Rabies in Asia Foundation (RIA)-India chapter World Rabies Day-2008 Quiz on Rabies
Single dose for rabies pre-immunization P. Khawplod 1, H. Wilde 2,T. Kamolthum 3,Visith Sitprija 1....
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Transcript of Single dose for rabies pre-immunization P. Khawplod 1, H. Wilde 2,T. Kamolthum 3,Visith Sitprija 1....
![Page 1: Single dose for rabies pre-immunization P. Khawplod 1, H. Wilde 2,T. Kamolthum 3,Visith Sitprija 1. 1Queen Saovabha Memorial Institute, The Thai Red Cross.](https://reader035.fdocuments.net/reader035/viewer/2022070305/55153c1955034673228b5c50/html5/thumbnails/1.jpg)
Single dose for rabies Single dose for rabies pre-immunizationpre-immunization
P. Khawplod1 , H. Wilde2 ,T. Kamolthum3 ,Visith Sitprija1.
1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand.
2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
3 Provincial Public Health Office of Pitsanulok , Thailand.
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The Ab response in incomplete PET casesThe Ab response in incomplete PET cases(1 - 3 injections)(1 - 3 injections)
SubjectsSubjects nn Day 0Day 0 Day 7Day 7 Day 14Day 14 Day 28Day 28
I. No previous I. No previous
rabies rabies
vaccinationvaccination1010 <0.03<0.03 0.060.06
(<0.03–0.2)(<0.03–0.2)
7.137.13(1.15-58.8)(1.15-58.8)
6.446.44(1.8-20.7)(1.8-20.7)
II. 1-3 II. 1-3
injections injections
previouslypreviously
20200.260.26
(<0.03-22.0)(<0.03-22.0)
6.736.73(1.1-80.5)(1.1-80.5)
38.9138.91(16.7-248.4)(16.7-248.4)
23.8623.86(6.7-175.6)(6.7-175.6)
All subjects received TRC-ID 2-2-2-0-1-1
(PVRV lot.no. L1012, potency 8.7
IU/0.5mL)
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Pre-exposure vaccination
Shorten time & reduce cost
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Objective :
To evaluate the immune memory of
two abbreviated pre-exposure rabies
vaccination schedules
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Study 1 One week schedule
( 3 injections on day 0,3,7)
Study 2 One clinic visit (Single dose)
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One week scheduleOne week schedule
Gr.A ID (2 sites) on day 0, 7 ,280, 7 ,28
Gr.B ID (2 sites) on day 0, 3, 70, 3, 7
Gr.C IM on day 0, 3, 70, 3, 7
PVRV potency 7.5 IU/0.5 mL
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PVRV potency 7.5 IU/0.5 mL
Booster : ID (2 sites) on day 0,3 1 year later
One week scheduleOne week schedule
Blood collection : before booster (1 year) , 7 and 14 days
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Group Day 360 Day 367 Day 374
A. IDx2 Age 18-35 GMT 0.96 29.14 49.39 day 0,7,28 M/F 5/11 Range 0.32-2.95 6.7-227.8 13.1-308.4
(n=16 ) >0.5 IU/ml 81% 100% 100%
B. IDx 2 Age 18-32 GMT 1.12 22.99 105.08 day 0,3,7 M/F 4/12 Range 0.30-4.76 5.9-295.4 26.1-496.7
(n=16 ) >0.5 IU/ml 94% 100% 100%
C. IM Age 18-40 GMT 0.97 35.16 125.0 day 0,3,7 M/F 8/12 Range 0.27-4.76 12.0-191.5 29.7-800.0
(n=20 ) >0.5 IU/ml 80% 100% 100%
Booster : ID(2 sites) on day 0,3 1 year later
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Previous vaccination
regimen Times
(yrs)
day0 day7 day14 day28
PVRV ID 8 mths 0.08 16.0 25.0 19.3
PVRV ID 1 neg 1.1 18.2 6.7
PVRV ID 2 0.18 5.0 16.7 11.8
PVRV ID 3 1.14 36.4 34.9 20.8
unknown IM 4 neg 2.4 30.6 32.0
No previous vaccination
TRC-ID2-2-2-0-1-1
neg 0.06 5.56 5.84
One injection for 1- 4 years( at QSMI )
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Conclusions:
3 injections on day 0,3,7 is as immunogenic as 3 injections on day 0,7,28
Provide at least 1 year of immune memory
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Single dose for rabies pre-immunizationSingle dose for rabies pre-immunization( one clinic visit )( one clinic visit )
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Pre-immunization
ID 0.1 ml (2 sites) on day 0
Single dose for rabies pre-immunizationSingle dose for rabies pre-immunization
Booster ( 1 year later )
ID 0.1 ml ( 2 sites ) on day 0, 3
PVRV lot no 0525 potency 7.5 IU/0.5mL
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Primary vaccinationPrimary vaccination Day 360( Before booster )
Day 367( 7 days)
Day 374( 14 days )
I. ID 0.1 ml (2sites) on day 0 I. ID 0.1 ml (2sites) on day 0 booster ID 0.1ml (2 sites )booster ID 0.1ml (2 sites )
day0,3day0,3 >0.5 IU/ml
0.41(0.06–3.7)
5/13
38%
9.15(3.36-22.6)
10/10
100%
51.96(13.6-141.4)
9/9
100%
Single dose rabies pre-immunizationSingle dose rabies pre-immunization
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Primary vaccinationPrimary vaccination Day 360 (Before booster)
Day 367( 7 days)
Day 374( 14 days)
I. ID 0.1 ml (2sites) on day 0I. ID 0.1 ml (2sites) on day 0
0.41(0.06–3.7)
5/13
38%
9.15(3.36-22.6)
10/10
100%
51.96(13.6-141.4)
9/9
100%
II.TRC-ID 2-2-2-0-1-1 (PVRV)II.TRC-ID 2-2-2-0-1-1 (PVRV)
No previous rabies vaccinationNo previous rabies vaccination<0.03<0.03
0.060.06(0.03 –0.15)(0.03 –0.15)
0%0%
5.565.56(1.15 - 53.8)(1.15 - 53.8)
100%100%
III.TRC-ID 2-2-2-0-1-1 (PCEC)III.TRC-ID 2-2-2-0-1-1 (PCEC)
No previous rabies vaccinationNo previous rabies vaccination<0.03<0.03
0.060.06(<0.03– 0.3)(<0.03– 0.3)
0%0%
8.548.54(1.56 – 27.3)(1.56 – 27.3)
100%100%
Single dose injection Single dose injection Single dose rabies pre-immunizationSingle dose rabies pre-immunization
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Conclusion:
One clinic visit
( ID 0.1 ml (2 sites) one time)
provide at least 1 year of immune memory
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Pre-immunization vaccination
ID 0.1 ml (1 site) on day 0
Booster ( 1 or 3 years later )
ID 0.1 ml ( 1 site ) on day 0, 3
PCEC Lot no 725 potency 7.25 IU/mL
Single dose for rabies pre-immunizationSingle dose for rabies pre-immunization
in Petchaboonin Petchaboon provinceprovince
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BoosterBooster : ID 0.1ml (1 site) on day 0,3 1 year later
Subject no. Day 360 Day 367 Day 374
01032 0.07 3.69 6.59
01042 0.1 2.29 6.04
01049 0.06 18.74 21.51
01070 0.18 2.62 22.15
01098 neg 5.00 9.72
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Subject no. Day 360 Day 367 Day 374
03022 0.27 2.09 20.57
03027 0.71 3.08 5.73
03050 0.13 4.18 4.42
03051 0.15 1.04 3.56
03059 0.46 1.68 5.98
03066 0.09 2.13 7.76
03082 0.07 1.00 19.28
03093 0.2 1.04 14.23
BoosterBooster : ID 0.1ml (1 site) on day 0,3 3 years later
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• 3 injections on day 0,3 and 7
• One clinic visit ID 0.1 ml ( 2 sites) one time
Provide immune memory at least 1 year or more
Conclusions:
![Page 20: Single dose for rabies pre-immunization P. Khawplod 1, H. Wilde 2,T. Kamolthum 3,Visith Sitprija 1. 1Queen Saovabha Memorial Institute, The Thai Red Cross.](https://reader035.fdocuments.net/reader035/viewer/2022070305/55153c1955034673228b5c50/html5/thumbnails/20.jpg)
• reliable booster vaccination
• long lasting
• ????
NEED FURTHER STUDIES
Application for rabies pre-immunization
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Thank you for your attention
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Bite Prevention
PET = 100%
Preventions
Exposed
Pre-exposure vaccination
Animal controlAnimal control