SARC Career Development Award Program Richard Gorlick, MD Lee Helman, MD.

SARC Career Development Award Program

Richard Gorlick, MD

Lee Helman, MD

SARC Career Development Award

Fund established 2007Initial award granted 2009

Incorporated into the SARC sarcoma SPORE in 2013

Purpose• To help prepare and support scientists working

in sarcoma as they begin their careers as independent researchers

SARC Career Development Award

Committee R. Gorlick, Co-Chair L. Helman, Co-Chair J. Crowley J. Fletcher M. Thornton

F. Hornicek D. Lev C. Mackall M. van de Rijn S. Schuetze L. Schwartz

SARC Career Development Program 2014

SARC Sarcoma SPORE Career Development AwardRequires awardees to be US citizens

SARC is interested in continued support of researchers internationally

Two funding opportunitiesUS based researcher International researcher

SARC SPORE CDA

CriteriaFinal year of clinical fellowship or postdoctoral

fellowship, or within five years of first faculty appointment

Demonstrated track record of interest and productivity in research relevant to sarcoma

US citizenFunding Level

$100,000 per year, for up to two years

International CDA

CriteriaFinal year of clinical fellowship or postdoctoral

fellowship, or within five years of first faculty appointment

Demonstrated track record of interest and productivity in research relevant to sarcoma

Citizenship outside USFunding Level

$100,000 per year, for up to two years

Application Process

Two step processLetter of IntentFull application

Letter of intent dueJanuary 3, 2014

Contact SARC with any [email protected]

mailto:[email protected]

2009 Career Development Award Recipients

• Anchorage-independent conditions as a model for micrometastatic disease in osteosarcoma

• Targeted therapy of Ewing’s Sarcoma via IGF-1R signaling cascade

Sandra Strauss, MD, PhDUniversity College London

Joseph Ludwig, MDUniversity of Texas, MD Anderson

Cancer Center


• Novel genomic approach to risk-stratify and identify relapse-associated copy number alterations in Ewing’s sarcoma

Patrick J. Grohar, MD, PhDFellow, National Cancer Institute

• Development of a Small Molecule Therapy Targeting EWS-FLI1

Joshua D. Schiffman, MDAssistant Professor, University of Utah


• Adoptive T-cell therapy for patients with metastatic sarcoma

Keila Enitt Torres, MD, PhDUniversity of Texas, MD Anderson

Cancer Center• The role of the

P13K/AKT/mTOR pathway in radiation associated sarcoma (RAS)

Seth M. Pollack, MDUniversity of Washington/Fred

Hutchinson Cancer Research Center


• Exploiting Argininosuccinate Synthase 1 Deficiency in Sarcoma.

Adrián Mariño-Enríquez, MD Harvard Medical School, Brigham and

Women’s Hospital, Department of Pathology

• Genome-wide functional characterization of GIST: Strategies to maximize kinase-inhibitor response

Brian A. Van Tine, MD, PhDWashington University, Division of Medical Oncology Director, and Assistant Professor,

Division of Medical Oncology


Simone Hettmer, MD,Dana Farber Cancer Institute

Cigall Kadoch, PhDBroad Institute

John Shern, MDNational Cancer Institute

• Identifying novel therapies in pediatric RMS using high-throughput screening for inhibitors of the PAX3-FOX01 Oncogenic transcription factor

• Evaluation of the contributions of candidate RMS-relevant genes/pathways in RMS malignancy

• Reversing the roles of misdirected chromatin remodeling in human synovial sarcoma

2014 Career Development Application Key Dates

January 3, 2014Letter of Intent

March 31, 2014Submission of Grant Proposal

July 1, 2013Funding Period Begins

SARC Career Development Award Program Richard Gorlick, MD Lee Helman, MD.

Documents

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