SEPTEMBER 2018 VOL 213 NO 3

Young adult functional outcomes among individuals with remitted, persistent and late-onset ADHDAgnew-Blais et al

Rising of the machines? Machine learning approaches and mental healthTiffin et al

Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disordersCalafato et al

Security of mind: twenty years of attachment theory and its relevance to psychiatryAdshead et al

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SEPTEMBER 2018 VOL 213 NO 3

ISSN 0007 - 1250

Editor Kamaldeep Bhui CBE

Associate EditorsShehzad AliDinesh BhugraMatthew BroomeAlistair BurnsPatricia CaseyMike CrawfordElena GarraldaSimon Gilbody(Editorials Editor)

Edgar JonesHelen KillaspyJulian LeffAnne Lingford-HughesPhilip McGuireGiles Newton-Howes(Reviews Editor)

Francis Anthony O’NeillFemi Oyebode(Book Reviews Editor)

(Executive Contents Editor)

Jan ScottJames ShearerSukhwinder ShergillSimon WesselyAllan Young

Editorial AdvisorsJohn GeddesMartin KnappSarah Byford

InternationalEditorial BoardRegi T. Alexander (UK)Ricardo Araya (UK)Amanda Baxter (Australia)Allan Beveridge (UK)(Book Reviews Editor)

Jonathan Bisson (UK)Alec Buchanan (USA)Peter Byrne (UK)(Executive Contents Editor)

Colin Campbell (UK)(Correspondence Editor)

(Debate Editor)

Mary Cannon (Ireland)Andrew Cheng (Taiwan)John Cookson (UK)Tim Crow (UK)Pim Cuijpers (TheNetherlands)Kimberlie Dean (Australia)Colin Drummond (UK)Sara Evans-Lacko (UK)Renee Fox (USA)Peter Haddad (UK)Madelyn Hicks (USA)Matthew Hotopf (UK)Robert Howard (UK)Khalida Ismail (UK)Assen Jablensky (Australia)Eileen Joyce (UK)Navneet Kapur (UK)Kenneth Kaufman (USA)Kenneth Kendler (USA)Michael King (UK)Stephen Lawrie (UK)William Lee (UK)Glyn Lewis (UK)Shôn Lewis (UK)Sean Lynch (UK)Kwame McKenzie (Canada)Gin Malhi (Australia)Nick Meader (UK)Nadia Micali (UK)Marco Mula (UK)Roger Mulder (New Zealand)Frank Njenga (Kenya)Aileen O’Brien (UK)(Debate Editor)

Michael Phillips (China)Alexandra Pitman (UK)Thomas Schulze (Germany)Cristiane Silvestre De Paula(Brazil)Emily Simonoff (UK)Julia Sinclair (UK)Swaran Singh (UK)Dan Stein (South Africa)Athula Sumathipala (UK)Nori Takei (Japan)

Derek Tracy (UK)Rachel Upthegrove (UK)J. L. Vazquez-Barquero(Spain)Melanie Wall (UK)Elizabeth Walsh (UK)Danuta Wasserman(Sweden)Richard Williams (UK)Kiriakos Xenitidis (UK)(Correspondence Editor)

Trainee EditorsJudith HarrisonJoseph Hayes

Statistical AdvisorsEva PetkovaStephen RobertsPak ShamMin Yang

StaffHead of PublishingElizabeth HayManaging EditorAlice ShuttleworthSenior PublicationsCoordinatorDianndra Roberts

Past EditorsEliot Slater 1961–72Edward H. Hare 1973–77John L. Crammer 1978–83Hugh L. Freeman 1984–93Greg Wilkinson 1994–2003Peter Tyrer 2003–13

SubscriptionsBritish Journal of Psychiatry (ISSN 0007-1250) is published monthly.The six issues starting January 2018 comprise Volume 212, the sixissues starting July 2018 comprise Volume 213. Orders from non-members of the College, which must be accompanied by payment,may be sent to any bookseller or subscription agent or direct to thepublishers: Cambridge University Press, Journals FulfilmentDepartment, UPH, Shaftesbury Road, Cambridge CB2 8BS, UK, emailjournals@cambridge.org; or in the USA, Canada and Mexico, toCambridge University Press, Journals Fulfilment Department,1 Liberty Plaza, Floor 20, New York, NY 10006, USA, email subscrip-tions_newyork@cambridge.org. Japanese prices for institutions areavailable from Kinokuniya Company Ltd, P.O. Box 55, Chitose, Tokyo156, Japan.

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Information about the College’s publications is available at https://www.rcpsych.ac.uk.

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Founded by J. C. Bucknill in 1853 as the Asylum Journal and known asthe Journal of Mental Science from 1858 to 1963.

©The Royal College of Psychiatrists 2018. Unless so stated, materialin the British Journal of Psychiatry does not necessarily reflect theviews of the Editor or the Royal College of Psychiatrists. The pub-lishers are not responsible for any error of omission or fact.

Printed in Great Britain by Henry Ling Limited, The Dorset Press, 23High East Street, Dorchester, Dorset DT1 1HD.

This journal issue has been printed on FSC™-certified paper and coverboard. FSC is an independent, non-governmental, not-for-profitorganization established to promote the responsible management ofthe world’s forests. Please see www.fsc.org for information.

The British Journal of Psychiatry is published monthly by the Royal College of Psychiatrists (a charity registered inEngland andWales (228636) and in Scotland (SC038369)). The Journal publishes original work in all fields of psychiatry.Manuscripts for publication should be submitted online at https://mc.manuscriptcentral.com/bjpsych.

All papers in this journal are peer-reviewed. No person is permitted to take any role in the peer-review of a paper inwhich they have an interest, defined as follows: fees or grants from, employment by, consultancy for, sharedownership in, or any close relationship with, an organisation whose interests, financial or otherwise, may be affectedby the publication of the paper.

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Contents

A33 Editorial BoardA35 Highlights of this issue

Editorials509 Rise of the machines? Machine learning approaches and

mental health: opportunities and challengesPaul A. Tiffin and Lewis W. Paton

511 Security of mind: 20 years of attachment theory and itsrelevance to psychiatryGwen Adshead

Review514 Neurotrophins, cytokines, oxidative stress mediators and

mood state in bipolar disorder: systematic review andmeta-analysesTobias Rowland, Benjamin I. Perry, Rachel Upthegrove,Nicholas Barnes, Jayanta Chatterjee, Daniel Gallacher andSteven Marwaha

Papers526 Young adult mental health and functional outcomes

among individuals with remitted, persistent and late-onset ADHDJessica C. Agnew-Blais, Guilherme V. Polanczyk, Andrea Danese,Jasmin Wertz, Terrie E. Moffitt and Louise Arseneault

534 On Worry – psychiatry in literatureAruna Rose Mary Kapanee

535 Use of schizophrenia and bipolar disorder polygenic risk scoresto identify psychotic disordersMaria Stella Calafato, Johan H. Thygesen, Siri Ranlund, EiriniZartaloudi, Wiepke Cahn, Benedicto Crespo-Facorro, Álvaro Díez-Revuelta, Marta Di Forti, Genetic Risk and Outcome of Psychosis(GROUP) consortium*, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky,Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Kuang Lin, ColmMcDonald, Andrew M. McIntosh, Andrew McQuillin, PsychosisEndophenotypes International Consortium (PEIC)*, Marco Picchioni,Dan Rujescu, Madiha Shaikh, Timothea Toulopoulou, Jim Van Os,Evangelos Vassos, Muriel Walshe, John Powell, Cathryn M. Lewis,Robin M. Murray, Elvira Bramon and Wellcome Trust Case ControlConsortium 2 (WTCCC2)

542 Stratification of the risk of bipolar disorder recurrences inpregnancy and postpartumArianna Di Florio, Katherine Gordon-Smith, Liz Forty, Michael R.Kosorok, Christine Fraser, Amy Perry, Andrew Bethell, Nick Craddock,Lisa Jones and Ian Jones

548 Fractional anisotropy of the uncinate fasciculus and cingulumin bipolar disorder type I, type II, unaffected siblings andhealthy controlsSonya F. Foley, Matthew Bracher-Smith, Katherine E. Tansey, Judith R.Harrison, Greg D. Parker and Xavier Caseras

555 Attention-deficit hyperactivity disorder and anxiety disordersas precursors of bipolar disorder onset in adulthoodSandra M. Meier, Barbara Pavlova, Søren Dalsgaard, MereteNordentoft, Ole Mors, Preben B.Mortensen and Rudolf Uher

Columns561 Corrigendum562 Book Reviews567 Contents of the American Journal of Psychiatry567 Contents of BJPsych Advances568 Kaleidoscope569 From The Editor’s Desk

Cover pictureHouse of Artists. The painted facade of theHouse of Artists, nowadays part of the ArtBrut Centre Gugging in Maria Gugging,Austria, is a unique artwork and historic tes-timony at the same time. On the formergrounds of a psychiatric hospital, itemerged as a special living space for its art-istically talented inhabitants, later to be wellknown in the art world as the group ofGugging Artists. For example artists likeJohann Hauser, Oswald Tschirtner orAugust Walla immortalized themselves art-istically through painting in bright colours on the surface of the walls of the for-mer hospital building. Founded as the “Centre for Art and Psychotherapy“ in1981 by the psychiatrist Leo Navratil, the institution was developed furtherby Navratil´s successor Johann Feilacher. Feilacher initiated in 1983 the paint-ing of the facade by the group of Gugging Artists – a powerful signal to theworld outside, as well as to the inhabitants of the centre. By changing thename to the title “House of Artists“ in 1986 a new orientation for the futurewas given: Hierarchical structures from the former psychiatric hospital andold labels like “patient“ were erased. Today, 13 persons are living in theHouse of Artists and its murals are still an artwork in progress – the paintingcontinues. For further information please visit: www.gugging.org. Creditline:East facade House of Artists, Maria Gugging, Photograph: Johann Feilacher.

We are always looking for interesting and visually appealing images for thecover of the Journal and would welcome suggestions or pictures, whichshould be sent to Dr Allan Beveridge, British Journal of Psychiatry, 21Prescot Street London E1 8BB, UK or bjp@rcpsych.ac.uk.

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