Sexualsteroid response elements LDL Rezeptor Lipoproteinlipase e NOS ACE System GABA Rezeptor...
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Transcript of Sexualsteroid response elements LDL Rezeptor Lipoproteinlipase e NOS ACE System GABA Rezeptor...
sexualsteroid response elementssexualsteroid response elements
• LDL Rezeptor• Lipoproteinlipase• e NOS• ACE System• GABA Rezeptor• Myelinscheiden• NFkB• Lunge• Gewicht
Geschlechtsspezifische Geschlechtsspezifische
HypercholesterinämieHypercholesterinämie
Geschlechtsspezifische Hypertonie
• Östrogenmangelbedingte Hypertonie
• Progesteronmangelbedingte Hypertonie
Estradiol stimulates eNOS not only in the uterus but also in the smooth muscles of blood vessels working like a nitro containing drug and protecting the endothelium
Verordnungsrate Psychopharmaka
400
300
200
100
0 <35 35 - 39 40 - 44 45 - 49 50 - 54 55 - 59 >60
pro 1000 Frauen bzw. Männer Frauen Männer
Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress.
Maguire J, Mody I
J Neurosci. 2007 Feb 28;27(9):2155-62.
Progesterone (5 mg/kg, twice daily) upregulates the expression of GABA(A)R delta subunits and enhances the tonic inhibition mediated by these receptors in dentate gyrus granule cells (DGGCs). These changes in males as well as ovarian cycle-induced changes in females can be blocked by finasteride, an antagonist of neurosteroid synthesis from progesterone.
inhibierender GABA Neurotransmittor inhibierender GABA Neurotransmittor hemmt präpuberträre GnRH-hemmt präpuberträre GnRH-
FreisetzungFreisetzung
Endocrine Reviews 22,111(2001)Endocrine Reviews 22,111(2001)
THE LANCET – Vol 358 Sep 8, 2001
Gender-specific diseases Known antigens
Addison´s disease 21-hydroxylaseCoeliac disease Tissue transglutaminaseType 1 diabetes GAD-65, insulin, IA-2AGraves´hyperthyroidism Thyroid-stimulating-
hormone receptorHashimoto´s thyroiditis Thyroid peroxidase,
thyroglobulinMyasthenia gravis Acetylcholine receptorGoodpasture´s syndrome TypeIV collagenPemphigus vulgaris Desmoglein 3Pernicious anaemia H/KATPase, intrinsic factorPrimary biliary cirrhosis E2 PDCVitiligo Tyrosinase, SOX-10Multiple sclerosis Myelin basic protein, myelin
oligodendritic glycoprotein
Systemic diseases
Systemic lupus Spliceosomal snRNP, Ro/Laerythematosus (SSA/SSB) particle,
histone and native DNASjögren´s syndrome Ro/La ribonuclear particle,
muscarinic receptorRheumatoid arthritis Citrillunated cyclic, peptide,
IgMDermatomyositis/polymyositis t-RNA synthetasesDiffuse systemic sclerosis TopoisomeraseLimited systemic sclerosis Centromere proteins(CREST)CREST= calcinosis, Raynaud´s phenomenon,
oesophageal dysmotility, sclerodactyly, and telangiectasia.
Nat Med. 2007 Mar;13(3):245-6
SLEEP APNOE SYNDROM NIMMT IN MENOPAUSE ZU
Block AJ et al.Am J Med 1980; 69:75-79
Leech JA et al. Chest 1988; 94:983-988
60% OF POSTMENOPAUSAL WOMEN HAD NOCTURAL
DESATURATION, HYPOPNEAS, APNEAS, WHEREAS ONLY 11% OF PREMENOPAUSAL WOMEN HAD
SUCH EVENT
Block AJ et al.Am J Med 1980; 69:75-79
IN PCO PATIENTINNEN20 – 44% SCHAFAPNOE
Vgontzas AN et al.J Clin Endocrinol Metab 2001; 86:517-520
PROGESTERON ERHÖHT GENIOGLOSSALE MUSKELAKTIVITÄT
Popovic RM et al.A Appl Physiol 1998; 84:1055-1062
ALKOHOL REDUZIERT DIE GENIOGLOSSALE
MUSKELAKTIVITÄT IN DER FOLLIKELPHASE, NICHT JEDOCH
IN LUTEALPHASE
Leiter JC et al.Am Rev Respir Dis 1987, 135:383-386
PROGESTERON SUBSTITUTION VERBESSERT
PRÄMENSTRUELLESASTHMA
Lancet 1988; 2:370
ASTHMA• CHRON. INFLAMMATION DER
LUFTWEGE MIT DEREN EINSCHRÄNKUNG
• FRAUEN HÄUFIGER BETROFFEN
• PRÄMENSTRUELLE ZUNAHME
ASTHMA
• ERHÖHTE IgE KONZENTRATION
• EOSINOPHILE
• Th2 ZYTOKINE VERMEHRT
ÖSTRADIOL
• VERSCHIEBT ZYTOKINE IN Th2 RICHTUNG
• REGT NO SYNTHASE AN
DIAMINOXYDASE IN EXTRAUTERINEN ORGANEN
DURCH ÖSTROGEN GEHEMMT:
URTIKARIARHINITISLIDÖDEM
REIZDARMDYSMENORRHOE
DIAMINOXIDASE DURCH ALKOHOL GEHEMMT
HISTAMINRHINITIS ALLERGICA
ASTHMA BRONCHIALEURTIKARIA
TACHYKARDIENINTESTINALE BESCHWERDEN
SCHWELLUNG DER AUGENLIDER