects from different regions of the world will bean inspiration as you seek to improve your ownprocesses.

Anton S. HuberMember of the Group Executive ManagementSiemens Automation and Drives

The positive experience resulting from successful projects andSchering’s confidence in Siemens’ pharmaceutical expertisewere some of the reasons why Schering again chose Siemensfor the automation of a new production in Berlin

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Specialty Chemicals24 Clean-and-Clear Production

Simatic IT and Simatic PCS 7 integrate processes

Comprehensive Solution26 One Building, One System

Schering continues successful collaboration with Siemens

Waste Water Treatment28 Double Score

Siemens implements innovative disposal conceptfor Infraserv Hoechst

Batch Production30 A Whole Bunch of Benefits

Simatic PCS 7 controls new steroids plant

TRENDS

European Pharma Market11 Innovation in the Balance

Brian Ager, Director General of EFPIA, on market climate and trends

31 DIALOGUE

EDITORIAL

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4 NEWS

L inde-KCA-Dresden is building a new turnkey poly-propylene plant for Slovnaft, near Bratislava in the

Slovakian Republic, with an annual capacity of 255,000tons of homopolymers and random and impact copoly-mers. Completion of the plant is planned for 2004.

Linde-KCA-Dresden was looking for a reliable analy-sis system to monitor the individual process steps.Siemens was able to beat some strong competitors towin the process analysis contract and will supply ananalysis house with several Maxum edition II processgas chromatographs. To be able to transport the sam-ples quickly from the expansive plant to analysis, bothprimary sample preparations in the field and secondarysamples at the analysis house have been implementedin the plant. In addition, the analysis house is also net-worked with the process control system. �

Siemens wins contract forprocess analysis at Linde-KCA-Dresden

Process analysis has a firmgrip on a complexapplication

Find out more:www.siemens.com/processanalyticsE-Mail: wolfram.schulze@linde-kca.comE-Mail: michael.gilluck@siemens.com

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INEOS Phenol is the world’s largestmanufacturer of phenol and acetone,

with production sites in Gladbeck, Ger-many; Antwerp, Belgium; and Mobile,Alabama, USA. In the course of the com-pany’s history, the Gladbeck site has ex-perienced significant development. Thecapacity of the plants at the beginning ofproduction in 1954 was a relatively mod-est 8,000 tons of phenol and 5,000 tonsof acetone. Today, Gladbeck is thelargest phenol plant in the world, withan annual capacity of 630,000 tons ofphenol and 390,000 tons of acetone.

When INEOS was looking for a part-ner to modernize the existing processautomation system for the entire fac-tory, the company first performed an ex-tensive comparison of various controlsystem suppliers. Simatic PCS 7, though

facing strong competi-tion, was able to establishitself as the winner. TheINEOS order includes re-placement of all the in-stalled control technologyon the entire site, withabout 8,000 I/Os, and themerging of two measure-ment stations.

One of the critical factors in the con-tract award, aside from INEOS’s previouspositive experience with Siemens in low-voltage projects, was the fact that PCS 7is a modern, innovative, and efficientcontrol system that is based on future-safe standards. The integrated safetytechnology and the high system avail-ability due to redundant solutions werealso decisive. In addition, PCS 7 offers

the possibility of replacing installed con-trol technology during ongoing opera-tion – allowing the Gladbeck plant tocontinue to operate without interrup-tion. �

Dow Olefinverbund GmbH,a subsidiary of the US

company Dow Chemical, ofMidland, Michigan, commis-sioned a new pilot plant formodification of ceramic fil-ters at its Schkopau site in No-vember. Siemens won thecontract to build an analysiscontainer with a Maxum edi-tion II process gas chromato-graph, an oxygen laser, andan FTIR spectrometer for theprocess analysis. This solu-tion allows the complex sam-ple flows of the plant to be analyzed reliably. The sample preparations and theanalyzers are installed in separate rooms.

The analysis house is networked with the process control system so that theoperating personnel in Schkopau are always informed about the current analy-sis values. �

Find out more:www.siemens.com/processanalyticsE-Mail: michael.gilluck@siemens.com

Find out more:www.siemens.com/chemicalsE-Mail: dieter.preuss@siemens.com

INEOS Phenol operates the world’s largestphenol plant in Gladbeck

Modernization of the world’s largestphenol plant at INEOS Phenol

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The new analyzer shelterat Dow in Schkopau

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5

itive prices and open up new markets, B.Braun is relying on optimized productionprocesses and a new generation of produc-tion technology.

Against fierce competition, Siemens andits partner, Lang und Peitler, won the con-tract to provide automation of the packageunit controller (PUC), including linking thePUC to the MES level. The project involvesthe coordination of about 70 package unitsfrom 10 different suppliers and will employthe Simatic PCS 7 V6 process control sys-tem. Siemens modified the existing qualifi-cation and validation system with B. Braunin advance, based on the latest GAMP 4regulations. Siemens is not only managingthe project and writing the specificationsbut is also supplying and configuring all thehardware and software – and is responsiblefor the qualification and commissioning ofthe entire PUC system as well. �

Siemens automates LIFE at B. Braun in Melsungen

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Siemens has received an order fromKonya Seker, the largest private sugar

producer in Turkey, to equip a new sugarrefinery in Cumra with automation andenergy technology. The total value of thecontract amounts to about 8.1 millioneuros.

The production facility is taking shapeon a greenfield site 50 kilometers south ofKonya in the highlands of Anatolia. It isthe only greenfield sugar refinery beingbuilt in Europe at the moment. Designedto handle 12,000 tons of sugar beet perday (corresponding to around 1,700 tonsof sugar), the plant is expected to go intoproduction at the end of 2004.

The Siemens project team is made upof both German and Turkish employees,guaranteeing a good level of local service.Under the terms of the contract, Siemenswill be supplying a turbo set for energyproduction, the drive and control technol-ogy, and the complete field instrumen-tation, networked by Profibus PA. TheSimatic PCS 7 process control system willbe used throughout as the control systemfor automation and energy production. �

Siemens outfits a sugar refinery in Turkey

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Find out more:www.siemens.com/sitrainE-Mail: anja.schmidt@siemens.com

A LBA-Holzkontor Brandenburg GmbHprovides fuel processing for a power

station near Berlin that is controlled com-pletely by Simatic PCS 7. Company man-agement decided to hold a Sitrain SimaticPCS 7 training course to ensure that theemployees were familiar with the functionsand operating options of the system andable to exploit optimization potential. Thiswas not a straightforward task, becauseinitial interviews revealed that the basicknowledge of the participants variedgreatly.

The employees are bulldozer or forkliftdrivers who prepare the fuel – old timbersuch as old furniture, railway ties, or treeroots – for burning. The Sitrain trainergladly accepted this challenge, however,

and every employee was trained to operatethe belts, shredders, and silos from the ter-minal. The type of teaching and the jointperformance of practical exercises moti-vated both the trainer and the participants,making this individually designed course ahuge success. �

Tailor-made SimaticPCS 7 course forbulldozer drivers

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The Leading Infusion Factory Europe(LIFE) in Melsungen will be the largest

facility of its kind in Europe. Production isscheduled to begin in October 2004, whenB. Braun will begin producing different ver-sions of the innovative Ecoflac plus infu-sion solution container for the global mar-ket. LIFE will almost double the previousproduction of infusion solutions in Europe.To supply international markets at compet-

LIFE production is scheduled tobegin in October 2004

Find out more:E-Mail: bernd.langhans@siemens.com

Find out more:www.siemens.com/chemicalsE-Mail: ruediger.sebastian@siemens.com

Sitrain’s Günther Thake giving ahands-on demonstration

process news 1/2004

6Process Instrumentation

TECHNOLOGY

P rocess automation systems are be-coming increasingly complex, par-ticularly with the emergence of digi-

tal fieldbuses and powerful MES softwarepackages. In order to be able to offer acomplete portfolio of modular automationsolutions, it is necessary to have the know-

how to develop the most important sys-tems and components synchronously inthe same direction. This necessity was theimpetus behind the strong consolidationprocess over the last 10 years, from whichSiemens has emerged as a major providerof automation solutions.

Current trends and developments in process instrumentation

Portfolio for the FutureSensors play a fundamental role in process automation: they are the eyes andears of production, and the information they provide forms the basis for everyaspect of process control. For this reason, in the late 1990s Siemens consider-ably expanded its range of process instrumentation equipment by investingmore in research and development and also by making specific acquisitions.Siemens is now able to offer a comprehensive range of equipment, from flowand filling level through weighing technology, gas chromatography, andspectrometry, as well as an extended gas analysis system. Siemens also uses its extensive automation know-how to turn new technological developmentsinto concrete solutions for the process industry.

Reliability par excellenceMagnetic-inductive (MID) flow meters are the most commonly usedelectronic flow meters, thanks to their accurate and reliable meas-

uring results and simple installation, commis-sioning, operation, and maintenance. They are

suitable for the flow measurement of almostall electrically conductive liquids, includingslurries, pastes, and pulps. Temperature, pres-

sure, viscosity, and density have no influenceon the measuring result.The new MID Sitrans F Magflo MAG 8000 from

Siemens is ideal wherever long lifespan andminimum service requirements are decisive criteria.The flow meter operates with an extremely effective

battery that lasts six years and can therefore beoperated without an external power supply –for example, as an external field device in thewater supply. The measuring range covers

three orders of magnitude so that the deviceencounters no problems with great fluctuations

in flow. Since the device is designed with an IP68degree of protection, the MAG 8000 can be installed

without an additional enclosure directly at the base ofthe supply lines.

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The greater complexity of the systemsalso has the result, however, of increasinginstallation and life-cycle costs. To coun-teract this trend, Siemens began, severalyears ago, basing its automation productsand systems on as homogeneous andstandardized a technology platform as pos-sible: Totally Integrated Automation (TIA).Throughout the life cycle of a plant – frominitial installation to maintenance andcare – TIA leads to enormous savings.

To be able to exploit the advantages ofTIA equally in all industries and processesbut still offer specific solutions, Siemensis currently developing TIA into a univer-sal technology platform that can easily beused as a basis for industry-specific devel-opment. With the consistent expansion ofTIA, it seems clear that following the in-creasing decentralization of systems, self-organization and even virtual technologywill find a foothold in automation.

Unity in variety

Despite the processes of consolidation andstandardization on the manufacturer side,plants still usually consist of a mixture ofdevices from different manufacturers thatare connected by and communicate via

various interfaces. It is obvious that such anetwork of devices cannot be managedwithout efficient process instrumentationengineering. One example of such a man-ufacturer-independent tool is the SimaticPDM (Process Device Manager), an inte-grated part of the Simatic PCS 7 processcontrol system, which can communicatewith more than 700 devices from variousmanufacturers. The only precondition is aHART Device Description, which is usuallyavailable for any new device.

Intelligent asset management

Sensors are the basis of modern require-ment-oriented asset management. Usingsensors, a maintenance server can collectand display all the information necessaryfor maintenance. The MES-level assetmanagement system can also be integrat-ed via standardized interfaces. The prod-uct data and information required formaintenance are usually available directly– in most cases via the Internet. The pro-cessing and visualization of this informa-tion assumes that all components thatsupply and process information are net-worked – a requirement satisfied by TIA.One example of the advantages of intelli-

gent asset management with the aid ofstatus monitoring by sensors has beenimplemented by Siemens in the PointekCLS 300 capacitive filling-level switch.

Maintenance becomes necessary whenthe limit switch is operated in caking me-dia. The limit of wear may be reached andthe switching function no longer guaran-teed in the event of increasing encrusta-tion. The degree of encrustation and theprobable remaining life is calculated anddisplayed by the diagnostic station. Grad-uated maintenance messages can be gen-erated with the aid of an operating-hourscounter. The limit values at which alarmmessages are transmitted can be adaptedto user-specific maintenance intervals. Asa result, the user knows when the sensorwill fail without maintenance and is ac-tively prewarned.

Digital future

Profibus has become an important com-munications standard in the world of au-tomation in recent years and covers theentire process, from the control to thefield level, with one protocol – and, withthe Profibus PA variant, even as far as ex-plosion hazardous areas of production. In

Do your massThe Sitrans F C measuringinstruments determine themass flow directly and withhigh precision using theCoriolis measuring principle. In addition, the devices alsodetermine exact volumetricflow, density, fractional flow,and temperature. They areeasy to install and are notsensitive to external vibrations.All measuring sensors consistof a single tube withoutwelding seams and can there-fore be cleaned easily with CIP systems or steam.

The most compact example of the Coriolis-flow measuringinstruments is the Sitrans F Massflo MASS 2100 DI 1.5. The mass flow meter can be connected with a single quick-release clamp and a single multipole connector – fast and low-cost. The device can beinstalled and commissioned in just 10 minutes. The central block andthe balanced pipe loops guarantee reliable long-term stability andeliminate influence from process conditions.

Series 6 “in situ”The 6 series analysis equipment family hasbeen expanded by a new addition. The newLDS 6 laser diode spectrometer combines thecompact, service-friendly design, the user-friendly operation, and the network capabilityof the 6 series with the well-known excellentperformance data of the in situ laser diodegas analysis system, with which a number ofIR-active substances can be measured.

The LDS 6 makes no compromises inperformance: robust fiber-optic sensors, aself-calibration function, and the split-secondcross-interference-free measurement provideaccurate results even under extreme meas-uring conditions – for example, directly in hotflue gases.

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8Process Instrumentation

TECHNOLOGY

production plants that have both a pro-cess and a discrete production part, all thelogistics can be operated with Profibus.

Although the majority of sensors in-stalled today are still connected to thecontrol system by a 4-20mA interface, alarge number of newly installed devicesare equipped with digital interfaces (ordigital information can, as in the case ofHART, be transmitted via the analog inter-face). Via digital communication systemssuch as Profibus, additional information –such as current device loads, failure prob-abilities, or information about the devicestatus – can be transmitted to the mastercontrol system.

At the same time, progress in micro-electronics allows ever-greater computerperformance in a confined space, with asimultaneous drop in energy consump-tion. Functions that were previously per-formed by the hardware and software ofthe control system are now often moved tointelligent peripheral components – forexample, complex diagnostic and controlfunctions. As a result, an increasing per-centage of devices are equipped with theirown intelligence. It is likely that within a

few years only process instruments thatcommunicate with the control level via adigital bus protocol will be available.

Big performance “miniaturized”

Another result of innovations in micro-electronics is that complex technologiescan be accommodated in increasinglycompact devices, making them of interestfor local application directly on site. Oneexample is mass spectrometry, which formany years was performed only as a sen-sitive analysis process in large lab spec-trometers. With the Quantra, Siemens hasdeveloped a compact, low-cost Fouriertransfer mass spectrometer that can beused online in the process, thanks to in-creased computing performance andminiaturized physics. The same holdstrue for gas chromatography, which hasbeen close to the process for longer butnow for the first time, with the MicroSAM,can be installed directly in the plant with-out an analysis cabinet.

One application that demands extrememiniaturization of devices is the microre-actor, such as is used in pharmaceuticalproduction as a process variant. However,

such plants have previously been con-structed only in a laboratory environmentand without professional automationtechnology. In a project sponsored by theGerman Ministry of Education, Scienceand Research, Siemens developed a proto-type microreaction plant equipped withindustrial automation technology in coop-eration with other project partners.

Basis of a successful strategy

The expansion of the company’s portfoliofor the process industry is a central com-ponent of Siemens’ business strategy. Animportant part of this portfolio is and willalways remain sensors and devices forprocess instrumentation, which are un-dergoing continuous development andwill be integrated into the Siemens systemlandscape even better in the future. �

Find out more:www.siemens.com/processinstrumentationE-Mail: hansgeorg.kumpfmueller@siemens.com

High-tech for the processThe Quantra is the world’s only FT-ICR mass spectrometerthat is compact and inexpensive enough to be used in thedaily process routine.

Quantra has anextremely good massresolution, can iden-tify substances withalmost identicalmasses reliably, andhas been designed foruse in the harsheveryday industrialenvironment. It needsno external vacuumpump and requiresonly a permanentmagnet rather thanthe superconductingmagnets normallyused.

Small gaschromatograph with a big performanceState-of-the-art microelectronics ensure thata whole process gas chromatograph can beaccommodated within a space of just 25 by23 centimeters. The MicroSAM includes allthe components necessary for separating anddetecting the measuring substances in apressurized housing.

process news 1/2004

Simatic PCS 7 Box is the latest varia-tion of the PCS 7 process control sys-tem and combines all the compo-

nents of a classic control system in thecompact structure of an industrial PC:process visualization and engineeringsystem, fieldbus, and SQL-based archivesystem.

The powerful Win AC component Slot-416-CPU is used as an integrated hard-ware controller. The standard input andoutput modules of the distributed SimaticET 200 systems are linked by the ProfibusDP interface of the Slot-CPU.

Simatic PCS 7 Box is designed for smallprocess applications such as pilot plants,laboratories, or packaging units and is al-so ideal for process engineering compa-nies. The system opens up totally new im-plementation possibilities because it of-fers a small footprint and eliminates theadditional wiring usually needed between

the automation system, the operating sys-tem, and the engineering system.

Everything on one PC

All control and monitoring tasks run onone PCI card in the PC with a dedicatedpower supply. Consequently, the automa-tion solution runs independently of themain PC and will still work even if the PCfails or is switched off. PCS 7 Box is a full-fledged control system with all the impor-tant properties of PCS 7, such as compli-ance with 21 CFR Part 11, and it is compat-ible with the S88-compliant Simatic Batchand the S95-compliant Simatic IT.

Simatic PCS 7 Box can, of course, be in-tegrated into existing Simatic PCS 7 sys-tems. This allows established processcontrol know-how to be used; there is noneed to waste time and money creatingnew software or retraining operating per-sonnel.

Find out more:www.siemens.com/pcs7E-Mail: roland.wieser@siemens.com

Control System on a PC: Simatic PCS 7 Box

Magic BoxFrom office applications to the plant floor, PCs have become ubiqui-tous in today’s production processes. So for small applications, whynot just put a complete process control system on a PC and use tech-nology that is already available? This is exactly what Simatic PCS 7Box accomplishes.

Flexible and expandable

Simatic PCS 7 Box can be easily extendedbecause it uses standard PCS 7 compo-nents, allowing other hardware and soft-ware components to be added at any time.The decisive advantage for the user: If re-quirements change because a test systemis to be expanded in a production plant,for example, this compact solution can beextended with further control systemcomponents. �

TECHNOLOGYProcess Control Technology

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Simatic PCS 7 Box:A process control system that fits in an industrial PC

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Flexible Processing with Simatic PCS 7

Problem SolvedTo meet the strict international requirements for the manufactureof pharmaceutical products, Hoffmann-La Roche pharmaceuticalsin Grenzach-Wyhlen had to equip its solutions plant with a newprocess control system. Good teamwork and the user-friendlySimatic PCS 7 ensured a trouble-free migration.

10Batch Production

CASE STUDY

Hoffmann-La Roche manufactures,packages, and sells pharmaceuticalproducts, including sterile bulk so-

lutions produced under clean-room con-ditions at the Grenzach-Wyhlen site.

Modernization according to strictregulations

The solutions plant in Grenzach, complet-ed in 1998, consists of two preparationtanks and transfer pipes to feed the solu-tions through a filtration unit into twomobile storage tanks. The plant is cleanedand sterilized by an integrated CIP/SIP sys-tem. Because the existing process controlsystem no longer met the increasinglystringent cGMP (current Good Manufac-turing Practice) requirements and the ris-ing demands of company operation, Hoff-mann-La Roche decided to upgrade theprocess control technology in 2002.

The company chose the Simatic PCS 7process control system, based on convinc-ing references from within the pharma-ceutical industry as well as on the efficientand flexible programmability of the sys-tem. The fact that Siemens would assistHoffmann-La Roche in complying with thecGMP regulations and was able to offer ex-cellent local support were also points inSiemens’ favor.

The PCS 7 process control system (withthe Simatic Batch package) controls andenables the visualization of all processesin the system. The management informa-

tion system MIS-Light archivesthe process data and theSimatic Advanced User Ad-ministrator ensures uniformaccess control in accordancewith the strict regulations ofthe Food and Drug Adminis-tration FDA and the EuropeanMedicines Evaluation AgencyEMEA.

In automatic operationmode, the basic functions ofthe Simatic Batch package au-tomatically execute, control, and log allbatches. The automation solution also al-lows manual operation of the plant, en-abling the operator to start basic func-tions without using recipe management.An additional revision mode has alsobeen implemented, allowing every indi-vidual unit to be operated from the opera-tor screen.

Start on schedule

Production began on schedule after quali-fication of the plant – due in large to theclose and cooperative partnership of allthose involved at Hoffmann-La Roche andSiemens. �

The staff at Hoffmann-La Roche keeps a close eye on the process with PCS 7

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Find out more:www.siemens.com/pharma E-Mail: hans-joachim.ihle@siemens.com

process news 1/2004

Brian Ager, Director General of EFPIA, on market climate and trends

Innovation in the Balance“Innovation is the lifeblood and the driving force of the pharmaceuticalindustry, as well as a key to any improvement in medical care. For over 100 years, Europe has been a powerhouse of pharmaceutical research andinnovation. In 2002 alone, research-based pharmaceutical companies havebeen investing nearly 20 billion Euro – almost a fifth of all industrial researchand development in Europe.”

process news 1/2004

11TRENDSEuropean Pharma Market

medicinal product. Each new medicine costs in therange of 600 to 900 million Euro to develop. Half themedicines that reach the final stage of clinical trialsstumble at that hurdle. Only three out of ten mar-keted medicines produce revenues that match or ex-ceed average research and development costs.

The escalating cost of research and developmentand the huge risks involved – since success is in noway guaranteed or proportional to the huge amountinvested – make individual companies highly vul-nerable. The ongoing restructuring and consolida-tion of the pharmaceutical industry through merg-ers and acquisitions is primarily a response to theneed to secure industry’s long-term competitive-

ness in a global, highly complex andincreasingly competitive environ-ment.

European Union initiativeaddresses industry concerns

The widespread concern caused bythe diminishing competitiveness of

the European pharmaceutical industry has lead the EuropeanCommission to put forward a package of practical proposals forenhancing innovation and provision of medicines in Europe.

EFPIA is part of the process and fully supports the stated ob-jective to help the European-based pharmaceutical industry re-gain its competitive edge and continue to make a valuable contri-bution to public health and the European science base.” �

Find out more:www.siemens.com/pharmawww.efpia.orgE-Mail: info@efpia.org

Y et, Europe’s pharmaceutical industry facesa series of challenges in the near future,states Brian Ager, Director General of the

European Federation of Pharmaceutical Industriesand Associations (EFPIA). “Although it remainsone of Europe’s best performing high-technologygrowth sectors, the research-based pharmaceuti-cal industry in Europe has gradually seen a steadytransfer of its research and development activitiesto the US, where policies and market conditionsare more favorable to pharmaceutical innovation.

The ability of European companies to fund in-creasingly costly research and development is de-clining under economic, technological and regula-tory pressures. New medicines aretoo often perceived as a cost, or athreat to healthcare systems, ratherthan an investment and a benefit.

Costs put restraints on innovation

At the research stage, it has becomeharder and more costly to get promis-ing new medicines through the pipeline to market. The rise ofbiotechnology and our expanding knowledge of genetics has ex-panded the possibilities of creating new solutions for treatingand preventing diseases, but made the task more complex. Due tothe growing sophistication of products and the complexity of reg-ulatory requirements it now takes an average of twelve to thir-teen years to turn a new promising compound into a marketable

“The escalating cost of research anddevelopment and the huge risks

involved make individual companieshighly vulnerable.”

Brian Ager, DirectorGeneral of EFPIA

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12Biotechnology

CASE STUDY

NVI and Siemens develop a standard for bioreactor instrumentation, analysis and automation

Long-termCooperationAt the moment it’s all part of the daily routine for every biotech company: virtually every new bioreactor isinstrumented and automated device-specifically. This practice has led to the development of isolated solutions thatare difficult to integrate into an overall concept, despite the fact that both the processes and the equipment arevery similar for the majority of applications. The Nederlands Vaccin Instituut (NVI) was looking for an alternative tothis time- and cost-intensive procedure and partnered with Siemens to create a detailed and comprehensive userrequirement specification that will form the basis for all future bioreactor projects at NVI.

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14Biotechnology

CASE STUDY

NVI, headquartered in Bilthoven inthe Netherlands, is a state-owned in-stitute responsible for guaranteeing

the availability of all vaccines required forgovernment vaccination programs. In addi-tion, NVI also has its own large research de-partment. Consequently, a wide variety ofprocesses are run in Bilthoven in a numberof different bioreactors – from small table-top bioreactors up to fully automatic biore-actors with a capacity of several hundredliters.

Lab-to-production platform

The automation system used in these biore-actors, however, was no longer state of theart. Moreover, NVI also wanted to create thepossibility of setting up all plants andprocesses on a uniform automation and in-strumentation platform to improve the effi-ciency of the processes, shorten implemen-tation times, and simplify validation. At thesame time, NVI was looking for a way to linkresearch and production in a more tightlyintegrated network and implement a com-

mon lab-to-production platform. The long-term aim of all these measures was to re-duce the overall production costs, as vac-cines must be produced in large quantitiesand as inexpensively as possible.

For the implementation of the standard-ization plans, NVI decided to work in closecooperation with Siemens from the verystart to achieve a tight integration ofbiotechnology and automation experience.Siemens had already proven its expertisein the automation of biotechnology proj-ects on other occasions – the Simatic PCS 7process control system, for example, hasbeen in successful use for some time in me-dia preparation at NVI. NVI was also im-pressed by Siemens’ involvement in such aprestigious project as Parametric Release(see page 14). Thijs Veerman, general di-rector of NVI, confirms: “When an automa-tion provider like Siemens is involved in along-term project such as Parametric Re-lease, we can be sure that that company isserious about its commitment to biotech-nology.”

Separation of process and equipment

The joint interdisciplinary project team ofNVI and Siemens first analyzed all the vari-ous existing bioreactors at NVI, includingthose used in media preparation, and com-piled a list of typical processes and tasks.

The bioreactors were divided into typi-cal modules with corresponding parame-ters, and then the instrumentation andcontrol strategies for the respective mod-ules were defined and determined.

However, to be able to divide the pro-cess into standardized modules, it was ab-solutely essential to create a strict separa-tion between the recipe (and thus the pro-cess-technical control) on the one handand the equipment used for it on theother. This approach enables a typicalbioreactor to be set up without any refer-ence to a specific application; the recipe

Pilot plant exploits the advantages of standardizationWithin this year, NVI will be implementing the user requirement specification (URS)resulting from its close cooperation with Siemens in a new plant.

The S4 category – the highest security level – pilot plant is to bring to marketmaturity a process developed on a laboratory scale, resulting in the production of anew kind of vaccine against pertussis. All the components of the plant have beenbuilt and automated for NVI according to the URS – and the advantages of the stan-dardization already appear to be paying off. The function and design specificationsfor the Simatic PCS 7 control system for the pilot plant were compiled within a fewweeks, so construction – along with the almost simultaneous implementation of the

control system – cancommence in April.Because Siemens hadproved to be an extreme-ly knowledgeable andexperienced partner inthe initial collaboration,NVI also chose Siemensto provide the controltechnology and intro-duced Simatic PCS 7 as astandard for the firsttime. The pilot plant isscheduled to begin pro-duction this fall.

process news 1/2004

15

used by the bioreactor contains the appli-cation-specific instructions. This separa-tion, which complies with the S88 recom-mendations, is being implemented at NVIas part of the standardization project.

Typical tasks

A batch process in biotechnology consistsof a series of several typical process steps.First, the bioreactor must be sterilized,along with the connected systems, unlessthey are separated from the bioreactor by

the appropriate sterile filters. Then thenutrient media are added and the reactoris inoculated with the cell culture. This isfollowed by the cultivation phase. In someprocesses, the medium is changed andreinoculated with a second culture. At theend of the process, the cultures or the de-sired products are harvested.

Various parameters must typically bemonitored and controlled during the pro-cess – for example, temperature, pH value,or dissolved oxygen.

Modular, generic, reusable

The results of the joint analysis wereevaluated and recorded in an extensiveuser requirement specification (URS).This URS will form the foundation for in-strumentation and automation specifica-tions of all future bioreactor projects atNVI and will also be used in the conver-sion of existing systems. The documenta-tion of the modularization and standard-ization phases also provides the basis forlater validation of the equipment. Everysingle module possesses the appropriatevalidation documentation, from the URSto the test results, in addition to the algo-rithm and instance-specific parameters.This object-oriented method means thatonly Installation Qualification (IQ) is nec-essary for validation when the modulesare reused – an enormous savings intime and costs.

The URS describes a library of equip-ment modules and the correspondingcontrol strategies. Different bioreactortypes and different processes and appli-cations – in both research and produc-tion – have been taken into account.

Thijs Veerman was especially im-pressed by Siemens’ customer-orientedapproach to the project. “We did not wanta highly complex and infinitely powerfulsolution,” he said, “but rather a systemthat would support us in the effective re-duction of our production costs. TheSiemens team did not simply try to sell ustheir products – they helped us to findthe simplest way to meet our require-ments. This showed us that Siemens un-derstood our situation.”

An excellent basis for further projects

The additional process and biotech ex-pertise that Siemens gained from thisproject will benefit future projects aswell. Negotiations are currently underway with other companies about modu-larizing and standardizing their bioreac-tor processes on the basis of the equip-ment modules. �

Find out more:www.siemens.com/pharmaE-Mail: jean-jacques.lieners@siemens.comE-Mail: hans.bijl@siemens.com

The various process steps and reactortypes are projected as modules in theautomation solution

NVI produces vaccines for all governmentvaccination programs in the Netherlands.The institute also has its own largeresearch and development department inwhich new vaccines are researched anddeveloped to market maturity

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process news 1/2004

16 CASE STUDY

These examinations often take a fewdays to several weeks to complete.They are not only a considerable

cost factor but is also prone to errors, asthe tests can only determine a conditionthat is already a thing of the past when thetests are completed. Until now, biotechcompanies have taken great care to ensurethat only perfect products leave their pro-duction plants (Bio Capacity Shortage). Ifthere is the slightest doubt that a batchmay not be up to standard, it is rejected. Inview of the current market changes in thehealth sector, however, many biotech com-panies are asking themselves whetherthey can still afford waste rates averaging30 percent, and how they can cost-effec-tively guarantee the high quality of theirproducts in the future.

A new environment demands newsolutions

The U.S. Food and Drug Administrationhas taken up this subject in its initiativepromoting a scientific and risk-basedmethod in pharmaceutical production. Inan initial draft of a future directive, theFDA suggests a quality assurance systemthat is already built into process planningand is totally integrated with the wholeproduction environment. The basic idea isto control the entire manufacturing pro-cess so that only products of perfect quali-ty can be produced.

The core of this FDA initiative is theprocess analytical technology (PAT), withwhich process states can be measured and evaluated online during the process.

Totally integrated qualityassurance for vaccineproduction

ParametricReleaseQuality tests are obligatory at the endof every production run – whether theproducts manufactured are automo-biles or pharmaceuticals. These qualitytests are particularly significant in thepharmaceutical and biotechnologyindustries. At present, it is extremelydifficult to get real-time informationabout the processes in the bioreactor.It is not possible to ascertain whether aprocess took place according to specifi-cations, whether the reactor was reli-ably sterile, whether the media werefree from contamination, or whetherthe end product was manufactured tothe required level of quality. This infor-mation is only available much later,after testing. A representative samplemust be taken from the finished batchand examined in the laboratory – andpossibly even in animal experiments –at great expense.

“For me this

project is

unique

because it is

the first

time that an

end user, a

machine manufacturer, and

an automation provider have

cooperated so closely.”

Thijs Veerman,General Director

of NVI

Research Project Pharma

process news 1/2004

17

Siemens has adopted this initiative andhas already implemented it in a PAT solu-tion for bioprocesses. This enables theprocess to be mastered in such a way thatthe end product achieves the requiredquality reliably and reproducibly. Para-metric release – unlike the release of prod-ucts after quality tests – is now based onproof that process specifications havebeen fully satisfied.

Interdisciplinary cooperation in theNetherlands

Prompt batch release based on process in-formation – parametric release – is an im-portant topic in the pharmaceutical in-dustry. One of the companies currentlypursuing this goal is the Nederlands Vac-cin Instituut (NVI). In a four-year project,

the institute is working with Siemens andfermenter manufacturer Applikon to re-search a solution that should largely re-place expensive laboratory tests. Theparametric release (PaRel) project, due tolast four years, is also sponsored by theDutch government. One aim of the PaRelproject is to further develop near-infraredspectroscopy so that it can be used as aninstrument for in-line bioprocess moni-toring. In this way, constant compliancewith process specifications can be guar-anteed.

A prerequisite for parametric release isthe availability of a detailed functionalprocess model and PAT measurements.Both provide information about the pa-rameters that could influence the processand allow conclusions to be drawn about

quality-relevant process information. ThePaRel project can use the results of theuser requirement specification (URS) atNVI for this.

The final step is to assess the currentstate of the process (from the processmodel and the PAT process information,using a mathematical correlation) and tobe able to forecast further developmentsin the process. This makes it possible tomeasure quality-relevant deviations andtake appropriate action without laborato-ry examinations.

Promising results

Research and development work on theanalysis and mathematical modeling isstill in progress, but initial results alreadylook very promising. The next stepplanned by NVI is to implement online ac-quisition of the process quality parame-ters and evaluation by PAT fingerprinttechnology within the year. �

Find out more:www.siemens.com/pharmaE-Mail: ingrid.maes@siemens.com

Many inspections on theway to product release –soon a thing of the past?NVI, Applikon, and Siemensare developing a solutionfor parametric release ofbiotechnologically manu-factured active pharma-ceutical ingredients

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process news 1/2004

18Supply Chain Management

CASE STUDY

Founded in 1980, Cosmed’s originalmission was medical device steriliza-tion. When the company moved from

the New York area to larger facilities inNewark, New Jersey, its focus expanded tosterilizing spices. Since then, Cosmed hasbuilt new facilities in nearby Linden, NewJersey, and Baltimore, Maryland, theyhave also opened sterilization plants inTexas, California, Illinois, Nevada, andRhode Island.

In 1995, Cosmed began thinking aboutintegrating process controls into other da-ta streams flowing into that facility. At thetime, separate vertical production-relatedsystems each generated printed reports,data which was manually entered into oth-er systems. Cosmed contends with a mul-titude of information streams, includingincoming customer orders, recipes whichdirect how sterilizing equipment shouldoperate when processing specific targetproducts, reports with historical datashowing how specific sterilizers were orare operating moment-to-moment inCosmed plants, and business informationfrom Cosmed’s front office.

Cosmed established objectives includ-ing reports that the new system shouldgenerate; system inputs/outputs; alarms;cross-application integration, and others.“We are a small privately owned companylooking for inexpensive ways to manageour business,” Operation Vice PresidentDavid Howe notes. “We wanted to keep thesolution as simple as possible using off-the-shelf technology.“

Simatic IT improves supply chain visibility and turnaround times

Managing ProcessInformationSince they first installed Simatic IT in one of their facilities, the sterili-

zation expert Cosmed has seen a dramatic decrease in numbers –

numbers they are very happy about: Nonconformity rates where

decreased by an order of magnitude and product turnaround times

shrank from several days to just 24 hours. That is why Cosmed is

more than just content with the new MES solution and has already

implemented Simatic IT in other sites.

each process step there, as therecipe directs. We continuallyoptimize the process we usearound the recipes, focusingon minimizing nonconformi-ties, minimizing downtime, andeliminating redundancy. Be-fore being changed over to thenew system, our facilities ex-perienced non-conformity ratesof about one percent. Cosmedfacilities using Siemens Simat-ic IT are experiencing noncon-formity rates that are a full or-der of magnitude lower.“

Turnaround has also changeddramatically. “Our old systemguaranteed Friday delivery forproducts received Monday forprocessing. Now, advance-sched-uled products received Mon-day are out of our plants with-in 24 hours.

And although we could per-form parametric release be-fore, Simatic IT now measuresprocess performance with suchdepth and issues such com-plete management reports thatour customers feel a greatersense of comfort now that theycan rely on the results.“

Integrated compliance

Following the first Simatic ITapplication, Cosmed has retro-fitted Simatic IT into other fa-

cilities. In addition to filling and manag-ing the supply chain, Simatic IT enablesCosmed to access historical data concern-ing any process performed at any timesince the system was introduced. Sincethe system provides full support for exist-ing industrial standards and ensures pre-cise execution of all process recipes, datait stores constitutes proof of compliancewith FDA and other regulations. Rightnow, Cosmed and Siemens are in theprocess of defining the upgrade of the ex-isting applications scheduled this year. �

State-of-the-art yet low costtechnology

To enable Cosmed to accom-plish all its objectives, Siemenshas installed Simatic IT Frame-work, designed to provide fullsupport for existing industrialstandards, and offer a highlycustomizable, scalable, com-ponent-based approach. Thefirst implementation of SimaticIT was completed in 1999 atCosmed’s Texas facility.

Simatic IT creates secure In-ternet links, which enable cus-tomers to enter orders, browseschedules, and review perform-ance data from their own busi-ness workstations. Customersreceive automatic email noti-fication when loads are re-ceived, sterilized, and shipped.“We now quantify and codifyproduction processes for spe-cific customers in an electron-ic database and push that in-formation across channels pro-vided by the Simatic IT Pro-duction Suite,” David Howe ex-plains.

Implementing the SimaticIT based solution was also oneof the most cost effective waysto solve Cosmed’s integrationtask. Had it adopted high-endalternative systems, Cosmedwould have required ISDN connections atall its factories, spending hundreds ofthousands of dollars for engineering, in-stallation, and operation. “To put up thissystem,” Howe says, “Cosmed is now pay-ing less than $500/month per connection,as little as $50/month, and we can connectto the VPN using a software client for out-side connections rather than requiring aconnection appliance.“

Process Improvements Cut Costs,Reduce Liability

Today Cosmed directly enters recipes intothe system without using intermediateforms and procedures. In the past, newprocesses were designed in a word proces-sor in a format which was understood bythe customer. Once the design was ac-cepted by both parties the process wastranslated into a recipe by a staff engineer.

process news 1/2004

19

Any error in the engineer’s input could re-sult in an expensive process failure. Withthe recipe designed in a format which canbe understood by a layman, Cosmed elim-inates the liability of reentering the pro-cess into the system after it has been ac-cepted by all parties.

“That is a major improvement for us,”David Howe says. “Our typical productsterilization process involves receiving,preconditioning, sterilization, aeration,and shipping,” David Howe explains. “Un-til we applied Simatic IT, we manuallymoved product from process to process,which was labor-intensive and time-con-suming. Now we simply move the productinto a single mammoth process chamber,capable of accommodating trailer-loads ofproducts, and we apply Simatic IT ‘on top’of the entire process. Products stay in oneplace while the Siemens system executes

Find out more:www.siemens.com/simatic-itE-Mail: pietro.paci@siemens.comE-Mail: mariella.pelosi@siemens.com

Cos

med

Cosmed’s mammoth process chamber can accomodate an entire trailer

Simatic IT integrates process data andorder status

Cos

med

process news 1/2004

20Fail-safe Control

CASE STUDY

O ver a period of 36 months andwith continuous planning, theDanish engineering company No-

vo Nordisk Engineering has built an enor-mous insulin factory, containing completeproduction lines from raw materials tofinished bulk products. Insulin is used totreat diabetics. The factory was built forNovo Nordisk, Denmark's largest pharma-ceutical company. Novo Nordisk has in-vested DKK 2.5 billion in the factory,known colloquially as IBP (Insulin BulkPlant).

IBP is the most sophisticated factory ofits kind and is four times the size of con-ventional insulin factories. The continu-ous production lines have necessitatedthe installation of a comprehensive, high-ly developed Fail Safe system in order toensure the greatest possible protection ofpersonnel, production and the environ-ment while at the same time allowing theplant to be shut down in a safe and appro-priate manner if, for example, a leakage ofinflammable fluids should occur.

Tight schedule

Novo Nordisk Engineering (NNE) choseSiemens to supply the sophisticated FailSafe system on the basis of a supplier sur-vey and a firm belief that Siemens was ca-pable of providing the necessary expertisefor the task.

On the basis of NNE's requirement andfunction specifications, Siemens suppliedthe entire Fail Safe system, complete withhardware and software and includingeverything from system design to the con-struction of the necessary panels. Siemensalso installed the panels and the cablesconnecting the many units.

The software was configured on the ba-sis of cause-and-effect diagrams providedby NNE. In addition, these diagrams wereused to prepare the plans for quality con-trol and testing that could ultimatelydemonstrate the functions of the Fail Safesystem. Siemens was responsible for opti-mising system design on the basis of thechosen concept, and for providing thenecessary hardware and system configu-ration.

The entire project was completed un-der a very tight schedule in which IBP wasbuilt and equipped in stages, each corre-sponding to a sixth of the final factorysize. This allowed independent tests andtrial runs to be performed in individualsections of the factory. It was a difficult

process in which many of the tests wereperformed at night so as to avoid inter-rupting the production validation beingcarried out during the day.

Safe production

Large quantities of alcohol are used in theproduction of insulin. The Fail Safe sys-tem therefore includes a large number ofsensors capable of detecting explosivegases. If excessive concentrations arerecorded, the plant is partially or com-pletely shut down. However, no more ofthe production line is shut down than nec-essary, allowing other parts to continueproduction. At IBP, the entire factory issupplied with raw materials from a centralstore. This design is more complicated

Largest ever fail-safe project in Denmark

Fail-Safe PharmaExpertiseThe Danish engineering company Novo Nordisk Engineering chose Siemens to supply the largest ever Fail Safe system inDenmark. The system is installed at one of the world's largestinsulin factories, owned by the pharmaceutical company Novo Nordisk, in Kalundborg.

process news 1/2004

21

than that of decentralized distributionand necessitates a very precise control ofthe system. The system therefore usesPLCs and Profibus technology, based onan open standard architecture. BothProfibus and the PLCs are approved by theGerman testing institute TÜV.

The Fail Safe system, which collectssome 800 signals from the productionlines, has three main functions: sharedemergency stop, substance detection, andhandling of alarms from the ventilationsystem.

Meets the most stringent requirements

Ethernet connections have been estab-lished at two operator panels in the twoIBP control rooms. Fermentation and raw

purification are monitored and regulatedfrom one of the control rooms while finepurification is controlled from the other.The Fail Safe system is segmented in thesame way as the process control system,thus making it simple to operate.

In addition, the system has a redun-dant design, meaning that one of the twoCPUs in the control room PLCs is con-stantly on standby, ready to take overshould the other fail. The two PLCs alsodouble for each other if faults occur. Fur-thermore, the network connecting all 19panels has a redundant design and com-municates via Profisafe on a conventionalProfibus DP net. Input and output signalsare handled via a modular ET 200M-FSsystem.

The Fail Safe system meets the require-ments of SIL 3 (Safety Integration Level) inaccordance with IEC/EN 61508, the new EUstandard which took effect this year. TheSiemens Fail Safe system thus meets themost stringent of safety requirements.

Among others, these include require-ments on system design and tolerances,elevated monitoring levels and redundantwiring. The Fail Safe system thereforechecks connections to all componentscontinuously, and its redundant wiring al-lows the system to switch automatically toan intact network should faults occur. Thesystem also meets the safety requirementscontained in the EU machinery directive,EN 954-1. The system installed at NovoNordisk is designed to SIL 2.

Flexible cooperation

“The Siemens engineers were extremelyflexible, working both day and night whennecessary. Often, the Fail Safe system hadto be tested under very difficult workingconditions where it was necessary to shutdown other parts of the plant,” says ClausDanielsen, project manager at NovoNordisk Engineering. “It was an ambitiousplan, but there has been a willingness tocooperate from both sides. Consideringthat this is the first system to be installedby Siemens in Denmark, the project hasrun smoothly. Problems have arisen alongthe way, but both the Danish and Germandivisions of Siemens have put great effortinto solving them.” �

Find out more:www.siemens.com/pcs7E-Mail: kasper.agerbaek@siemens.com

The Kalundborgsite is NovoNordisk’s mainmanufacturingfacility for insulin

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Novo Nordisk: A focusedhealthcarecompany• 18,000 employees, 65 percent

of whom are based in Denmark

• Turnover of 25 billionDanish

Crowns in 2002

• Diabetes care accounts for 70

percent of turnover

• Production facilities in seven

countries

• Represented in 68 countries

throughout the world

process news 1/2004

AstraZeneca insisted on the highestlevels of security and reliability in thepower supply systems at its newfactory complex for manufacturingtablets in Plankstadt. Totally Inte-grated Automation (TIA) and TotallyIntegrated Power (TIP) ensure that allproduction units are optimallysupplied with power at all times.

A straZeneca is one of the four lead-ing research-based drug manufac-turers in Germany. In Plankstadt,

AstraZeneca produces innovative drugsfor clinical and outpatient applications,among other things, in a new factory com-plex for manufacturing tablets.

TIA and TIP meet the highest demands

One of the most important components ofany production system is the energy sup-ply. The reliability and security of the en-ergy supply is obviously of crucial impor-tance for production, especially in thepharmaceutical industry, with its strin-gent quality standards.

In addition to requiring high levels ofreliability and security, AstraZeneca alsostipulated that the energy supply for thePlankstadt factory should help reduce theplant’s life-cycle costs by using mainte-nance-free resources. Moreover, the sup-ply must have the ability to be connectedto a central HMI station and the buildingcontrol system.

Totally Integrated Automation (TIA)and Totally Integrated Power (TIP) meetthese high demands and provide a uni-form connection between the automationlevel and the process control system. Thisensures that all systems – from safety re-lays to energy consumption to operationof the power switches – can be monitoredand controlled from one place.

A constant supply

Two supply units distribute the energythrough 20-kilovolt and 400-volt low-volt-

age systems. All plants are designed ac-cording to the n-1 principle: a secure pow-er supply is also guaranteed during sys-tem failures – for example, if a trans-former fails or has to be switched off forretrofitting or modifications.

The factory-internal supply uses a ringnetwork to ensure a steady supply accord-ing to the supply security demand of thepower consumers. A redundant supplythrough a parallel or ring circuit is avail-

able at all times. In addition, importantparts of the plant (such as the computer orthe Simatic controller) are connected toan uninterruptible power supply in thecase of a total system failure. �

Siem

ens

Siem

ens

Reliable power supply at AstraZeneca

Energy? Sure

Two main supply systems, redundant transformers, and optional ring or parallel circuit structures guarantee a reliable energy supply at AstraZeneca

22Power Supply

CASE STUDY

Find out more:www.siemens.com/pharmaE-Mail: georg.seefried@siemens.com

for incinerator plants with a view to re-usethem on future incinerator projects. ThePCS 7 platform has proven to be a good fitfor the continuous and discrete control re-quirements inherent in an incinerationplant. �

Simatic PCS 7 control system for Incinerator in Taiwan

Strategic ProjectThe new Wu-Jih incinerator plant is a key strategic project for CTCI, Taiwan’slargest EPC contractor. CTCI have significant experience in the design andconstruction of incineration plants, having completed six major plants since1993. However, Wu-Jih is the company’s first BOT (Build-Operate-Transfer) envi-ronmental project. System reliability was a key issue when CTCI was looking for a process control system – and with Simatic PCS 7, Siemens Taiwan was able tosecure the process control system contract for engineering, supply & site services.

process news 1/2004

23CASE STUDY

T he Wu-Jih Incinerator Plant is a newcombined industrial and municipalwaste incinerator commissioned by

the Taichung County Government, Taiwan.The plant is designed to incinerate 600 T/dof municipal waste and 300T/d of indus-trial waste whilst producing 25 MW of elec-tricity. System reliability was a key ele-ment of CTCI’s selection criteria for thesystem. PCS 7’s flexible architecture andcomprehensive redundancy features at alllevels within the system provided the ide-al solution.

Redundant, high-availability systems

The plant comprises two incinerator lines,plant utilities and the power generationarea. Simatic PCS 7 provides integratedcontrol for all areas. Each process area isequipped with a high availability redun-dant PCS 7 automation system. Remote I/Ocommunicates via redundant fiber-opticProfibus DP providing a cost effective androbust I/O solution.

Dual fiber-optic Ethernet ring commu-nications are installed at the plant levelfor communications between controllersand the servers, and a single electricalEthernet ring for redundant communica-tions with the engineering & operator sta-tions. A multi-client / server architecture is employed with redundant servers andmulti-screen engineering and operatorstations providing flexible engineeringand operator interfaces. Three additionaloperator stations will be installed in theoffice area and a demonstration room infuture.

Control and monitoring of the powersystems has been implemented with a

Sicam Sequence of Events (SOE) systemthat time-stamps the data at a resolutionof one millisecond. The Sicam system isseamlessly integrated into PCS 7 so thatthese data are available directly within theoperator stations without the need of sep-arate SOE viewers or printers.

Standardization for future projects

CTCI and Siemens engineers have collabo-rated closely during project execution todevelop a set of standard control modules

Waste Incineration

Find out more:www.siemens.com/pcs7E-Mail: vincent.lin@siemens.comE-Mail: abram.ziegelaar@siemens.com

The new Wu-Jih plant helps keep Taiwan’s air clean

Siem

ens

process news 1/2004

24Specialty Chemicals

CASE STUDY

R eckitt Benckiser Produktions GmbH,part of the Reckitt Benckiser Group,was formed in 1999 by a merger of

Benckiser Group and the British companyReckitt & Coleman. In 2003, on its 20-plusproduction lines in Ladenburg, the com-pany produced more than 100,000 tons ofdishwashing detergents (in tablet and pow-der form) and water softeners for theworldwide market.

Networking and integration

Production is divided into three large units:the logistics section, where the solid andliquid raw materials are delivered (eitherin BigBags by truck or by tanker) andstored; the mixing plant, the actual heartof production, where the powders aremixed with liquid components and storedin containers for manufacture; and finallythe production lines on which the tabletsare pressed or the powder is packaged.

The company’s existing automationtechnology no longer met the standardsof modern production plants, however.Reckitt Benckiser wanted to increase pro-ductivity and simplify process optimiza-tion, in particular by networking and inte-grating all information more closely.Another aim was to minimize the numberof interfaces and different components andto build up the automation system on a uni-form platform. In addition, the interactionbetween the individual process steps hadto be improved.

Standardized components

The final decision for modernization wasmade in August 2002. The PCS 7 processcontrol system was selected – not only be-cause Reckitt Benckiser had already hadpositive experiences with the Simatic tech-nology. The strength of PCS 7 lies above allin the uniformity of the Totally IntegratedAutomation (TIA) platform, which isthe foundation of all Siemens au-tomation solutions. PCS 7, as anintegral part of TIA, enablesintegration of all regula-tion and control sys-tems into a common

Simatic IT and Simatic PCS 7 integrate processes

Clean-and-ClearProductionReckitt Benckiser sells its products successfully in more than 180 countries, withwell-known brands such as Calgon, Calgonit, Kukident, and Sagrotan. Thecompany understands how to retain its leading position in a fiercely competitivemarket with innovative products. It is thus no surprise that the production facilitiesin the company’s Ladenburg plant must always be state of the art. The automationtechnology for the production system was completely overhauled last year andconverted to Simatic PCS 7 – with striking results: productivity was increasedconsiderably, while the vertical integration of information with Simatic IT ensuresgreater transparency and availability.

system, which makes production particu-larly transparent and reproducible. Addi-tional convincing arguments were the er-gonomic design of the HMI level and thepossibility of linking the system to the com-pany management information systems viastandardized products and interfaces.

Extremely tight schedule

In the implementation, Reckitt Benckisercoordinated the necessary equipmentretrofitting while Siemens was responsiblefor delivering the hardware and switchgearcabinets, completing all the electrical in-stallations, creating the software, and in-tegrating all components. Testing, com-missioning, and trial operation wereperformed jointly in the end.

process news 1/2004

25

verters of the weighing units were inte-grated with the process control system viaProfibus DP.

All material containers were equippedwith writable and readable data chips of theMoby F non-contact ID system, which wasalso seamlessly integrated with PCS 7. Thisenables Reckitt Benckiser to trace the flowof materials through production. The pre-vious recipe system, based on a SCADA ap-plication, was also replaced by SimaticPCS 7. The basic recipes for the productionwere downloaded via a central Simatic ITserver connected to the existing ERP sys-tem. (Simatic IT is the modular MES fromSiemens; in addition to the communicationfunctions between the company and au-tomation levels, it also offers a number ofcoordinated functions that optimize theplant operation during all phases of pro-duction.) The more flexible processing ofthe recipes in the AS 417 automation sys-tems increases the number of batches pro-duced per day and considerably increasesthe overall production capacity of the plant.In the final modernization step, the con-tinuous powder production process was in-tegrated into Simatic PCS 7.

The benefits of converting the plant tothe new process control systems include a clear display of the operating and plant

Mehr zum Thema:www.siemens.com/pcs7E-Mail: hans-joachim.franzreb@siemens.comE-Mail: roland.wieser@siemens.com

parameters. Operators can now monitorweighing processes continuously and in-tervene when necessary. A sophisticatedalarm system provides advance warning ofinitial deviations from the nominal state inthe process and points to possible causesin the event of a fault.

Further steps planned

Based on the success of the previous ap-plication, even closer coordination andmonitoring of the production processes isplanned. Reckitt Benckiser has alreadytaken the first steps in this direction: theinstallation of a bar-code reader in the Big-Bag raw material input and monitoringwith Moby F at 12 dosing stations that sup-ply material to 120 containers. The Moby Fdata storage and reading systems are inte-grated with PCS 7 via Profibus DP and caneasily operate in harsh ambient conditions.The next step is already being planned: theentire production process – from incominggoods to discharge to the packaging units– is to be continuously monitored, evalu-ated, and archived. �

Because production in Laden-burg runs around the clock, Siemens

was given a time limit of four week-ends with a maximum of 24 hours for

the changeover. Thanks to the high de-gree of standardization of the PCS 7 com-

ponents, as well as the commitment andhard work of the project team, this ex-tremely tight schedule was met.

Increased capacity and transparency

The conversion began with the replace-ment of the old weighing technology by Si-warex M. The 63 new weighing controllersincreased the dosing accuracy while speed-ing up the dosing processes. In addition,a considerable reduction in dosing vari-ance was achieved. The frequency con-

Integrated processes contribute to muchhigher productivity

The Simatic ET 200M systems are locateddirectly on site in Ladenburg

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process news 1/2004

26Comprehensive Solution

CASE STUDY

S chering is a research-based pharma-ceutical company that makes majorcontributions to medical progress

and improving quality of life through in-novative medications. This area also in-cludes diagnostic imaging solutions,which enable diseases to be diagnosedearlier and treated more specifically.These solutions supply the physician withimportant information about the condi-

tion of bones, vessels, and other organs.The best-known diagnostic imaging sys-tems include magnetic resonance tomog-raphy (MRT) and ultrasound, in additionto the classic X-ray, as well as computed to-mography (CT), a further development ofX-ray technology. To improve the contrastbetween the different kinds of tissue, spe-cial radiopaque media are frequently usedin X-ray, CT, and MRT examinations.

Complete new plant

Until recently, the production and packag-ing of Schering’s sterile products tookplace at two different sites. To optimizetransport routes and save valuable pro-duction time, Schering has now combinedall processes – from preparation of the so-lutions to packaging and delivery – in anew plant at a single site in Berlin. Thenew plant was to be built from scratch, in-cluding the process technology and allnecessary electrical and process controlinstallations, in a building that was beingmodernized and expanded at the sametime. The focal points were recipe-con-trolled production and validation-relatedexecution.

The plant was completed on a very tightschedule by a consortium consisting of aplant engineering company and Siemensas the supplier for electrical technology,field technology, and the process controlsystem. The complex processes used in themanufacture of the sterile products re-quire a highly sophisticated process solu-tion that must be very closely linked to thecorresponding control technology.

Based on the process and automationconcepts of the Schering Technology/En-

Schering continues successful collaboration with Siemens

One Building, One SystemThe partnership between Schering AG and Siemens goes back many years. The two companies previously collaborated on several successful projects atthe Schering site in Bergkamen. The positive experience with these projectsand Schering’s resulting confidence in Siemens’ pharmaceutical expertisewere two of the reasons why Schering again chose Siemens for the automa-tion of a new production in Berlin for sterile injection and infusion products.

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Over the rooftops of the Schering AGplant in Berlin

process news 1/2004

27

gineering Pharmaceuticals Division, theplant engineers first designed the pro-cess-technical implementation. Based onthis implementation, Siemens then devel-oped the appropriate automation struc-ture. Thanks to Schering’s effective coor-dination and assistance, the tight engi-neering schedule was met.

Clear structuring of the processes

The Simatic PCS 7 process control systemis structured based on customer specifica-tions, so that every preparation and stor-age tank is assigned to an automation sta-tion and an operating terminal, as far aspossible. The automation solution is basedon the fully automatic operating mode ofthe plant at recipe level, with subordinateoperable subrecipes; basic operations andfunctions are based on a machine-neutralbatch structure. The process control sys-tem is linked to Schering’s managementlevel for the transmission of recipe param-eters and feedback of batch logs.

In addition to the process control sys-tem, Siemens also provided the completeelectrical supply, including uninterrupt-ible power supply, low-voltage switch-gear, and distributed I/Os via Profibus DP.Qualification support was also provided.

Close-to-process systems

The HMI system consists of the distrib-uted operating stations and servers thatare assigned to the respective productionsegments, with every server providingcomplete HMI functions for a particularsegment. The data is recorded during arecipe run and transferred to a separatebatch system at the end of the batch. Aspecial protocol server creates, saves, andoutputs the batch log. The job data can bereceived by the management level andthe batch data reported back via a specialinterface.

The engineering station is connectedvia a terminal and system bus. It is usedfor software creation and maintenance aswell as plant optimization and trou-bleshooting during operation. Importantplant documentation is stored on the en-gineering station.

Plant personnel can access the processthrough locally installed terminals. Be-cause these terminals are sometimes in-stalled on the preparation vessels in theclean rooms, Siemens has designed theterminals for clean room compatibility.The process I/O interfaces have also beeninstalled as close as possible to the pro-

cess. Data from valve clusters, Simatic ET200 systems, frequency converters, theSiwarex M weighing systems, and subor-dinate controllers with allocated visuali-zation, along with feedback from thecountless manual valves and other in-struments, are picked up locally via Profi-bus DP.

Further projects underline goodcooperation

Numerous order expansions were neces-sary in the course of the project. The flex-ible project team was able to make theseadditions to the existing structures effec-tively – thanks in large to good teamwork.In addition, Siemens received further or-ders during the course of the project –which underlines the potential for part-nership between Siemens and Scheringon future projects as well. �

Find out more:www.siemens.com/pharmaE-Mail: bernd.moeckel@schering.deE-Mail: axel.janke@schering.deE-Mail: joerg.sawatzky@siemens.com

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Careful inspections ensure the quality of the sterile productsproduced in Berlin

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From preparation of the solutions to packing: all processes are combinedunder one roof at Schering

28 CASE STUDY

Siemens implements innovative disposalconcept for Infraserv Hoechst

Double ScoreDue to the constantly increasingly complex composition of wastewater, specially adapted processes are penetratingareas that were previously the private domain of complex,multistage processes. Both ecological and economicconsiderations in this context make it necessary tointegrate new waste-treatment systems into existing plantstructures. The safe disposal of waste, the protection ofthe environment, and adherence to recycling principlescan be combined in perfect harmony, as the project forInfraserv Hoechst impressively demonstrates.

Waste Water Treatment

A lmost two years ago, the world’slargest production plant for themanufacture of inhalable human

insulin went into operation at IndustrialPark Hoechst near Frankfurt, Germany, insummer 2001. Another similarly large in-sulin plant has recently begun productionin the Industrial Park as well. Relativelylittle wastewater is produced by theseplants; however, due to the high nitrogencontent and strict municipal require-ments, this wastewater could not be dis-posed of in the biological wastewatertreatment plant operated on site. As soonas this became evident, the industrialpark operators, Infraserv Hoechst, beganplanning a new treatment plant for waste-water containing urea.

Concept with double benefits

After comparative studies of variousprocesses and numerous location discus-sions, Infraserv Hoechst decided to buildan innovative two-stage evaporation plantin the industrial estate’s sewage sludgecombustion facility.

Infraserv had worked successfully withSiemens in the past and was therefore cer-tain that Siemens had the expertise to pro-vide the necessary technology for the newtreatment plant. It was also important to

process news 1/2004

The heart of the new waste-water treatment plant is atwo-stage falling-film evapo-rator plant – the diagram illus-trates the working principle ofthis type of evaporator

process news 1/2004

29

link the control technology with the al-ready installed Teleperm M systems.

The thermodynamic design and thematerials for the evaporators were speci-fied by Siemens and built by a plant engi-neering company with many years of ex-perience in building special evaporatorsystems. By using the steam produced bythe second evaporation phase to heat thefirst evaporation stage, the previouslynecessary amount of steam can be re-duced by almost 50 percent. Preheatingthe wastewater containing urea with thesteam condensates saves additional ener-gy. The steam produced in the heatingboilers of the sewage sludge combustionplant heats the second evaporation stage.

This sophisticated concept of combin-ing the various plants finally tipped thebalance in favor of the decision to concen-trate the wastewater by evaporation. An-other advantage of this plant combinationis the use of the resulting concentrate inthe combustion plant to reduce NOx con-centrations in the flue gas. This method iswell known in combustion technology andis used in many power stations, combus-tion plants, and in the cement industry tominimize flue gas NOx emissions. As a re-sult, Infraserv Hoechst can both clean thewastewater containing urea and reduceNOx emissions – and therefore benefitstwice from the new disposal concept.

Close cooperation for trouble-freeimplementation

Reliability was the key factor in the choiceof the control system. Because SimaticPCS 7 could produce good references inmany other projects, Infraserv also choseSiemens for the process automation – notleast because Siemens had already devel-oped and successfully implemented a ma-ture migration strategy for the SimaticPCS 7 process control system on many oc-casions. In addition, the Infraserv person-nel had had positive experiences withTeleperm M.

Siemens was responsible for the com-pilation of the license documents andthe engineering, construction, assembly,commissioning, and training of operatingpersonnel. It was important to minimizethe disruption of ongoing operations dur-ing the installation and commissioning ofthe new plant. The Siemens team, headedby project manager Karlheinz Steyer,therefore worked very closely with thestaff of the sewage sludge combustionplant and operation assistant Rainer We-ber at Infraserv Hoechst during all phasesof the project. That way, the new facilitycould be integrated into the existing plantstructure and a rapid, trouble-free imple-mentation of the project during the ongo-ing operation of the combustion facility

was guaranteed. The new plant was con-nected to the company’s steam systemduring a scheduled operating shutdownof the sewage sludge combustion plant.

The new evaporation plant was com-pletely automated with Simatic PCS 7.Moreover, Siemens also supplied thepump motors. The new control systemwas linked to the existing Teleperm M sys-tems via a gateway – during ongoing op-eration.

Successful synthesis of economy and ecology

“We have satisfied both the requirementsof the pharmaceutical companies and theaims of Infraserv Hoechst: the wastewatergenerated is treated and disposed of safe-ly, while at the same time the plant oper-ates absolutely reliably and cost-effec-tively,” Karlheinz Steyer noted, comment-ing on the results of the project. “And, ofcourse, the evaporation plant also com-plies with current regulations.” InfraservHoechst also has a favorable impression ofthe Siemens team performance, as a cus-tomer feedback evaluation at the end ofthe project revealed. �

Find out more:www.siemens-axiva.comE-Mail: karlheinz.steyer@siemens.com

High above IndustrialPark Hoechst: the new evaporatorjust before installation

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ity while at the same time being flexibleenough to allow manual changes to recipeparameters as well as multi-purpose use.Also, the new system should allow for lat-er expansions and provide open interfacesto integrate third-party and legacy sys-tems.

Comprehensive solution based onSimatic PCS 7

Simatic PCS 7 and Simatic Batch couldmeet all these requirements: the entireprocess control system features a com-plete redundant architecture at the levelof supervision, control and network forhigh system availability. It can manage upto 1800 distributed I/O, including distrib-uted modules located in the hazardouszones. Through Siemens Batch Flexiblesoftware, the main processing phases canbe run in automatic as well as semi-auto-matic mode. The PCS 7 system controlsall actions from raw material loadingthrough synthesis up to air conditioning.

The local Siemens team, who was re-sponsible for project development andimplementation, chose a client-server ar-chitecture based on Windows NT to ensuremaximum production security. Four ofthe five multi-clients are directly installedin the hazardous zone of the plant. PCS 7also integrates a Simatic Siwarex weigh-ing system and communicates via Profi-bus with other automation systems in theplant.

Thanks to the excellent Siemens proj-ect management, everything from specifi-cation data structuring up to the valida-tion protocols was prepared compliant tocGMP recommendations and according toFDA regulations. Together with standardtools integrated in PCS 7, this greatly re-duced validation expenses.

Multiple benefits in day-to-dayproduction

Batch by batch, PCS 7 demonstrates its ad-vantages in everyday production: shorterdowntimes between batches increaseplant productivity, while a better processcontrol enhances production quality. �

Find out more:www.siemens.com/pharmaE-Mail: francesca.bruzzone@siemens.comE-Mail: yves.masson@siemens.com

process news 1/2004

30Batch Production

CASE STUDY

F armabios S.p.A is situated in Gropel-lo Cairoli, Italy and specializes in theproduction of active pharmaceutical

ingredients, in particular steroids and an-tibiotic cephalosporines. Since the prod-ucts are also exported to the USA, all pro-

duction processes including automationsystems have to be compliant with FDAregulations.

Moreover, Farmabios required that thesystem of the new steroids plant had to bevery robust to ensure high plant availabil-

Simatic PCS 7 controls new steroids plant

A Whole Bunch of BenefitsThe Italian pharmaceutical company Farmabios is constantly striving to improveits products through ongoing research and new syntheses strategies while atthe same time reducing production costs in order to be able to supply evenmore customers on all world markets. In 2001, Farmabios decided to double its steroids production capacity by building a new totally automated batchproduction plant. Siemens was able to secure the automation contract, andwith its high performance, reliability, and user-friendliness Simatic PCS 7ensures production quality while greatly reducing downtimes.

Always ready to listen: Forum forProcess and analysis device usersThe continuous dialogue with customers and partners in all indus-tries is an important part of Siemens’ company strategy – this isespecially true in process automation and instrumentation. Tofurther promote the dialogue with users, Siemens has founded itsown forum devoted to process and analysis device users in thechemical industry. The aim of this forum is to provide backgroundinformation and discussion points on important topics in processinstrumentation and analysis as well

forumchemical.pia@siemens.com

The article “Cooperation in the Cement Industry” in Process Newsissue 4/2003 has lead to some misinterpretation regarding the ProcessControl System ECS of the Danish company FLSmidth Automation.Therefore we would like to clarify that FLSmidth Automation will of course keep their own ECS in their portfolio as an independentsolution and technology provider of cement automation. Cematbased on PCS 7 will from now on be a preferred external processcontrol system of the global leader of cement making equipment.

infosinfosDo you want to know more about the Siemens Automation andDrives systems and solutions for the process industry? Simplyvisit our information portal on the Internet:

www.siemens.com/processautomation

onlineonline

e-business

www.siemens.com/processnewsHere you can download the current issue and past issues ofProcess news in PDF format, and search directly for articles aboutspecific topics, technologies or systems in the Reference Center.

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process news 1-04PublisherSiemens Aktiengesellschaft,Bereich Automation and Drives (A&D), Gleiwitzer Str. 555, 90475 Nuremberg

www.siemens.de/automation

Group Executive ManagementHelmut Gierse, Anton S. Huber, Alfred Ötsch

Responsible for ContentPeter Miodek

Responsible for Technical ContentCornelia Dürrfeld

ConceptChristian Leifels

EditorCornelia Dürrfeld, Siemens AG, A&D SPSiemensallee 84, 76187 Karlsruhe, GermanyTel.: +49 (0)7 21/5 95-25 91Fax: +49 (0)7 21/5 95-63 70cornelia.duerrfeld@siemens.com

Editorial CommitteeCatherine Derkosh, Dr. Michael Gilluck,Achim Heim, Hans-Jürgen Huber, Walter Huber,Michael Lang, Bernd Langhans, Harald Mag,Yves Masson, Hartmut Oesten, Mariella Pelosi,Rüdiger Selig, Roland Wieser

Publishing HousePublicis KommunikationsAgentur GmbH, GWACorporate Publishing ZeitschriftenP.O. Box 3240, 91050 Erlangen, GermanyTel.: +49 (0) 91 31/91 92-5 01Fax: +49 (0) 91 31/91 92-5 94

publishing-magazines@publicis-erlangen.de

Editorial Staff: Dr. Beate Bellinghausen, Robert Engelhardt, Dorit Gunia, Christoph Manegold, Kerstin Purucker (Editor in Chief)

Layout: Axel Kornemann, Reinhard Sorger, Jürgen Streitenberger, Werner Völkl

Copy Editors: Regina Severing, Irmgard Wagner,Olaf Wolff (Editor in Chief), Sabine Zingelmann

Jobnummer 002100 RPE41

DTP: Doess, Nuremberg

Druck: Stürtz AG, Würzburg

process news is published quarterly

Circulation: 25,500

© 2004 by Siemens Aktiengesellschaft Munich and Berlin.

All rights reserved by the publisher.

This edition was printed on environmentally-friendly chlorine-free paper.

ISSN 1430-2292 (Print)

The following products are registered trademarks of Siemens AG:MOBY, SICAM, SIMATIC, S7-300, WIN AC, SITRANS,SIWAREX, TELEPERM, TOTALLY INTEGRATEDAUTOMATION

If trademarks, trade names, technical solutions or similar are not listed above, this does not imply that they are not registered.

The information provided in this magazinecontains merely general descriptions orcharacteristics of performance which in case ofactual use do not always apply as described orwhich may change as a result of furtherdevelopment of the products. An obligation toprovide the respective characteristics shall onlyexist if expressly agreed in the terms of contract.

Order No.: E20001-M6104-B100-X7600

Printed in Germany

31DIALOGUE

Field technology fully integrated –costs drastically reduced!

Reduce hardware costs, simplify installation, speed up commissioning and enjoy optimummaintenance with precise diagnostics and fast fault recovery. The solution: SIMATIC® PCS 7,the process control system that fully integrates field technology, enabling direct access fromfield-level engineering and operator stations. With all the advantages of Totally IntegratedAutomation. And international field bus standard PROFIBUS-DP/PA (IEC 61158), redundant andintegrated right down to hazardous areas. Open for the connection of PROFIBUS and HART fielddevices – the largest line of intelligent field devices available. Cost-saving thanks to centralengineering, including the SIMATIC process device manager.SIMATIC PCS 7. Setting a New Standard of Integration!

Want more information? No problem!Fax: ++800 74 62 84 27, Infoservice AD/Z0819

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