Direttore: Prof. Paolo Martelletti

Scuola di Specializzazione in Medicina Interna

09/11/2016Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

Pagina 2

ESAME I ANNO

Dott.ssa Mara La Rocca

Scuola di Specializzazione in Medicina Interna

aa 2014/15Sapienza Università di Roma

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

09/01/17 Pagina 3

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

JAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 409/11/2016Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

27.000 decessi all’anno in USA

Patogenesi:

Ospite suscettibile

Paziente esposto a terapia antibiotica

Sufficiente esposizione al microrganismo• C.d. è parte della flora batterica

intestinale normale• Le spore di C.d. sopravvivono

nell’ambiente per mesi

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 509/11/2016

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 609/11/2016Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 709/11/2016

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 809/11/2016

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Kaplan-Meier Plot Showing Survival Free From Clostridium difficile Infection (CDI) Through 14 Days, Stratified According to the Antibiotics Received by the Prior Bed Occupant

Pagina 909/11/2016

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Pagina 1009/11/2016Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed

Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same BedJAMA Intern Med. Published online October 10, 2016. doi:10.1001/jamainternmed.2016.6193

Schematic Depicting Risk Factors Significantly Associated With Increased Risk for Clostridium difficile Infection (CDI)Multiple risk factors were identified related to the subsequent patient but, of all the potential risk factors examined that were related to the prior bed occupant, only antibiotics were associated with increased risk for CDI in subsequent patients. ICU indicates intensive care unit.