Samplicity Filtration System: The Ideal Sample Prep System
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Break free fromroutine sample prepSamplicity Filtration System
EMD Millipore is a division of Merck KGaA, Damstadt, Germany
http://www.millipore.com/lab_filtration/flx4/samplicity&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SP -
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Breaking the sampleprep bottleneck:Doing more with less
The overall trend in chromatography is to do more
with lessmore samples, more complex analyses,
more analyses per sample, with less volume, lower
concentrations, in less time, with fast analytical
techniques such as Ultra-High Pressure Liquid
Chromatography (UHPLC).
Even though efcient, high quality sample prep is crucial
in obtaining reliable data from these ultrasensitive
techniques, there have been few recent advances in
sample prep technology. As a result, its often sample
preparation, not analysis, thats the rate-limiting
bottleneck in chromatography.
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The rst vacuum-driven system with the designed in
exibility to lter 1 to 8 samples directly into standard
HPLC sample vials, the Samplicity Filtration System has the
potential to break the sample prep bottleneck. Just attach
a vacuum pump, load your samples, and ip the lever.
Recover your particulate-free samples in seconds.
Built upon decades of our membrane ltration expertise,
the systems Millex Samplicity lters have a unique
funnel shape for easy pipette loading and are provided
in strips of four for faster loading. The lter strips are
perforated for use with fewer samples.
The ideal sample prep systemfor most chromatographers
The Solution:EMD Millipores Samplicity Filtration SystemThe rst vacuum-driven system with the designed in fexibility to lter 1 to 8 samples directly into standard
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Over 60% of Chromatographersprocess 10 - 100 samples a day
Low Throughput(1 - 10 Samples/Day)
Medium Throughput(10 - 100 Samples/Day)
High Throughput(>96 Samples/Day)
Most chromatographers (65%, according to a recent
EMD Millipore survey) process 10-100 samples a day into
vials. For them, single-sample syringe lters, robotics and
plate-based ltration systems are equally impractical.
The Samplicity Filtration System eliminates the tedium of
syringe ltration and the space requirements and expense
of robotics.
The Samplicity Filtration System is ideal for QC and R&D
labs along with users in diverse elds, including:
Drug dissolution testing mandatory evaluation of the
dissolution rate of solid dosage forms in the digestive
tract
Food safety testing foods and beverages for unknown
and known toxins, including glycol, melamine, and
cyanobacteria
Cosmetics separation and detection of cosmetic
ingredients and formulations
Biofuels analysis and extraction of lipids from algae
and other biomass Pharmacokinetic/pharmacodynamic (PK/PD) testing
quantication of interactions of drugs with the body
with respect to time
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Faster processing time:
Up to eight samples in seconds.
No sample foaming or bubbles, for better
sample recovery and accurate autosampling.
To compare the speed of the Samplicity system with
syringe ltration, either four or eight 1.0 mL samples of
1% Pepto-Bismol (viscosity 7-10 cP) were ltered by 13
users. On average, the Samplicity system accelerated four-
sample ltration by 26%, and it accelerated eight-sample
ltration by 35%.*
In the Samplicity systems unique design, the vials are
held at an angle and the tip of the lter touches the side
of the vial as the sample is being ltered. These features
reduce foaming and sample spillover and trapping of air
bubbles at the bottom of vials. This is especially important
when working with vials containing low volumes or conical
inserts.
Ergonomic benets: Less force, more comfort.
Average user ratings of manual force required and comfort
levels for operating syringe lters vs. the Samplicity
Filtration System show the Samplicity system requires
virtually no manual force for ltration.*
*The information presented is based on preliminary development results. Device performance in specic applications may be different.
The Samplicity Filtration Systemoutperforms manual ltration.
4 Samples(26% time savings)
8 Samples(35% time savings)
0
50
100
150
200
250
300
350
Syringe Filtration
Samplicity System
AverageRatings
SamplicitySyringe
6.54
10
8
6
4
2
0
0.69
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Starting volume: 500 L Starting volume: 500 L
150 L 400 L
Syringe ltration Samplicity ltration
Built on over 40 years ofmembrane expertise,Millex Samplicity lters were designed with the best, most
versatile membrane for ltering chromatography samplesour
hydrophilic polytetrauoroethylene (PTFE) lters retain >95%
of particulate impurities.
Higher yields for small sample volumes: low holdup volume enables
you to do more analyses with each precious sample.
Millex Samplicity Filtersprovide maximum versatility with highest quality.
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Low extractables from hydrophilic PTFE: broad chemical
compatibility of hydrophilic PTFE means fewer leached impurities
can contaminate the sample for downstream analysis.
Mass spectrometry detects few extractable impurities from Millex syringe lter (A) con-
taining a 0.45 m pore, hydrophilic PTFE membrane. In contrast, a syringe lter containing
0.45 m pore polypropylene membrane (non-Millipore, B) shows signicant extractables.
3.0E+06
Peak
In
tensity
Highest Peak Intensity: 0.8 E5
2.5E+06
2.0E+06
1.5E+06
1.0E+06
5.0E+06
0.0E+06
100 200 300300 400 500 600
M/Z
700 800 900 1000
A. Millex Filter Unit, PTFE
3.0E+06
Peak
Intensity
Highest Peak Intensity: 2.5 E6
2.5E+06
2.0E+06
1.5E+06
1.0E+06
5.0E+06
0.0E+06
100 200 300300 400 500 600
M/Z
700 800 900 1000
B. Non-Millipore, Polypropylene
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Hydrophilic PTFE membrane consistently provides greater than 90% drug recovery in the
rst mL of ltrate, indicating low drug binding to PTFE compared to nylon. Four drug
samples were ltered through Millex lters containing PTFE or nylon.
Pre-washing Millex Samplicity Filters is easy.If your application requires pre-washing lters prior to nal ltration and analysis, a
waste tray can be inserted into the Samplicity system to facilitate this step. When pre-
washing lters using the Samplicity system, the waste tray is placed on the base in place
of the vial tray and the solvent or sample is ltered through the Millex Samplicity lters
using vacuum, similar to normal operation. Once the lters are pre-washed, the same
lters would be used for sample ltration and collection into vials.
A. PTFE
100%
PercentDrug
Recovery
Volume Filtered, mL
90%
80%
70%
60%
50%
40%
0 1 2 3 4 5 6 7 8 9 10 11
Ranitidine
Acetaminophen
Ibuprofen
Loratidine
B. Nylon
,
100%
Percent
Drug
Recovery
Volume Filtered, mL
90%
80%
70%
60%
50%
40%
0 1 2 3 4 5 6 7 8 9 10 11
Ranitidine
Acetaminophen
Ibuprofen
Loratidine
Low analyte binding: waste less sample during ltration so you can
accurately quantitate low levels of analytes present in the sample.
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Now you can truly do more with less.Combine the Samplicity Filtration System with state-of-the-art separation technologies.
Solvents through Filters
Filtered samples
from Samplicity system
Ultrapure Water
Columns
Chromatogram
Break free from routine sample prepand enjoy successful chromatography.
The Samplicity system provides higher yields with low
hold-up volume, fast processing, and ease of use. And in
addition to ergonomic benets, the system creates less
waste than syringe ltration and eliminates the need to
segregate syringe waste.
Together with EMD Millipores mobile phases, solvent
ltration systems, columns, and water purication systems,
the Samplicity Filtration System is the key to staying on
the cutting edge of chromatographic separation.
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Required Accessories for Samplicity Filtration System
Description Catalogue Number
Chemical Duty Pump, 115 V/60 Hz WP6111560
Chemical Duty Pump, 220 V/50 Hz WP6122050
Chemical Duty Pump, 100 V/5060 Hz WP6110060
Samplicity Filtration SystemChoose the unit color to t your lab bold blue or glossy green!
Samplicity Systems and Accessories Catalogue Number
Samplicity Filtration System, Glossy Green SAMPSYSGR
Samplicity Filtration System, Bold Blue SAMPSYSBL
Samplicity Filtration System Vial Trays, 2/pack SAMVIALTR
Samplicity Filtration System Waste Trays, 5/pack SAMWASTTR
Samplicity Filtration System Tube Set Assembly SAMTUBING
Samplicity Filtration System Replacement Lid SAMSYSLID
Millex Samplicity Filters Catalogue Number
Millex Samplicity Filters, 0.20 m Hydrophilic PTFE, 96/pack SAMPLG001
Millex Samplicity Filters, 0.45 m Hydrophilic PTFE, 96/pack SAMPLCR01
Millex Samplicity Filters, 0.20 m Hydrophilic PTFE, 384/pack SAMPLG004
Millex Samplicity Filters, 0.45 m Hydrophilic PTFE, 384/pack SAMPLCR04
To place your order or for complete product informationvisit www.millipore.com
http://www.millipore.com/catalogue/item/WP6111560&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6122050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6110060&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSGR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSBL&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMVIALTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMWASTTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMTUBING&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMSYSLID&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG001&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR01&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG004&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR04&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6110060&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6122050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/WP6111560&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR04&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG004&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLCR01&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPLG001&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMSYSLID&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMTUBING&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMWASTTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMVIALTR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSBL&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SAMPSYSGR&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SP -
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Related Products: Featured Mobile Phases and Columns for Liquid ChromatographyAvailable from www.emdchemicals.com
Description Catalogue Number or URL
Acetonitrile, LiChrosolv Gradient Grade 1.00030
Ethanol, LiChrosolv Gradient Grade 1.11727
Methanol, LiChrosolv Gradient Grade 1.06007
Acetonitrile, LiChrosolv Hypergrade for LC-MS 1.00029
Methanol, LiChrosolv Hypergrade for LC-MS 1.06035
Purospher STAR RP-18 Endcapped UHPLC Columns 1.50650
Chromolith monolithic ready-to-use HPLC columnswww.emdchemicals.com/
chromatography
Related Products: Mobile Phase Filtration
Disc FiltersAvailable from www.millipore.com
Filter Holders
Description Catalogue Number
0.2 m Durapore PVDF Membrane Filter, 47 mm GVWP04700
0.2 m Durapore PVDF Membrane Fi lter, 90 mm GVWP09050
0.2 m Millipore Express PLUS PES membrane Filter, 47 mm GPWP04700
0.2 m Millipore Express PLUS PES membrane Filter, 90 mm GPWP09050
0.2 m Omnipore PTFE Membrane Filter, 47 mm JGWP04700
0.2 m Omnipore PTFE Membrane Filter, 90 mm JGWP09025
0.2 m Nylon Membrane Filter, 47 mm GNWP04700
0.2 m Fluoropore Membrane Filter, 47 mm FGLP04700
Stericup-GP Filter, 500 mL SCGPU05RESteritop-GP Filter, 500 mL SCGPS05RE
Description Catalogue Number
47 mm, all glass lter holder with 250 mL funnel XX1504700
90 mm glass lter holder with stainless steel screen,
with 1 L funnel
XX1009020
Filter forceps, blunt-tipped, sterilizable XX6200006P
http://www.emd-chemicals.com/life-science-research?WT.mc_id=5USEN1039http://www.emd-chemicals.com/products/EMD_CHEM-1.50650?WT.mc_id=5USEN1039http://www.emdchemicals.com/chromatography/c_Ttyb.s1Ly6IAAAEWmuAfVhTl?WT.mc_id=5USEN1039http://www.emdchemicals.com/chromatography/c_Ttyb.s1Ly6IAAAEWmuAfVhTl?WT.mc_id=5USEN1039http://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GVWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GVWP09050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GPWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GPWP09050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/JGWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/JGWP09025&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GNWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/FGLP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SCGPU05RE&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SCGPS05RE&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/XX1504700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/XX1009020&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/XX6200006P&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.emd-chemicals.com/life-science-research?WT.mc_id=5USEN1039http://www.millipore.com/catalogue/item/XX6200006P&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/XX1009020&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/XX1504700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SCGPS05RE&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/SCGPU05RE&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/FGLP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GNWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/JGWP09025&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/JGWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GPWP09050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GPWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GVWP09050&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.millipore.com/catalogue/item/GVWP04700&cid=BIOS-S-EPDF-1173-1107-SPhttp://www.emd-chemicals.com/products/EMD_CHEM-1.50650?WT.mc_id=5USEN1039http://www.emdchemicals.com/chromatography/c_Ttyb.s1Ly6IAAAEWmuAfVhTl?WT.mc_id=5USEN1039http://www.millipore.com/?cid=BIOS-S-EPDF-1173-1107-SP -
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LiChrosolv, Chromoligh and Purospher are registered trademarks and EMD Millipore and the M logo aretrademarks of Merck KGaA, Darmstadt, Germany.Durapore, Stericup, Millex, Milli-Q, Millipore Express are registered trademarks and Samplicity, Millex Sam-plicity, Omnipore, Fluoropore, Millivac and LC-Pak are trademarks of Millipore Corporation.Lit. No. PB0018EN00 07/2011 LS-SBU-11-04354 Printed in the U.S.A.2011 Millipore Corporation. All rights reserved.
Use Milli-Q ultrapure water purication systems to ensure that your mobile phases are
free of organic contaminants, for the best, most reproducible chromatographic results.
Especially when tted with a 0.2 m nal lter, Milli-Q systems are the ideal water source
for UHPLC, LC-MS, and other ultrasensitive analyses.
Laboratory Water Systems for ChromatographyLearn more at www.millipore.com/labwater.
Description Catalogue Number
Milli-Q Integral 15 Pure (15 L/hour) and Ultrapure Water Production Unit with built-in resistivity
and TOC meter
ZRXQ015T0*
Milli-Q Advantage A10 Ultrapure Water Purication System Z00Q0V0WW*
LC-Pak point-of-use polisher for the production of at least 500 L of ultrapure water for organictrace analysis
LCPAK0001*
*Contact your local EMD Millipore sales representative for a country-specic part number.
High Quality Ultrapure WaterCan Improve Chromatographic Performance
www.millipore.com
To Place an Order or ReceiveTechnical AssistanceIn the U.S. and Canada, call toll-free 1-800-645-5476
For other countries across Europe and the world,
please visitwww.millipore.com/ofces
For Technical Service, please visit
www.millipore.com/techservice
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