Storage and transportation of blood and components Dr Sima Zolfsghari Anaraki MD-ACP IRANIAN BLOOD...
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Transcript of Storage and transportation of blood and components Dr Sima Zolfsghari Anaraki MD-ACP IRANIAN BLOOD...
Storage and transportationof blood and components
Dr Sima Zolfsghari Anaraki MD-ACP
IRANIAN BLOOD TRANSFUSION CENTER
Storage and Transportation
Blood & blood products are labile biological materials which need to be kept under the right conditions to ensure that they remain viable, safe and clinically effective
Blood and products need to be transported under the right condition
to maintain product viability to ensure product security
storage
storage conditions need to be
appropriate and correct for each product
temperature cleanliness agitation (platelets)
storage needs to be secure to prevent unauthorized access
to people to insects / vermin etc
storage needs to be monitored to ensure that the correct conditions are maintained
continuous temperature monitoring alarm system on all storage equipment
Storage Temperature for Blood And Components
Storage before processingif unit will be processed for Plt preparation within 8h
storage at + 22 - + 24o C
if unit will be processed for plasma preparation within 6-8h
storage at +1 - +10 o C
Storage after processingwhole blood & red cells +1 - +6 Cfresh frozen plasma - 18o C or lowercryoprecipitate - 18o C or lowerplatelet concentrate + 22 - + 24o C
Importance of Safe Storage
Blood must be stored at a
temperature
between + 1o c to + 6o c. to maintain oxygen carrying
capacity to maintain its viability to minimize growth of any bacterial
contamination
Plasma must be rapidly frozen and
stored
at - 18o c or lower to maintain coagulation factor
levels (fVIII, fV)
Proper Storage of Blood
Units of the blood should be standingUpright in baskets laid flat on the shelf
Air circulation
Never store blood in the door ofrefrigerator
Never store food items in
blood bank refrigerator
Check for signs of deterioration of blood during storage
Look for Hemolysis in the
plasma.
Look for any change in the
colour in the Red Cells e.g.
Purple/ Black indicate
contamination.
Look for any clots.
Storage Precautions of Blood And Components
Blood to be stored at +1- +6o C Never allowed to freeze - red cells FFP stored below - 18o C or lower Temperature of refrigerators must be checked twice a day Door of freezer must be kept closed If plasma is to be thawed, temperature should never go above +37o C If frozen plasma thawed, it should be kept at +1 - + 6o C and used within 24 hours
Storage of Untested/quarantined Blood
Label storage area according to status
quarantine (unavailable): products that havenot been tested or have been partially tested.restrictive access to such products
released (approved): products available for use
rejected (non-confirming): products do notconform and are awaiting disposal
Ensure that there is no mix up of quarantined products with tested (approved) products
Monitoring and Checking
Monitoring of the cold chain temperature monitoring start, during, destination
Monitoring the distribution system time taken from A to B integrity of the packaging upon arrival
Labeling accuracy clarity adequacy
Monitoring Temperature of Refrigerators
Use of thermometers early in the morning & at the end of working daytop, middle, bottom shelf
Documentationthermal charts / manual records
Temperature record
Date Time Shelf Temp Action
I9/12 8am High 4o c none
19/12 2 pm low 10o c to be checked in 1 hour
19/12 8 pm low 6o c none
Transportation
Distribution conditions need to be appropriate for the product
temperature time taken
Packaging needs to be appropriate sturdy enough to protect the product able to maintain the product at correct temp should have adequate label (content, handling and storage)
The Cold Chain
System for storing & transporting blood and components in as safe a way as possible to maintain all the functions of the component
Two essential parts of cold chain people to organize and manage storage and transportation equipment to store and transport blood and plasma safely
Maintaining the Cold Chain
The cold chain is central to the storage and distribution of blood and products
the correct temperature must be maintained
The cold chain runs from donor to the patient
The length of the time that products are not at the correct storage temp must be defined
Procedures for detail action to be taken in case of “out of specification” products must be in place
Transportation of Blood and Products
Transport containers must be kept
clean and regularly disinfected condensation often occurs, the moisture being an ideal place for bacteria to multiply
If sealed ice packs are used, they must be regularly cleaned and disinfected
If ice packs are home-made using ice, the ice must be changed regularly to prevent growth of contaminants
Transportation
Distribution needs to be secure
BTS transport or external agency
the product should arrive at its destination in
the time expected
the product has not been damaged in transport
the product has not been interfered with
Protecting the Product
Packaging that protects the product from physical damage Packaging that maintains the optimum temperature Clean packaging to minimize the risk of microbial contamination Physical separation of cellular products from any ice packs used to maintain temperature Reliable transportation
Documentation
Documentation is needed to record key
parameters during storage and distribution temperature at the start, during, destination
product dispatched and actually received times of dispatch and receipt destination of product integrity of the product integrity of the transport container allowable “out-of-specification” temp and
duration
Temperature Data Loggers Tempreture .deta loggers is a small device housed in a fully Weld sealed,crevice free,robust hygenic plastic tag. Device uses patented induction technique for set up & deta down load powered by an internal battery. Device can be programmed to log at intervals from 1 min.upto 255 minutes with a temperature range of –30°C to + 70°C
Comprehensive & user friendly
window software.
Device helps in validation of
packing
methods used for transportation
of
blood/blood components.
Device helps to validate fridges
&
freezers used for storage.
Temperature Data Loggers
Reception of Blood / Product
Record the time of arrival
Measure & record the temperature in the
container Inspect blood or the product for any signs
of hemolysis or contaminationMeasure & record the temperature of blood
(sandwich method)
Summary
Storage and transportation of blood & product need to be controlled to ensure that the quality of product is maintained from donor to patient
Storage conditions need to be defined, implemented and monitored
Distribution conditions are especially important
The cold chain needs to be maintained
Monitoring is essential
Red blood cell package
Platelet package
حمل ونگهداري پالكت در دمايدرجه سانتي گراد 24-20
Plasma
Two kind of plasma
Every month boxes have to get clean with disinfectant
Every 3 months freezer & refrigerator have to be clean with disinfectant
The name of technician who is responsible for
cleaning
The name of technician who is responsible for
cleaning
Every 3 months freezer have to be clean with disinfectant and defrost