Stereoselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Allylation.

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2005 Pyrrole derivatives R 0120 Stereoselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Allylation. — A novel route to 3-tosyl-4,5-cis-disubstituted γ-lactams (V) and (VII) using a diastereoselective Pd-catalyzed intramolecular allylation of amino acid-derived allylic carbonates (IV) and (VI) is described. — (CRAIG*, D.; HYLAND, C. J. T.; WARD, S. E.; Chem. Commun. (Cambridge) 2005, 27, 3439-3441; Dep. Chem., Imp. Coll., London SW7 2AZ, UK; Eng.) — M. Paetzel 48- 127

Transcript of Stereoselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Allylation.

Page 1: Stereoselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular Allylation.

2005

Pyrrole derivativesR 0120 Stereoselective γ-Lactam Synthesis via Palladium-Catalyzed Intramolecular

Allylation. — A novel route to 3-tosyl-4,5-cis-disubstituted γ-lactams (V) and (VII) using a diastereoselective Pd-catalyzed intramolecular allylation of amino acid-derived allylic carbonates (IV) and (VI) is described. — (CRAIG*, D.; HYLAND, C. J. T.; WARD, S. E.; Chem. Commun. (Cambridge) 2005, 27, 3439-3441; Dep. Chem., Imp. Coll., London SW7 2AZ, UK; Eng.) — M. Paetzel

48- 127