Seminar Series – Week Commencing 4 November 2019

Name of Presenter Title of Presentation Date Time Venue Further

Information Seminar Series

Frontiers in Cancer Science - Singapore

4 – 6 November 2019 Frontiers in Cancer Science – Singapore

11th Annual Conference: – Converging the latest cancer discoveries around the world, FCS 2019 promises ground-breaking and innovative insights into cancer research. Join them to learn from the foremost cancer experts as they share their newest findings.

Keynote speaker Sir Gregory Winter Cambridge University & Various international speakers

CLICK HERE

FCS 2019

For further information and to register:

FCS2019

2019 Child Health Symposium Keynote Speakers: Prof Lyn Beazley & Prof Tobias Kollman

Save the Date 6 - 8 November 2019 Plus:

Breakfast Sessions See program updates at:

Poster Evening Event Child Health Symposium 2019

CLICK HERE

PROGRAM BOOKLET

CLICK HERE

BREAKFAST SESSIONS

REGISTRATION

Telethon Kids Institute Government of Western

Australia – Child & Adolescent Health Service

Perth Children’s Hospital Foundation

Professor Greg Goodall RNA biology snapshots: (1) a microRNA controlling neuroendocrine differentiation and neuroblastoma; (2) formation and export of circular RNAs

7 November 2019 12pm – 1pm McCusker Auditorium, Harry Perkins Institute of Medical Research, Nedlands Campus

CLICK HERE

Perkins Seminar Series

Marianne Costa, UWA Studies on the biosynthesis of the antibiotic gladiolin from Burkholderia gladioli

7 November 2019 12 noon Bayliss Building Lecture Theatre G33 CLICK

HERE

The Bayliss Seminar Series

UPCOMING SEMINARS

Florian Busch, ANU

Photorespiration in the context of metabolism and anatomy

11 November 2019 12 noon Bayliss Building Lecture Theatre G33

CLICK HERE

The Bayliss Seminar Series

Accelerating Child Health Research Distinguished Speakers include: Prof Bob Hancock Prof Scott Tebbutt Prof Jianguo (Jeff) Xia Prof Peter Gething Prof Pinaki Panigrahi

11 – 13 November 2019 - A Systems Biology Symposium Save the Date

Symposium Themes: Precision Health - Multi-omics applications - Systems epidemiology - Data integration & visualization Mon – Tues: - Speakers presentations Wed: - Interactive data workshops (numbers are limited)

Enquiries: mitali.manzur@telethonkids.org.au Abstract Submissions: Respiratory.research.centre@telethonkids.org.au (limited numbers selected, 300 word limit)

CLICK HERE

Respiratory Research Centre &

Centre for Personalised Medicine for Children

Pawsey Training on Scientific Workflow Tools Nextflow lead developers: Paolo Di Tommaso & Evan Floden

11 – 14 November 2019 Nextflow Workshop and Hackathon at Pawsey: Comprehensive Nextflow Training: from Basics to Real User Cases

Watch this video to know what to expect during this session: https://www.youtube.com/watch?v=LG8Bwc69c58&feature=youtu.be

• Two days of workshop introduce the basic concepts and syntax of Nextflow • Two days of hackathon enable participants to apply Nextflow to a pipeline of their choice • By the end of the event, participants can confidently develop and deploy their own workflows using NextFlow, seeing increases in portability, reproducibility and scalability

CLICK LINK

Nextflow

Workshop Pawsey

Pawsey Supercomputing Centre

Registration essential – places limited:

Nextflow Workshop Pawsey (Discounted early-birds rates are

available through October 18)

9 Barossa Meeting - Cell Signalling in Cancer Medicine Various International & National Speakers

12 – 15 November 2019 Conference Themes: Angiogenesis, apoptosis, cancer therapeutics, carcinogenesis, epithelial-mesenchymal transition, cancer genomics, immunotherapy, lipid signaling, metabolism, signaling networks, stem cells, translational medicine, tumour microenvironment, cellular plasticity/heterogeneity, therapy resistance

CLICK HERE

Centre for Cancer Biology

A/Prof Rabindra Tirouvanziam

Mechanisms of inflammatory airway disease in cystic fibrosis: from models to patients

13 November 2019 12pm – 1pm Telethon Kids Institute Seminar Room Level 5, Perth Children’s Hospital

CLICK HERE

Telethon Kids Research Seminars

Raine Prof Mary Wlodek

Critical periods and lifestyle interventions programming development disease risk

14 November 2019 12pm – 1pm Bayliss Building Lecture Theatre G33

CLICK HERE

The Bayliss Seminar Series

Dr Shirley McGough, Curtin Uni

Qualitative Research Methods 15 November 2019 12.30pm – 1.30pm Perth Children’s Hospital, Level 5, PCH Auditorium

CLICK LINK

Qualitative Research Methods

Research Skills Seminar Series Research Education Program

Contact: researcheducationprogram@health.w

a.gov.au

Mr Michael Phillips Development and evaluation of an artificial intelligence (AI) algorithm to detect malignant melanoma in smartphone images

15 November 2019 3pm 4th Floor Seminar Room, MRF Building, Rear 50 Murray Street, Perth

CLICK HERE

RPH Medical Research Forum Seminar Series 2019

Dr Kirsty Short Influenza in chronic disease patients: understanding the fundamentals to improve patient care

20 November 2019 12pm – 1pm Telethon Kids Institute Seminar Room Level 5, Perth Children’s Hospital

CLICK HERE

Telethon Kids Research Seminars

Prof W. Murray Thomson Editor-in-Chief - Community Dentistry and Oral Epidemiology, Assoc Editor - European Journal of Oral Sciences

Poor oral health casts a long shadow: findings from the Dunedin Study

20 November 2019 6pm Kenneth JG Sutherland Lecture Theatre, UWA Dental School, 17 Monash Ave, Nedlands

CLICK HERE

AJ Herman Fellowship Lecture UWA Dental School

RSVP mandatory by 5pm Tuesday 12

November: Events-dent-ohcwa@uwa.edu.au

Australian Society for Medical Research National Scientific Conference

20 - 21 November 2019 - ASMR NSC 2019 Ebbs and Flows - From Discovery to Practice

Featuring:- Firkin Orator, Prof Daniel Drucker, Lunenfeld-Tanenbaum Research Institute, Toronto Edwards Orator, Prof Christobel Saunders AO, UWA & Royal Perth Hospital

For more information about registration & abstracts please click below: ASMR NSC 2019 Registration & Abstract

(Abstract submission deadline extended until 6 October 2019)

CLICK HERE

WA Maritime Museum Victoria Quay, Peter Hughes Dr,

Fremantle WA 6160

Maritime Museum Website http://museum.wa.gov.au/museums/

maritime/

A/Prof Sue Skull (CAHS)

Ethics Processes for Clinical Research in WA

22 November 2019 12.30 – 1.30pm Perth Children’s Hospital, Level 5, PCH Auditorium

CLICK LINK

Ethics Processes

Research Skills Seminar Series Research Education Program

Contact: researcheducationprogram@health.

wa.gov.au

Dr Christopher Minson Kenneth and Kenda Singer Professor

Heat therapy: An ancient practice to target modern diseases

27 November 2019 1pm John Bloomfield Lecture Theatre, UWA School of Human Sciences adjacent to Parkway Entrance 3.

Google Map Link Here

CLICK HERE

School of Human Sciences Seminar Series

Dr Riccardo Natoli, ANU

Blinded by the light: the role of miRNA in light induced retinal degenerations

28 November 2019 3pm Sarich Neuroscience Research Institute Building, Bryant Stokes Seminar Room, Ground Floor

CLICK HERE

The Bryant Stokes Neuroscience Seminar Series

The 6th Annual EMBL Australia Postgraduate Symposium (EAPS19)

27 – 29 November 2019 EAPS19 - From Models to Systems Deciphering Biological Complexity

Registrations Open – 10 June 2019 Registrations Close - 1 November 2019 Abstract Submissions Close – 6 September 2019

Meet interstate and international speakers and researches from various disciplines. Invited speakers:- Prof Christine Wells, (Uni Melbourne) Prof Nadia Rosenthal, (Jackson Laboratories USA) Dr Damien Bates, BioCurate Dr Chris Langmead, Monash Inst. of Pharmaceutical Sciences Dr Talitha Santini, UWA Dr Irene Gallego Romero, Uni Melbourne Prof Matt Sweet, Inst. of Molecular Bioscience, UQ Prof. Ricky W. Johnstone, Peter MacCallum Cancer Centre A/Prof Enzo Porrello, Murdoch Children’s Research Inst.

CLICK HERE

Victorian Comprehensive Cancer Centre, Melbourne

For more information & to register:

EAPS19

A/Prof Jasper Schipperijn

Changing the Built Environment changes children’s behavior

2 December 2019 3pm – 4pm Telethon Kids Institute Seminar Room Level 5, Perth Children’s Hospital

CLICK HERE

Telethon Kids Research Seminars

Nicole Sheers Airway clearance techniques: why, what, and when? A clinician-researcher’s approach

3 December 2019 12pm – 1pm The Conference Room, The Niche. 11 Aberdare Road, Nedlands

CLICK HERE

Telethon Kids Research Seminars

2020 SEMINARS

Mixomics Instructor: Dr Kim-Anh Lê Cao

3-5 February – Mixomics Beginner workshop for microbiome-omics data analysis More details on the attached flyer, we also have made a 50 min webinar available to present the different methods and their application: http://mixomics.org/2019/09/webinar-mixomics-in-50-minutes/

Four RHD student bursaries to cover 50% of the registration costs are generously supported by WAHTN. Register your interest here: Mixomics

CLICK HERE

WAHTN/WAHMCC

Human Genome Meeting 2020

5 – 8 April 2020 Perth Convention & Exhibition Centre Abstracts for the 24th Annual Human Genome Meeting in either Oral Presentation or Poster Presentation are invited - please submit to: HGM 2020 Abstracts Submission – Oral Abstract Submissions close Friday 10 January Midnight AWST Poster Abstract Submissions close Friday 7 February Midnight AWST

CLICK LINK

Registration

HUGO HGM 2020

GAP 2020 - Global Academic Programs

11 -13 May 2020 MD Anderson Cancer Center Global Academic Programs is coming to Australia

Call for Abstracts is now open - Registration open 1 September 2019 - Sponsorship opportunities available

CLICK HERE

GAP 2020

To Register and for Abstract Submissions:

www.gap2020.com.au

Program Booklet 6-8 November 2019

Please check the webpage for any final updates to the program: pch.health.wa.gov.au/childhealthsymposium

2019 Child Health Symposium Full Program

Wednesday 6 November

7:30am - 9:00am Breakfast Session 'Putting the ‘I’ in research' facilitated by the Consumer and Community Health Research Network (CCHRN) of WAHTN.

The Manda, Level 6, Telethon Kids Institute

10:00am - 10:30am Morning Tea and Event Registration Foyer PCH Auditorium, Level 5

10:30am - 12:00pm Symposium Official Opening Plenary Speaker Session: Professor Lyn Beazley

PCH Auditorium, Level 5

12:00pm - 1:00pm Lunch Collegiate Lounge, Level 5

1:00pm - 2:30pm Concurrent Oral Presentations: Research presentations with clinical and research updates

• Prevalence of chronic wet cough and PBB in Aboriginal children Andre Schultz, CAHS Respiratory Medicine Consultant

• Penicillin allergy SHACK Study; Survey of Hospital and Community Knowledge Katherine Collins, CAHS Innovation and Improvement Unit

• Structural changes on chest computed tomography in children with cerebral palsy Katherine Langdon, CAHS Paediatric Rehabilitation Consultant

• The Role of Community Mothers in the Kwinana and Cockburn Communities Ailsa Munns, Curtin University

• ActivRett: Parent and therapist perspectives on 'uptime' activities in Rett syndrome Nick Buckley, Telethon Kids Institute

PCH Auditorium, Level 5

• RCT of a pre-emptive intervention for infants showing early signs of autism Kandice Varcin, Telethon Kids Institute

• Bacterial reservoirs in the middle ear of otitis-prone children are associated with repeat ventilation tube insertion Elke Seppanen, Telethon Kids Institute

• Child-parent screening for familial hypercholesterolaemia Andrew Martin, CAHS General Paediatrics Consultant

• Planning and Promoting Adolescent & Young Adult Services (PAPAYAS) - The transition process and experience in Perth, WA Kelsey Gill, WA Department of Health

• The effects of hypoxia and exercise in individuals with type 1 diabetes Cory Dugan, University of Western Australia

Telethon Kids Seminar Room, Level 5

2:30pm - 3:00pm Afternoon Tea Collegiate Lounge, Level 5

3:00pm - 4:30pm Future Clinical Scientific at PCH: RACP WA State Paediatric Training Research Award

The Advanced trainee program culminates with a project oral presentation. These presenters are on their way to be consultants and clinical scientists of the future at CAHS. • Health profile of Syrian and Iraqi refugee children upon arrival

to Western Australia: physical, psychosocial, developmental and educational complexity, Kristen Lindsay

PCH Auditorium, Level 5

2019 Child Health Symposium Full Program

• Review of systemic to pulmonary shunts: A seventeen year experience at a tertiary paediatric hospital, Giulia Peacock

• Enterobacteriaceae sepsis in young infants-trends, resistance and outcomes in Western Australia, Aleisha Anderson

• Respiratory health inequality starts early: The impact of social determinants on the aetiology and severity of bronchiolitis in infancy, David Foley

• Tertiary staff utilisation of interpreters for families with limited English proficiency, Sam Brophy-Williams

• The impact of CGM availability: real world data from a population based clinic, Elaine Sanderson

Wednesday 6 November – Evening Session

4:30pm – 7.00pm Research Poster Session and Networking Meet the people behind the research who have posters on display

Clinical Research Pathways at CAHS – meet the researchers an event for prospective clinical trainees and researchers

Collegiate Lounge, Level 5

‘Pitch your Research’ Consumer Involvement Session A short oral presentation by the researchers, followed by feedback from consumer and community members in attendance. (registration from 5pm, presentations from 6-7pm)

Feasibility of a targeted exercise intervention to improve bone health in youth Paolo Chivers, CAHS Allied Health

Poorer perinatal outcomes for mothers with intellectual disability and their infants Jenny Fairthorne, Telethon Kids Institute

The impact of new universal child influenza programs in Australia Chris Blyth, CAHS Infectious Diseases Consultant

Does early oral Vitamin D supplementation and UV-light exposure have an impact on allergic disease outcome in infancy? Kristina Rueter, CAHS Immunology Consultant

Rapid diagnosis of rare genetic disease in paediatric patients Vanessa Fear, Telethon Kids Institute

PCH Auditorium, Level 5

2019 Child Health Symposium Full Program

Thursday 7 November

7:30am - 9:00am Breakfast Session Utilising social media in research, Dr Kenneth Lee

The Manda, Level 6, Telethon Kids Institute

10:00am - 10:30am Morning Tea Collegiate Lounge, Level 5

10:30am - 11:10am The Aboriginal Health 1,000 Families Grand Challenge Presented by Glenn Pearson, Deputy Director, Aboriginal Health, Telethon Kids Institute

PCH Auditorium, Level 5

11:10am - 12:00pm

Lightning Talks (3 minute research presentations)

• Diffuse Excessive High Signal Intensity (DEHSI) on Term Equivalent MRI to Predict Disability in Preterm Infants: A Systematic Review and Meta-Analysis Saumil Desai, CAHS Neonatal Unit

• Managing respiratory disease in children with cerebral palsy: Systematic review Marie Blackmore, Ability Centre

• Exploring the experiences of public sector secondary school nurses who encounter young people with mental health problems Anita Moyes, CACH Clinical Nurse Specialist, Mental Health

• The Prevalence and Profile of Adolescents with Pre- versus Post-Puberty Onset of Gender Non-Conforming Behaviours: Perspectives from the GENTLE Cohort Cati Thomas, CAHS Gender Diversity Service

• Cardiovascular testing detects latent dysfunction in childhood leukaemia survivors Treya Long, CAHS Burns Unit

• Developing a frontline treatment for neonatal sepsis Breanna Knight, Telethon Kids Institute

• The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis Gail Alvares, Telethon Kids Institute

• Yarning with community in support of research Valerie Swift, Telethon Kids Institute

• Spatial clustering of notified tuberculosis in Ethiopia: a nationwide study Kefyalew Addis Alene, Organ, Telethon Kids Institute

• Defective Cystic Fibrosis Epithelia May Not Induce Airway Neutrophil Reprogramming Samantha A McLean, Telethon Kids Institute

• Nephrotic Syndrome: An Update on Epidemiology and Changing Trends in Western Australia Nadia Tan, CAHS Paediatrics Resident Medical Officer

PCH Auditorium, Level 5

12:00pm - 1:00pm Lunch Collegiate Lounge, Level 5

1:00pm - 2:00pm

Global Perspectives in Child Health • Who dies, where and why? Professor Tobi Kollmann, Head

Systems Vaccinology, Telethon Kids Institute • Infection, inflammation, and vaccine alternatives Professor

Pinaki Panigrahi, Georgetown University • Geospatial analysis in the global fight against malaria

Professor Peter Gething, Kerry M Stokes Chair of Child Health, Telethon Kids Institute & Curtin University

PCH Auditorium, Level 5

2019 Child Health Symposium Full Program

2:00pm - 3:00pm

Lightning Talks (3 minute research presentations) • Child Development Services Evaluation & Redesign: Optimising

Family Centred Practice Martyn Symons, Telethon Kids Institute • Lumbar Punctures in 'Fever without Source' infants at Perth

Children's Hospital Ruby Osman-Mulrany and Kirby Rex, Notre Dame University Medical School

• Catching up kids with cochlear implants Anita Campbell, CAHS Infectious Diseases

• Development of a causal model of pulmonary exacerbations of cystic fibrosis Yue Wu, Telethon Kids Institute

• Repeat maternal Tdap-vaccination does not enhance infant immune-interference Sonia McAlister, Telethon Kids Institute

• Risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy Minda Sarna, Curtin University School of Public Health

• Reducing Vancomycin associated nephrotoxicity in children Megan Nettleton, CAHS Child Development Service

• Defective epithelial cell repair in the upper and lower asthmatic airways Thomas Iosifidis, Telethon Kids Institute

• The effect of body composition on the accuracy of continuous glucose monitoring Claire Lim, CAHS Diabetes and Endocrinology

• Treatment Outcomes for a Day Program for Adolescent Borderline Personality Disorder Kevin Runions, CAHS Mental Health

• CARS (Clinician Automotive Registry by Subspecialisation) review Jikol Friend, CAHS Surgery

• Early versus late parenteral nutrition for critically ill term and late preterm infants: Cochrane Review Kwi Moon, CAHS Pharmacy

PCH Auditorium, Level 5

3:00pm - 3:30pm Afternoon Tea Collegiate Lounge, Level 5

3:30pm - 5:00pm

Concurrent Oral Presentations: Research presentations with clinical and research updates • CHK Kinase Inhibition Amplifies the Effects of Chemotherapy in

Pineoblastoma Jessica Buck, Telethon Kids Institute • Evidence from practice: Evaluation of A Therapeutic Day Program

in CAMHS Rosemary Skinner, CAMHS Family Pathways • Disease-specific bone changes in youth at risk of secondary

osteoporosis Kiranjit Joshi, Paediatrics - Diabetes and Endocrinology The Role of Primary Care in Transitioning Adolescents to Adult Health Services Rachel Wixon, CAHS Graduate Officer PROTECT: IV pentoxifylline in premature neonates with late-onset sepsis Amy Stenning, CAHS Neonatal Unit

PCH Auditorium, Level 5

• Immunisation Status in Children with Down Syndrome in WA Hannah Barnett, Notre Dame University Medical School

• Developmental-behavioural and psychosocial comorbidities within a Child Development Service cohort Ariel Mace, CAHS General Paediatrics Consultant

• Saliva for assessing vitamin A status in extremely preterm infants: a diagnostic study Abhijeet Rakshasbhuvankar, CAHS Neonatal Unit

• Applying knowledge translation to tailor therapy services to address consumer needs Jodie Armstrong, CAHS Community Health

• Kupi - Drinking water and chronic disease Christine Jeffries-Stokes, CAHS Medical Services Consultant

Telethon Kids Seminar Room, Level 5

2019 Child Health Symposium Full Program

Friday 8 November

7:30am - 9:00am Breakfast Session Assessing pragmatism in Randomised Controlled Trials using PRECIS 2 with Julie Marsh and Prof Merrick Zwarenstein

The Manda, Level 6, Telethon Kids Institute

10:00am - 10:30am Morning Tea Special event for Allied Health Week Collegiate Lounge, Level 5

10:30am - 12:00pm

High Value Health Care empowered research Hosted by Dr Aresh Anwar, CAHS Chief Executive Value-based healthcare is about ensuring patients get the right care at the right time in the right setting. It also involves helping patients avoid unnecessary care, which can reduce harm caused by over-testing and over-diagnosis. Ensuring we investigate where we can improve the system and outcomes is an important step in achieving this. • Evolution of the Peripherally Inserted Central Catheter (PICC)

service Neil Hauser, CAHS Anaesthesia Consultant • Audit of ferric carboxymaltose use and safety in 144 cases at

Perth Children's Hospital Claire Mitchell, CAHS Pharmacy • Intravenous pentoxifylline is safe in preterm infants with sepsis

or NEC Simone Schueller, CAHS Neonatal Unit • Children with bronchiolitis: Choosing Wisely Luke Campbell,

Notre Dame University Medical School • Optimising infection prevention in at-risk children without a

spleen Vanessa Verissimo, CAHS General Paediatrics

PCH Auditorium, Level 5

12:00pm - 1:00pm Campus research initiatives, plus symposium awards announcements and closing

PCH Auditorium, Level 5

1:00pm - 2:00pm Lunch Collegiate Lounge, Level 5

Acknowledging CAHS Allied Health staff during Allied Health Week.

Breakfast sessions 7.30 to 9.00am, The Manda, Level 6 Telethon Kids Institute

Wednesday 6 November: Putting the 'I' in Research

This interactive Breakfast Session facilitated by the Consumer and Community Health Research Network (CCHRN) of WAHTN will provide an opportunity to see what consumer and community ‘involvement’ looks like across all realms of the research spectrum. Bringing together researchers, consumers, community members and advocates this session will allow discussion on the practical processes, outcomes and ideas of involving consumers and community members in research and how to obtain great outcomes for all.

Register Now for Wednesday Breakfast Session

Thursday 7 November: Utilising social media for research studies

Join Dr Kenneth Lee for this session to find out how he has successfully used social media platforms to recruit and study how patients and health professionals digest health-related information. During this session he will share his tips and challenges for using this platform for health research.

Register Now for Thursday Breakfast Session

Friday 8 November: Assessing pragmatism in Randomised Controlled Trials using PRECIS 2

Join international expert Professor Merrick Zwarenstein to find out how to best design your trial to cover the myriad of variables that impact your end data. PRECIS is a tool to help trialists make design decisions consistent with the intended purpose of their trial. PRECIS-2 provides a valuable tool to support clinical researchers in the best possible trial design.

Register Now for Friday Breakfast Session

After graduate studies at the University of Adelaide in enzymology and protein chemistry, Greg Goodall undertook postdoctoral

training at the Roche Institute of Molecular Biology in New Jersey, USA. Subsequently moving to Switzerland to work with Witold Filipowicz at the Friedrich Miescher Institute, he embraced the world of RNA and post-transcriptional mechanisms of gene regulation, and has continued in this research field since returning to Adelaide where he is now a Section Leader in the Centre for Cancer Biology, SA Pathology, co-Director of the Centre for Cancer Biology’s ACRF Cancer Genomics Facility. His recent work has been on microRNAs and circular RNAs involved in cell invasion, epithelial to mesenchymal transition, and cancer metastasis. Abstract (1) The miR-200 family of microRNAs are well known to control EMT and to inhibit migration and invasion of breast and prostate cancers. However, our recent experiments indicate that miR-200 acts as a regulator of sympathethic neuron and chromaffin cell differentiation, and as a tumour suppressor in the neuroblasts that can give rise to neuroblastoma. I will descibe the regulatory pathway involved. (2) I will discuss mechanisms controlling specific circRNA formation in epithelial and mesenchymal cells, and the mechanism by which circRNAs are exported from the nucleus.

12:00noon till 1:00pm For more information, please contact Louise Winteringham on

louise.winterignham@perkins.org.au Followed by a light lunch sponsored by GenScript

McCUSKER AUDITORIUM, HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH, NORTH CAMPUS

Professor Greg Goodall Head, Gene Regulation Section University of South Australia

"RNA biology snapshots: (1) a microRNA controlling neuroendocrine differentiation and neuroblastoma; (2) formation and export of circular RNAs"

THURSDAY 7 NOVEMBER 2019

THE BAYLISS SEMINAR SERIES

Presenter: Marianne Costa – UWA

Title: Studies on the biosynthesis of the antibiotic gladiolin from Burkholderia gladioli

Date: Thursday 7 November 2019 @ 12 noon

Venue: Bayliss Building Lecture Theatre G33

If you have suggestions for speakers, please contact our seminar coordinators Nicole Smith nicole.smith@uwa.edu.au and Heng Chooi yitheng.chooi@uwa.edu.au with the details and to make arrangements for an invitation.

THE BAYLISS SEMINAR SERIES

Presenter: Florian Busch – ANU

Title: Photorespiration in the context of metabolism and anatomy

Date: Monday 11 November 2019 @ 12 noon

Venue: Bayliss Building Lecture Theatre G33

If you have suggestions for speakers, please contact our seminar coordinators Nicole Smith nicole.smith@uwa.edu.au and Heng Chooi yitheng.chooi@uwa.edu.au with the details and to make arrangements for an invitation.

Accelerating Child Health Research A Systems Biology Symposium

Co-hosted by The Respiratory Research Centre & The Centre for Personalised Medicine for Children

11-13 November 2019

Auditorium, Perth Children’s Hospital

Monday & Tuesday: Speaker Presentations

Wednesday: Interactive Data Workshops (numbers are limited)

ABSTRACT SUBMISSIONSA limited number of oral presentations will be selected from submitted abstracts.

We strongly encourage early and mid career researchers to apply. If you wish to be considered, please submit your abstract (300 word limit)

respiratory.research.centre@telethonkids.org.au. Please note there will be no poster presentations at the Symposium.

Prof. Bob Hancock Canada Research Chair in Health and Genomics; Director, Centre for Microbial Diseases and Immunity Research, University of British Columbia

Prof. Scott Tebbutt Division of Respiratory Medicine, University of British Columbia; Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver

Prof. Jianguo (Jeff) Xia Canada Research Chair in Bioinformatics and Big Data Analytics, McGill University, Canada

Prof. Peter Gething Kerry M Stokes Chair of Child Health, Telethon Kids Institute & Curtin University; Professor of Epidemiology, The Big Data Institute, University of Oxford

Prof. Jaap GoudsmitChief Scientific Officer, Human Vaccines Project; Prof. of Epidemiology, Harvard T.H. Chan School of Public Health; University of Amsterdam.

SYMPOSIUM THEMES

DISTINGUISHED SPEAKERS INCLUDE

THE RESPIRATORY RESEARCH CENTRE

Precision health

Multi-omics applications

Data integration & visualisation

Systems epidemiology

Enquiries:

Alex Beesley alex.beesley@telethonkids.org.auMitali Manzur mitali.manzur@telethonkids.org.au

REGISTER NOW

Cell Signalling in Cancer Medicine

International Speakers

Organising Committee

Program Committee

Centre forCancer Biology

International Advisory Committee Vishva Dixit, Richard Flavell, Wanjin Hong, Tony Hunter, Joseph Schlessinger, John D Scott

Program updates www.centreforcancerbiology.org.au

Yeesim Khew-Goodall and Stuart Pitson (Co-Convenors), Claudine Bonder, Angel Lopez, Michael Samuel, Hamish Scott

Claudine Bonder, Cameron Bracken, Susan Branford, Anna Brown, Michael Brown, Richard D’Andrea, Loretta Dorstyn, Guillermo Gomez,Phillip Gregory, Chris Hahn, Natasha Harvey, Sharad Kumar, Angel Lopez, Stuart Pitson, Jason Powell, Paul Reynolds, Nirmal Robinson, David Ross, Michael Samuel, Andreas Schreiber, Quenten Schwarz, Hamish Scott, Vinay Tergaonkar, Damon Tumes

Ivan Dikic Goethe University School of Medicine, Frankfurt, Germany Lucy Godley University of Chicago, IL, USA

Ming Lei Shanghai Jiao Tong University School of Medicine, China Shiva Malek Genentech, CA, USA

Madelon Maurice University Medical Center, Utrecht, Netherlands Gerry Melino University of Cambridge, UK

Erik Sahai Francis Crick Institute, London, UKTuomas Tammela Memorial Sloan Kettering Cancer Center, NY, USA

Wee Wei Tee Institute of Molecular and Cell Biology, SingaporeKaren Vousden Francis Crick Institute, London, UK

Conference Themes Angiogenesis, apoptosis, cancer therapeutics, carcinogenesis, epithelial-mesenchymaltransition, cancer genomics, immunotherapy, lipid signalling, metabolism, signalling networks, stem cells,translational medicine, tumour microenvironment, cellular plasticity / heterogeneity, therapy resistance

Marie-Liesse Assalin-Labat Walter and Eliza Hall Institute, VICKate Burbury Peter MacCallum Cancer Centre,VIC

Lisa Butler University of Adelaide, SAHMRI, SAThomas Cox Garvan Institute of Medical Research, NSW

Sarah-Jane Dawson Peter MacCallum Cancer Centre,VICCharley de Bock Children’s Cancer Institute, NSW

Paul Ekert Children’s Cancer Institute, NSWDavid Komander Walter and Eliza Hall Institute, VIC

Steven Lane QIMR Berghofer, QLDFabienne Mackay University of Melbourne, VIC

Marina Pajic Garvan Institute of Medical Research, NSWBelinda Parker Peter MacCallum Cancer Centre,VIC

Clare Scott Walter and Eliza Hall Institute, VICDaniel Thomas SAHMRI, University of Adelaide, SAPaul Timpson Garvan Institute of Medical Research, NSW

Anne Voss Walter and Eliza Hall Institute, VICVi Wickramasinghe Peter MacCallum Cancer Centre,VIC

Alpha Yap Institute of Molecular Bioscience, UQ, QLD

National Speakers

Registration and Abstract submission deadline extended to 30 September 2019- slots still available for selected abstract talks

Telethon Kids

Research Seminars

Wednesday 13 November 2019

12pm – 1pm

Telethon Kids Institute Seminar Room

Level 5, Perth Children’s Hospital

A light lunch will be provided at 11.45am

for those attending the seminar

Invited Guest Speaker

A/Prof Rabindra Tirouvanziam

Department of Pediatrics

Emory University School of Medicine

Center for CF and Airways Disease Research

Children’s Healthcare of Atlanta

Rabindra Tirouvanziam earned his engineering degree in Biotechnology at the Paris Institute of Technologyfor Life, Food and Environmental Sciences (Agro-Paris Tech, France) in 1994 and his PhD in DevelopmentalBiology, Lung Physiology and Immunology at the College de France and CNRS (Paris, France) in 1998. He thentrained as a Postdoctoral Fellow (1999-2004), Research Associate (2004-2008) and Instructor (2008-2011) atStanford University (CA, USA). He joined Emory University as faculty in the Department of Pediatrics andmember of the Immunology and Molecular Pathogenesis graduate program in 2011.

Research in his laboratory includes patient- and model-based studies of lung diseases such as cystic fibrosis(CF), chronic obstructive pulmonary disease (COPD), asthma, as well as other disease conditions, suchas malaria and bullous pemphigoid. The laboratory emphasizes sample analysis from patients and animalmodels using direct, high-content analyses by flow / image cytometry (for cells), proteomicsand metabolomics (for fluids) to study immunometabolic pathways and their relation to disease. Fundingsources include DARPA (PREPARE program), NIH/NHLBI, NHMRC, and the US CF Foundation.

A major contribution made by the laboratory is the discovery of a new fate of human neutrophils afterrecruitment to the airway lumen, with significant reopening of the chromatin, de novogene expression, regulatory functions toward epithelial cells, macrophages, and T-cells, and high avidity forextracellular particles (including viruses), opening critical avenues for therapeutic targeting. Following this invivo discovery, the Tirouvanziam laboratory developed an in vitro model of airway transmigration which fullyrecapitulates this new fate of human airway neutrophils and enables to mass-produce them and target them invitro.

Mechanisms of inflammatory airway disease in cystic fibrosis:

from models to patients

Streaming link : click herePassword telethonkids_seminar

THE BAYLISS SEMINAR SERIES

Presenter: Raine Professor Mary Wlodek

Title: Critical periods and lifestyle interventions programming development disease risk

Date: Friday 14 November 2019 @ 12pm – 1pm

Venue: Bayliss Building Lecture Theatre G33

If you have suggestions for speakers, please contact our seminar coordinators Nicole Smith nicole.smith@uwa.edu.au and Heng Chooi yitheng.chooi@uwa.edu.au with the details and to make arrangements for an invitation.

LIGHT REFRESHMENTS WILL BE SERVED IMMEDIATELY FOLLOWING THE PRESENTATION

RPH MEDICAL RESEARCH

FORUM

Seminar Series 2019

4th Floor Seminar Room Medical Research Foundation Building Rear 50 Murray St, Perth WA 6000 Friday @ 3pm Enquiries: W/Prof Markus Schlaich Ph: 08 9224 0382 E: markus.schlaich@uwa.edu.au

TIME: FRIDAY, 15 NOVEMBER 2019 @ 3pm VENUE: 4th Floor Seminar Room, MRF Building, Rear 50 Murray Street, Perth PRESENTER: Mr Michael Phillips TITLE: “Development and evaluation of an artificial intelligence (AI) algorithm

to detect malignant melanoma in smartphone images”

Born and grew up in old South Wales, Michael was educated at the University of London (B.Sc. Hons. I) and later the University of Nottingham Medical School (M.Med.Sci.). He became a political refugee when UK declared war on Argentina and moved to Western Australia. After too long teaching research methods and statistics to UG and PG students he became a biostatistician at WAIMR and later added RPH where he set up the MRF Biostatistics unit. With authorship of almost 600 publications and about 6,000 citations he has started to reduce his working time and increase holiday and gardening time.

Telethon Kids

Research Seminars

Wednesday 20 November 2019

12pm – 1pm

Telethon Kids Institute Seminar Room

Level 5, Perth Children’s Hospital

A light lunch will be provided at 11.45am

for those attending the seminar

Invited Guest Speaker

Dr Kirsty Short

ARC DECRA Research Fellow

School of Chemistry and Molecular Biosciences

The University of Queensland

Dr. Kirsty Short is an ARC DECRA research fellow at the School of Chemistry andMolecular Biosciences, The University of Queensland. She completed a PhD in 2013 atthe Department of Microbiology and Immunology at the University of Melbourne. In2013 she was also awarded an NHMRC CJ Martin Early Career Fellowship to go to theNetherlands to work in the Department of Virosciences at Erasmus Medical Centre.She returned to Australia at the end of 2015 to work at the University of Queensland.In 2017 she established her own independent research group studying influenza viruspathogenesis. Her group works on many different aspects of the influenza includinghow the influenza virus affects different animal species, the role of the immune systemin severe influenza virus infections and the interactions between severe influenza andchronic medical conditions such as diabetes and obesity.

Influenza in chronic disease patients: understanding the fundamentals to improve patient care

Streaming link : click herePassword telethonkids_seminar

PROFESSOR W. MURRAY THOMSON

AJ HERMAN FELLOWSHIP LECTURE

The UWA Dental School is delighted to host Professor W. Murray Thomson as the 2019 AJ Herman Fellowship Lecturer. Professor Thomson is an experienced dental researcher and specialist in dental public health. He is Editor-in-Chief of Community Dentistry and Oral Epidemiology,

and Associate Editor for the European Journal of Oral Sciences. Professor Thomson conducts research in the broad fields of dental epidemiology, dental public health and dental health services. His work over the years has had considerable impact in socio-dental epidemiology, health services research and understanding of the oral health of older people. His influential life-course work in the renowned Dunedin Study has been complemented by his pivotal role in the development and testing of a number of important self-report measures now in wide use in oral health care. His contribution to new knowledge is best evidenced by his inclusion as one of the top contributors to dental public health research in the last half century in a published bibliometric analysis (doi: 10.1111/cdoe.12249).

To date, Professor Thomson has published 351 research papers and 5 book chapters in the scientific literature; his Scopus h index is 48, and his Google Scholar h index is 70. Professor Thomson was a co-recipient of the Prime Minister’s Science Prize in 2016 and has been honoured with two IADR Distinguished Scientist Awards (the 2010 H. Trendley Dean Memorial Award and the 2014 Geriatric Oral Research Award).

Professor Thomson will be speaking on the topic: “Poor oral health casts a long shadow: findings from the Dunedin Study”

Overview of the topic: Imagine what we could find out about oral health if we followed an entire birth cohort from the cradle to the grave. The Dunedin Multidisciplinary Health and Development Study is one such study, having followed 1037 individuals born in Dunedin in 1972-3, with the most recent assessments undertaken at age 45. It has produced unprecedented and important information on the natural history of oral health and disease through the life course. In this presentation, Professor Thomson will share some findings from that study.

Please register your attendance with the event coordinator: Jane Burnell, RSVP mandatory at events-dent-ohcwa@uwa.edu.au by 5.00pm Tuesday 12 November 2019. Light refreshments will be served from 6.00pm with the lecture to commence at 6.30pm. This is an excellent, complimentary continuing education event brought to you by the UWA Dental School.

“Poor oral health casts a long shadow: findings from the Dunedin Study”

School of Human Sciences Seminar Series

Title: Heat Therapy: An ancient practice to target modern diseases

Presenter: Christopher T. Minson, Phd Kenneth and Kenda Singer Professor

When: Wednesday 27 November 2019 @ 1pm

Venue: John Bloomfield Lecture Theatre, UWA, School of Human Sciences (Exercise and Sport

Science) adjacent to Parkway Entrance 3. Parking on Parkway and in UWA carpark entrances 3 & 4.

https://goo.gl/maps/D1RQGxN5wGNUZfdRA

Presentation Summary: Chronic heat exposure, in the form of saunas, hot water baths, and sweat lodges have been utilized in many cultures for thousands of years. While repetitive bouts of heat exposure is generally believed to be healthy, it is only recently that we are beginning to understand the full benefits of ‘heat therapy’ across the spectrum of human health. Passive heating results in a rise in body temperature and changes in cardiovascular hemodynamics, including altered shear patterns of blood flow. There is growing evidence that these responses to acute heat stress combine over repetitive sessions to provide a stress-resistant profile to counter inflammation and oxidative

stress, as occurs with aging and chronic disease, as well as from acute damaging events such as ischemia-reperfusion injury. There is also growing evidence heat therapy can be used to target metabolic dysfunction in obesity and diabetes through improvements in insulin signaling in fat and muscle cells. This ancient therapy needs broader application to treat modern diseases, particularly in those not able to obtain the full benefits of exercise.

Speaker Biography: Dr. Christopher Minson is the Kenneth and Kenda Singer Professor of Human Physiology. His research focuses on topics related to integrative cardiovascular physiology in humans. His lab investigates how we can use exposures to extreme environments to gain a healthy and resilient physiology. He is also involved in projects related to endocrine function in women, biomarkers of aging and the risk of cardiovascular and metabolic diseases, and finding novel ways to improve thermal comfort and safely in work environments. He also works with elite athletes in the use of environmental stressors to improve performance.

Christine Page (Mon - Wed) Academic Services Officer School of Human Sciences, Faculty of Science Service • M309, 35 Stirling Hwy, Perth WA 6009 Australia T +61 8 6488 7126 • E christine.page@uwa.edu.au

CRICOS Code: 00126G

Blinded by the light: the role of miRNA in light induced retinal degenerations

Summary of the Presentation: Age-Related Macular Degeneration (AMD) is the leading cause of blindness in the western world, affecting ~200 million people globally with an expected prevalence of ~288 million by 2040. Unless treatments are found to slow the progression of these diseases, 1 in 7 of us over the age of 50 will be affected by degeneration of our central vision, leading in many cases to irreparable blindness. In this seminar Dr. Riccardo Natoli (The Australian National University, Canberra) will discuss his laboratory's work on retinal microRNA (miRNA), the master regulators of gene transcription, and how by understanding their role in retinal degenerations we might develop novel therapeutics and diagnostics for treating retinal diseases such as AMD.

Short Bio

I am interested in novel strategies that reduce the severity and progression of Age-related Macular Degeneration (AMD). I aim to understand the factors that cause photoreceptors to die, and identify novel ways to protect them from degeneration. My recent work focuses on the role of microRNA (miRNA) in the degenerating retina, and examines their potential use as therapeutics. My ground-breaking work into understanding and treating this disease is funded by competitive funding agencies (such as Ophthalmic Research Institute of Australia, Retina Australia and the National Health and Medical Research Council), industry partnerships (such as EyeCo, BetaTherapeutics and Thermo Fisher Scientific), through innovation investment funding (Discovery Translational Fund) and in 2018 was awarded the prestigious ANU Translational Fellowship, all contributing to achieving my aim to address this major global health issue. I have also developed a non-invasive treatment strategy to revolutionise the management of premature infants at risk of developing Retinopathy of Prematurity (ROP) and increasing survivability, currently and ongoing collaboration with members of the ANU Medical School and Canberra Hospital. I have contributed to 50 publications, as well as presented at international and national conferences including the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, International Society for Eye Research (ISER) the International Symposium on Retinal Degeneration (RD). I consider research-led education as an integral part of a researcher’s career. I am a lecturer in genetics and cell biology in the ANU Medical School, supervise/co-supervise 6 PhD students. I helped to establish, and convene the JCSMR HDR Mentoring Program, as well as am 2nd Year Coordinator for the ANU Medical School. In 2017, I established Clear Vision Research to support the next generation of vision researchers (www.clearvisionresearch.com).

First 25 registrants

for early bird deal!

Friday 6th September

Abstract submissions

close

Join us in Melbourne for EAPS19 to present your research to your peers and

hear from world-class researchers! We welcome and

encourage all Honours,Masters & PhD Students to

attend and submit an abstract.

Invited speakersProf. Christine Wells, The University of Melbourne

Prof. Nadia Rosenthal, The Jackson Laboratories (USA)Dr. Damien Bates, BioCurate

Dr. Chris Langmead, Monash Institute of Pharmaceutical SciencesDr. Talitha Santini, The University of Western Australia

Dr. Irene Gallego Romero, The University of MelbourneProf. Matt Sweet, Institute of Molecular Bioscience, UQ

Prof. Ricky W. Johnstone, Peter MacCallum Cancer CentreA/Prof. Enzo Porrello, Murdoch Children’s Research Institute

Follow us!w https://eaps.org.au/

f @EMBLAphdsymposium @EMBLAuSymposium

Monday 10th June

Registration Open

Friday 1st November

Registration close

Meet interstate and international

speakers and researchers from

various disciplines!

The 6th Annual EMBL Australia Postgraduate Symposium

From Models to SystemsDeciphering Biological Complexity

27-29 November 2019Victorian Comprehensive Cancer Centre, Melbourne

Telethon Kids

Research Seminars

Monday 2 December 2019

3.00pm – 4.00pm

Telethon Kids Institute Seminar Room

Level 5, Perth Children’s Hospital

Invited Guest Speaker

Assoc Professor Jasper SchipperijnResearch Unit, Active Living

University of Southern Denmark

Jasper Schipperijn is an Associate Professor with the Research Unit for Active Living atthe University of Southern Denmark. His research focuses on studying the relationbetween the built and natural environment and human behavior, and in particularevaluating the effect of changes to the environment on behavior. One of his interestlies in developing methods to objectively describe behavior and the environment thatbehavior takes place in. Much of his work builds on intervention studies or naturalexperiments that involved changes to the built environment, e.g. creating orrenovating schoolyards, urban green spaces, public open space, and bicycling facilities.Jasper has published over 85 peer-reviewed articles and numerous reports andpopular publications.Jasper has an extensive international network and he is president-elect for theInternational Society of Physical Activity and Health (ISPAH).

“Changing the Built Environment changes children’s behaviour”

Streaming link : click herePassword telethonkids_seminar

Tuesday 3 December 2019

12pm – 1pm

Conference Room; The Niche

11 Aberdare Road, Nedlands

A light lunch will be provided at 11.30am

RSVP: piper.marsh@mdwa.org.auor 9380 3400

Telethon Kids

Research Seminars

Nicole SheersPhD Candidate, Institute for Breathing and SleepSenior Respiratory Physiotherapist, Victorian Respiratory Support Service, Austin Health

Airway clearance techniques: why, what, and when?

A clinician-researcher’s approach

Nicole is a senior physiotherapist with extensive clinicalexperience in implementing non-invasive ventilationand providing acute and long-term respiratoryphysiotherapy management for adults with chronicventilatory failure.

She has completed a randomised controlled trialinvestigating the effects of Lung Volume Recruitment(“breath-stacking”) on respiratory function, symptomsand quality of life of people living with NeuromuscularDisease, and will shortly submit her PhD on this topic.She was a member of the 228th EuropeanNeuromuscular Centre (ENMC) International Workshopon Airway Clearance Techniques in NeuromuscularDisorders which produced two “State of the Art”publications in this field, and has presented at nationaland international conferences and workshops.

Beginner workshop for microbiome-omics data analysis 3-5 Feb 2020, Perth (AUS)

Complex microbial networks have a central role in the provision and regulation ofecosystems. Multiple microbial biotechnology applications are contributing to globalefforts to achieve sustainability - through purification of wastewater, waste valorisation,bioenergy production, or to understand the role of microbiome in human disease andhealthy states.

Statistical analysis of microbiome data is challenging due to the inherent characteristicsof the data, such as high sparsity and compositional structure. Our workshop will discussthese challenges, and introduce major concepts of multivariate dimension methodsdeveloped in mixOmics. Methods in mixOmics make no distributional assumptions, arehighly flexible for unsupervised (exploratory), supervised (classification) and integrationanalyses. Various analytical frameworks will be presented ranging from dataexploration, selection of markers, integration with other omics datasets andintroduction to time-course analysis. Each methodology will be illustrated on realbiological studies. The third day is ‘BYO data’ day where you can reinforce yourlearnings on your own study! Note that the workshop is not limited to microbiome dataonly, as we will cover general omics data integration concepts. More information on ourwebsite.

Pre-requisite: a good working knowledge in R programming (e.g. handling data frame, perform simple calculations and display simple graphical outputs) to fully benefit from the course.

Instructor: Dr Kim-Anh Lê Cao

Four RHD students bursaries to cover 50% of the registration costs are generously sponsored by WAHTN. Register your interest here. EOI closes: 4 Nov 5pm AEST. Bursary recipients and registration link will be sent after this date.

Hosted by West Australian Heath Translational Network (WAHTN) and WA Human Microbiome Collaborating Centre (WAHMCC), Curtin University.