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  • Scientific Contributions

    from the EPIC Project

    European Prospective Investigation into Cancer and Nutrition

  • Scientific Contributions from the EPIC Project

    2 3

    Scientific Contributions from the EPIC Project

    This dossier was prepared by the Barcelona EPIC coordinating centre, of the Unit of Nutrition, Environ- ment and Cancer, Cancer Research Programme, Catalan Institute of Oncology (ICO-IDIBELL).

    August 2011

    INDEX

    1. ABOUT EPIC 4

    2. CENTERS AND PRINCIPAL INVESTIGATORS 5

    3. ASSOCIATED PROJECTS 8

    4. MAIN CONTRIBUTIONS

    4.1. Rerearch Published in Top Medical Journals 9

    4.2. Research Published from Participation in International Cohorts Consortiums 12

    4.3. Other Main Contribution From the EPIC Study 17

    4.3.1. Aero-Digestive Tract and Oesophageal Cancer 17

    4.3.2. Lung Cancer 17

    4.3.3. Gastric Cancer 19

    4.3.4. Pancreas Cancer 22

    4.3.5. Colorectal Cancer 23

    4.3.6. Breast Cancer 26

    4.3.7. Ovarian Cancer 30

    4.3.8. Endometrial and Cervical Cancer 31

    4.3.9. Prostate Cancer 32

    4.3.10. Bladder Cancer 35

    4.3.11. Renal Cancer 36

    4.3.12. Lymphomas 37

    4.3.13. Brain Cancer 38

    4.3.14. Cancer Incidence 38

    4.3.15. Dietary Intake and Life Style 39

    4.3.16. Smoking 46

    4.3.17. Cardiovascular Disease 47

    4.3.18. Methodology 48

    4.4. Contributions from Spanish EPIC cohort 50

  • Scientific Contributions from the EPIC Project

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    Scientific Contributions from the EPIC Project

    1. ABOUT EPIC

    EPIC was promoted by the International Agency of Research of Cancer (IARC-WHO) and initially funded by the the Europe Against Cancer Program of the European Commission and National Agencies and Governments. It was designed to in- vestigate the relationships between diet, nutritional status, lifestyle, genetic and environmental factors and the incidence of cancer and other chronic diseases. EPIC is the largest study on diet and health with blood samples, ever undertaken, having recruited over half a million (520,000) people of both sexes in ten European countries: Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom.

    Within these countries, EPIC scientists are based in 23 research centres: one in France (Paris), Greece (Athens) and Norway (Tromsø), two in Denmark (Aarhus and Copenhagen), Germany (Heidelberg and Potsdam), Sweden (Malmo and Umea), the Netherlands (Bilthoven and Utrecht) and the United Kingdom (Cambridge and Oxford), five in Italy (Florence, Milan, Naples, Ragusa and Turin) and six in Spain (Asturias, Barcelona, Granada, Murcia, Pamplona, and San Sebastian). EPIC is co- ordinated by Dr Elio Riboli, Head of the Division of Epidemiology, Public Health and Primary Care at the Imperial College London in the United Kingdom.

    Recruitment into the study, which was initiated in 1992, was principally from the general population, aged mostly 30-69 years, and took place between 1993 and 1999. Detailed information on diet and lifestyle was obtained by questionnaire, and anthropometric measurements and blood samples were taken at recruitment. The biological samples are stored in liquid nitrogen for laboratory analyses. By studying a very large sample of individuals in different countries with differing diets, using carefully designed and validated questionnaires and biological markers, EPIC is producing more scientific information about the determinants of chronic diseases than any previous study.

    EPIC is now preparing for a new assessment of dietary and lifestyle information, new anthropometric measurements, and the collection of a second blood sample from surviving individuals from the original cohort. It is planned to follow-up the study participants for at least the next 10-15 years, to continue studying the role of nutrition, lifestyle and susceptibility factors in cancer development as well as for other chronic diseases such as cardiovacular diseases, diabetes, neurological diseases and ageing

    Further information can be found at http://epic.iarc.fr/.

    2. CENTERS AND PRINCIPAL INVESTIGATORS

    Lyon/France

    International Agency for Research on Cancer (IARC-WHO)

    PI: Dr. Isabelle Romieu

    London/United Kingdom

    Imperial College London

    PI: Dr. Elio Riboli (Coordinator)

    Denmark

    The Danish Cancer Society, Institute of Cancer Epidemiology. Copenhague.

    PI: Dr. Anne Tjønneland

    Dept of Epidemiology, Institute of Public Health, Aarhus University. Aarhus.

    PI: Dr. Kim Overvad

  • Scientific Contributions from the EPIC Project

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    Scientific Contributions from the EPIC Project

    France

    INSERM. Institut Gustave Roussy

    PI: Dr. Françoise Clavel-Chapelon

    Germany

    Division of Cancer Epidemiology. German Cancer Research Centre. Heidelberg.

    PI: Dr. Rudolph Kaaks

    Department of Epidemiology. Deutsches Institut für Ernährungsforschung. Potsdam.

    PI: Dr. Heiner Boeing

    Greece

    WHO Collaborating Center for Food and Nutrition Policies. Department of Hygiene, Epidemiology and Medical Statistics. National and Kapodistrian University of Athens Medical School. Athens.

    PI: Dr. Antonia Trichopoulou

    Italy

    Molecular and Nutrional Epidemiology Unit, ISPO. Cancer Prevention and Research Institute. Florence.

    PI: Dr. Domenico Palli

    Department of Predictive and Prevention Medicine. Fondazione IRCCS Istituto Nazionale dei Tumori. Milan.

    PI: Dr. Vittorio Krogh

    U.O.S. Registro Tumori e U.O.C. Anatomia Patologica , Ospedale “Civile M.P.Arezzo” ASP 7. Ragusa.

    PI: Dr. Rosario Tumino

    Imperial College London and HuGEF Foundation. Turin

    PI: Dr. Paolo Vineis

    Dipartimento di Medicina Clinica e Sperimentale Universita di Napoli, Federico II. Naples.

    PI: Dr. Salvatore Panico

    Norway

    Institute of Community Medicine. University of Tromsø.

    PI: Dr. Eiliv Lund

    Spain

    Unit of Nutrition, Environment and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology. Barcelona.

    PI: Dr. Carlos A. González

    Dirección General de Salud Pública y Participación. Consejería de Salud y Servicios Sanitarios de Asturias.

    PI: Dr José R. Quirós

    Escuela Andaluza de Salud Pública. CIBER de Epidemiología y Salud Pública. Granada.

    PI: Dr. Maria José Sánchez

    Department of Epidemiology. Consejería de Sanidad y Consumo. Murcia.

    PI: Dr. Carmen Navarro

    Instituto de Salud Pública. Gobierno de Navarra.

    PI: Dr. Aurelio Barricarte

    Subdirección de Salud Pública de Gipuzkoa. Gobierno Vasco. San Sebastian.

    PI: Dr. Miren Dorronsoro

    Sweden

    Dept of Surgery. Malmö University Hospital. Lund University. Malmö.

    PI: Dr. Jonas Manjer

    Dept of Public Health and Clinical Medicine. Umeå University. Umeå.

    PI: Dr. Göran Hallmans

    The Netherlands

    Centre for Nutrition and Health. National Institute of Public Health and the Environment (RIVM). Bilthoven.

    PI: Dr. Bas Bueno de Mesquita

    Julius Center for Health Sciences and Primary Care. Dept of Epidemiology. University Medical Center Utrecht. Utrecht.

    PI: Dr. Petra HM Peeters

    United Kingdom

    Institute of Public Health. University of Cambridge. Cambridge.

    PI: Dr. Kay-Tee Khaw

    Cancer Epidemiology Unit. University of Oxford. Oxford.

    PI: Dr. Timothy Key

  • Scientific Contributions from the EPIC Project

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    Scientific Contributions from the EPIC Project

    3. ASSOCIATED PROJECTS

    » InterAct (Diabetes type II)

    » EPIC Heart (Cardiovascular Diseases)

    » EPIC Elderly (Ageing)

    » Neuro-EPIC (Neuro degenerative diseases)

    4. MAIN CONTRIBUTIONS

    4.1. RESEARCH PUBLISHED IN TOP MEDICAL JOURNALS

    1. Schütze M, Boeing H, Pischon T, Rehm J, Kehoe T, Gmel G, Olsen A, Tjønneland AM, Dahm CC, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Zylis D, Kaaks R, Rohrmann S, Palli D, Berrino F, Tumino R, Vineis P, Rodrí- guez L, Agudo A, Sánchez MJ, Dorronsoro M, Chirlaque MD, Barricarte A, Peeters PH, van Gils CH, Khaw KT, Wareham N, Allen NE, Key TJ, Boffetta P, Slimani N, Jenab M, Romaguera D, Wark PA, Riboli E, Bergmann MM.

    Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study.

    BMJ. 2011 Apr 7;342:d1584. doi: 10.1136/bmj.d1584.

    2. van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, Jenab M, Pischon T, Jansen EH, Frohlich J, Ayyobi A, Overvad K, Toft-Petersen AP, Tjønneland A, Hansen L, Boutron-Ruault MC, Clavel-Chapelon F, Cottet V, Palli D, Tagliabue G, Panico S, Tu- mino R, Vineis P, Kaaks R, Teucher B, Boeing H, Drogan D, Trichopoulou A, Lagiou P, Dilis V, Peeters PH, Siersema PD, Rodríguez L, González CA, Molina-Montes E, Dorronsoro M, Tormo MJ, Barricarte A, Palmqvist R, Hallmans G, Khaw KT, Tsilidis KK, Crowe FL, Chajes V, Fedirko V, Rinaldi S, Norat T, Riboli E.

    Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition.

    Gut. 2011 Mar 7.

    3. Johansson M, Relton C, Ueland PM, Vollset SE, Midttun Ø, N