Blood Pressure

Section 5, Chapter 15

Blood Pressure

• Blood pressure is the force the blood exerts against the inner walls of the blood vessels

• Usually refers to pressure in systemic arteries

Arterial blood pressure:Arterial blood pressure:

• Rises with ventricular contractions and falls as ventricles relax

• Systolic pressure is the maximum pressure during ventricular contraction

• Diastolic pressure is the minimum pressure when the ventricles relax

1. Cardiac Output- volume of blood ejected from one ventricle per minute

• Product of heart rate and stroke volume

Stroke Volume

• Volume of blood expelled from ventricle with each contraction

• Average = 70 milliliters per beat (mL/beat) for adult male

Factors that influence blood pressure

Heart Rate

• Average = 72 beats per minute

Stroke Volume 70 mL/beat

X Heart Rate70 beats/minute

= Cardiac Output5040mL/minute

Example:

Factors that influence blood pressure

Cardiac output (and blood pressure) increases with an increase in stroke volume or heart rate.

2. Blood Volume

• Average blood volume in adults = 5 Liters (1.3 gallons)

• As blood volume increases, blood pressure initially increases

3. Peripheral Resistance

• Peripheral resistance = friction between blood and blood vessels

Factors that influence blood pressure

• Peripheral resistance = friction between blood and blood vessels

• Vasoconstriction increases resistance and increases blood pressure

• Vasodilation decreases blood pressure

4. Viscosity of blood

• Viscosity = resistance of a fluid to flow (thickness of a fluid).

• Blood cells and some plasma proteins increase the viscosity of blood.

• Anemia (deficiency of red blood cells) reduces viscosity & lowers

blood pressure

Factors that influence blood pressure

Figure 15.24. Some of the factors

that influence arterial blood pressure

Control of Blood Pressure

A combination of factors control blood pressure. These include stroke

volume, heart rate, and peripheral resistance:

Figure 15.36 Controlling cardiac output and peripheral resistance regulates blood pressure

Control of Blood Pressure

Factors that affect stroke volume

• End-diastolic volume (EDV)

• Volume of blood in ventricles at the end of ventricular diastole

• Ventricles are filled with blood

• End-systolic volume (ESV)

• Volume of blood in ventricles at the end of ventricular systole• Volume of blood in ventricles at the end of ventricular systole

• Only 60% of blood is expelled from heart during a normal contraction

• Increasing the force of ventricular contractions decreases ESV

• Stroke volume = EDV– ESV

• Increase stroke volume by increasing EDV or decreasing ESV

stroke volume

Stroke Volume is directly related to the force of ventricular contraction.

Two events that occur in the ventricles coincide with stroke volume:

1. End-diastolic volume (EDV)

Volume of blood in ventricles at the end of ventricular diastole

As ventricles fill with blood, muscle fibers are mechanically

stretched - preloadstretched - preload

2. End-systolic volume (ESV)

Volume of blood in ventricles at the end of ventricular systole

A normal health heart expels 60% of blood present in ventricle.

stroke volume

Stroke Volume is the difference between end diastolic

volume (EDV) and end systolic volume (ESV): Stroke Volume = EDV - ESV

Frank-Starling Principle:

• The ability of a heart muscle to generate force depends on the original • The ability of a heart muscle to generate force depends on the original

stretch of a muscle prior to contraction (similar to stretching a rubber band)

• The degree of stretch (preload) of the myocardial fibers before contraction

determines the stroke volume

• A greater end diastolic volume results in a greater force of contraction,

leading to a greater stroke volume.

•Blood pressure rapidly decreases as the blood moves through the

arterial system and into the capillary network.

•Little pressure remains in the veins, therefore heart actions contribute

very little to venous return.

Venous Return

Figure 15H

Blood pressure decreases as blood

moves away from the heart.

•Venous return depends on:

•Skeletal muscle contractions – massaging actions push blood towards heart

•Respiratory movements – generates pressure in abdominal and thoracic cavities

•Changes in pressure pushes blood along veins

•Vasoconstriction – contraction of smooth muscles in tunica media

Venous Return

•Vasoconstriction – contraction of smooth muscles in tunica media

•Sympathetic reflexes vasoconstrict the smooth muscles in veins, which can

propel additional blood from venous reservoir towards the heart.

ARTERIAL SYSTEM

Aorta

•Main trunk of the systemic circulation.

Divisions of the aorta

•Aortic root = attachment to heart

•Ascending Aorta

•Aortic arch

•Thoracic aorta

•Abdominal aorta

STRUCTURES AT AORTIC ROOT

1. Aortic Valve

2. Aortic Sinus

• Swelling at aortic root

3. Right and left coronary arteries

• Supply blood to myocardium of the heart• Supply blood to myocardium of the heart

• Myocardial infarction = blocked coronary artery

3. Aortic Bodies

• Chemoreceptors - monitor CO2 & O2 levels in blood

BRANCHES OF AORTIC ARCH

1. Brachiocephalic Artery

Brachiocephalic artery divides into:

• Right common carotid artery -Supplies blood to

right side of face and head

• Right subclavian artery - Supplies blood to right

armarm

2. Left common carotid artery – supplies blood to left

side of face and head

3. Left subclavian artery – supplies blood to left arm

Figure 15.42 The major branches of the aortic arch are highlighted in yellow.

End of Section 5, Chapter 15