SEEINGIS BELIEVINGThe Emprint™ SX ablation platform gives you confidence in targeting accuracy with real-time 3-D ultrasound navigation1,2

THE FIRST AND ONLY INTEGRATED ABLATION PLATFORMWITH REAL-TIME 3-D ULTRASOUND NAVIGATION

The Emprint™ SX ablation platform is a cutting-edge, integrated surgical navigation and ablation platform that reduces procedural complexity and this has been shown to improve the targeting accuracy of soft tissue ablation.3–5

∙ Navigation software has been shown to improve successful antenna placement versus standard ultrasound guidance upon first attempt.3

∙ 3-D visualization of the potential ablation zone helps ensure complete coverage of the target.3,6

∙ Thermosphere™ technology creates predictable, spherical ablation zones.7

∙ Intuitive interface with a step-by-step guided setup and context-sensitive troubleshooting, makes the system easy to use.1

Fully integrated ablation and navigation hardware platform

Designed with an intuitive interface1 to help staff easily set up the system

System cart is designed to have small footprint and mobile for use in the OR

Platform is compatible with laparoscopic and open (BK™ and Aloka™) ultrasound transducers

HD touch screen to control and display the ablation system

Reinforced antenna shaft

IMPROVES SUCCESSFUL ANTENNA PLACEMENT

% First time hit* * *#

USG 3DG

Nov Int Exp

USG 3DG USG 3DG

Hit

Miss

3-D US Guidance significantly improves 1st time target rate. *p<0.001 USG vs. 3DG US. #p<0.05 Exp vs. Nov and Int, n = 40 targeting attempts per group

100

80

60

40

20

0

Targeting and antenna placement using ultrasound is challenging. Failure to accurately place a MWA antenna increases the risk of incomplete ablation and local recurrence.

To master antenna placement requires time, practice, and a comprehensive understanding of anatomical landmarks.

A recent study evaluated whether the Emprint™ SX ablation platform affected time and accuracy of antenna placement in a laparoscopic training model.3 This study concluded that this unique 3-D ultrasound guided (3DG) ablation platform improves successful antenna placement versus standard ultrasound guidance (USG). Results were independent of user experience and improvements were most pronounced in inexperienced users.

System characteristics that enable these results include:

∙ Advanced 3-D tracking shows the position of the Emprint™ SX ablation antenna and ultrasound transducer relative to the surgeon’s perspective in real-time.2

∙ Projected antenna path allows trajectory planning prior to antenna placement.1,3,6

Targets (7–10 mm) were set in agar within a laparoscopic training device. Novices (no surgical experience), intermediates (surgical residents), and experts (HPB surgeons) were asked to locate and hit targets using a MWA antenna. Participants located 10 targets using ultrasound only and 10 targets using the Emprint™ SX ablation system. There were 4 participants per experience group.

% Hit <30 seconds* * *§

100

80

60

40

20

0USG 3DG

Nov Int Exp

USG 3DG USG 3DG

3-D US Guidance significantly improves time to hit target following acquisition. *p<0.001 USG vs. 3DG US. §p<0.05 Exp vs. Nov and Int, n = 40 targeting attempts per group

Hit

Miss

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5920 Longbow DriveBoulder, CO 80534

800.255.8522303.581.6898

SKU Brand Descriptor

CASYS100 Emprint™ SX Ablation platform with Thermosphere™ technology

SKU Brand Descriptor

CAFG1 Emprint™ SX Field generator

CAFGCART1 Emprint™ SX Field generator cart

CAFGSP1 Emprint™ SX Field generator spacer

CAUS1SN Emprint™ SX Ultrasound surgical navigation application

SKU Brand Descriptor

CA15L2N Emprint™ SX Short navigation antenna with Thermosphere™ technology

CA20L2N Emprint™ SX Standard navigation antenna with Thermosphere™ technology

CA30L2N Emprint™ SX Long navigation antenna with Thermosphere™ technology

CAAL9132 Emprint™ SX Open ultrasound tracking sensor

CAAL9150L Emprint™ SX Laparoscopic ultrasound tracking sensor

CABK8816 Emprint™ SX Open ultrasound tracking sensor

CABK8666L Emprint™ SX Laparoscopic ultrasound tracking sensor

References1. Based on internal test report #RE00097926, Validation survey memo. June 2017.

2. AIM™* Software Design Specification (Internal Document) Jan 2017.

3. Sastry, AV, Swet, JH, Murphy KJ, et al. A novel 3-dimensional electromagnetic guidance system increases intraoperative microwave antenna placement accuracy. HPB 2017.

4. Based on internal document #RE00122445. Ablation Navigation Competitive Assessment and Outlook. 2017.

5. Based on internal document #RE00079331. Revolution Hardware Architecture Design. 2017.

6. Based on internal test report #RE00085823, Emprint™ SX system validation report.April 2017.

7. Based on Internal report #RE00059555, Emprint™ SX system bench tissue performance verification. March 2017.

*Navigation software provided by InnerOptic Technology, INC