Stahl's Essential Psychopharmacology

The Essential Psychopharmacology franchise began 15 years ago as a published offshoot of my lectures for mental health professionals.

I have always had to ‘see’ something before I could understand it, especially disease mechanisms and drug actions, and thus developed a compendium of figures and diagrams for my lectures. With my long term illustrator Nancy Muntner, we gradually developed a ‘visual language’ for psychopharmacology with icons and figures that have become the signature feature of Stahl’s Essential Psychopharmacology.

The original textbook explained how drugs work but not how to use them, so the Prescriber’s Guide was created as a companion to the textbook. For this, in addition to our characteristic use of unique icons, we also included standard evidence based drug information. I also added ‘tips and pearls’ based on the art of psychopharmacology and derived as much from my experience in clinical practice as from the evidence.

Subsequently, Stahl’s Illustrated evolved to answer the need for a distillation of focused therapeutic areas in a highly visual and easy to digest format in the size of a pocketbook.

And now, I am pleased to announce that all of these resources are also available via your computer at Stahl’s Essential Psychopharmacology Online.

What’s Inside:Stahl’s Essential Psychopharmacology ....... page 2

The Prescriber’s Guide ................................ page 3

Stahl’s Illustrated series ....................... page 4 – 5

Stahl’s Essential Psychopharmacology Online .................................................. page 6 – 7

Excerpted Volumes and other resources .... page 8

Stephen M. Stahl, MD, PhD, is Adjunct Professor of Psychiatry at UC San Diego and Chairman of the Neuroscience Education Institute, Carlsbad. He has conducted numerous research projects awarded by the National Institute of Mental Health, the Veteran’s Administration, and the pharmaceutical industry. The author of more than 400 articles and chapters, Dr. Stahl is an internationally recognized clinician, researcher, and teacher in psychiatry with subspecialty expertise in psychopharmacology.

Stahl’sEssentialPsychopharmacology

Essential. Trusted. Indispensable.

Stahl’s Essential Psychopharmacology has established itself as

the preeminent source of education and information in its field. Featur-

ing the author’s highly-praised writing style and clear, easy-to-follow

illustrations, it is indispensable for all professionals and students in

mental health. This thoroughly updated and much-expanded third

edition takes account of advances in neurobiology and recent clinical

developments to explain the concepts underlying the drug treatment

of psychiatric disorders.

· Four chapters of all-new material: Psychiatric Genetics; Chronic

Pain and Functional Somatic Syndromes; Disorders of Sleep and

Wakefulness; Disorders of Cognition

· New coverage of theories of schizophrenia

· Clinical developments in sleep disorders and chronic pain

· Additional neurotransmitter systems

· The latest developments in the field, including information

on obesity and addiction

· All art completely redrawn – 30 percent more illustrations

· New layout for improved readability

The text that started it all. Now in its third edition.

Stahl’sEssentialPsychopharmacologyNeuroscientific Basis and Practical Applications


2008/1000 pages/901 color images/108 tablesPaperback/ISBN 978-0-521-67376-1/List Price: £45.00

“All of Dr. Stahl’s writing is characterized by

clarity of presentation and a notable ability to

transform complicated scientific principles into

readily understood prose. Characteristically he

illustrates his instructions with informative,

charming, and sometimes witty cartoon figures

and diagrams. Dr. Stahl has a gift for teaching, and

it is a pleasure to recommend this book.”

– Journal of Clinical Psychiatry

“Dr. Stahl’s latest edition remains the clearest book

covering all the latest advances and developments

in psychopharmacology. The method of teaching

through illustration and conceptual form should

continue to make it very popular.”

– Doody’s Review Service

“Essential reading . . . I would thoroughly

recommend this book to anyone who works

with psychotropic drugs – or has the task of

teaching others about them!”

– The American Journal of Psychiatry

For more details or to order

+44 (0) 1223 326 050

[email protected]

www.cambridge.org/stahl

2

http://www.cambridge.org/9780521673761

The Prescriber’s Guide is the indispensable companion to Stahl’s main

textbook. It provides essential information on how to use psychotropic

drugs, making characteristic use of Stahl’s unique icons together with

standard evidence based drug information. Also included are ‘tips and

pearls’ based on the art of psychopharmacology, derived from the author’s

experience in clinical practice as well as from the evidence.

• Over100drugscovered

• Iconsforeasyreference

• Thelatestregulationsanduses

• FDAUse-in-Pregnancyratings

• Indexesbyname,use,andclass

Every drug in The Prescriber’s Guide is succinctly covered in five

categories: General Therapeutics, Dosing and Use, Side Effects, Special

Populations, and Pearls. All uses and indications have been fully revised

and updated for the latest information necessary to anyone prescribing

psychotropic drugs.

New in 2009 The third edition

of the essential quick reference for

every prescribing doctor or nurse

The

Prescriber’s

GuideStahl’s Essential Psychopharmacology

The

Prescriber’s

Guide2009/688 pages/Color throughout

Paperback/ISBN 978-0-521-74399-0/List Price: £43.00

Did you know, these books and others are available in an innovative online format? See pages 6-7 for details.

3


The books in the Stahl’s Illustrated series are designed to be fun. In

full-color throughout, with illustrations in the style of his classic Essential Psychopharmacology and Prescriber’s Guide, they provide a speedy way

to learn or review specific concepts in psychopharmacology.

The visual learner will find that these books make psychopharmacol-

ogy concepts easy to master, while the non-visual learner will enjoy a

shortened text version of complex psychopharmacology concepts.

Within each book, each chapter builds on previous chapters, synthesiz-

ing information from basic biology and diagnostics to building treat-

ment plans and dealing with complications and comorbidities. And, to

help guide the reader toward more in-depth learning about particular

concepts, each book ends with a Suggested Reading section.

Stahl’sIllustrated

seriesStahl’sIllustrated

series

A brand new series from

Stephen Stahl

For visual learners or for

those seeking a quick review

4

For more information

+44 (0) 1223 326 050

[email protected]


2009/168 pages/Color throughout/Paperback ISBN 978-0-521-75850-5/List Price: £24.99

Antipsychotics: Chapter 2 45

DA neuron

5HT neuron

nigrostriatal pathway BA

block5HT2Areceptor

SDA

DA neuron

5HT neuron

EPS

nigrostriatal pathwayEPS

Combined 5HT2A/D2 ReceptorBlockade Leads to Less EPS

FIGURE 2.28. When postsynaptic D2 receptors are blocked by antagonists, especially long-term, this can result in the occurrence of EPS. This can also occur with 5HT2A/D2 antagonists if only the DA blocking property is ac-tive, as represented in (A).

When both D2 and 5HT2A receptors are blocked by SDAs, then the 5HT2A blockade actually opposes the actions of the D2 blockade. Blocking 5HT2A receptors leads to increased DA re-lease, as 5HT normally inhibits DA release (B).

Increased levels of DA in the synapse will then compete with the SDAs for the D2 receptors on the postsynaptic neurons, thus preventing full inhibition. Reversal of D2 blockade therefore pre-vents the occurrence of EPS, similarly to what is seen in compounds with rapid D2 dissociation.



Antidepressants: Chapter 3 77

FIGURE 3.5. Dosing and interaction information for bupropion.

Dosing

Formulation:Bupropion: 75, 100 mg tablets. SR: 100, 150 and 200 mg tablets. XL: 150 and 300 mg tablets

Dosage Range:Bupropion: 225-450 mg in 3 divided doses (150 mg maximum single dose). SR: 200-450 mg in 2 divided doses (200 mg maximum single dose). XL: 150-450 mg once/day (450 mg max dose)

Approved For:Major depressive disorder and nicotine addiction

PearlsMay improve cognitive slowing. Reduces hypersomnia and fatigue. May be e�ective if SSRIs have failed, or with “poop out”

Use with caution in children. Dose may need to be lower initially. May be used for ADHD in children and adolescents and for smoking cessation in adolescents. Watch for induction of mania or suicidal ideation

Pregnancy risk category C (some animal studies show adverse e�ects, no controlled studies in humans)

Side e�ects IIVia weak CYP450 2D6 inhibi-tion, may increase concentrations of other drugs. Do not use with MAOIs, thioridazine

Use with caution in patients with cardiovascular disease

Monitor patients with renal impair-ment closely. Lower initial dose, give less frequently

Monitor patients with hepatic impairment closely. Lower initial dose, give less frequently

Bupropion: Tips and Pearls

Side e�ects I

Rare seizures, induction of mania and suicidality

Antidepressants_Minibook.indd Sec2:77 1/23/2009 1:02:39 PM

118 Stahl’s Illustrated

How Does L-methylfolate Work? Part 3:By Enhancing BH4 Production, Boosts

Trimonoamine Synthesis

FIGURE 6.6. The rate limiting enzyme for dopamine (DA) and for norepinephrine (NE) synthesis is tyrosine hydroxylase (top panel). In the absence of BH4 cofactor, tyrosine hydroxylase is inactive (left, depicted as sleeping blue enzyme). Note also that this blue enzyme lacks BH4 binding (depicted as an empty 4) and that it cannot bind tyrosine (depicted as a stellate binding site that does not � t the round tyrosine icon). However, when BH4 binds to tyrosine hydroxylase, it “activates” the enzyme (depicted as turning purple when the yellow 4 binds as cofactor), leading to a change in the stellate binding site to a round shape in the purple enzyme. Now tyrosine can bind and be converted into both DA and NE. A similar action occurs at tryptophan hydroxylase, the rate limiting enzyme for serotonin (5HT; 5-hydroxytryptamine synthe-sis) (bottom).

Antidepressants_Minibook.indd Sec2:118 1/23/2009 1:03:28 PM

negativesymptompharmacy

1st-linetreatment

2nd-linetreatment

SDA DPA

amisulpride clozapinemodafinilantidepressant

NRI

negativesymptoms

deficit1

2 to environmentaldeprivation

2 to EPS

2 to dep

2 to positivesymptoms

Due Sep 2009/164 pages/Color throughout/PaperbackISBN 978-0-521-13322-7/List Price: £24.99

Due Sep 2009/167 pages/Color throughout/PaperbackISBN 978-0-521-13315-9/List Price: £24.99

Did you know, these books and others are available in an innovative online format? See pages 6-7 for details.

5







Online


Online

Now online, and more user-friendly than ever

stahlonline.cambridge.org

Ordering Information

Visit stahlonline.cambridge.org and click on the Subscribe Today button.

Pricing for individuals*

Oneyearaccessforoneuseronly

. . . . . . . . . . . . . . . . . . . . . . . £125

Pay-per-view 48 hours access

. . . . . . . . . . . . . . . . . . . . . . . . £25

Special value bundle

Oneyearaccessforoneuseronly

PLUS one copy of Stahl’s Essential Psychopharmacology, 3E (ISBN 978-0-521-74609-0) . . . . . . . . . . . . . . . . . . . . . . . £145

* Licenses sold at prices for individuals are for

one user only; institutions using codes assigned

to individual users will have their access blocked

Information for institutional and corporate libraries

6

For pricing, further information and 30 day trial requests please contact

+44 (0) 1223 326 489

[email protected]



Features the full text and all the illustrations from the latest editions of

Stahl’s Essential Psychopharmacology and The Prescriber’s Guide, and the

books currently available in the Stahl’s

Illustrated series, all searchable on the same platform.

Updates and related content added

several times each year.

• Search drugs by class, name, type,

or use across all content, then

easily filter your results

• Usequick search for easy use

during patient appointments

• Download illustrations and tables for presentations and

lectures

• Cite, bookmark or take notes

at the click of a button

• Link directly to suggested

readings

• Useone-click access to the

Neuroscience Education Institute’s

CME portal*

*For CME information, see page 8

7

Specialized subject expertise

Third Edition 2008206 pages

190 color images16 tables

ISBN 978-0-521-71413-6List Price: £25.00

Excerpted chapters from Stahl’s Essential Psychopharmacology


249 color images25 tables

ISBN 978-0-521-71412-9 List Price: £25.00

Stahl’s Essential Psychopharmacology Depression and Bipolar Disorder

Stahl’s Essential Psychopharmacology Antipsychotics and Mood Stabilizers


ISBN 978-0-521-75900-7List Price: £21.99

For those specializing in a specific therapeutic area, The Prescriber’s Guide is available in the form of two smaller volumes, each of which contains relevant drug information excerpted directly from the third edition.


ISBN 978-0-521-74396-9List Price: £22.99

The Prescriber’s Guide Antidepressants

The Prescriber’s GuideAntipsychotics and Mood Stabilizers

CME InformationAccreditation Statement: The Neuroscience Education Institute is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.CME Credit Designation: The maximum number of credits available varies per certified book. Please refer to a specific book for the number of credits available. Physicians should only claim credit commensurate with the extent of their participation in an activity.Sponsorship Information: Sponsored by the Neuroscience Education Institute.Support: These activities are supported solely by the sponsor. Neither the Neuroscience Education Institute nor Stephen M. Stahl, MD, PhD has received any funds or grants in support of these educational activities.

For those specializing in a specific therapeutic area, Stahl’s Essential Psychopharmacology is available in the form of two smaller volumes, each of which contains relevant chapters excerpted directly from the third edition.

Excerpted drugs from The Prescriber’s Guide

Other related resources

International Journal of NeuropsychopharmacologyEditor-in-Chief: Alan Frazer, UT Health Science Center, San Antonio, USAISSN 14611457/8 issues per year/Volume 12, 2009journals.cambridge.org/pnp

Psychological MedicineEditors: Kenneth S. Kendler, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA and Robin M. Murray, Institute of Psychiatry, London, UKISSN 00332917/12 issues per year/Volume 39, 2009journals.cambridge.org/psm

Behavioral and Brain SciencesAn International Journal of Current Research and Theory with Open Peer CommentaryCo-Editors: Paul Bloom, Yale University, New Haven, USA and Barbara L. Finlay, Cornell University, Ithaca, USAISSN 0140525X/6 issues per year/Volume 32, 2009journals.cambridge.org/bbs

Philosophy of PsychopharmacologyDan J. Stein, University of Cape Town, South Africa2008/224 pages/Hardback/ ISBN 978-0-521-85652-2/List Price: £29.99

Ethno-psychopharmacology: Advances in Current PracticeChee H. Ng, Bruce S. Singh and Edmond Y. K. Chiu, University of Melbourne, Australia; Keh-Ming Lin, National Health Research Institutes, Taiwan2008/200 pages/Hardback/ ISBN 978-0-521-87363-5/List Price: £55.00

Pediatric and Adolescent Psychopharmacology: A Practical Manual for PediatriciansDonald E. Greydanus, Joseph L. Calles, Jr and Dilip R. Patel, Michigan State University, East Lansing, USA2008/320 pages/Paperback/ ISBN 978-0-521-70567-7/List Price: £35.00

For more details or to order

+44 (0) 1223 326 050

[email protected]






journals.cambridge.org/pnp

journals.cambridge.org/psm

journals.cambridge.org/bbs

Stahl's Essential Psychopharmacology

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