Stemcells
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Transcript of Stemcells
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DEFINITION
Stem cells are the generic cells which are
a class of undifferentiated cells
that are able to differentiated into
specialized cell
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SOURCES
THE MAJOR SOURCES OF STEMCELLS ARE Embryos Adult tissues/organs Umbilical cords Cadavers (survival of neural progenitor
cells from human post-mortem tissues up to 20hr after death)
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TYPES
BASED ON THE TYPE OF ORIGIN AND POTENCY
EMBRYONIC STEM CELLS ADULT STEM CELLS
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PROPERTIES
Self-renewal The ability to go through numerous
cycles cell division by maintaining undifferentiated state
Potency The capacity to differentiate into
specialized cell types
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Self-renewalTwo mechanisms are involved • Obligatory asymmetric replication• Stochastic differentiation
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POTENCYPotential classification includes Totipotent: Ex: zygote Pluripotent: Ex: embryonic stem cells Multipotent: Ex: hematopoietic stem
cells(RBC&WBC) Oligopotent: Ex: lymphoid/myeloid stem cells Unipotent: Ex: muscle stem cells
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IDENTIFICATION
Examining chromosomes under microscope
Presence of surface markers 1.Transcription factors like
proteins oct-4,nanog,sox-2 2.Cellsurface antigens-
glycolipids,keratan sulfate antigen
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STEM CULTURES
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TREATMENTS
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THERAPIES
ADULT STEMCELL TRANSPLANT BONE MARROW STEM CELLS ADULT STEMCELL TRANSPLANT PERIPHERAL BLOOD STEM CELLS UMBILICAL CORD BLOOD STEM
CELL TRANSPLANT
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Umbilical Cord Blood Stem Cell Transplant
BONE MARROW STEM CELLS
STEM CELL TRANSPLANTS
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CAN THESE STEM CELLS CURE HEART DISEASES?
Rodent Model of Myocardial Infarction
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Heart Muscle Repair with Adult Stem Cells
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CONCLUSION
Now days these stem cells are effectively used in the treatment of heart diseases & addressing the nations leading causes of death.
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