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Section I

General questions

Medical ethic and deontology in therapeutic practice.

Extragenital diseases and pregnancy: contraindications for pregnancy, therapeutic

approach to pregnant women with hypertension, valvular heart disease,

glomerulonephritis.

Main nosological entities

RESPIRATORY SYSTEM DISEASES

Acute and chronic (non-obstructive) bronchitis: etiology, pathogenesis, clinical

manifestations, diagnostics, clinical variants, complications, treatment.

Pneumonia: etiology, pathogenesis, basic clinical manifestations, diagnostics,

classification, severity, complications. Basic treatment strategies.

Pneumonia caused by atypical pathogens: clinical peculiarities, diagnostics,

treatment.

Chronic obstructive lung disease: background characteristic, etiology and

pathogenesis, risk factors, diagnostics, stages of disease, treatment, complications,

prophylaxis.

Bronchial asthma: etiology, pathogenesis, basic clinical manifestations, clinical

variants, diagnostics, complications, treatment principles.

Pleural diseases and pleural effusion: etiology, pathogenesis, basic clinical

manifestations, diagnostics, differential diagnostics between exudate and transudate,

treatment principles.

Pulmonary heart: etiology, pathogenesis, basic clinical manifestations, diagnostics,

classification, treatment principles.

CARDIOVASCULAR SYSTEM DISEASES

Ischemic heart disease: etiology, pathogenesis, risk factors, classification,

prophylaxis.

Clinical forms of angina pectoris, diagnostics, patient management, treatment

principles.

Myocardial infarction: etiology, pathogenesis, clinical variants (typical and

atypical). Myocardial infarction diagnostics. Patient management, treatment principles.

Complications of myocardial infarction.

Arterial hypertension: etiology, pathogenesis, clinical manifestations,

classification, diagnostics, risk stratification, treatment principles.

Symptomatic hypertension: classification, diagnostics, treatment strategies.

Somatoform autonomic dysfunction: etiology, pathogenesis, clinical variants,

diagnostics, treatment principles.

Myocarditis: etiology, pathogenesis, classification, clinical manifestations,

diagnostics, treatment principles.

Cardiomyopathy: definition, classification, clinical variants, diagnostics, treatment

principles.

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Pericarditis: etiology, pathogenesis, classification, clinical manifestations,

diagnostics, treatment principles.

Infective endocarditis: etiology, pathogenesis, diagnostic criterions, classification,

clinical picture, diagnosis verification methods. Indications for cardiosurgical treatment

or pharmacological therapy. Basic principles of antibacterial therapy.

Chronic heart failure: etiology, pathogenesis, basic clinical manifestations,

classification, diagnostics, treatment principles.

Cardiac arrhythmias: classification. Antiarrhythmic drugs.

Extrasystole: etiology, pathogenesis, classification, clinical manifestations,

diagnostics, prognosis, treatment principles.

Heart blocks: etiology, pathogenesis, clinical manifestations, diagnostics,

prognosis, treatment principles.

Interventional and cardiosurgical technologies in cardiovascular diseases:

Интервенционные и кардиохирургические технологии при болезнях системы

кровообращения: criteria of patient selection for coronary angiography, indications for

interventions.

GASTROINTESTINAL SYSTEM DISEASES

Gastroesophageal reflux disease: pathogenesis, clinical manifestations,

diagnostics, treatment principles.

Functional gastric indigestion and chronic gastritis: cause of pathology, clinical

manifestations, classification, diagnostics, treatment principles.

Gastroduodenal ulcer disease: etiology, pathogenesis, clinical manifestations,

diagnostics, treatment strategies.

Chronic cholecystitis: etiology, clinical manifestations, diagnostics, treatment

principles.

Chronic hepatitis: etiology, pathogenesis, classification, basic clinical and

biochemical syndromes, diagnostics, treatment principles.

Liver cirrhosis: etiology, classification, morphological characteristic, clinical

laboratory syndromes, diagnostics, complications, treatment principles.

Chronic pancreatitis: etiology, pathogenesis, clinical variants, diagnostics,

treatment principles.

Irritable bowel syndrome. Basic clinical manifestations, diagnostics, treatment

principles.

Bowel inflammatory diseases (Chron's disease, ulcerative colitis). Basic clinical

syndromes, diagnostics, treatment principles.

RENAL DISEASES Acute glomerulonephritis: etiology, pathogenesis, clinical variants, diagnostics,

treatment principles.

Chronic glomerulonephritis: etiology, pathogenesis, clinical and morphological

variants, diagnostics, outcomes, treatment principles.

Tubulo-interstitial nephritis: cause of development, clinical manifestations,

diagnostics, treatment.

Chronic pyelonephritis: etiology, pathogenesis, clinical manifestations,

diagnostics, treatment strategies.

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Renal amyloidosis: etiology, pathogenesis, clinical manifestations, diagnostics,

outcomes, treatment strategies.

Nephrotic sydrome: etiology, clinical and laboratory criteria, treatment.

Chronic kidney disease: classification, diagnostics. Treatment strategies according

to the stage, indications for medical rehabilitation expert board (MREB).

RHEUMATIC DISEASES

Acute rheumatic fever: etiology, pathogenesis, clinical manifestations,

diagnostics, treatment.

Mitral valve disease: etiology, hemodynamic compromise, clinical manifestations,

treatment strategies.

Aortic valve disease: etiology, hemodynamic compromise, clinical manifestations,

treatment strategies.

Osteoarthritis: etiology, pathogenesis, classification, clinical manifestations,

diagnostics, disease course, treatment.

Rheumatoid arthritis: etiology, pathogenesis, classification, disease course,

outcomes, treatment.

Gout: etiology, pathogenesis, clinical manifestations, classification, diagnostics,

disease course, treatment.

System lupus erythematosus: etiology, pathogenesis, clinical manifestations,

diagnostics, disease course, outcomes, treatment.

Dermatomyositis: etiology, pathogenesis, clinical manifestations, diagnostics,

disease course, outcomes, treatment.

Systemic sclerosis: etiology, pathogenesis, basic clinical manifestations,

diagnostics and treatment principles.

Systemic vasculitides: main nosological entities, diagnostics and treatment

principles.

Reactive arthritides: etiology, clinical manifestations, diagnostics, treatment.

Spondyloarthritides: Спондилоартриты: basic forms, clinical manifestations,

diagnostics, treatment.

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BLOOD SYSTEM DISEASES

Anemia: etiology, pathogenesis, classification, clinical manifestations, diagnostics,

treatment principles.

Leukemia: etiology, pathogenesis, classification, clinical manifestations,

diagnostics, treatment principles.

Polycythaemia vera: etiology, pathogenesis, clinical manifestations, diagnostics,

outcomes, treatment principles. Secondary polycythaemia.

Multiple myeloma: clinical manifestations, diagnostics, treatment.

Hemorrhagic diathesis: etiology, pathogenesis, classification. Clinical

manifestations and treatment of trombocytopenic purpura.

Section II

METABOLIC AND ENDOCRINE SYSTEM DISEASES

Diffuse toxic goiter (Graves-Bazedov's disease): etiopathogenesis, clinical

picture, diagnostics, treatment principles.

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Hypothyroidism: etiology, pathogenesis, basic clinical manifestations,

diagnostics, treatment principles.

Nodular goiter: etiology, pathogenesis, clinical manifestations, treatment.

Diabetes mellitus: classification, characteristics of clinical manifestations,

treatment and prophylaxis for type 1 diabetes mellitus and type 2 diabetes mellitus.

Classification of diabetes mellitus complications. Long-term complications of

diabetes, principles of treatment. Differential diagnostics of diabetic comas.

Obesity: classification, diagnostics, treatment.

CLINICAL IMMUNOLOGY, ALLERGOLOGY

Autoimmune diseases: pathogenesis, clinical manifestations. Pathogenetic (basic)

therapy of autoimmune diseases. Diagnostics of autoimmune diseases.

Laboratory methods for diagnostics of autoimmune diseases. Immunocorrectors.

Clinical and laboratory diagnostics of immunodeficiencies.

The role of the study of HLA-antigens in the diagnostics of internal diseases.

Types of allergic reactions. Pseudoallergy. Paraclinical methods of diagnostics of

allergy.

Nosological forms associated with specific types of allergic reactions. Specific

desensitization in allergic diseases.

Side effects of drugs: etiology, pathogenesis, classification, clinical manifestations

and course, treatment.

PHTHISIOPULMONOLOGY

Organization of the internist work on early detection and prevention of

tuberculosis among the population.

Methods of examination of patients with suspected tuberculosis of the respiratory

system. Required diagnostic minimum, additional methods of examination.

Methods of bacteriological diagnostics of tuberculosis. Patient examination for the

detection of mycobacterium tuberculosis.

Differential diagnostics of infiltrative processes in the lungs (infiltrative

tuberculosis, pneumonia, lung atelectasis).

Differential diagnostics of rounded formations in the lungs (focal tuberculosis,

tuberculoma, lung tumors).

Differential diagnostics of pulmonary dissemination (disseminated tuberculosis,

sarcoidosis, carcinomatosis, alveolitis).

Differential diagnostics of cavities in the lungs (cavernous tuberculosis, abscess,

lung cancer).

Caseous pneumonia. Clinical picture, diagnostics, differential diagnostics and

treatment.

Miliary tuberculosis of the lungs. Clinical picture, diagnostics, differential

diagnostics and treatment.

Chronic forms of tuberculosis (cavernous, fibrous-cavernous, cirrhotic). Clinical

picture, diagnostics, differential diagnostics and treatment.

Pleurisy. Clinical picture, diagnostics, differential diagnostics and treatment.

Tuberculous meningitis. Clinical picture, diagnostics, differential diagnostics and

treatment.

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Pulmonary hemorrhage, clinical picture, diagnostics, differential diagnostics,

emergency aid.

Spontaneous pneumothorax, clinical picture, diagnostics, differential diagnostics,

emergency care.

Sarcoidosis. Etiology, pathogenesis, classification of clinical forms.

Sarcoidosis of the respiratory system. Clinical picture, diagnostics, differential

diagnostics and treatment.

Current principles and methods of treatment of tuberculosis. Clinical categories of

patients in chemotherapy.

Current international strategies for the fight against tuberculosis.

HIV-associated tuberculosis, clinical picture, diagnostics, treatment and

prevention.

Multi-drug-resistant tuberculosis (definition, tactics of treatment).

Section III

EMERGENCY AND URGENT CONDITIONS AND MEDICAL CARE

AT THEIR OCCURANCE

Emergency medical care in case of pulmonary hemorrhage.

Status asthmaticus (acute severe asthma exacerbation) urgent treatment.

Acute respiratory failure: causes, diagnostics, differential therapy.

Asthma attack urgent care. Tactics of primary care physician at intractable asthma

attack.

Diagnostics and emergency treatment of spontaneous pneumothorax.

Urgent therapy of pulmonary bleeding and hemoptysis.

ST-segment elevation acute coronary syndrome: pre-hospital organizational and

diagnostic measures, urgent medical care, choice of reperfusion method (pre-hospital

thrombolysis, primary PCI, pharmaco-invasive strategy).

Non-ST-segment elevation acute coronary syndrome: pre-hospital organizational

and diagnostic measures, urgent medical care, risk stratification with the GRACE scale.

Urgent measures in case of intractable chest pain syndrome.

Syncopes in internal diseases: classification, risk stratification for adverse

outcomes, urgent medical care, indications for hospitalization.

Hypertensive crisis urgent medical care in the outpatient setting and in hospital.

Paroxysmal atrial fibrillation: clinical features, diagnostics, urgent activities in the

outpatient setting and in hospital.

Emergency treatment for acute left ventricular failure.

Diagnostics of aortic aneurysm dissection. Urgent medical care.

Emergency medical care for pulmonary edema.

Diagnostics and urgent therapy of pulmonary embolism.

Emergency medical care for a paroxysmal wide QRS complex tachycardia

(ventricular tachycardia).

Emergency medical care for a paroxysmal narrow QRS complex tachycardia

(supraventricular tachycardia).

Emergency medical measures in ventricular tachycardia.

Urgent medical care in case of complete atrioventricular block.

“An acute abdomen”: definition, clinical picture, tactics of internist.

Diagnostics and treatment tactics at biliary colic.

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Diagnostics and urgent measures for hepatic coma.

Diagnostics and urgent medical care for gastrointestinal bleeding.

Emergency medical care and tactics at unspecified coma.

Alcohol poisoning: clinical manifestations, urgent medical care.

Acute adrenal insufficiency: diagnostics, treatment principles and urgent medical

care.

Acute kidney failure: diagnostics, urgent therapy.

Uremic coma: clinical picture, diagnostics, urgent medical care.

Diagnostics and urgent measures for agranulocytosis.

Urgent therapy for hypoglycemic coma.

Urgent therapy for hyperglycemic coma.

Anaphylactic shock: diagnostics, urgent measures.

Urticaria and angioedema: urgent medical care, medical tactics.

Lyell's syndrome. Urgent measures.

Urgent medical care for acute impairment of cerebral circulation.

Urgent medical care for delirium.

Section IV

INFECTIOUS DISEASES

Typhoid fever, paratyphoid A, B. Pathogenesis, clinical manifestations, diagnosis,

complications of typhoid fever, differential diagnosis, treatment.

Hepatitis A and E: epidemiology, clinical manifestations, diagnosis, treatment.

Acute hepatitis B, D. Etiology, epidemiological features and clinical

manifestations. Marker diagnostics, principles of treatment and prevention of post-

exposure and vertical transmission of infection.

Diagnosis and treatment of complications of acute viral hepatitis. Acute liver

failure.

Acute hepatitis C. Etiology, epidemiological features and clinical manifestations.

Marker diagnostics, principles of treatment and prevention.

Chronic hepatitis B, D. Marker diagnostics. Natural course, approaches to therapy.

Chronic hepatitis C. Natural course, diagnosis, approaches to therapy.

Definition of jaundice. Differential diagnosis of jaundice.

Meningococcal infection: clinical classification, principles of diagnosis and

therapy, prevention.

Meningococcal infection: meningococcal meningitis. Clinical manifestations.

Diagnostics. Treatment.

Meningococcal infection: meningococcemia, clinical manifestations, diagnosis,

treatment. Fulminant form of meningococcemia. Intensive therapy.

Meningococcal infection: complications. Principles of therapy of infectious-toxic

shock, edema-swelling of the brain.

Enterovirus infection: human enterovirus, epidemiology, pathogenesis, clinical

forms, treatment.

Tick borreliosis: etiology, pathogenesis, clinical picture of the I stage of the

disease, diagnosis, treatment.

Tick borreliosis: etiology, pathogenesis, clinical picture of stage II of the disease,

diagnosis, treatment.

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Differential diagnosis of meningitis.

Tick-borne encephalitis: clinical manifestations, diagnosis, treatment.

Herpetic infection. Classification. Epstein-Barr virus infection: clinical

manifestations, diagnosis, treatment.

Herpetic infection. Classification. Localized forms of herpetic infection (Herpes

labialis, herpes nosalis). Clinical manifestations, diagnosis, principles of therapy.

Herpetic infection. Classification. Localized forms of herpetic infection (Herpes

zoster). Clinical manifestations, diagnosis, principles of therapy.

Herpetic infection. Varicella, cytomegalovirus infection. Clinical manifestations,

diagnosis, principles of therapy.

Influenza: clinical manifestations, diagnosis, indications for etiotropic therapy,

complications. Adenovirus infection. Clinical features, approaches to diagnosis, treatment,

complications. Course features of acute respiratory diseases in children and the elderly.

Food toxic infection: etiology, clinical picture. First aid for food toxic infection.

Principles of therapy.

Botulism: etiology, clinical picture, diagnosis, treatment, prevention. Intensive

therapy.

Pathogenetic classification of infectious diarrhea. Degrees of dehydration.

Indications for the appointment of antibiotic therapy. Principles of rehydration.

Cholera: etiology, classification, clinical picture, diagnosis, complications.

Principles of treatment.

Salmonellosis: clinical manifestations, diagnosis, treatment and prevention.

Shigellosis: etiology, clinical manifestations, diagnosis, treatment, prevention.

Differential diagnosis of diarrhea (infectious and non-infectious diarrhea).

Malaria: etiology, clinical picture, diagnosis, differential diagnosis, complications

of malaria, treatment, prevention.

HIV infection: etiology, diagnosis, treatment, prevention. Early clinical signs of

HIV infection.

Characteristics of major opportunistic infections. Clinical manifestations and

treatment of neurotoxoplasmosis.

Characteristics of major opportunistic infections. Pneumocystis pneumonia.

Clinical picture, diagnosis, treatment.

Clinical indications for testing for HIV infection in outpatient department.

Sepsis: etiology, pathogenesis, modern clinical classification.

Sepsis: syndrome of multiple organ failure. Septic shock.

Diagnosis and treatment of sepsis. Antibacterial therapy. Pathogenetic therapy of

complicated sepsis.

Erysipelas: etiology, clinical picture, complications, diagnosis, treatment.

Tetanus: etiology, clinical picture, complications, diagnosis, principles of therapy,

prevention.

Rabies: etiology, prevalence, clinical manifestations, diagnosis, prevention.

Leptospirosis: etiology, characteristics of the pathogen, epidemiology. Sources of

infection and transmission routes. Clinical picture, diagnosis, treatment.

Hemorrhagic fever with kidney syndrome. Clinical picture, laboratory diagnostics,

treatment.

Trichinellosis: etiology, pathogenesis, clinical picture, diagnosis, treatment.

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Diphtheria in adults: etiology, pathogenesis, clinical picture, laboratory

diagnostics, treatment.

Infectious-toxic, hypovolemic, anaphylactic shock. Modern approaches to

emergency therapy.

Fever of unclear etiology in the clinical manifestations of infectious diseases.

Differential diagnosis of exanthem (meningococcal infection, measles,

leptospirosis, infectious mononucleosis, lime-borreliosis).

Plague, anthrax: prevalence, etiology, transmission routes, clinical picture,

laboratory diagnosis, treatment.

Section V

LIST OF MAJOR MEDICINES.

For each of the following medicines, the graduate should name the clinico-

pharmacological group, the characteristics of the drug, indications and

contraindications to use, side effects, be able to prescribe a prescription.

1. Azithromycin

2. Allopurinol

3. Ambroxol

4. Aminophylline

5. Amiodarone

6. Amlodipine

7. Amoxicillin

8. Atorvastatin

9. Atropine sulfate

10. Acetylsalicylic acid

11. Acetylcysteine

12. Acyclovir

13. Beclomethasone

14. Bisoprolol

15. Budesonide

16. Valsartan

17. Warfarin

18. Verapamil

19. Amicacin

20. Hydrochlorothiazide

21. Gliklazid

22. Dexamethasone

23. Digoxin

24. Diclofenac

25. Diltiazem

26. Diphenhydramine

27. Doxycycline

28. Domperidone

29. Drotaverine

30. Iron sulfate with ascorbic acid

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31. Zopiclone

32. Ibuprofen

33. Isosorbide mononitrate

34. Indapamide

35. Ipratropium bromide

36. Captopril

37. Carvedilol

38. Ketorolac

39. Clarithromycin

40. Clemastine

41. Clopidogrel

42. Levothyroxine

43. Levofloxacin

44. Linezolid

45. Lysinopril

46. Losartan

47. Loperamide

48. Loratadine

49. Magnesium sulfate

50. Mebendazole

51. Meloksicam

52. Meropenem

53. Methylprednisolone

54. Metoclopramide

55. Montelukast

56. Metoprolol

57. Methotrexate

58. Metronidazole

59. Metformin

60. Moxonidine

61. Insulin

62. Nebivolol

63. Nimesulide

64. Nifedipine

65. Oseltamivir

66. Omeprazole

67. Ofloxacin

68. Paracetamol

69. Pentoxifylline

70. Perindopril

71. Prednisolone

72. Procainamide

73. Propaphenone

74. Propranolol

75. Ramipril

76. Rosuvastatin

77. Salbutamol

78. Salmeterol

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79. Sertraline

80. Sotalol

81. Spironolactone

82. Strophantin K

83. Terbinafin

84. Tramadol

85. Tiotropium bromide

86. Trinitrate of glycerin

87. Torasemide

88. Ursodeoxycholic acid

89. Fenoterol

90. Fluconazol

91. Furosemide

92. Celecoxib

93. Ceftazidim

94. Cefuroxim

95. Cefepim

96. Ceftriaxone

97. Ciprofloxacin

98. Enalapril

99. Epinephrine

100. Etacizin

Head of the 1st Department of Internal diseases,

professor S.E. Alexeychick

Head of the 2nd Department of Internal diseases,

professor N.F. Soroka

Head of the Department of Cardiology and Internal diseases,

professor N.P. Mitkovskaya

Head of Department of Polyclinic therapy,

associate Professor E.V. Yakovleva

Head of Department of Infectious diseases,

professor I.A. Karpov