Sialogogue and Anti-sialogogue
-
Upload
foysal-sirazee -
Category
Documents
-
view
857 -
download
53
Transcript of Sialogogue and Anti-sialogogue
![Page 1: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/1.jpg)
SIALOGOGUE AND ANTI-SIALOGOGUE AND ANTI-SIALOGOGUESIALOGOGUE
DR.FOYSAL SIRAZEEDR.FOYSAL SIRAZEEBDS(DU),MS(FINAL PART),BDS(DU),MS(FINAL PART),
BSMMU,DHAKA.BSMMU,DHAKA.
![Page 2: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/2.jpg)
SIALOGOGUESIALOGOGUE#Definition…………#Definition…………
....Sialogogue are the Sialogogue are the
agents or drugs agents or drugs which are used which are used to increased to increased salivation due to salivation due to dryness of mouth dryness of mouth or any other or any other reasons.reasons.
![Page 3: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/3.jpg)
Classification of Classification of sialogoguesialogogue
####sialogogue
Agent which increasesalivary reflex…
*Bitter food*Hot food
*Spicy food*Alcohol
Saliva substitute*Anti-bacterial agent
*Complex mixture of salt*Sorbitol or sweetener
*Cellulose and* Flavoring agent
Cholino-mimetic drugs*Pilocarpin
*Neostigmine*Physostigmine
![Page 4: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/4.jpg)
HOT AND SPICY FOODHOT AND SPICY FOOD
![Page 5: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/5.jpg)
SOUR FOODSSOUR FOODS
![Page 6: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/6.jpg)
BITTER FOODSBITTER FOODS
![Page 7: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/7.jpg)
Sialogogues agentsSialogogues agents
![Page 8: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/8.jpg)
XEROSTOMIAXEROSTOMIA#Definition…..#Definition…..The term xerostomia or The term xerostomia or
“dry mouth” refers to “dry mouth” refers to a subjective complaint a subjective complaint of dryness involving of dryness involving the oral mucosa and the oral mucosa and oro-pharynx that may oro-pharynx that may or may not be or may not be accompanied by accompanied by salivary gland hypo salivary gland hypo function, an objective function, an objective decrease in salivary decrease in salivary flow.flow.
![Page 9: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/9.jpg)
Etiologic factors/Causes of Etiologic factors/Causes of xerostomiaxerostomia
Potential etiologic factors for Potential etiologic factors for Xerostomia and/or Salivary Xerostomia and/or Salivary
gland Hypo function…….gland Hypo function…….#Mediations------#Mediations------ *Antihistamines*Antihistamines *Decongestants*Decongestants *Antidepressants*Antidepressants *Sedatives/ anxiolytic*Sedatives/ anxiolytic agentagent *Anti-hypertensive *Anti-hypertensive
agent agent *Anti-cholinergic agent*Anti-cholinergic agent *Anti- neoplastic agent*Anti- neoplastic agent *Anti-psychotic agent*Anti-psychotic agent#Radiation therapy#Radiation therapy
![Page 10: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/10.jpg)
Etiologic factors/Causes of Etiologic factors/Causes of xerostomiaxerostomia…..continue…..continue
#Systemic diseases-----#Systemic diseases----- *Sjögren’s syndrome*Sjögren’s syndrome *Diabetes mellitus*Diabetes mellitus *Diabetes insipidus*Diabetes insipidus *Sarcoidosis*Sarcoidosis *Human Immunodeficiency *Human Immunodeficiency
Virus Virus *(HIV) infection*(HIV) infection *Hepatitis C infection*Hepatitis C infection *Graft versus host disease *Graft versus host disease *Parkinson’s disease*Parkinson’s disease
![Page 11: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/11.jpg)
Etiologic factors/Causes of Etiologic factors/Causes of xerostomiaxerostomia…..continue…..continue
#Electrolyte loss-------#Electrolyte loss------- *Decreased fluid intake*Decreased fluid intake *Hemorrhage*Hemorrhage *Vomiting*Vomiting *Diarrhea*Diarrhea
#Local factors------#Local factors------ *Smoking*Smoking *Excessive caffeine *Excessive caffeine
intakeintake *Mouth breathing*Mouth breathing *Alcohol abuse*Alcohol abuse
![Page 12: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/12.jpg)
Examples of Common medications associated Examples of Common medications associated With Xerostomia and/or Salivary gland Hypo With Xerostomia and/or Salivary gland Hypo
function ………function ………#Anti-Histamines…..#Anti-Histamines….. *Diphenhydramine*Diphenhydramine *Chlorpheniramine*Chlorpheniramine#Decongestants …..#Decongestants ….. *Pseudo ephedrine*Pseudo ephedrine#Anti-Depressant …..#Anti-Depressant ….. *Amitriptyline*Amitriptyline *Fluoxetine*Fluoxetine *Paroxetine*Paroxetine *Citalopram*Citalopram#Sedatives/anxiolytic …..#Sedatives/anxiolytic ….. *Diazepam*Diazepam *Lorazepam*Lorazepam *Alprazolam*Alprazolam
![Page 13: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/13.jpg)
Examples of Common medications Examples of Common medications associated With Xerostomia and/or associated With Xerostomia and/or Salivary gland Hypo function ………Salivary gland Hypo function ………
#Anti-Hypertensive agent …..#Anti-Hypertensive agent ….. *Methyldopa*Methyldopa *Chlorothiazide*Chlorothiazide *Furosemide*Furosemide *Metoprolol*Metoprolol *Calcium channel *Calcium channel
blockersblockers#Anti-Cholinergic agent …..#Anti-Cholinergic agent ….. *Atropine*Atropine *Scopolamine*Scopolamine#Anti-Psychotic agent …..#Anti-Psychotic agent ….. *Haloperidol*Haloperidol * Phenothiazine * Phenothiazine
derivativesderivatives
![Page 14: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/14.jpg)
Management of Management of XerostomiaXerostomia
Management of xerostomia involves……Management of xerostomia involves……1.Patient education, diet, and lifestyle 1.Patient education, diet, and lifestyle
modifications; modifications; 2. Management of systemic diseases and 2. Management of systemic diseases and
medication use;medication use;3.Prevention of dental and oral mucosal 3.Prevention of dental and oral mucosal
diseases; diseases; 4. Palliative management of symptoms; and4. Palliative management of symptoms; and5. Sialogogues or salivary gland stimulants.5. Sialogogues or salivary gland stimulants.
![Page 15: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/15.jpg)
ANTI-SIALOGOGUEANTI-SIALOGOGUE#Definition …..#Definition ….. AntiAnti--Sialogogues are the agents Sialogogues are the agents
or drugs which are used to or drugs which are used to decreased salivation due to decreased salivation due to excessive salivation in mouth or excessive salivation in mouth or any other reasons.any other reasons.
![Page 16: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/16.jpg)
Classification of anti-Classification of anti-SialogoguesSialogogues
ANTI-SAIALOGOGUE
LOCALLY ACTING SYSTEMICALLY ACTING
e.g. ASTRINGENTS CHOLINERGIC ANTAGONISTCNS DEPRESSANTS
e.g. Morphine,Opium.
ANTI-MUSCARINICe.g.. Atropine,Scopolamine
ANTI-NICOTINIC
AUTONOMIC GANGLIONIC BLOCKERe.g. Hexamittonium
![Page 17: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/17.jpg)
PTYALISMPTYALISM#Definition ……#Definition …… It is a clinical It is a clinical
condition condition characterized by characterized by excessive secretion excessive secretion of saliva from of saliva from major or minor major or minor salivary glands of salivary glands of oral region.oral region.
![Page 18: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/18.jpg)
CAUSES OF PTYALISMSCAUSES OF PTYALISMSA. Pathos-physiological causes….A. Pathos-physiological causes…. a) Physiological causes….a) Physiological causes…. *Pregnancy,*Pregnancy, *Malnutrition,*Malnutrition, *Menstruation,*Menstruation, b) Pathological causes….b) Pathological causes…. 1) CNS causes….1) CNS causes…. *Bell’s palsy,*Bell’s palsy, *Hysteria,*Hysteria, *Rabies,*Rabies, *Stroke,*Stroke, *Parkinson’s disease.*Parkinson’s disease.
![Page 19: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/19.jpg)
CAUSES OF PTYALISMSCAUSES OF PTYALISMS……(continue)(continue)
2) Endocrine causes….2) Endocrine causes…. *Exophthalmia goiter.*Exophthalmia goiter. 3) GIT causes….3) GIT causes…. *Nausea and vomiting,*Nausea and vomiting, *Gastro esophageal reflex.*Gastro esophageal reflex. 4) Oral causes….4) Oral causes…. *Stomatitis,*Stomatitis, *ANUG.*ANUG.B. Drug induced…..B. Drug induced….. a)Cholinomimetic agent…..a)Cholinomimetic agent….. *Pilocarpine,*Pilocarpine, *Neostigmine,*Neostigmine, *Physostigmine.*Physostigmine. b)Others agent….b)Others agent…. *Mercury,*Mercury, *Iodine.*Iodine.
![Page 20: Sialogogue and Anti-sialogogue](https://reader033.fdocuments.net/reader033/viewer/2022061103/5401b3bddab5ca6a2f8b459a/html5/thumbnails/20.jpg)
MANAGEMENT OF MANAGEMENT OF PTYALISMSPTYALISMS
Management of ptyalism depends Management of ptyalism depends upon the causes….upon the causes….
Speech therapySpeech therapy Behavioral therapyBehavioral therapy Radiation therapyRadiation therapy MedicationsMedications SurgerySurgery