Smooth Muscle Spindle-shaped cells 2-10 m across & ~100 m long Have a thin endomysium Organized...
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Transcript of Smooth Muscle Spindle-shaped cells 2-10 m across & ~100 m long Have a thin endomysium Organized...
Smooth Muscle
Spindle-shaped cells 2-10m across & ~100m long Have a thin endomysium Organized into longitudinal and circular layers Found in walls of contractile organs (except the heart)
Innervation of Smooth Muscle Lacks neuromuscular junctions Innervating nerves form varicosities Varicosities release neurotransmitters into synaptic
clefts called diffuse junctions
Microscopic Anatomy of Smooth Muscle
SR less developed than in sk mus & lacks specific pattern
No T tubules Plasma membranes have caveoli Ca2+ sequestered in extracellular space near caveoli Thin and thick filaments present, but no visible
striations
Intermediate filaments attached at “dense bodies” More thick filaments per thin filament Thick filaments have heads along their entire length No troponin complex Myofilaments arranged diagonally
Organization of Myofilaments in Smooth Muscle
Contraction of Smooth Muscle
Synchronized contraction sheets of smooth muscle
Gap junctions electrically couple cells action potentials transmitted cell to cell
Some smooth muscle cells: Act as pacemakers and set the contractile pace for
whole sheets of muscle Are self-excitatory and depolarize without external
stimuli
Contraction Mechanism Actin and myosin interact via to the sliding filament
mechanism Resting State
Actin bound by caldesmon Myosin light chain (MLC) dephosphorylated Intracellular [Ca2+] low
Rise in intracellular Ca2+ triggers contraction Ca2+ enters from the extracellular space (some from SR) Increase in [Ca2+ ] caused by:
Excitation by neurotransmitters (extracellular Ca) Hormonal signaling via receptors & 2nd messengers (SR
Ca) Ca flux can be inhibited by various inhibitory stimuli –
hormonal & neuronal
Role of Ca2+ for Contraction
Ca2+ binds to calmodulin (Cam) Ca-Cam binds to & activates myosin light chain
kinase (MLCK) CaCam binds to & inactivates caldesmon
Active caldesmon binds actin CaCam-inactivated caldesmon can’t bind actin The free actin is available for myosin to bind Activated MLCK phosphorylates myosin head
region allowing cross bridges with actin to form
Special Features of Smooth Muscle Contraction
Unique characteristics of smooth muscle include: Smooth muscle tone Slow, prolonged contractile activity Low energy requirements Response to stretch
Response to Stretch
Smooth muscle exhibits a phenomenon called stress-relaxation response in which: Smooth muscle responds to stretch only briefly, and
then adapts to its new length The new length, however, retains its ability to
contract This enables organs such as the stomach and
bladder to temporarily store contents
Hyperplasia
Certain smooth muscles can divide and increase their numbers by undergoing hyperplasia
estrogen’s effect on the uterus During pregnancy, estrogen stimulates uterine
growth to accommodate growing fetus
Types of Smooth Muscle: Single Unit
The cells of single-unit smooth muscle, commonly called visceral muscle: Contract rhythmically as a unit electrically coupled via gap junctions exhibit spontaneous action potentials arranged in opposing sheets exhibit stress-relaxation response
Types of Smooth Muscle: Multiunit
Multiunit smooth muscles are found: airways of lungs arteries arrector pili muscles internal eye muscles
characteristics include: Rare gap junctions Infrequent spontaneous depolarizations Structurally independent muscle fibers rich nerve supply, 1/motor units Graded contractions in response to neural stimuli
Muscular Dystrophies
Group of inherited muscle degeneration diseases Muscle fibers atrophy Muscle tissue replaced by connective tissues (scar
tissue)
Duchenne Muscular Dystrophy (DMD) sex-linked recessive inheritance (gene on X
chromosome) 1/3500 live male births caused by a defect in the gene encoding the protein dystrophin
dystrophin helps maintain muscle cell integrity during use