Skin Care-Anti-ageing Low carb meals &snacks Healthy Joints ...
Transcript of Skin Care-Anti-ageing Low carb meals &snacks Healthy Joints ...
Skin Care-Anti-ageingSkin Care-Anti-ageing
Low carb meals &snacksLow carb meals &snacks
Healthy JointsHealthy Joints
Energy-Sport nutritionEnergy-Sport nutrition
Hair care productsHair care products
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1000®
4000
Part I. What is NatiColPart I. What is NatiCol®®??
The Weishardt company introduces,NatiCol® 1000 and NatiCol® 4000, a complete range of marine hydrolyzedcollagen
NatiCol® is selectively derived fromfish skin & scales which have beenconsumed by mankind for a long time.
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Part I. NatiColPart I. NatiCol®® Flow chart Flow chart
Weishardt International is certified
ISO 9001/2000
Concentration
Degreasing
Purification
Enzymatic hydrolysis
Sterilisation
Extraction
Acid treatment
Filtration
Spray-drying
100% Fish & Scales skin
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Part I. NatiColPart I. NatiCol®® Traceability Traceability
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Integrating the fish activity from beginning to end, Weishardt controls each step. All raw material is veterinary controlled.
Weishardt controls each step and can guarantee total traceability from the farm to the delivered batch.
Part I. NatiColPart I. NatiCol®® safety safety
Applying gelatine process affords the best security.
2 sterilisations assure the best bacteriology.
Ionic demineralisation and filtrations the maximum purity and highest collagen ratio.
Weishardt, while purchasing various species worldwide guarantees the best long term security, for you and your customers.
Choosing NatiColNatiCol®® means also avoiding some risks and questions
regarding BSE for bovine collagen, avian flu for chicken collagen or any epizootic disease which could appear localy.
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Part I. NatiColPart I. NatiCol®® composition? composition?
NatiCol® contains:
・ 93-95% protein mainly collagen peptides type I.・ Less than 6% water・ Less than 2% mineral salts
NatiCol® is:
Carbohydrate FREE Fat FREE PURINE FREE CHOLESTEROL FREE OGM FREE PRESERVATIVE FREE
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Part I. NatiColPart I. NatiCol®® molecular weight molecular weight
Weishardt has developed two molecular weights covering the main market needs and adaped to various applications.
NatiCol® 4000 is close to usual Marine collagen found on the market (Av<4000Da). Its very high organoleptic properties make Naticol 4000 one of the most appreciated and make the difference!
NatiCol® 1000 is obtained through a special process in order to obtain low molecular weight short chains of peptides (Av<2000Da)It is particularly adapted to topic applications. Due to its faster assimilation by organism, it can be also adapted to some oral applications.
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Part I. NatiColPart I. NatiCol®®
1000 1000 specificityspecificity
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Molecular weight Distribution (MWD)
0,3-1 Kda minimum 40% 1-2 Kda 30%
NatiCol® has an extraordinary level oflow molecular weight which makes it so
unique compared to conventional collagen
®Brand X
MWD (Kda)
0,3-1 Kda3-5 Kda
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1000
4000
Part I. NatiColPart I. NatiCol®® Amino-acid (AA) compositionAmino-acid (AA) composition
NatiCol® contains:
・ 27.6% of Glycine・ 23% of Proline & Hydroxyproline
which are the main components of skin
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0 5 10 15 20 25 30
Glycine
Proline
Hydroxyproline
Ac. glutamique
Ac. aspart ique
Alanine
Arginine
Serine
Histidine
Hydroxylisine
Tyrosine
NatiCol® contains:
8 essentials amino- acids which represents
14,5% of the total AA
0 0,5 1 1,5 2 2,5 3 3,5
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Tréonine
Tryptophane
Valine
Esse
ntia
l AA
(%)
AA
(%)
85.5%
14.5%
Part I. NatiColPart I. NatiCol®® Amino-acid (AA) compositionAmino-acid (AA) composition
CHEMICAL INDEX ( way to look for the ideal protein) Naticol index is 146 bearing in mind that above 100 means complete
protein. Only the absence of Tryptophane is a limiting factor as for all collagens.
The index of amino-acids (Pro, Hypro, Gly) necessary for skin is double that of soy or milk protein.
0,00 5,00 10,00 15,00 20,00 25,00 30,00
Aspartic acid
Thréonine
Sérine
Glutamic acid
Proline
Hydroxyproline
Glycine
Alanine
Valine
Cystéine
Méthionine
Isoleucine
Leucine
Phénylalanine
Tyrosine
Lysine
Hydroxylisine
Histidine
Arginine
Scales
NaticolAA composition varies slightly according to age, food and origin.
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I. NatiColI. NatiCol®® solubility solubility
100% Natural Fish Collagen 2 types: Powder (Pd) & Micro-granulated (MG) White powder, Odourless
Excellent solubility in cold water (5%) Highly dispersible (up to 30% of MG) Very good clarity
Brand X®
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Part I. NatiColPart I. NatiCol®® Key benefits Key benefits
■ 100% Natural Marine product■ 2 types: Powder & Micro-granulated■ 93 to 95% of pure Collagen■ High level of oligo-peptides ■ High level of essential amino-acids■ Neutral taste and odour■ Excellent solubility in cold water■ Halaal certified
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NatiCol is a natural source of collagen type I, the
major protein found in connective tissues and
skin (more than 75%) which plays an essential
role in maintaining skin tone, suppleness &
elasticity. Unfortunately after the age of 25
collagen synthesis reduces at a rate of 1,5% a
year. By the age of 45 collagen levels can have
fallen by as much as 30% 1,2,3.
The external effects of this process are the appearance of wrinkles, fine lines & dry skin
Part II. NatiColPart II. NatiCol®® Skin benefits Skin benefits
Epidermis
Dermis
Hypodermis
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Part II. NatiColPart II. NatiCol®® Skin benefits Skin benefits
• NatiCol provides a pure & concentrated level of marine collagen (95%). Used in rejenuvating formulaes it help to replenish the body’s own
collagen and provides essential nutrients to re-build collagen cells due to its small molecule (tripeptides) and its high bioavailability.
• Regular use of products integrating NatiCol marine collagen may help slow the signs of
ageing by increasing Collagen synthesis, skin elasticity & firmness and reduce fine lines and
wrinkles .
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Part II. NatiColPart II. NatiCol®® Skin care markets & Skin care markets & applicationsapplications
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1. Topical cosmetic products 2. Oral cosmetic products
Skin care markets
Skin Anti-ageing Anti-wrinkle effect
Reduce fine lines Skin firmness Skin elasticity
Increase collagen synthesis
Applications
Part II. NatiColPart II. NatiCol®® Cosmetic use Cosmetic use
COSMETIC USE
DOSAGE/FREQUENCY
SAFETY/TOLERANCE
• NatiCol® can be used in topical cosmetic anti-age and skin care preparations (cream, lotions, emulsions).
• NatiCol® can be used in oral cosmetic «Cosmetofood» anti-age and skin care preparations (tablets, soft gels, beauty drink..)
NatiCol® is 100% safe and has a good tolerance.
1. Topical Dosage: 0,2 to 2%2. Oral Dosage: 5g per day4. Frequency of use: Daily or twice daily for 2-4 months3. Solubility : NatiCol is soluble in water, by stirring at room temperature.
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Part II. NatiColPart II. NatiCol®® Cosmetofood suggested formulationsCosmetofood suggested formulations
Example 2: Cosmetic supplements (sticks) for instant drinks
•NatiCol® (marine Collagen) : 800mg• Acerola extract (vit C) : 100mg• CoQ10 : 10 mg• Marine Chondroitin sulfate : 100 mg• Flavour
Example 1: Cosmetic supplements (tablets, capsules) for anti-wrinkle and anti-ageing effect
•NatiCol® (marine Collagen) :1000mg•Vitamin C : 100mg•Vitamin A (retinol) : 50 mg• OPC (grape seed extract) : 50 mg
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Part II. NatiColPart II. NatiCol®® Cosmetofood suggested formulationsCosmetofood suggested formulations
Example 3: Cosmetic Supplements for Skin Whitening & Anti-ageing effect
•NatiCol® (marine Collagen) :800mg•Fytoperfect (skin whitening complex) : 800mg•Vitamin C : 100 mg•Vitamin E : 100 mg
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Part II. NatiColPart II. NatiCol®®
Cosmetic suggested Cosmetic suggested formulationsformulations
Example 5: Cosmetic cream for anti-wrinkle & moisturizing effect
• NatiCol® (95% pure marine Collagen) : 2%• Other ingredients: Vitamin E, Soy& Advocate oil, Glycerin, perfume, sodium sulfate, preservatives….
Example 4: Cosmetic gel for anti-wrinkle effect
• NatiCol® (95% pure marine Collagen) : 2%• Other ingredients: Carpobol , Glycerin, Perfume, sodium sulfate,
ethanolamin, preservatives
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Part II. BibliographyPart II. Bibliography
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• Babraj JA et al 2005: Collagen synthesis in human musculoskeletal tisues and skin. Am J. Ph. Endocrinol Metab. 289 (5) : 864-9.
• Fligiel SE et al (2003): Collagen degradation in aged/phodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro. J. Invest. Dermatol. 120, (5) 842-8.
• Chung JH (2001): Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J. Invest. Dermatol. 117, (5): 1218-24.
• Reuther T et al (2004): Active ingredients in dermatocosmetics. Hautartz.. 55 (7) :630-6.
Part III. NatiColPart III. NatiCol : Function in : Function in healthy jointshealthy joints
Both ends of the bone (epiphysis) -covered by the
articular cartilage- are kept in position by the joint capsule.
The synovial membrane binds the 2 articular surfaces and
secretes a synovial fluid which ensures cartilage lubrification.
Epiphysis
Articular cartilage
surface
Joint capsule
Synovial membrane
Epiphysis
Part III. NatiCol- Normal Articular Part III. NatiCol- Normal Articular CartilageCartilage
•Articular cartilage is a connective tissue made of cellular components (Chondrocytes) and an extracellular matrix , formed by collagen fibres and a gel called fundamental substance.
•This « fundamental substance » contains free proteoglycanes and free glycoproteines..
•Proteoglucanes are large molecules made up of a long chain of hyaluronic acid bound with protein and GlycoAminoGlycans (mainly Chonroitin sulfate).
Chondrocytes(Joint cells)
Extracellular matrix
Part III. What are Chondrocytes?Part III. What are Chondrocytes?
Chondrocytes are cells that help cartilage to grow and stay healthy.
They synthesize the collagen and proteoglucanes that form the extracellular matrix, the basis of
the cartilage tissue
Part III. What are GAGs?Part III. What are GAGs?
GlycosAminoGlycanes(GAGs)-previously called mucopolysaccharides-are large molecules formed by the
repetition of more than 100 polyssacharide units.
Chondroitin sulfate(CS) is the main GAG found in the articular cartilage.
CS is a glucoside sulfate polymer (50-100 Kda) formed by the repetition of dissacharide units of galactosamine and
glycuronic acid.
CS has a strong electronegative structure which confers a high hydrophobic capacity.
Part III. What is Collagen?Part III. What is Collagen?
•Collagen is an essential and major component of connective tissues (joints, tendons, cartilage, ligaments, blood vessels), and makes up 25% of the total protein mass.
•It is a complex trimer structural protein with a high level of glycine and proline and morever contains Hydroxyproline and Hydroxylysine found in very few other proteins
• There are 3 main types of collagen:
•Type I and III (found mainly in skin, tendon and bone)
•Type II (found exclusively in cartilage)
Part III. NatiColPart III. NatiCol
Healthy Joints markets & Healthy Joints markets & applicationsapplications
1. Senior Joint Health 2. Sportsmen Joint health 3. Menopausal women
Joints markets
1. Osteoarthritis2. Healthy Joint functions3. Osteoporosis
Applications
Part III. What is Osteoarthritis?Part III. What is Osteoarthritis?
Osteoarthritis (OA) is the most common form of age-related disease in people aged 65 and older.
It is a degenerative joint disease characterised by the breakdown of joint articular cartilage, triggering pain, stiffness
and swelling.
Rheumatoid arthritis (RA) is an autoimmune disease different from OA. In fact, the immune system attacks the body’s own
tissue as though it were a foreign invader.
People with RA produce rheumatoid factor, an immunity-related substance that targets the synovial membrane (protective layer that
encases joints). The consequences are severe pain and inflammation, joint pain and loss of joint movement & functions.
Part III. How does NatiCol work?Part III. How does NatiCol work?
Clinical studies have shown that hydrolysed collagen targets and has a positive effect on joint tissue 1, 2, 3,4, 7.
Daily supplements of 6-10 g of hydrolysed collagen are generally admitted to reduce pain and improve mobility when use with complementary ingredients.
It has been suggested that hydrolysed collagen stimulates chondrocyte production, which is involved in the biosynthesis of type II collagen, essential to new cartilage formation. 1, 2, 4, 6,
Part III. BibliographyPart III. Bibliography
• Oesser S Seifert J. (2003): Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cutured with degraded collagen. Cell Tissue Res. 311 (3) : 393-9.
• Oesser S et al (1999) : Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Nutrient matabolism 129, 1891-1895.
• Deal Cl, Moskowitz RW (1999): Nutraceuticals as therapetic agents in osteoarthritis. The role of glycosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am. 25 (2) : 379-95
• Moskowitz RW (2000): Role of Collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum.. 30 (2) : 87-99.
• Takeda et al 1982 (1982) : ACute and subacute toxicity studies on collageb wound dressing (CAS) in mice and rats. J Toxicol Sci. 7 (2): 63-91.
• Pesakova V, Stol M, Adam M. (1990) : Comparison of the influence of gelatine and collagen substrates on growth of chondrocytes. Folia Biol. 36 (5): 264-70.
• Novotna et al. (1991): The role of cartilage minor collagens in inducing arthritis. Z. Rheumato. 50 (2): 93-8.