Silk and Silicon Based Bio-Integrated Electronics - Slides
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Transcript of Silk and Silicon Based Bio-Integrated Electronics - Slides
![Page 1: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/1.jpg)
Dissolvable films of silk fibroin for
ultrathin conformal bio-integrated
electronics
Dawn John Mullassery
Electrical and Computer EngineeringUniversity of British Columbia
1
The Paper
John A Rogers 2
Overview
bull Motivation and Background
bull The technology
bull Future
3
httpwwwsingularitysymposiumcommoores-lawhtml
MOORErsquos LAW
ldquoThe observation made in 1965 by Gordon Moore co-founderof Intel that the number of transistors per square inch onintegrated circuits had doubled every year since theintegrated circuit was invented Moore predicted that thistrend would continue for the foreseeable futurerdquo
- Webopedia
4
Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 2: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/2.jpg)
The Paper
John A Rogers 2
Overview
bull Motivation and Background
bull The technology
bull Future
3
httpwwwsingularitysymposiumcommoores-lawhtml
MOORErsquos LAW
ldquoThe observation made in 1965 by Gordon Moore co-founderof Intel that the number of transistors per square inch onintegrated circuits had doubled every year since theintegrated circuit was invented Moore predicted that thistrend would continue for the foreseeable futurerdquo
- Webopedia
4
Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 3: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/3.jpg)
Overview
bull Motivation and Background
bull The technology
bull Future
3
httpwwwsingularitysymposiumcommoores-lawhtml
MOORErsquos LAW
ldquoThe observation made in 1965 by Gordon Moore co-founderof Intel that the number of transistors per square inch onintegrated circuits had doubled every year since theintegrated circuit was invented Moore predicted that thistrend would continue for the foreseeable futurerdquo
- Webopedia
4
Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 4: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/4.jpg)
httpwwwsingularitysymposiumcommoores-lawhtml
MOORErsquos LAW
ldquoThe observation made in 1965 by Gordon Moore co-founderof Intel that the number of transistors per square inch onintegrated circuits had doubled every year since theintegrated circuit was invented Moore predicted that thistrend would continue for the foreseeable futurerdquo
- Webopedia
4
Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 5: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/5.jpg)
Bio-Integration
6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 6: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/6.jpg)
Bio-Integration
6
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 7: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/7.jpg)
Existing Technology ndash Utah
httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024
7
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 8: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/8.jpg)
Electro - Corticography
Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 9: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/9.jpg)
Two main areas
bull Bio-integrated or Biocompatible electronics
bull Transient electronics or Bioresorbableelectronics
9
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 10: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/10.jpg)
Bio-Integrated Electronics
bull Epidermal Electronics
bull Non ndash uniform surfaces inside the body
10
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 11: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/11.jpg)
Bio-Integrated Electronics - Brain
11
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 12: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/12.jpg)
Bio-Integrated Electronics - Brain
12
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 13: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/13.jpg)
httprogersmatseillinoisedumultimediaphp
13
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 14: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/14.jpg)
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal
14
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 15: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/15.jpg)
Bio-Integrated Electronics - Cardiac
Electrophysiology
A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 16: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/16.jpg)
httprogersmatseillinoisedumultimediaphp
16
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 17: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/17.jpg)
Bio-Integrated Electronics -
Spatiotemporal cardiac measurements
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal
ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor
17
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 18: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/18.jpg)
Bio-Integrated Electronics - Advantages
bull High resolution results
bull Less complicated process
bull Similar process can be used for epidermal electronics
bull Non ndash invasive method
18
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 19: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/19.jpg)
Transient Electronics
Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 20: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/20.jpg)
Thin Silicon Membranes Dissolve
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 20
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 21: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/21.jpg)
Water Soluble Silicon
Silicon for Transient Electronics
bull Silicon Thickness - 35 nm
bull Dissolution Time ndash 10 days
bull Water ndash 04 ml
Silicon for Regular Electronics
bull Silicon Thickness -700 microm
bull Dissolution Time ndash600 to 1000 years
bull Water - 8 L
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 21
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 22: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/22.jpg)
Silk membranes dissolve
22
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 23: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/23.jpg)
Transient Electronic Device
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 23
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 24: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/24.jpg)
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 24
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 25: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/25.jpg)
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 25
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 26: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/26.jpg)
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
26
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 27: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/27.jpg)
Why a novel approach
bull Biomedical Purposes
bull Environmental Sensors
bull Consumer Electronics
27
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 28: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/28.jpg)
Biomedical Application ndash Transient Electronics
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE
28
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 29: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/29.jpg)
Biomedical Application ndash Surgical Site
Infections
A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 29
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 30: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/30.jpg)
Edible and Good
Magnesium ~ 100 mg vs ~ 300 mg
Silicon ~ 2 microg vs ~ 10 mg
30
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 31: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/31.jpg)
Biomedical Applications
bull Drug Delivery
bull Electronic Aspirin
31
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 32: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/32.jpg)
Environmental sensors amp e- waste
32
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 33: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/33.jpg)
httprogersmatseillinoisedumultimediaphp
33
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 34: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/34.jpg)
Next Few Years amp Future
bull Human body
bull Non ndash biomedical applications
bull Further R amp D required
34
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 35: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/35.jpg)
Why will this be a classic paper
bull New approach to existing techniques of biomedical methods
bull Any form of biological surface ndash with minimal invasion
bull Not limited to biomedical
35
36
![Page 36: Silk and Silicon Based Bio-Integrated Electronics - Slides](https://reader030.fdocuments.net/reader030/viewer/2022020120/5876a4e71a28abd6508b5f31/html5/thumbnails/36.jpg)
36