Sertaconazole | apollo +9191 46 950 950

Sertaconazole | apollo +9191 46 950 950

Sertaconazole

CAS Number : 99592-32-2

Molecular Weight : 437.77 g/mol

Molecular Formula : C20H15Cl3N2OS

Systematic (IUPAC) : 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

Type : small molecule

Description

Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin

infections such as athlete’s foot.

Categories

Antifungal Agents

Taxonomy

Kingdom : Organic

Classes

Benzyl Alcohols and Derivatives

Benzothiophenes

Phenethylamines

Substructures

Benzyl Alcohols and Derivatives

Ethers

Benzene and Derivatives

Aryl Halides

Halobenzenes

Benzothiophenes

Imidazoles

Phenethylamines

Heterocyclic compounds

Aromatic compounds

Cyanamides

Thiophenes

Pharmacology

Indication : For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of

age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton

floccosum.

Pharmacodynamics : Sertaconazole is an

imidazole/triazole type antifungal agent. Sertaconazole is a highly selective inhibitor of fungal cytochrome P-

450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This

enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of

normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for

the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Sertaconazole exhibits in vitro activity

against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in

normal and immunocompromised animal models for systemic and intracranial fungal infections due to

Cryptococcus neoformans and for systemic infections due to Candida albicans.

Mechanism of action : Sertaconazole interacts with

14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As

ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in

increased cellular permeability causing leakage of

cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane

phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair

triglyceride and/or phospholipid biosynthesis.

Absorption : Bioavailability is negligible.

Protein binding : >99% to plasma

Affected organisms : Yeast and other fungi

Why is this medication prescribed?

Sertaconazole is used to treat tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Sertaconazole is in a class of medications called

imidazoles. It works by slowing the growth of fungi that cause infection.

How should this medicine be used?

Sertaconazole comes as a cream to apply to the skin. It is usually applied twice a day for 4 weeks. Use

sertaconazole cream at around the same times every day. Follow the directions on your prescription label

carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use sertaconazole

exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Your symptoms should improve in the first two weeks of your treatment. Continue to use sertaconazole cream

even if your condition improves. If you stop using sertaconazole cream too soon, your infection may not be

completely cured and your symptoms may return. If your symptoms do not improve or if they get worse, call

your doctor.

Sertaconazole cream is only for use on the skin. Keep sertaconazole cream away from your eyes, nostils,

mouth, lips, vagina, and rectal area and do not swallow the medication.

If you clean the affected area, allow it to dry, and then gently rub the cream into the skin. Wash your hands

with soap and water after applying sertaconazole cream. Do not use any bandages, dressings, or wraps unless

directed to do so by your doctor.

Other uses for this medicine

Sertaconazole cream may be used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly

rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or

buttocks), tinea versicolor (fungal infection that causes brown or light colored spots on the chest, back, arms, legs, or neck), and tinea manuum (fungal infection on the hands). Sertaconazole cream may also be used to treat yeast infections of the skin. Talk to your doctor about the risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using sertaconazole cream,

tell your doctor and pharmacist if you are allergic to sertaconazole, any other antifungal medications such as

clotrimazole (Lotrimin), ketoconazole (Nizoral), or

miconazole (Desenex, Lotrimin AF); any of its ingredients, or any other medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional

supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of

your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had any medical condition.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant

while using sertaconazole cream, call your doctor.

What special dietary instructions should I

follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the

missed dose and continue your regular dosing schedule. Do not apply extra cream to make up for a missed dose.

What side effects can this medication cause?

Sertaconazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

irritation, itching, burning or stinging in the place where you applied the medication

dry skin

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

redness, tenderness, swelling, pain, or warmth in the place where you applied the medication

blistering or oozing in the place where you applied the medication

Sertaconazole may cause other side effects. Call your doctor if you have any unusual problems while using this

medication.

What storage conditions are needed for this

medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room

temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that

is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish sertaconazole

cream, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter)

medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You

should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of

emergencies.

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