Shiftwork and Fatigue: Understanding the Human Machine

Shiftwork and Fatigue:Understanding the Human Machine

Andrew Moore-EdeDirector of Client Services

© 2017 Circadian International, Inc

HUMAN DESIGN SPECSThe Biological Clock (SCN) & Circadian Rhythms

Spinal Cord

Hypothalamus Cortex

Brain StemPituitary

Optic NerveEye

SCN

• Virtually every function in the body follows a predictable Circadian (daily) rhythm that is controlled by our Biological Clock (SCN)

• Hormone Secretions, Digestion, Body Temperature• Sleep and Alertness levels

• Disrupted circadian rhythms create health, safety and performance challenges for shiftworkers


HUMAN DESIGN SPECS: Circadian Rhythm of Alertness

20

15

5

0

12 15 18 21 24 03 06 09 12

10

Aler

tnes

s Le

vel (

MSL

T)

Time of Day

Most Olympic Track & Field Records Set

Fifteen-fold Increase In Industrial Accidents

Dangerously Drowsy

Full Alertness

Reduced Alertness

Drowsy

Moderate Alertness


HUMAN DESIGN SPECS:Productivity by Time of Day

16

-2.5

-2

-1.5

-1

-0.5

0

0.5

1

1.5

Noon2 P

M4 P

M6 P

M8 P

M10

PM

Midnigh

t2 A

M4 A

M6 A

M8 A

M10

AM

Time of Day

Rela

tive

Effic

ienc

y

Productivity decreases at night by 5-10%

Source: Folkard S and Tucker P. “Shift work, safety and productivity” Occupational Medicine 2003;53:95-101.

What are the Costs and Risks of Shiftwork?

© 2017 Circadian International, Inc 6

OVERALL COSTS OF SHIFTWORK

Extended hours operations cost U.S. businesses over $200 billion annually (~$11,000 per employee)


COSTS OF SHIFTWORK:Absenteeism

Five times higher for extended hours employees (12.4% vs. 2.4%)

Major reasons cited for Absenteeism:

Balancing work/family life

Reduced sleep (i.e. fatigue)

Higher incidence of sickness/health issues


COSTS OF SHIFTWORK:Turnover

Shiftworkers average: 9.8% per year, vs. 3.4% overall

Turnover of new hires in double digits

Average cost of replacing an extended hours employee: $30,115

Turnover costs $2,255 per extended hours employee per year, compared to $624 per day worker


COSTS OF SHIFTWORK:Health Care Costs

Shiftworkers exhibit higher rates of certain health issues:

18

Obstructive Sleep Apnea 300%-400% higher

Gastrointestinal Disorders 200%-300% higher

Cardiovascular Disease 200%-300% higher

Musculoskeletal Problems 150%-200% higher

Health and Wellness Costs 200%-300% higher

© 2017 Circadian International, Inc 10 Source: CIRCADIAN, Financial Opportunities in Extended Hours Operations

COSTS OF SHIFTWORK:Average Cost of an Accident/Injury: Day vs. Night

Average Night Cost = $10,200 Average Day Cost = $6,200

Increased cost of nightshift accidents based on insurance company claims data

Avg. Night

Avg. Day


COSTS OF SHIFTWORK:Productivity

Fatigue Causes: Reduced reactions times

& coordination Miscommunication /

misunderstanding Decreased motivation

(burnout) Impaired decision

making (risk-taking)…Which Leads To: Inappropriate/slow response Low morale Increased human error/procedural

deviations

Productivity decreases at night by 5-10%

-2.5

-2

-1.5

-1

-0.5

0

0.5

1

1.5

Noon2 P

M4 P

M6 P

M8 P

M10

PM

Midnigh

t2 A

M4 A

M6 A

M8 A

M10

AM

Time of Day

Rela

tive

Effic

ienc

y

Fatigue Risk Management Systems

The optimal way to manage and reduce employee fatigue risk and improve productivity


FATIGUE RISK MANAGEMENT SYSTEMSEmergence as Global Standard for 24/7 Operations

1890 Commercialization of electric light

1908-1999 Hours of Service regulations attempt fatigue control by limiting the number of hours of work per day, per week and/or per month

1970-1990 Advances in circadian sleep science show fatigue inadequately controlled by limiting work-rest hours – “compliant but unsafe”

1990-2005 Early development of comprehensive fatigue risk management systems (FRMS)

2005-2017 Widespread international adoption and introduction of regulations & standards requiring FRMS


Goa

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Act

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iden

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Fatigue-related Errors

Sufficient Staffing Levels

Defense 1Sufficient Sleep Opportunity

Shift / Duty scheduling, Overtime policies, Fatigue risk models

Sufficient Sleep Obtained

Employee training Sleep disorder treatment & compliance

Sufficient Workplace Environment

Sufficient Alertness Behavior

Peer monitoring Fitness for duty audit, Fatigue monitoring

Schedule Driven Fatigue Risk

Sleep Deprivation Lifestyle stress

Workplace Environment Fatigue

Excessive overtime Staffing Imbalance

Workload-Staffing BalanceProportional 24/7 staffing

Workplace design,

Regulating Blue Light

SLEEP ALERTNESS

Defense 2 Defense 3 Defense 4 Defense 5

Fatigue Risk Root Cause Analysis

Fatigue Risk Management System: 5 Defenses & Feedback Loop


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Defense 1


Workload-Staffing BalancingProportional 24/7 staffing

SLEEP ALERTNESS


FRMS DEFENSES IN DEPTH#1. STAFF-WORKLOAD BALANCE

CAUSES OF INADEQUATE STAFFING• Increasing production but not automation or employees• Creep from 5 to 6 to 7 day operations with 3 crews• Workload fluctuates across 168 hour week but shifts

are equally staffed• Employees addicted to overtime, management likes

low headcount, cautious about hiring

SYMPTOMS OF INADEQUATE STAFFING• Excessive average overtime • Increased absenteeism rates• Unplanned open shifts• Increase in fatigue-related errors/incidents• Burn-out, high stress levels


HOURS PER WEEK AND INJURY RATE

0

1

2

3

4

5

6

7

8

9

10

<40 40-44.9 45-49.9 50-54.9 55-59.9 60-64.9 >65

Hours/week

Inci

denc

e ra

te p

er 1

00 w

orke

r-ye

ars

Source: Dembe et al. 2005 (Occup Environ Med), based on 89,729 person years of work

Working 60+ hours per week (e.g., 5 x 12-hr shifts) was associated with a 23% increased hazard rate


Histogram of Fatigue Index - mean: 40.58 std_dev: 20.44 std_err: 0.69

Fatigue Index10095908580757065605550454035302520151050

Freq

uenc

y in

Per

cent

4

3

2

1

0

(n=868)

Probability of DO

T-Recordable Accidents

0

0.1

0.2

0.3

0.4

0.5

0.6

DEFENSE TOOL - CAS FATIGUE MODEL VALIDATION Employee CAS Fatigue Score vs. Accident Rate

LowFatigue

HighFatigue

AverageFatigue

HIGHRISK

EMPLOYEES

Time of Day00222018161412100806040200222018161412100806040200

Dat

e

8/24/20028/22/20028/20/20028/18/20028/16/20028/14/20028/12/20028/10/2002

8/8/20028/6/20028/4/20028/2/2002

7/31/20027/29/20027/27/20027/25/20027/23/2002

BEST PREDICTOR OF HUMAN ERROR RISK IS CAS FATIGUE SCORE CALCULATED FROMPREVIOUS 7-14 DAYS WORK-REST PATTERN


FATIGUE RISK FACTORS

• Duration of shift • Number of consecutive working days• Time off between shifts• Time off between blocks of consecutive shifts

OTHER CIRCADIAN FACTORS

• Fixed versus rotating• Speed of rotation• Direction of rotation• Start/end times of shifts• Regularity/Irregularity of shift times

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SLEEP

Defense 2

FRMS DEFENSES IN DEPTH#2. SHIFT SCHEDULING


WHAT’S THE BEST SHIFT SCHEDULE?

Unlimited number of schedules for a 7-day operationMON TUE WED THU FRI SAT SUN

1 D D D D D - -

2 E E E E E - -

3 N N N N N - D

4 D D D D - - E

5 E E E E - - N

6 N N N N - D D

7 D D D - - E E

8 E E E - - N N

9 N N N - D D D

10 D D - - E E E

11 E E - - N N N

12 N N - D D D D

13 D - - E E E E

14 E - - N N N N

15 N - D D D D D

16 - - E E E E E

17 - - N N N N N

18 - D D D D D -

19 - E E E E E -

20 - N N N N N -

MON TUE WED THU FRI SAT SUN

1 D D D D D D D

2 - - E E E E E

3 E E - - N N N

4 N N N N - - -

7 - 2, 7 - 2, 7 - 3


1 D D D D D D D

2 - E E E E E E

3 E - N N N N N

4 N N - - - - -

7 - 1, 7 - 1, 7 - 5

Day Shift

CREW WEEK MON TUE WED THU FRI SAT SUN1 D D D D D D D

A 2 - - D D D D D

Crew 3 D D - - D D D

4 D D D D - - -

Evening Shift

CREW WEEK MON TUE WED THU FRI SAT SUN1 - - E E E E E

B 2 E E - - E E E

Crew 3 E E E E - - -

4 E E E E E E E

Night Shift

CREW WEEK MON TUE WED THU FRI SAT SUN1 N N - - N N N

C 2 N N N N - - -

Crew 3 N N N N N N N

4 - - N N N N N

Swing Shift

CREW WEEK MON TUE WED THU FRI SAT SUN1 E E N N - - -

D 2 D D E E N N N

Crew 3 - - D D E E E

4 N N - - D D D

7-2,7-2,7-3


1 D D - - N N N

2 - - D D - - -

3 N N - - D D D

4 - - N N - - -

2-2, 3-2, 2-3


OperatingParameters

SHIFT SCHEDULE DESIGN CONSIDERATIONSBest Schedule is Site Specific

Health andSafety

Parameters

EmployeeParameters

Criteria

A

BC

Involve employees in the process

Transfers ownership of the new schedule to the employees

Ensures best schedule is achieved

Avoids costly distractions/disruptions (and sometimes permanent damage) that accompanies many scheduling changes

Will improve employee health, safety, and quality of life

Will improve operational efficiency


• CAUSES OF INADEQUATE SLEEP DURATION & QUALITY Giving sleep a low priorityPoor sleep planningBedroom not suited for day sleepLack of family awareness/supportUndiagnosed/untreated sleep disorders

• SYMPTOMS OF INADEQUATE SLEEP DURATION & QUALITYChronic sleepiness & fatigueSleep episodes on the jobMicrosleeps on the highwaySnoring, multiple wakings, apneasFatigue-related errors/incidents

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SLEEP

Defense 2 Defense 3

FRMS DEFENSES IN DEPTH#3: FATIGUE TRAINING & SLEEP DISORDERS


DEFENSE # 3: COMMUNICATION, EDUCATION & TRAINING

Training On Managing Fatigue and a Shiftwork Lifestyle Should Cover:

Human Design Specs Getting Better Sleep Staying Safe and Alert Nutrition & Health Family & Social Life

Multiple delivery modes Classroom training (“Managing a Shiftwork Lifestyle”) Train-the-Trainer – building internal competence Fatigue Training Online – with testing & certification Newsletters, booklets, video


BENEFITS OF FATIGUE TRAININGImproved Sleep Duration

Average duration of daytime sleep obtained (when working night shift) prior to and after shiftwork lifestyle training.

4.85.8

01234567

Before Training After Training

Ho

urs

of

Day

tim

e S

leep

Source: Dawson 2009


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Job Task & Workplace Environment Fatigue



Workplace design,

Regulating Blue Light

SLEEP ALERTNESS


FRMS DEFENSES IN DEPTH#4: JOB & WORKPLACE DESIGN


DEFENSE 4: WORKPLACE ENVIRONMENT

KEY DETERMINANTS OF SAFETY & PERFORMANCE

Light Temperature Humidity Sound Level Sound Pattern Aroma


Growing Awareness of the Health Risk of Light at Night

The primary human concern with nighttime lighting include… potential carcinogenic effects related to melatonin suppression, especially breast cancer.

Other diseases that may be exacerbated by circadian disruption include:

• Obesity• Diabetes• Depression• Mood Disorders• Reproductive problems

“Epidemiological studies have found that long-term night-workers have a higher risk of breast cancer risk than women who do not work at night.

These studies have involved mainly nurses and flight attendants. The studies are consistent with animal studies that demonstrate that constant light, dim light at night, or simulated Chronic jet lag can substantially increase tumor development.

Other experimental studies show that reducing melatonin levels at night increases the incidence or growth of tumors.”

Shiftwork that involves circadian disruption is “probably carcinogenic to humans”

2007 2012

Exposures to artificial light at night (ALAN) or changes in the timing of exposures to natural light (such as with ‘jet lag’) may disrupt biological processes controlled by endogenous circadian rhythms, potentially resulting in adverse health outcomes. NTP is interested in understanding the health effects of circadian disruption related to ALAN and shift work. NTP’s Office of the Report on Carcinogens (ORoC) and Office of Health Assessment and Translation (OHAT) plan to conduct health hazard assessments focusing on cancer (ORoC) and non-cancer health outcomes (OHAT).

NIH Workshop: Shift Work at Night, Artificial Light at Night, and Circadian Disruption

2016

© 2017 CIRCADIAN Proprietary

https://ntp.niehs.nih.gov/pubhealth/roc/index.html

http://ntp.niehs.nih.gov/pubhealth/hat/index.html

https://ntp.niehs.nih.gov/pubhealth/roc/candidates/index-6.html


2001 Discovery: Circadian Clock (SCN) uses blue wavelengths to track day and night*

SCNCircadian Clock

Bio-Active Blue Light

Thousands of Years

100 Years

*Brainard GC, et al. The Journal of Neuroscience 2001.


Risks of Light at Night Increased by Blue-Rich Energy-Efficient Lighting

Improved Energy Efficiency

Extended Lifetime (Reduced Replacement & Labor Costs)

AND Increased Bio-Active Blue Exposure Risk

Lumensper Watt

LED Lighting provides: INCANDESCENT FLOURESCENT LED



It’s Not “Good Blue” vs. “Bad Blue”… It’s Time of Day

Daytime Electric Light Nocturnal Electric Light

Day Benefits• Increased Alertness• Increased Vigilance• Increased Productivity• Sleep Improvement• Mood Improvement• Health Improvement

Night Costs• Sleep Disruption• Breast/prostate/colon cancers• Obesity/diabetes Type 2

metabolic syndrome• Cardiovascular disease• Depression/mood disorder

Blue Blue



QUESTION:

If blue light exposure at night disrupts circadian rhythms,

what’s the best light solution for shiftwork operations?


CIRCADIAN Light Center: Human Subject Medical Studies

• Controlled for: Daytime Light Exposure, Work Schedule, Illumination (Lux), Diet and Environment

• Simulation: 24/7 day and night work shifts Full length 12-hour shifts

• Sleep Lab facility including EEG• Blood tests (lipids, cardiac markers)• Glucose Tolerance tests (Diabetes)• 24 hour urine melatonin collection• Salivary Melatonin 30 minute intervals• Blood pressure• Alertness & performance tests• Mood and Depression scale test• Human Subject testing under IRB approval

LED product development guided and optimized by medical research

Multiple SPDs of polychromatic white light tested for 24/7 human effectiveness


Conventional Blue-Pump LED

Wavelength (nm)400 500 600 700

Rad

iant

Flu

x ( µ

W/n

m)

0

10000

20000

30000

40000

50000

CIRCADIAN® Night LED

Wavelength (nm)400 500 600 700

Rad

iant

Flu

x ( µ

W/n

m)

0

10000

20000

30000

40000

50000

60000

Bio-Active BlueBio-Active Blue

LM-79 Fixture Data

2%20% 3100K

CIRCADIAN® Day LED

3900K

Developing Day and Night LED Chips to Control Blue Light


Is there a solution? Bright White Energy-Efficient LED Light 24/7with Low Blue Night and High Blue Day

NIGHT DAY NIGHT

High Quality White Light 24/7

% Bio-Active Blue

LOW

HIGH

Timing the Dosing of Bio-Active Blue Light

CIRCADIAN® Autonomous Control Board

CIRCADIAN® Light Engine with Day & Night LED Chips


Blue-Depleted White Light Restores Melatonin at Night

Mel

aton

in (p

g/m

l)

Time of Day

Conventional Blue Pump LED



Wait a Minute!Wouldn’t Restoring Melatonin Make Night Shift Workers Sleepy?

One of the greatest myths in sleep physiology is that:

“Melatonin is the Sleep Hormone”

In fact…

• Nocturnal animals are most active when melatonin peaks at night

• Infusions of physiological levels of melatonin do not induce sleep Only high pharmacological doses of melatonin are sophorific

• No correlation between the percent suppression of melatonin by light at night and percent change in sleepiness

• Alertness can be increased by blue-depleted light which restores melatonin

Melatonin is really the darkness hormone and not the sleep hormone


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related Errors














Job stimulationWorkplace design, Light color filtering,

SLEEP ALERTNESS


FRMS DEFENSES IN DEPTH#5: FATIGUE MONITORING


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Job stimulationWorkplace design, Light color filtering,

SLEEP ALERTNESS


Fatigue Risk Root Cause Analysis

FRMS DEFENSES IN DEPTH#6 ROOT CAUSE ANALYSIS & FEEDBACK


FACTS™: Web-Based and Easy-to-Use(facts.circadian.com)


1) Fatigue RiskMitigation:

Policies, Practices & Technology

3) Fatigue RiskData Collection

and Analysis

2) Fatigue RiskManagement

Communication &Training

4) Fatigue RiskManagement

ProgramEvaluation

Develop a written

Fatigue Risk Management

Plan

Senior Management:

makes acommitment to

reducing fatigue in operation

Project Team: Conduct gap

analysis to identify existing fatigue

programs and gaps in

defense

Developing a Fatigue Risk Management Plan

ControllingFatigueHazards

Continuous Improvement

OBJECTIVES


1. Fatigue is inherent in all shiftwork operations

2. Costs, risks and liabilities of fatigue are substantial ($11,000 USD per shiftwork employee)

3. FRMS are the optimal way to manage and reduce employee fatigue risk and improve productivity

4. Take Action: Create a FRMS Plan, Strengthen Defenses (staffing, scheduling, training, environment, policies, etc.)

CONCLUSIONS

Shiftwork and Fatigue: Understanding the Human Machine

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