www.strandls.com

Overview of Strand Life Sciences

I. About Strand

II. Our Capabilities

III. Our Executive Team

IV. Our Partners

V. Our Strengths

About Strand

2000 -onwards Founded in 2000, 230+ employees

www.strandls.com www.strandls.com

About Strand

Founded in 2000, headquartered in Bangalore, India with US corporate headquarters in San Francisco

India’s first major academic spin-off has 230 employees; 50% computer science and 50% life science & clinical PhDs

Mature personalized medicine business in India

Leaders in genomic research software with 2,000 licenses worldwide and deep relationships with large corporations such as Agilent and L’Oreal

Bioinformatics at Strand

Several thousand

publications referring

these

www.strandls.com

Partners & Customers

Europe

North America

China & Japan

India

Australia

Atlas Clinic

Russia

www.strandls.com

Experience & Thought Leadership

VIJAY CHANDRU, PhD SCOTT STORRER, MBA RAMESH HARIHARAN, PhD KALYANASUNDARAM 'KAS' SUBRAMANIAN, PhD THIRU P. REDDY, MS

Co-founder, Chairman and Chief Executive Officer

• MIT (PhD), Purdue, IISc • Tech Pioneer – WEF • Fellow Indian Academy of

Sciences & Engineering

President, Strand Genomics

• Boston University • General Electric, CIGNA,

Cardinal Health, Genomind

Co-founder and Chief Technology Officer

• Courant(PhD), Max Plank, IISc , IIT –D

• MIT TR100

Chief Scientific Officer • Johns Hopkins (PhD),

IIT-B • Novartis, Entelos

Executive Vice President, Business Operations

• West Virginia • Bayer, Incyte

Talent from Premier Institutions & Universities

Board of Directors Advisory Board

VIJAY CHANDRU, PhD Co-founder, Chairman & CEO DAVID WETHERELL Managing Partner, Biomark Capital RAVI VENKATESAN Ex-Chairman, Microsoft India

RAMESH HARIHARAN, PhD Co-founder and CTO DOUGLAS LIND, MD Managing Director, Biomark Capital

CHARLES CANTOR, PhD CHARLES DeLISI, PhD SWAMI MANOHAR, PhD Co-founder V. VINAY, PhD Co- founder

ERIC EASTMAN, PhD KAL RAMNARAYAN, PhD D. BALA SUBRAMANIAN, PhD

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Our Clinical Platforms

• Personalized Medicine LDTs for Oncology & Inherited Diseases

• Strand SmartLab

• StrandOmics™ • A platform for

variant interpretation and reporting built for interpreters by interpreters

• GeneSpring®

• Strand® NGS • Gene expression

analysis software covering microarray and newer NGS technologies

Clinical Testing at Strand

Rare Inherited Disease

Germline Cancer Risk

Somatic Tumor Profiling

Cardiology

Ophthalmology

Tests ordered by clinicians from ~100+

hospitals

Off-the-shelf

panels

NGS Panels at Strand Today!

Strand –designed

panels

NGS Systems Illumina HiSeq 2500 MiSeq x3 Ion Torrent Ion Proton ABI SoLID AB3500 Sanger

ASSAYS Rigorous R&D High sensitivity NABL/CAP/CLIA

INTERPRETATION 55 Curators/Interpreters US Board certified Medical Geneticists Pathologists Genetic Counsellors

Clinical Operations: Bangalore

• >100 Hospitals and Clinics – Physicians ordering

tests • Central Reference Lab • Our Tests

– Gene Panels, Exomes

Access to one of the World’s largest patient pools

MILESTONES IN INDIA

Clinical Operations: Aurora, Colorado

BioScience Park at the Anschutz Medical Center

Preveen Ramamoorthy PhD VP Clinical Diagnostics Lab Director, Strand Genomics Inc.

Strand-Triesta Cancer Care Joint Venture (Strand/HCG) for cancer care using multi-gene tests.

• (51,000 new patients/year, 31 Hospitals in network)

– Standard of Cancer Care – Lung, Breast, Ovarian and

Colorectal Cancers – ~20,000 tests/year

Strand Translational Lab At Mazumdar-Shaw Medical Center

• Panel Designs • Cost Engineering

Biocon Research Centre

Major Partnerships in India

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Strand Innovation for Rapid Turn Around Time on Clinical Tests

Turnaround time as soon as in 7 days rather than weeks – comparable to single gene tests*

Graphics Processing Unit (GPU) based acceleration of data analysis to further improve TAT.

Automated laboratory and informatics workflows

Automation, data integration and manual data curation for interpretation and reporting

www.strandls.com

Strand® “Standard-of-Care” Report (part of StrandAdvantage test)

16

8 gene-report with quick turn-around-time (1 week)

Provides all the NCCN recommended gene tests for each cancer

Is bridged to the 48 gene and 161 gene test

No additional sample needed

Results in 2 weeks

161-gene Cancer panel Covers known oncogenes and tumor suppressor genes Genes that can help guide the choice of therapy options Predictors of response or resistance to targeted and chemotherapy drugs Markers for prognosis Those involved in drug metabolism

Turnaround time in days rather than weeks – comparable to single gene tests*

Strand SmartLab

Strand Core Platform Smartlab Experts

• Lab blueprint • Validated Panels and

Tests • LIMS+Sample tracking • Bioinformatics • Interpretation &

Reporting • Curation (45 scientists)

• Lab Director • Bioinformaticians • Genetic Counselors • Quality personnel • Clinical testing

personnel

Build, Operate and Transfer model to deliver a turnkey solution enabling laboratories and hospitals to develop in-house capabilities in NGS based diagnostics. Helps retain revenues and profits over time.

www.strandls.com

SmartLab Model

Differentiated offering: sets apart Strand as an end-to-end player – organically building on top of the PM Lab business

Fee for service contract or JV or hybrid models Build Operate and Transfer a fully functional CAP standard

laboratory equipped with Strand products and protocols.

Clinical interpretation / reporting is done by/at Strand

Target: Large hospital systems or Univs. or Dx/Path lab with expected volume of >5000 NGS panel tests per month

Strand products and interpretation services to SmartLab will earn ongoing revenues and royalties for us

Benefits of SmartLab to Community Hospitals

Bringing in lost revenue from referral tests.

More comprehensive test menu offering; Disruption of competition.

Improved Clinical Practice; Capacity Building; Localization due to regional variations in ethnicities; Better turnaround times with local processing; Sovereignty of bio-samples not compromised.

1. Capture revenue 2. Differentiated Lab 3. Value additions

www.strandls.com

Strand Strengths

Leaders in genomic software with over 2,000 licenses worldwide and growing

14-year-old company, financially strong and continually investing in innovation

Access to several hundred computer science, life science and clinical science PhDs

Unmatched capabilities in genomic software and personalized medicine

Harsha K. Rajasimha, PhD VP, Global Business Development

Harsha@strandls.com

Strand Web Links

• Corporate Website: www.strandls.com •Strand Centers for genomics and personalized medicine: www.strandcenters.com • Strand genomics software products

• Strand-NGS: www.strand-ngs.com • StrandOmics: www.strandomics.com • GeneSpring GX: http://genespring-support.com

Follow us on Twitter @StrandLife, Facebook and Linkedin

Thank you!