Small Animal Ventilator for Hyperpolarized Helium MRI
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Transcript of Small Animal Ventilator for Hyperpolarized Helium MRI
Small Animal Ventilator for Hyperpolarized Helium MRI
Ashley Anderson III, Micah Brown, Matt Smith, Chris Wegener
Client: Dr. Sean FainAdvisor: Dr. Willis Tompkins
MRI compatible ventilator system Deliver 20% O2 and 80% He-3 in
same breath Allows constant scanning of the He-3 in
MRI rather than every 4 breaths
Client Requirements
Background - Helium MRI
Newer technique Same MRI scanner
Convention is H Here, tuned to Helium
(48.6 MHz) Breath of Helium Displays respiratory
channels
Project Concept
• Each syringe feeds off of independent gas reservoirs
• Gas mixing occurs right before entering small animal
First Generation Prototype
Currently in use in animal studies Only using one syringe Not compatible with small syringes
for mouse studies
Modifications to G1
Reinforced syringe clips
Larger motor Eliminated
O2 chaser breath
Calibration
Results using manometer testing. Graph shows small deviation from entered volumes.
Second Generation Concept
Second Generation Prototype
Created in Solidworks
Smaller components
Interchangeable syringes
Adjustable axle support
Second Generation Prototype
Large motor Motor shielding Precision
machining Can be
disassembled
From Solidworks to Reality
Does it move?
Did we meet client requirements?
Gear ratios allow the appropriate 80/20 gas output ratio
MRI Safe materials Motor shielded for RF Rat/Mouse
compatible
Future Work
Calibration testing Volume delivery Timing
Software development Simultaneous 3He/O2 delivery Inspired time based on %Insp and RR Valve switching
Mixing testing (imaging)
Questions?